scholarly journals Endometrioid Paraovarian Borderline Cystic Tumor in an Infant with Proteus Syndrome

2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Liliana Vasquez ◽  
Mariela Tello ◽  
Ivan Maza ◽  
Monica Oscanoa ◽  
Milagros Dueñas ◽  
...  
Keyword(s):  
Germ Cell ◽  
Genital Tract ◽  
Germ Cell Tumors ◽  
Cystic Tumor ◽  
Proteus Syndrome ◽  
Rare Syndrome ◽  
Epithelial Tumors ◽  
Adnexal Tumor ◽  
Borderline Malignancy ◽  
Asymptomatic Infant

Ovarian and paraovarian neoplasms are uncommon in children, mainly originating from germ cell tumors and, least frequently, epithelial tumors. There is an association between genital tract tumors and Proteus syndrome, a rare, sporadic, and progressive entity, characterized by a postnatal overgrowth in several tissues caused by a mosaic mutation in the AKT1 gene. We describe a 20-month-old asymptomatic infant with Proteus syndrome who developed an endometrioid paraovarian borderline cystic tumor. This is the youngest patient so far reported in the literature with this rare syndrome and an adnexal tumor of borderline malignancy. A total of nine patients have been described with female tract tumors and associated Proteus syndrome, which includes bilateral ovarian cystadenomas and other benign masses. A paraovarian neoplasm is extremely rare in children and could be considered a criterion for Proteus syndrome. Standardized staging and treatment of these tumors are not well established; however, most authors conclude that these neoplasms must be treated as their ovarian counterparts.

scholarly journals NI-11 Clinical significance of intracystic diffusion hyperintensity lesions remaining after treatment of intracranial germ cell tumor

2020 ◽  
Vol 2 (Supplement_3) ◽  
pp. ii14-ii14
Author(s):  
Motoki Takano ◽  
Takeshi Takayasu ◽  
Ushio Yonezawa ◽  
Akira Taguchi ◽  
Kazuhiko Sugiyama ◽  
...  
Keyword(s):  
Germ Cell ◽  
Clinical Significance ◽  
Cyst Wall ◽  
High Intensity ◽  
Mature Teratoma ◽  
Germ Cell Tumors ◽  
Residual Tumor ◽  
Cystic Tumor ◽  
Intracranial Germ Cell Tumor ◽  
Intensity Lesion

Abstract Background and purpose: About 30% of intracranial germ cell tumors are mixed germ cell tumors and teratomas are often found as those components. Intense chemoradiotherapy is performed according to the malignancy of the histopathology, but high-intensity lesion inside the cystic tumor on diffusion weighted imaging (DWI) sometimes remains after completion of the chemoradiotherapy. In this study, we examined the clinical significance of the DWI high-intensity lesion remaining in the cyst. METHODS: Five patients after initial chemoradiotherapy were resected residual tumor by craniotomy at our hospital from 2009 to 2019. Preoperative gadolinium-enhanced MRI defined the non-contrast-enhanced part of the tumor as intracystic, and DWI intensity was classified by its look as low-intensity, equal-intensity, and high-intensity compared to the cortex of the same slice. DWI signals in the solid area, cyst wall, and cyst were evaluated. Results: All cases were mature teratoma in histopathology, and no other tumor components were observed. On DWI, the cyst wall and solid part were visualized with low signal. High-intensity lesions and equal-intensity lesions in the cyst cavity were found in 3 and 1 cases, respectively. In these cases, pathological findings revealed a keratin-like substance in the cyst. Discussion: The intracystic high and equal intensity lesions on DWI removed after completion of chemoradiotherapy are considered to reflect the keratin-like component of mature teratoma. If DWI- high intensity and equal intensity lesions remain in the cyst of the tumor after the completion of chemoradiotherapy, tumor shrinkage cannot be expected even if the chemotherapy is strengthened. In such cases, we should consider to removing them by surgery. Conclusion: When DWI high and equal intensity lesions are found in the cysts of tumors remaining after chemoradiotherapy for intracranial germ tumors, it is possible that mature teratoma remains.

Histopathological profile of ovarian tumors in a tertiary care center- a descriptive study

2021 ◽  
Vol 9 (4) ◽  
pp. 1010
Author(s):  
Anitha Pallikkara V. ◽  
Shameem K. Ummer Ali
Keyword(s):  
Germ Cell ◽  
Malignant Tumors ◽  
Care Center ◽  
Tertiary Care ◽  
Age Groups ◽  
Germ Cell Tumors ◽  
Ovarian Tumors ◽  
Benign Tumors ◽  
Medical College ◽  
Epithelial Tumors

Background: Ovarian neoplasms are a heterogeneous group of tumors with varied clinical, morphological and histological features. Ovarian cancer accounts for about 3% of all cancer in females and is the 5th most common cause of death due to cancer because most ovarian tumors spread beyond ovary by the time of diagnosis. The objective of the study was to document the histological pattern and prevalence of ovarian tumors in specimens received at department of pathology government medical college Alappuzha.Methods: This was a prospective study of 18 months duration which comprised of 245 cases of ovariectomy and ovariotomy specimens received in the department of pathology, govt. T.D medical college Alappuzha, Kerala. After detailed and thorough gross examination of the specimens, bits from representative areas were routinely processed and stained with H and E. Tumors were classified as per WHO classification. Appropriate immunohistochemical studies were performed wherever required.Results: Out of 245 cases studied, majority were benign tumors (78.36%), followed by malignant tumors (15. 11%). Borderline tumors comprised (6.53%) of the total cases. Age groups studied ranged from 11-70 years. Epithelial tumors were the most common (76.32%) followed by germ cell tumors (17.55%), sex cord stromal tumors (5.03%) and carcinoma arising in germ cell tumors (0.81%). Serous cystadenoma was found to be the commonest benign tumor and serous cystadenocarcinoma was the commonest malignant ovarian neoplasm.Conclusions: Surface epithelial tumors were the most common ovarian tumors. The maximum number of tumors were noted in the age group 21-40 years. Malignant tumors were common above 40 years. 

scholarly journals Histopathological patterns of ovarian tumors at BPKIHS

2012 ◽  
Vol 10 (2) ◽  
pp. 87-97 ◽  
Author(s):  
A Pradhan ◽  
A K Sinha ◽  
D Upreti
Keyword(s):  
Germ Cell ◽  
Clinical Presentation ◽  
Abdominal Mass ◽  
Germ Cell Tumors ◽  
Ovarian Tumors ◽  
Histological Diagnosis ◽  
Metastatic Tumors ◽  
Cross Sectional ◽  
Epithelial Tumors ◽  
Wide Range

Introduction: Ovarian tumors account for fifth most common cause of cancer related death in females involving a variety of histological diagnosis. It accounts for 6% of all cancers. Though it is one of the treatable cancers due to its sensitivity to anticancer therapies, it frequently does not result in symptoms until the cancer has spread extensively.Objectives: To study the incidence, histopathological spectrum and clinical correlates of ovarian tumours at B.P. Koirala Institute of Health Sciences (BPKIHS).Methods: A cross-sectional study was undertaken during a period of one year (1st Jan. 31st Dec 2006). The tumors were classified according to WHO classification after thorough examination of H&E slides under light microscope. Data on clinical presentation and physical findings were also recorded in each case.Results: There were a total of 83 cases. Surface epithelial tumors emerged as the commonest variety accounting for 47%, followed by Germ cell tumors (45.8%). Sex . cord stromal tumors and metastatic tumors accounted 3.6% each. The age range was 10 . 86 years. Metastatic tumors involved younger age groups. Abdominal mass was the commonest clinical presentation followed by pain abdomen.Conclusion: At BPKIHS, ovarian tumors were found to occur in wide range of age (10-86years) with abdominal mass and pain abdomen being the commonest mode of clinical presentation .Histology revealed that surface epithelial tumors and germ cell tumors together constitute the large majority of the case (92.8%). An accurate histological diagnosis and staging is therapeutically and prognostically important.DOI: http://dx.doi.org/10.3126/hren.v10i2.6570 Health Renaissance 2012; Vol 10 (No.2); 87-97 

scholarly journals Clinicomorphological Study Of Ovarian Lesions

2014 ◽  
Vol 3 (4) ◽  
pp. 17-24
Author(s):  
Sushna Maharjan
Keyword(s):  
Germ Cell ◽  
Abdominal Mass ◽  
Germ Cell Tumors ◽  
Malignant Neoplasm ◽  
Benign Tumors ◽  
Malignant Neoplasms ◽  
Presenting Symptoms ◽  
Epithelial Tumors ◽  
Neoplastic Lesions ◽  
The Common

This prospective study was conducted at College of Medical Sciences-Teaching Hospital (CMS-TH) during December 2008 to May 2010. One hundred and fifty cases were analyzed. Age of the patients, parity, presenting symptoms, types of sur­gery, clinical diagnosis and complications were retrieved from case sheets. Surface epithelial tumors were more frequently observed above 30 years of age, (62.07%) cases. During 1st to 3rd decades of life, 62.8% germ cell tumors were seen; and sex cord tumors were seen in age group 41-60 years only. For all age groups, benign tumors were common than malignant tumors. There were 10.7% unmarried patients, 5.33% nulliparous, 35.55% of parity 1 to 2; 4% pregnant and 20 % postmeno­pausal women. There were 86.67% cases neoplastic, and 13.33% non-neoplastic ovarian lesions; 93.85% benign, 5.38% malignant and 0.77% borderline tumors. Surface epithelial tumors were the most common tumors (53.84%) followed by germ cell tumors (43.85%), constituted 46.7% and 38% among all ovarian lesions. The commonest benign tumors were serous cystadenomas and mature cystic teratomas, constituted 40% cases each. Dysgerminoma was the common malignant neoplasm (2.31%), all were seen in adolescents. Most of the other malignant neoplasms were observed above 40 years of age. Seventy percent (70%) of non-neoplastic lesions were hemorrhagic corpus luteum cysts. The commonest presenting symptom was pain in the lower abdomen (82%) followed by abdominal mass/ or distension (48.7%). Constitutional symp­toms were observed in malignant cases only. Grossly, majority of the ovarian lesions were of size ranging 5 to 15 cm; and 89.93% cystic lesions. There were 48.7% lesions in the right ovary and 45.3% in the left ovary; 6% bilateral ovarian lesions, all of which were observed in benign and non-neoplastic lesions. The common complication observed was torsion (6.7%) followed by rupture of the cysts (6%). Journal of Chitwan Medical College 2013; 3(4); 17-24 DOI: http://dx.doi.org/10.3126/jcmc.v3i4.9549

scholarly journals Histological Variants of Ovarian Tumour in Bangladeshi Women

2017 ◽  
Vol 5 (1-2) ◽  
pp. 40-44
Author(s):  
Shafeya Khanam ◽  
Maliha Rashid ◽  
Zebunnessa Parvin ◽  
Shahnaz Akter Jahan ◽  
Mirza Md Asaduzzaman ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Ovarian Tumour ◽  
Ovarian Tumors ◽  
Benign Tumour ◽  
Epithelial Tumors ◽  
Histological Variants ◽  
Epithelial Origin ◽  
Ovarian Tumours ◽  
Serous Tumors

Objective: Types of ovarian tumour are widely divergent and no age group is immune from ovarian tumour; but certain ages are more vulnerable to develop certain types of tumours. By far, very few studies describing the histological types and subtypes of ovarian tumour in the context of Bangladeshi population have been conducted. The present study was intended to find the histological variants of ovarian tumours in our women. Methods: The present study was carried out in Dhaka Medical College Hospital between July 2001 to June 2002. The total number of patients admitted with a clinical diagnosis of ovarian tumour during the study period was 238, while the total number of gynaecological admissions was 3189. In the present study every alternate patients of ovarian tumour who consented to participate in the study were included as long as 110 cases were met. After admission, history and clinical presentation were recorded and every case was followed till discharge. Provisional diagnosis was made clinically and by ultrasound when 14 cases were excluded for they did not have ovarian tumour at all. The remaining 96 cases were operated and were confirmed by operative and histopathological findings. Results: In the present study proportion of ovarian tumours was 6.52% of all gynecological admissions. The mean age of the patients was found to be 39.5 ± 6.3 years. The peak age incidence of benign ovarian tumors was found to lie between 21-50 years. Malignant ovarian tumors, however was found more commonly after the age of 50 years. After histopathological confirmation of the precise nature of the 96 ovarian tumors, it was found that benign tumour comprised 77% of the cases with malignant tumors occurring in the rest 23%. Among them tumours of epithelial origin formed 70.8% of all ovarian tumors, germ cell tumors 25% and sex-cord stromal tumours made up 4.2%. Among the epithelial tumors, serous tumors were most frequently seen (61.7%), followed by mucinous tumors (35.3%). The percentage of benign serous cystadenomas was 35.5%. The ratio between serous and mucinous cystadenocarcinoma was almost 2:1. Germ cell tumour found in this study was of moderate frequency (25%). Among them 15.6% were mature teratoma (dermoid cyst) followed by 5.2% dysgerminoma. Endodermal sinus tumors were relatively low (3.1%) and there was a case of immature or malignant teratoma. Sex-cord-stromal tumours were of lowest frequency (4.2%) and classified as ovarian fibroma, granulosa-cell tumor and Krukenberg tumour. Conclusion: The study concluded that benign tumour comprised three-quarters of all ovarian tumours with the rest being malignant. Tumours of epithelial origin forms the main bulk, germ cell tumors about one-quarter and sex-cord stromal and metastatic tumors the least. Among the epithelial tumors, serous tumors were most frequently seen, followed by mucinous tumors. Ibrahim Card Med J 2015; 5 (1&2): 40-44

Serum Lactate Dehydrogenase Isoenzyme 1 and Relapse in Patients with Nonseminomatous Testicular Germ Cell Tumors Clinical Stage I

2001 ◽  
Vol 40 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Finn Edler von Eyben ◽  
Ebbe Lindegaard Madsen ◽  
Ole Blaabjerg ◽  
Per Hyltoft Petersen ◽  
Hans von der Maase ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Germ Cell ◽  
Clinical Stage ◽  
Germ Cell Tumors ◽  
Serum Lactate ◽  
Stage I ◽  
Serum Lactate Dehydrogenase ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Dehydrogenase Isoenzyme
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