scholarly journals Risk Factors for Reduced Salivary Flow Rate in a Japanese Population: The Hisayama Study

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Kenji Takeuchi ◽  
Michiko Furuta ◽  
Toru Takeshita ◽  
Yukie Shibata ◽  
Yoshihiro Shimazaki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Serum Albumin ◽  
Regression Model ◽  
Flow Rate ◽  
Salivary Flow ◽  
Community Dwelling ◽  
Salivary Flow Rate ◽  
Multivariate Logistic Regression Model ◽  
Plaque Score

The purpose of this study was to determine distinct risk factors causing reduced salivary flow rate in a community-dwelling population using a prospective cohort study design. This was a 5-year follow-up survey of 1,377 community-dwelling Japanese individuals aged ≥40 years. The salivary flow rate was evaluated at baseline and follow-up by collecting stimulated saliva. Data on demographic characteristics, use of medication, and general and oral health status were obtained at baseline. The relationship between reduced salivary flow rate during the follow-up period and its predictors was evaluated after adjustment for confounding factors. In a multivariate logistic regression model, higher age and plaque score and lower serum albumin levels were significantly associated with greater odds of an obvious reduction in salivary flow rate (age per decade, odds ratio [OR] = 1.25, 95% confidence interval [CI] = 1.03–1.51; serum albumin levels <4 g/dL, OR = 1.60, 95% CI = 1.04–2.46; plaque score ≥1, OR = 1.53, 95% CI = 1.04–2.24). In a multivariate linear regression model, age and plaque score remained independently associated with the increased rate of reduced salivary flow. These results suggest that aging and plaque score are important predictors of reduced salivary flow rate in Japanese adults.

scholarly journals Salivary flow rate and the risk of cognitive impairment among Korean elders: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Minh-Tung Do ◽  
Huong Vu ◽  
Jong-Koo Lee ◽  
Sang-Min Park ◽  
Joung-Sik Son ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Flow Rate ◽  
Salivary Flow ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Salivary Flow Rate ◽  
Multivariable Logistic Regression Analysis ◽  
Sectional Study ◽  
Cross Sectional ◽  
Denture Status

Abstract Background Salivary function has been suggested to be associated with cognitive impairment. However, the effect of salivary flow rate (SFR) on cognitive impairment remains unclear. This study aimed to investigate whether SFR is associated with cognitive impairment among Korean elders. Methods This cross-sectional study included 649 elders aged 65 and older in the Korean community-dwelling population. Cognitive impairment was assessed using the Mini-Mental Status Examination. Unstimulated SFR was measured and dichotomized. Denture status, age, sex, education level, smoking, drinking, diabetes, hypertension, and obesity were considered confounders. Multivariable logistic regression analysis was applied to assess the adjusted association. Stratified analysis by sex and denture status was performed to clarify the effect modification. Results Participants without cognitive impairment showed a higher SFR level than those with cognitive impairment (0.81 mL/min for non-cognitive impairment versus 0.52 mL/min for cognitive impairment, p < 0.001). After controlling for confounders, participants with low SFR (< 0.3 mL/min) were more likely to have cognitive impairment by 1.5 times than participants with normal SFR (odds ratio [OR] = 1.5, confidence interval [CI] = 1.05–2.10). The association of low SFR with cognitive impairment was higher in women and dentate participants: about 10% higher in women (OR = 1.63, CI = 1.07–2.50) and about 22% higher in dentate participants (OR = 1.82, CI = 1.41–2.90). Conclusions Salivary flow rate is independently associated with cognitive impairment among Korean elders. The association was modified in females and dentate elders. Physicians and dentists should consider low SFR and cognitive impairment as a risk factor between them in clinics.

Salivary flow rate and risk of malnutrition - a study among dentate, community-dwelling older people

Gerodontology ◽  
2012 ◽  
Vol 30 (4) ◽  
pp. 270-275 ◽  
Author(s):  
Anna-Maija H. Syrjälä ◽  
Päivi I. Pussinen ◽  
Kaija Komulainen ◽  
Irma Nykänen ◽  
Matti Knuuttila ◽  
...  
Keyword(s):  
Older People ◽  
Flow Rate ◽  
Salivary Flow ◽  
Community Dwelling ◽  
Salivary Flow Rate ◽  
Community Dwelling Older People

scholarly journals Unstimulated Saliva-Related Caries Risk Factors in Individuals with Cystic Fibrosis: A Cross-Sectional Analysis of Unstimulated Salivary Flow, pH, and Buffering Capacity

2016 ◽  
Vol 51 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Alaa A. Alkhateeb ◽  
Lloyd A. Mancl ◽  
Richard B. Presland ◽  
Marilynn L. Rothen ◽  
Donald L. Chi
Keyword(s):  
Risk Factors ◽  
Cystic Fibrosis ◽  
Dental Caries ◽  
Flow Rate ◽  
Salivary Flow ◽  
Buffering Capacity ◽  
Salivary Flow Rate ◽  
Caries Prevalence ◽  
Caries Risk ◽  
Salivary Ph

Salivary flow rate, pH, and buffering capacity are associated with dental caries, but studies from the cystic fibrosis (CF) literature are inconclusive regarding these salivary factors and caries. The aim of this study was to evaluate these factors and their associations with dental caries in individuals with CF. Unstimulated whole saliva was collected from individuals aged 6-20 years at Seattle Children's Hospital CF Clinic, USA (n = 83). Salivary flow rate was measured in milliliters per minute. Salivary pH was assessed using a laboratory pH meter. Buffering capacity was assessed by titration with HCl. The outcome measure was caries prevalence, defined as the number of decayed, missing, or filled primary and permanent tooth surfaces. Spearman's rank correlation coefficient and the t test were used to test for bivariate associations. Multiple variable linear regression models were used to (1) run confounder-adjusted analyses and (2) assess for potential interactions. There was no significant association between salivary flow rate or buffering capacity and caries prevalence. There was a significant negative association between salivary pH and caries prevalence, but this association was no longer significant after adjusting for age. There was no significant interaction between salivary flow rate and buffering capacity or between antibiotic use and the 3 salivary factors. Our results indicate that unstimulated salivary factors are not associated with dental caries prevalence in individuals with CF. Future studies should investigate other potential saliva-related caries risk factors in individuals with CF such as cariogenic bacteria levels, salivary host defense peptide levels, and medication use.

scholarly journals Association between anorexia and hyposalivation in community-dwelling older adults in Japan: a 6-year longitudinal study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yuki Ohara ◽  
Hisashi Kawai ◽  
Maki Shirobe ◽  
Keiko Motokawa ◽  
Yoshinori Fujiwara ◽  
...  
Keyword(s):  
Older Adults ◽  
Longitudinal Study ◽  
Flow Rate ◽  
Independent Predictor ◽  
Japanese Version ◽  
Salivary Flow ◽  
Community Dwelling ◽  
Salivary Flow Rate ◽  
Age Related ◽  
Loss Of Appetite

Abstract Background Hyposalivation is associated with the nutritional status. Anorexia of ageing, defined as an age-related decrease in appetite and food intake, presents even in healthy adults and is considered an independent predictor of malnutrition, frailty, and mortality. However, the relationship between anorexia and hyposalivation of ageing is unclear. Thus, the present longitudinal study aimed to investigate the incidence of hyposalivation and its relationship with anorexia in community-dwelling older people in Japan. Methods The study population comprised 220 individuals (80 men and 140 women) aged 65–86 years at baseline. The participants underwent comprehensive health check-ups, including dental examinations and anthropometry, and face-to-face interviews in 2013 and 2019. Hyposalivation was determined on the basis of the unstimulated salivary flow rate measured using the modified cotton roll method. Anorexia was defined as a score of ≤29 in the Japanese version of the Council on Nutrition Appetite Questionnaire. Logistic regression analyses were used to test whether the presence of anorexia at baseline was an independent predictor of hyposalivation. Results Hyposalivation developed at a rate of 19.5% during the 6-year observation period. Anorexia was observed in 95 (43.2%) participants at baseline. After adjusting for potential confounding factors, anorexia (adjusted odds ratio [AOR], 2.65; 95% confidence interval [CI], 1.26–5.57) and polypharmacy (AOR, 3.29; CI, 1.06–10.19) were significant predictors of hyposalivation. Conclusion Loss of appetite is independently correlated with and a risk factor for hyposalivation in older adults. Anorexia of ageing may have negative effects on the salivary flow rate in such settings. Salivation should be a standard feature in clinical assessments of the older adults.

scholarly journals Prevalence of root caries in relation to various risk factors in a sample of subjects aged (25-64) years in Erbil city: A cross sectional study

2020 ◽  
Vol 3 (2) ◽  
pp. 79-88
Author(s):  
Tara Talib ◽  
Vian Majeed
Keyword(s):  
Risk Factors ◽  
Flow Rate ◽  
Educational Level ◽  
Systemic Disease ◽  
Salivary Flow ◽  
Tooth Brushing ◽  
Salivary Flow Rate ◽  
Plaque Index ◽  
Root Caries ◽  
Gingival Index

Backgrounds: Root surface caries is a significant oral public health problem among humans' due to improvements in health care, long life expectancy, and increasing demand to maintain oral health. The objective of this study was to determine the prevalence of root caries in subjects in Erbil city and its relation to various risk factors. Subjects and methods: The study was conducted in twelve primary health care centers in different directions of the city. A total of 2600 subjects (1352 males and 1248 females) attending these centers aged 25-64 years old were examined. The following clinical parameters were evaluated: root caries index, plaque index, gingival index, unstimulated salivary flow rate, other related factors as behavioral habits, oral practices, and educational level were assessed by means of multiple choice questionnaires by direct interview. Results: The results of this study showed that the prevalence of root caries was (22.3%) and the mean value of root caries was (33.650±16.504) in the whole sample with statistically significant age differences of both. Males were more prevalent in root surface caries than females with significant differences. Results showed that the mandibular teeth were more affected than the maxillary teeth, and that mandibular first molars were the mostly affected teeth by root caries. Prevalence of root caries was significantly associated with these risk factors: gingival index, plaque index, unstimulated salivary flow rate, educational level, wearing removable partial dentures, frequency of snacks, tooth brushing and frequency of tooth brushing, systemic disease and use of medication, while the results showed no association between prevalence of root caries and smoking. Conclusions: The results indicate that adults and older aged individuals in Erbil city have a high prevalence of root caries and high experience of root caries as expressed by root caries index and the prevalence of root caries was associates with these risk factors: Gingival index, Plaque index, unstimulated salivary flow rate, educational level, wearing removable partial dentures, frequency of snacks, tooth brushing and frequency of tooth brushing, systemic disease and use of medication while there was no association with smoking. Keywords: Root caries, Risk factors, Root caries index, Unstimulated salivary flow rate, Behavioral habits.

scholarly journals Effect of a newly developed pastille on the salivary flow rate in subjects with dry mouth symptoms: a randomized, controlled, monocentric clinical study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
S. Bielfeldt ◽  
D. Wilhelm ◽  
C. Neumeister ◽  
U. Schwantes ◽  
K. -P. Wilhelm
Keyword(s):  
Surface Tension ◽  
Flow Rate ◽  
Gum Arabic ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Dry Mouth ◽  
Main Ingredient ◽  
Control Product ◽  
Swallowing Problems ◽  
The Mean

Abstract Background Xerostomia is associated with several diseases and is a side effect of certain drugs, resulting from reduced saliva secretion. Often, aged and sometimes younger people suffer from (idiopathic) xerostomia. Chewing gum and sucking pastilles may relieve symptoms of xerostomia by increasing the salivary flow rate due to the mechanical effect of sucking and gustatory stimulation. Swallowing problems and the urge to cough or experiencing a tickling sensation in the throat might be alleviated through a reduction in dry mouth symptoms. We investigated whether a pastille containing four polysaccharides increased the salivary flow rate and relieved the symptoms of dry mouth. Methods Participating subjects with xerostomia were randomized into two equally balanced treatment groups. Subjects received the pastille on Day 1 and a control product (Parafilm®) on Day 3, or vice versa. Unstimulated saliva was collected every 2.5 min for 0–10 min. Stimulated saliva was collected after subjects sucked the pastille or the control product. The salivary flow rate was determined gravimetrically, and, in parallel, the feeling of dry mouth was assessed using a visual analog scale. Saliva surface tension was measured in pooled saliva samples (0–5 min of sampling). Additionally, in stimulated saliva from six subjects who sucked the pastille, the presence of the main ingredient—gum arabic—was examined by Raman spectroscopy. Results Chewing the pastille significantly increased the mean salivary flow rate by 8.03 g/10 min compared to the mean changes after chewing the control product (+ 3.71 g/10 min; p < 0.0001). The mean score of dry mouth was significantly alleviated by the pastille (− 19.9 ± 17.9 mm) compared to the control product (− 3.3 ± 18.1 mm). No difference between the two products was seen regarding the saliva surface tension. Gum arabic was present in the saliva of all investigated subjects for up to 10 min after sucking the pastille. Conclusions The pastille was well tolerated and effective in increasing the salivary flow rate and reducing mouth dryness after sucking. These results were in line with the detection of the main ingredient, gum arabic, in saliva for up to 10 min after sucking the pastille. Trial registration German Register Clinical Trials (Deutsches Register Klinische Studien, DRKS) DRKS-ID: DRKS00017393, Registered 29 May 2019, https://www.drks.de/drks_web/navigate.do?navigationId=trial. HTML&TRIAL_ID = DRKS00017393.

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