scholarly journals Evaluation of Ovarian Reserve with Anti-Müllerian Hormone in Familial Mediterranean Fever

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Ali Şahin ◽  
Savaş Karakuş ◽  
Yunus Durmaz ◽  
Çağlar Yıldız ◽  
Hüseyin Aydın ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Reproductive Age ◽  
Healthy Individuals ◽  
Ovarian Volume ◽  
Pelvic Ultrasonography ◽  
M694v Mutation ◽  
Significant Difference ◽  
Mediterranean Fever

Objective. To investigate ovarian reserves in attack-free familial Mediterranean fever (AF-FMF) patients at the reproductive age by anti-Müllerian hormone (AMH), antral follicle count (AFC), ovarian volume, and hormonal parameters.Methods. Thirty-three AF-FMF patients aging 18–45 years and 34 healthy women were enrolled and FSH, LH, E2, PRL, and AMH levels were measured in the morning blood samples at 2nd–4th days of menstruation by ELISA. Concomitant pelvic ultrasonography was performed to calculate AFC and ovarian volumes.Results. In FMF patient group, median AMH levels were statistically significantly lower in the M69V mutation positive group than in the negative ones (P=0.018). There was no statistically significant difference in median AMH levels between E148Q mutation positive patients and the negative ones (P=0.920). There was also no statistically significant difference in median AMH levels between M680I mutation positive patients and the negative ones (P=0.868). No statistically significant difference was observed in median AMH levels between patients who had at least one mutation and those with no mutations (P=0.868). We realized that there was no difference in comparisons between ovarian volumes, number of follicles, and AMH levels ovarian reserves when compared with FMF patients and healthy individuals.Conclusions. Ovarian reserves of FMF pateints were similar to those of healthy subjects according to AMH. However, AMH levels were lower in FMF patients with M694V mutation.

scholarly journals Ovarian reserve in women with obesity

2019 ◽  
Vol 16 (3) ◽  
pp. 69-75
Author(s):  
Olga R. Grigoryan ◽  
Robert K. Mikheev ◽  
Elena N. Andreeva ◽  
Ivan I. Dedov
Keyword(s):  
Ovarian Reserve ◽  
Antral Follicle ◽  
Reproductive Age ◽  
Reference Ranges ◽  
Obese Patients ◽  
Class Iii ◽  
Multicenter Studies ◽  
Ovarian Volume ◽  
Obesity Class ◽  
Significant Difference

BACKGROUND: One of the consequences of obesity for the female body is a decrease in fertility. It is shown that impaired reproductive function in obese patients can be associated, in particular, with a decrease in ovarian reserve. AIMS: To evaluate the ovarian reserve function in female patients of reproductive age with different classes of obesity in comparison with women without obesity. MATERIALS AND METHODS: This study evaluated 320 caucasian women, age 20-30 years, without obesity (BMI30, n=80) and with obesity WHO class I-III (n=80 per class). Anthropometrics, serum concentrations of anti-Mullerian hormone (AMH), inhibin B, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone, and testosterone were compared on the 2-3 day of menstrual cycle as ovarian volume and antral follicle count (AFC). RESULTS: We reveal statistically significant difference in following parameters in normal BMI women in comparison with obesity women: AMH, testosterone, ovarian volume and AFC. Moreover, we reveal significant difference between patients with different WHO class of obesity. But even in class III obesity parameters remained within reference ranges. CONCLUSIONS: Ovarian reserve function parameters progressively decrease with increase of obesity class in subjects, but ovarian reserve parameters were in normal reference range even in class III obese patients. Further large randomized multicenter studies are required to find influence of obesity in relation to ethnicity and other factors to ovarian reserve function.

Left–right differences in ovarian volume and antral follicle count in 1423 women of reproductive age

2016 ◽  
Vol 33 (4) ◽  
pp. 320-323 ◽  
Author(s):  
Anne-Sofie Korsholm ◽  
Helene Westring Hvidman ◽  
Janne Gasseholm Bentzen ◽  
Anders Nyboe Andersen ◽  
Kathrine Birch Petersen
Keyword(s):  
Antral Follicle ◽  
Antral Follicle Count ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Ovarian Volume

Late-Onset Famılıal Medıterranean Fever: Sıngle-Center Experıence And Lıterature Revıew

2020 ◽  
Author(s):  
Okan Aydin ◽  
Bugra Han Egeli ◽  
Huri Ozdogan ◽  
Serdal Ugurlu
Keyword(s):  
Familial Mediterranean Fever ◽  
Mutation Frequency ◽  
Late Onset ◽  
Disease Onset ◽  
Exon 2 ◽  
M694v Mutation ◽  
Significant Difference ◽  
Mediterranean Fever ◽  
Group 2 ◽  
Group 1

Abstract Introduction: Familial Mediterranean Fever (FMF) is an autoinflammatory disease characterized by recurrent fever and serositis attacks. The disease onset occurs before 20 years of age in 90% of patients. Rarely, the disease onset occurs after 40 years of age. Aim: We aimed to compare the patients with early and late-onset of disease. Methods: We did a retrospective analysis of 2020 patients registered in our FMF center in the years 2008-2017. Patients with disease onset after the age of 40 (Group 1) were collected. The control group (Group 2), disease onset before the age of 20, was randomly selected with twice amount of the study group. Demographic, clinical and genetic data were recorded. Results: Out of 2020 patients, 41 were in group 1 (2.02%). The male to female ratio was 1:1.7 in both groups. The delay of diagnosis was 5.6±5.75 years in group 1, 10.7±12.3 years in group 2. In terms of clinical features, the only significant difference between two groups belonged to fever seen in 26 (63.4%) patients in group 1 and 67 (81.7%) patients in group 2 (p=0,026). M694V mutation frequency was higher in group 2 whereas exon 2 mutation frequency was higher in group 1. The mean colchicine dose in the 6 months was 1.38±0.64 mg in group 1, 1.61±0.47 mg in group 2. Discussion: In patients with late disease onset, the results of decreased mean colchicine dose during the last 6 months, decreased fever ratio, and increased exon 2 mutation frequency might point out to mild disease severity. Keywords: Familial Mediterranean Fever, late-onset, early-onset, MEFV mutation, colchicine

scholarly journals Effect of obesity on ovarian reserve parameters in mid-reproductive age women

F1000Research ◽  
2012 ◽  
Vol 1 ◽  
pp. 43 ◽  
Author(s):  
Hanan Altaee ◽  
Zaid Abdul Majeed Al-Madfai ◽  
Zainab Hassan Alkhafaji
Keyword(s):  
Body Weight ◽  
Ovarian Reserve ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Reproductive Age ◽  
Obese Women ◽  
Blood Samples ◽  
Reproductive Age Women ◽  
Significant Difference ◽  
Early Follicular Phase

Background: The initiation and maintenance of reproductive functions are related to an optimal body weight in women. Body weight affects the ovarian reserve, which is basically an estimate of how many oocytes (eggs) are left in the ovaries.Objective: To study the relationship between obesity and serum and ultrasound markers of ovarian reserve in mid-reproductive age women (21–35 years old).Patients and methods: Twenty participants (“obese”) had a body mass index (BMI) of 30 to 35 kg/m2 and another 20 participants (“non-obese”) had a BMI 20–29 kg/m2. The obese women had a mean age of 27.9 years and the non-obese women had a mean age of 29.5 years. Blood samples were collected from all participants, anthropometric measurements were calculated, and transvaginal ultrasonography was performed to measure the antral follicle count (AFC) during the early follicular phase. The blood samples were assayed for antimüllerian hormone (AMH), follicle-stimulating hormone (FSH) and estradiol (E2).Results: There was no significant difference between the two groups regarding ovarian reserve markers and there is no significant correlation between these markers and BMI, except for serum E2 in the obese group.Conclusion: Obesity has no effect on the levels of serum FSH, AMH, or AFC indicating that obesity is unlikely to affect ovarian reserve in the mid-reproductive age group.

Analysis of mutations of the MEFV gene in women with infertility and familial Mediterranean fever

2021 ◽  
pp. 27-38
Author(s):  
П.О. Соцкий ◽  
О.Л. Соцкая ◽  
Т.Ф. Саркисян ◽  
А.С. Айрапетян ◽  
А.Р. Егиазарян ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Mefv Gene ◽  
Delayed Diagnosis ◽  
Reproductive Age ◽  
Clear Correlation ◽  
Renal Amyloidosis ◽  
Reproductive Disorders ◽  
M694v Mutation ◽  
Mediterranean Fever ◽  
Fertile Women

Изучение взаимосвязи между мутациями в гене MEFV и бесплодием создает предпосылки для оптимизации диагностики и профилактики репродуктивных нарушений у женщин с семейной средиземноморской лихорадкой (ССЛ). Цель: поиск корреляций между мутациями в гене MEFV и бесплодием в большой когорте армянских пациенток. В период с 1998 по 2018 годы в Центре медицинской генетики и первичной охраны здоровья были обследованы 32 000 человек на наличие мутаций в гене MEFV. Из этой группы выбраны женщины (4577) репродуктивного возраста (18-49 лет), у которых был установлен клинический диагноз ССЛ на основании критериев Тel-Hashomer, подтвержденный генетическим тестированием. Комплексное обследование репродуктивной функции произведено у 373 женщин: 211 пациенток с ССЛ и у 162 женщин с репродуктивными расстройствами без ССЛ. Обнаружено, что гомозиготный генотип M694V/M694V, выявленный у 11,5% женщин с ССЛ, ассоциируется с тяжелым клиническим течением и развитием амилоидоза у 1,5% (р=0,028). Бесплодие чаще встречается у гомозиготных по M694V (90,9%) и M680I (100%) пациенток (р<0,009). Наиболее распространенная у армянских женщин репродуктивного возраста мутация M694V (40,7%) при бесплодии встречается чаще (69,7%), чем у фертильных женщин (30,3%) (p<0,009). Выявлена ассоциация между нерегулярным применением колхицина или использованием низкой дозы препарата и бесплодием у пациенток с ССЛ (88,4%) (р<0,001). Отсроченная диагностика свыше 10 лет наблюдалась у 80,7% бесплодных пациенток с ССЛ по сравнению с 19,3% у фертильных женщин (р<0,007). Таким образом, бесплодие в значительной степени связано с гомозиготными генотипами по мутациям M694V или M680I, которые ассоциируются с более тяжелым течением заболевания. Пациентки с ССЛ имеют сопоставимые репродуктивные показатели с женщинами без ССЛ. Бесплодие формируется под влиянием таких модифицирующих факторов, как социальный статус, нерегулярный прием колхицина, задержка диагностики свыше 10 лет. The study of the relationship between mutations in the MEFV (MEditerranean FeVer) gene and infertility creates opportunity for optimizing the diagnosis and prevention of reproductive disorders in women with familial Mediterranean fever (FMF). Data were collected from the patients registered in 1998- 2018 at the Center for Medical Genetics and Primary Health Care. From the cohort of 32000 patients analyzed for mutations in the MEFV gene, only women (4577) of reproductive age (18-49 years old) were selected, with clinical diagnosis FMF according to the International Tel-Hashomer criteria and confirmed by genetic testing. Comprehensive monitoring of reproductive function was performed in 373 women - 211 FMF patients and 162 non FMF women with reproductive disorders. Homozygous genotype M694V/M694V (11.5%) is associated with severe disease and renal amyloidosis (1.5%) (p=0.028). Infertility was revealed in 90.9% patients homozygous for M694V and 100% for M680I mutations (p<0.009). M694V mutation in population of women of reproductive age was more common in FMF patients with infertility (68.8%) compare to fertile women (31.2%) (p<0.009). A clear correlation between irregular uptakes or a low dose of colchicine and infertility among investigated FMF patients (88.4%) (p <0.001) was revealed. A delayed diagnosis of over 10 years was observed in 80.7% of infertile patients with FMF compared with 19.3% in fertile women (p<0.007). Infertility is largely associated with homozygous M694V or M680I genotypes of MEFV gene. Patients with FMF have a comparable prior-reproductive system with healthy controls. Infertility is formed under the influence of modifying factors such as social status, irregular intake of colchicine, and delayed diagnosis for more than 10 years.

INTERRELATIONSHIP OF AMH WITH CLINICAL, HORMONAL AND SONOGRAPHIC PARAMETERS IN PATIENTS WITH POLYCYSTIC OVARIAN DISEASE

2021 ◽  
pp. 66-68
Author(s):  
Uma Jain ◽  
Urvi Gupta
Keyword(s):  
Cycle Length ◽  
Polycystic Ovary ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Reproductive Age ◽  
Ovarian Volume ◽  
Diagnostic Potential ◽  
The Mean ◽  
Criteria For Diagnosis ◽  
High Level

INTRODUCTION: Polycystic ovary syndrome (PCOS) is a frequently encountered problem in reproductive endocrinology, affecting approximately 6% of women of reproductive age. anti-mullerian hormone (AMH) also known as Mullerian inhibiting, substance is produced by granulosa cells of the preantral and small antral ovarian follicles in women and reect the ovarian reserve. Women with PCOS will often have a high number of antral follicles and, as a result, an equally high level of AMH in their blood. it has an inhibitory inuence on the actions of FSH and positively correlated with LH. Various studies demonstrated that oligo/anovulatory women with PCOS have signicantly higher serum concentrations of AMH. MATERIAL AND METHOD: This is a retro respective study of 54 PCOS patients from rst January 2019 to 13 April 2021 at a private gynaecology clinic in district Shivpuri. Data were collected from the medical records of the patients including age, height, weight, waist circumference, BP and modied Ferriman gallway score for hirsutism, Biochemical and hormonal values like LH, FSH, LH/FSH ratio, TSH, Prolactin and AMH, and lipid prole values were also obtained from the records. Abdominal or Vaginal ultrasound was used to assess the ovarian volume antral follicular count. RESULTS: In our study, the age of patients ranges from 20-39 years and a majority of the patients were in the age group of 21-30 years 75.28%) The Mean age of PCOS patients was 23.89. In our study, the mean cycle length of patients was 54.08 and it ranged from 28-190 days. The mean 2 BMI 25.8kg/m2 and modied FG score were 8.1. On ultrasound mean antral follicle count was 26.2 and the mean ovarian volume was 9.4 cm . In hormonal studies mean LH was 11.5, mean FSH was 3.4 and AMH was 4.34 and Testosterone was 2.1. In bio-chemical parameters increased Cholesterol, triglycerides, LDL, VLDL level and decreased HDL level were found in 31.48% of patients and with increased AMH. CONCLUSION: In our study, we found increased AMH concentration in correlation with increased cycle length in cases of oligomenorrhea, clinical hyperandrogenism, increased LH, increased AFC and increased ovarian volume. Our study concluded that AMH levels as an adjunct to existing Rotterdam criteria for diagnosis of PCOS had good diagnostic potential.

Should fertile women quit drinking alcohol to produce better quality oocytes?

Zygote ◽  
2020 ◽  
pp. 1-3
Author(s):  
Burcu Ozbakir ◽  
Pinar Tulay
Keyword(s):  
Alcohol Consumption ◽  
Young Women ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Control Group ◽  
Social Drinkers ◽  
Antral Follicles ◽  
Healthy Women ◽  
Significant Difference

Summary Alcohol consumption has long been shown to affect both fetal health and pregnancy. In this study, antral follicle count, maturation level of oocytes including morphological assessment and number of metaphase I (MI), metaphase II (MII) and germinal vesicle (GV) stage oocytes obtained from young women (age < 30 years old) with or without alcohol consumption were investigated. In total, 20 healthy women who were social drinkers and 36 healthy women who do not consume alcohol were involved in this study. Women in both study and control groups were undergoing controlled ovarian stimulation. The antral follicle count and the number and quality of the oocytes retrieved were evaluated and recorded. In total, 635 antral follicles, 1098 follicles and 1014 oocytes with 820 MII, 72 MI and 78 GV stage oocytes were collected from the social drinkers. In the control group, 628 antral follicles, 1136 follicles and 1085 oocytes with 838 MII, 93 MI and 102 GV stage oocytes were evaluated. The results of this study showed that the antral follicle count was very similar in both groups. The number of oocytes and MII stage oocytes was slightly higher in the control group, although it was not a significant difference. This study showed that although the consumption of alcohol may have adverse effects post-implantation, it may not have a solid effect during oogenesis in young women. The results of this study are especially important in clinical settings as some women who are social drinkers undergo in vitro fertilization treatments.

scholarly journals Common Mediterranean Fever (MEFV) Gene Mutations Associated with Ankylosing Spondylitis in Turkish Population

2012 ◽  
Vol 33 (3) ◽  
pp. 113-118 ◽  
Author(s):  
Serbulent Yigit ◽  
Ahmet Inanir ◽  
Nevin Karakus ◽  
Esra Kesici ◽  
Nihan Bozkurt
Keyword(s):  
Ankylosing Spondylitis ◽  
Mefv Gene ◽  
Gene Mutations ◽  
Turkish Population ◽  
M694v Mutation ◽  
Significant Difference ◽  
Mediterranean Fever ◽  
Genomic Dnas ◽  
Polymerase Chain ◽  
Turkish Patients

Ankylosing spondylitis (AS) is a common inflammatory rheumatic disease. Mediterranean fever (MEFV) gene, which has already been identified as being responsible for familial Mediterranean fever (FMF), is also a suspicious gene for AS because of the clinical association of these two diseases. The aim of this study was to explore the frequency and clinical significance ofMEFVgene mutations (M694V, M680I, V726A, E148Q and P369S) in a cohort of Turkish patients with AS. Genomic DNAs of 103 AS patients and 120 controls were isolated and genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. There was a statistically significant difference of theMEFVgene mutation carrier rates between AS patients and healthy controls (p= 0.004, OR: 2.5, 95% CI: 1.32–4.76). This association was also observed in allele frequencies (p= 0.005, OR: 2.3, 95% CI: 1.27–4.2). A relatively higher frequency was observed for M694V mutation in AS patients than controls (10.7% versus 4.2% ,p= 0.060). There were no significant differences between MEFV mutation carriers and non-carriers with respect to the clinical and demographic characteristics. The results of this study suggest thatMEFVgene mutations are positively associated with a predisposition to develop AS.

Effect of resveratrol administration on ovarian morphology, determined by transvaginal ultrasound for the women with PCOS

2021 ◽  
pp. 1-18
Author(s):  
Amir Pejman Hashemi Taheri ◽  
Behnaz Moradi ◽  
Amir Reza Radmard ◽  
Milad Sanginabadi ◽  
Mostafa Qorbani ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Polycystic Ovary ◽  
Transvaginal Ultrasound ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Ovarian Volume ◽  
Exact Test ◽  
Ovarian Morphology ◽  
The Mean

Abstract Background: Intake of resveratrol has been associated with improved ovarian morphology under in vitro and in the animal models; however, this finding has not been confirmed in trials. The aim of our study was, therefore, to use a placebo-controlled approach with the detailed assessment of the ovarian morphology by applying transvaginal ultrasound to examine the effectiveness of this therapeutic approach in this group of women. Methods: Forty-one women with polycystic ovary syndrome (PCOS) were randomly assigned (1:1) to 3 months of daily 1000 mg resveratrol or placebo. Random assignment was done by blocked randomisation. Our primary endpoints were the change in the ovarian volume, stromal area and antral follicle count per ovary (FNPO) from the baseline to 3 months. Secondary endpoints were improvement in the distribution of follicles and ovarian echogenicity. Differences between the resveratrol and control groups were evaluated by Chi-square, fisher’s exact test and repeated-measures of ANOVA. Results: The mean age of all participants was 28.61 ± 4.99 years, with the mean BMI of 28.26 ± 5.62 kg/m2. Resveratrol therapy, as compared with placebo, was associated with a significantly higher rate of improvement in the ovarian morphology (p= 0.02). Women who received resveratrol had a more dominant follicle than those getting placebo, with a significant reduction in the ovarian volume (p<0.05). However, the number of FNPO, stromal area, ovarian echogenicity and distribution of follicles were not significantly altered (P>0.05). Conclusions: Treatment with resveratrol significantly reduced the ovarian volume and PCOM, thus suggesting a disease-modifying effect in PCOS. Trial registration: IRCT, IRCT2017061917139N2. Registered 7 July 2017, http://irct.ir/trial/15836.

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