scholarly journals Ordinary and Activated Bone Grafts: Applied Classification and the Main Features

2015 ◽  
Vol 2015 ◽  
pp. 1-19 ◽  
Author(s):  
R. V. Deev ◽  
A. Y. Drobyshev ◽  
I. Y. Bozo ◽  
A. A. Isaev
Keyword(s):  
Growth Factors ◽  
Biological Effects ◽  
Bone Grafts ◽  
Bone Substitutes ◽  
Bone Defects ◽  
Biologically Active ◽  
Active Components ◽  
Or Gene ◽  
Large Bone ◽  
Large Bone Defects

Bone grafts are medical devices that are in high demand in clinical practice for substitution of bone defects and recovery of atrophic bone regions. Based on the analysis of the modern groups of bone grafts, the particularities of their composition, the mechanisms of their biological effects, and their therapeutic indications, applicable classification was proposed that separates the bone substitutes into “ordinary” and “activated.” The main differential criterion is the presence of biologically active components in the material that are standardized by qualitative and quantitative parameters: growth factors, cells, or gene constructions encoding growth factors. The pronounced osteoinductive and (or) osteogenic properties of activated osteoplastic materials allow drawing upon their efficacy in the substitution of large bone defects.

scholarly journals Ordinary and Activated Osteoplastic Materials

2015 ◽  
Vol 22 (1) ◽  
pp. 51-69
Author(s):  
R. V Deev ◽  
A. Yu Drobyshev ◽  
I. Ya Bozo
Keyword(s):  
Growth Factors ◽  
Medical Devices ◽  
Bone Defects ◽  
Biological Action ◽  
Biologically Active ◽  
Active Components ◽  
Qualitative And Quantitative ◽  
Or Gene ◽  
Large Bone ◽  
Large Bone Defects

Osteoplastic materials are highly required medical devices for bone defects substitution and filling the areas of bone tissue atrophy. Based on analysis of modern groups of osteoplastic materials, features of their composition, mechanisms of biological action, and indications for clinical use, the applied classification which divides the medical items into ordinary and activated categories is proposed. The main differential criterion is the presence of certain biologically active components in the material composition: growth factors, cells or gene constructions encoding growth factors that are standardized by qualitative and quantitative parameters. Pronounced osteoinductive and (or) osteogenic properties of activated osteoplastic materials enable counting on their effectiveness in replacement of large bone defects.

scholarly journals Ordinary and Activated Osteoplastic Materials

2015 ◽  
pp. 51-69 ◽  
Author(s):  
R. V. Deev ◽  
A. Yu. Drobyshev ◽  
I. Ya. Bozo
Keyword(s):  
Growth Factors ◽  
Medical Devices ◽  
Bone Defects ◽  
Biological Action ◽  
Biologically Active ◽  
Active Components ◽  
Qualitative And Quantitative ◽  
Or Gene ◽  
Large Bone ◽  
Large Bone Defects

Osteoplastic materials are highly required medical devices for bone defects substitution and filling the areas of bone tissue atrophy. Based on analysis of modern groups of osteoplastic materials, features of their composition, mechanisms of biological action, and indications for clinical use, the applied classification which divides the medical items into ordinary and activated categories is proposed. The main differential criterion is the presence of certain biologically active components in the material composition: growth factors, cells or gene constructions encoding growth factors that are standardized by qualitative and quantitative parameters. Pronounced osteoinductive and (or) osteogenic properties of activated osteoplastic materials enable counting on their effectiveness in replacement of large bone defects.

scholarly journals Vascularization of Nanohydroxyapatite/Collagen/Poly(L-lactic acid) Composites by Implanting Intramuscularly In Vivo

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Hai Wang ◽  
Xiao Chang ◽  
Guixing Qiu ◽  
Fuzhai Cui ◽  
Xisheng Weng ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Orthopaedic Surgery ◽  
Bone Substitutes ◽  
Bone Defects ◽  
Large Defect ◽  
Natural Bone ◽  
Composition And Structure ◽  
Large Bone ◽  
Large Bone Defects

It still remains a major challenge to repair large bone defects in the orthopaedic surgery. In previous studies, a nanohydroxyapatite/collagen/poly(L-lactic acid) (nHAC/PLA) composite, similar to natural bone in both composition and structure, has been prepared. It could repair small sized bone defects, but they were restricted to repair a large defect due to the lack of oxygen and nutrition supply for cell survival without vascularization. The aim of the present study was to investigate whether nHAC/PLA composites could be vascularized in vivo. Composites were implanted intramuscularly in the groins of rabbits for 2, 6, or 10 weeks (n=5×3). After removing, the macroscopic results showed that there were lots of rich blood supply tissues embracing the composites, and the volumes of tissue were increasing as time goes on. In microscopic views, blood vessels and vascular sprouts could be observed, and microvessel density (MVD) of the composites trended to increase over time. It suggested that nHAC/PLA composites could be well vascularized by implanting in vivo. In the future, it would be possible to generate vascular pedicle bone substitutes with nHAC/PLA composites for grafting.

ANALYSIS OF EXPEDIENCY TO USE PLATELET-ENRICHED PLASMA FOR TREATMENT OF ANDROGENETIC ALOPECIA

2020 ◽  
pp. 64-67
Author(s):  
Yu. S. Ovcharenko ◽  
O. A. Salyenkova
Keyword(s):  
Growth Factors ◽  
Hair Growth ◽  
Platelet Rich Plasma ◽  
Biological Effects ◽  
Practical Experience ◽  
Biologically Active ◽  
Androgenetic Alopecia ◽  
Published Data ◽  
Active Components ◽  
Characteristic Features

A detailed analysis of the published data on the use of platelet−enriched plasma for the treatment of androgenetic alopecia has been performed. Based on the results, it has been suggested that platelet−rich plasma may be considered as a new treatment for pathological hair−related conditions, including androgenetic alopecia. Information on platelet morphology, characteristics of biologically active substances released from activated platelets have been provided. It has been substantiated that platelets play a crucial role in hemostasis and tissue regeneration by stimulating the cell chemotaxis, proliferation, differentiation, angiogenesis and deposition of the extracellular matrix. Among the many active components of platelets involved into the recovery of damaged tissue, the growth factors have been particularly noted. The influence of growth factors on the regulation of hair growth cycles has been established. Based on the analysis of their biological effects, the diversity of their action in the regulation of hair growth has been emphasized. Characteristic features of some growth factors, insulin−like growth factor (IGF), have been determined and described, their role in damaged tissue repair, angiogenesis, proliferation and cell differentiation has been noted. The practical experience of application of platelet−enriched plasma in various branches of medicine is summarized, proposals concerning the use of this method as a new way of treatment of androgenetic alopecia have been provided. The question of standardization of this method, study and substantiation of differentiated use of platelet−enriched plasma depending on the stage of androgenetic alopecia in men and women remains debatable. Key words: androgenetic alopecia, platelet−enriched plasma, platelets, growth factors.

scholarly journals Autologous bone grafts with MSCs or FGF-2 accelerate bone union in large bone defects

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Hiroaki Murakami ◽  
Tomoyuki Nakasa ◽  
Masakazu Ishikawa ◽  
Nobuo Adachi ◽  
Mitsuo Ochi
Keyword(s):  
Bone Grafts ◽  
Bone Defects ◽  
Bone Union ◽  
Autologous Bone ◽  
Autologous Bone Grafts ◽  
Large Bone ◽  
Large Bone Defects

scholarly journals Factors related to large bone defects of bipolar lesions and a high number of instability episodes with anterior glenohumeral instability

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Noboru Matsumura ◽  
Kazuya Kaneda ◽  
Satoshi Oki ◽  
Hiroo Kimura ◽  
Taku Suzuki ◽  
...  
Keyword(s):  
Humeral Head ◽  
Glenohumeral Joint ◽  
Three Dimensional ◽  
Clinical Results ◽  
Bone Defects ◽  
Symptom Duration ◽  
Glenohumeral Instability ◽  
Explanatory Variables ◽  
Large Bone ◽  
Large Bone Defects

Abstract Background Significant bone defects are associated with poor clinical results after surgical stabilization in cases of glenohumeral instability. Although multiple factors are thought to adversely affect enlargement of bipolar bone loss and increased shoulder instability, these factors have not been sufficiently evaluated. The purpose of this study was to identify the factors related to greater bone defects and a higher number of instability episodes in patients with glenohumeral instability. Methods A total of 120 consecutive patients with symptomatic unilateral instability of the glenohumeral joint were retrospectively reviewed. Three-dimensional surface-rendered/registered models of bilateral glenoids and proximal humeri from computed tomography data were matched by software, and the volumes of bone defects identified in the glenoid and humeral head were assessed. After relationships between objective variables and explanatory variables were evaluated using bivariate analyses, factors related to large bone defects in the glenoid and humeral head and a high number of total instability episodes and self-irreducible dislocations greater than the respective 75th percentiles were evaluated using logistic regression analyses with significant variables on bivariate analyses. Results Larger humeral head defects (P < .001) and a higher number of total instability episodes (P = .032) were found to be factors related to large glenoid defects. On the other hand, male sex (P = .014), larger glenoid defects (P = .015), and larger number of self-irreducible dislocations (P = .027) were related to large humeral head bone defects. An increased number of total instability episodes was related to longer symptom duration (P = .001) and larger glenoid defects (P = .002), and an increased number of self-irreducible dislocations was related to larger humeral head defects (P = .007). Conclusions Whereas this study showed that bipolar lesions affect the amount of bone defects reciprocally, factors related to greater bone defects differed between the glenoid and the humeral head. Glenoid defects were related to the number of total instability episodes, whereas humeral head defects were related to the number of self-irreducible dislocations.

scholarly journals Tissue engineered vascularized periosteal flap enriched with MSC/EPCs for the treatment of large bone defects in rats

2017 ◽  
Vol 39 (4) ◽  
pp. 907-917 ◽  
Author(s):  
Christoph Nau ◽  
Dirk Henrich ◽  
Caroline Seebach ◽  
Katrin Schröder ◽  
John H. Barker ◽  
...  
Keyword(s):  
Bone Defects ◽  
Periosteal Flap ◽  
Large Bone ◽  
Large Bone Defects
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