scholarly journals Hopf Bifurcation, Cascade of Period-Doubling, Chaos, and the Possibility of Cure in a 3D Cancer Model

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Marluci Cristina Galindo ◽  
Cristiane Nespoli ◽  
Marcelo Messias

We study a cancer model given by a three-dimensional system of ordinary differential equations, depending on eight parameters, which describe the interaction among healthy cells, tumour cells, and effector cells of immune system. The model was previously studied in the literature and was shown to have a chaotic attractor. In this paper we study how such a chaotic attractor is formed. More precisely, by varying one of the parameters, we prove that a supercritical Hopf bifurcation occurs, leading to the creation of a stable limit cycle. Then studying the continuation of this limit cycle we numerically found a cascade of period-doubling bifurcations which leads to the formation of the mentioned chaotic attractor. Moreover, analyzing the model dynamics from a biological point of view, we notice the possibility of both the tumour cells and the immune system cells to vanish and only the healthy cells survive, suggesting the possibility of cure, since the interactions with the immune system can eliminate tumour cells.

1992 ◽  
Vol 06 (16n17) ◽  
pp. 1055-1061
Author(s):  
GOVINDAN RAJESH ◽  
SUPREETI DAS ◽  
JAYANTA K. BHATTACHARJEE

A Lorenz-like model due to Veronis for onset of convection in a rotating fluid layer is analysed for Rayleigh numbers higher than the point at which stationary convection occurs. The most outstanding feature is that for Taylor numbers above a critical value, the Hopf bifurcation does lead to a finite amplitude stable limit cycle via a hysteretic transition. This limit cycle undergoes a sequence of period doubling bifurcations to form a Feigenbaum attractor which then makes a transition to the Lorenz-like attractor.


2013 ◽  
Vol 344 ◽  
pp. 61-65
Author(s):  
Li Juan He ◽  
Yu Cun Zhou

It proves that steering wheel shimmy is a vibration of stable limit cycle occurring after Hopf bifurcation, which is elaborated by nonlinear dynamics theory, and the control objectives of shimmy are proposed according to its bifurcation properties. Numerical analysis of bifurcation characteristics has been conducted with a nonlinear shimmy model whose parameters come from a domestic automobile with independent suspension. The results indicate that when the speed reaches 49.98Km/h, supercritical Hopf bifurcation occurs to the system and stable limit cycle appears, i.e. wheels oscillate around the kingpin at the same amplitude; when the speed comes to 76.30 Km/h, Hopf bifurcation occurs again and limit cycle disappears. The bifurcation speed and amplitude of limit cycle match the shimmy speed and amplitude measured from road experiments very well, which confirms the conclusions that shimmy is a vibration of stable limit cycle occurring after Hopf bifurcation at critical speed.


2006 ◽  
Vol 16 (05) ◽  
pp. 1375-1387 ◽  
Author(s):  
TIANSHOU ZHOU ◽  
GUANRONG CHEN

This paper presents a novel result on the effect of coupling through both analytical and numerical investigations on linearly coupled systems including chaotic and nonchaotic systems. It is found that when a single system has potential of oscillation but is currently in a "marginal" state to produce a limit cycle via Hopf bifurcation due to the change of a parameter, an appropriate coupling strength can excite the potential limit cycle such that the coupled system oscillates synchronously. Similarly, when a stable limit cycle is at the "margin" of a chaotic attractor in a single system, a certain coupling strength can induce the potential chaotic attractor such that the coupled system has a synchronous chaotic behavior. This excitation mechanism is different from the traditional function of coupling in that the latter mainly drives the coupled system to synchronize with the ongoing dynamics of a single system but does not recover its disappearing dynamics. This newly observed synchronization is called coherent synchronization to distinguish it from various common types of synchronization. Several numerical examples are presented for quantitative description of this interesting phenomenon.


Author(s):  
Abdulghafoor Jasim Salim ◽  
Kais Ismail Ebrahem ◽  
Suhirman

Abstract: In this paper we study the stability of one of a non linear autoregressive model with trigonometric term  by using local linearization method proposed by Tuhro Ozaki .We find the singular point ,the stability of the singular point and the limit cycle. We conclude  that the proposed model under certain conditions have a non-zero singular point which is  a asymptotically salable ( when  0 ) and have an  orbitaly stable limit cycle . Also we give some examples in order to explain the method. Key Words : Non-linear Autoregressive model; Limit cycle; singular point; Stability.


2016 ◽  
Vol 26 (02) ◽  
pp. 1650034 ◽  
Author(s):  
Jicai Huang ◽  
Xiaojing Xia ◽  
Xinan Zhang ◽  
Shigui Ruan

It was shown in [Li & Xiao, 2007] that in a predator–prey model of Leslie type with simplified Holling type IV functional response some complex bifurcations can occur simultaneously for some values of parameters, such as codimension 1 subcritical Hopf bifurcation and codimension 2 Bogdanov–Takens bifurcation. In this paper, we show that for the same model there exists a unique degenerate positive equilibrium which is a degenerate Bogdanov–Takens singularity (focus case) of codimension 3 for other values of parameters. We prove that the model exhibits degenerate focus type Bogdanov–Takens bifurcation of codimension 3 around the unique degenerate positive equilibrium. Numerical simulations, including the coexistence of three hyperbolic positive equilibria, two limit cycles, bistability states (one stable equilibrium and one stable limit cycle, or two stable equilibria), tristability states (two stable equilibria and one stable limit cycle), a stable limit cycle enclosing a homoclinic loop, a homoclinic loop enclosing an unstable limit cycle, or a stable limit cycle enclosing three unstable hyperbolic positive equilibria for various parameter values, confirm the theoretical results.


2016 ◽  
Vol 13 (6) ◽  
pp. 172988141665774
Author(s):  
Taihui Zhang ◽  
Honglei An ◽  
Qing Wei ◽  
Wenqi Hou ◽  
Hongxu Ma

Differing from the commonly used spring loaded inverted pendulum model, this paper makes use of a two-mass spring model considering impact between the foot and ground which is closer to the real hopping robot. The height of upper mass which includes the upper leg and body is the main control objective. Then we develop a new kind of control algorithm acting on two levels: The upper level aims to achieve the desired velocity of the upper mass based on a stable limit cycle, where three different controllers are used to regulate the limit cycle; the target of the lower level is to drive the system to converge to the desired state and control the contact force between the foot and ground within an appropriate range based on the inner force control at the same time. Simulation results presented in this paper confirm the efficiency of this control algorithm.


Author(s):  
Melissa Vellela ◽  
Hong Qian

Recent studies on stochastic oscillations mostly focus on the power spectral analysis. However, the power spectrum yields information only on the frequency of oscillation and cannot differentiate between a stable limit cycle and a stable focus. The cycle flux, introduced by Hill (Hill 1989 Free energy transduction and biochemical cycle kinetics ), is a quantitative measure of the net movement over a closed path, but it is impractical to compute for all possible cycles in systems with a large state space. Through simple examples, we introduce concepts used to quantify stochastic oscillation, such as the cycle flux, the Hill–Qian stochastic circulation and rotation number. We introduce a novel device, the Poincaré–Hill cycle map (PHCM), which combines the concept of Hill’s cycle flux with the Poincaré map from nonlinear dynamics. Applying the PHCM to a reversible extension of an oscillatory chemical system, the Schnakenberg model, reveals stable oscillations outside the Hopf bifurcation region in which the deterministic system contains a limit cycle. Bistable behaviour is found on the small volume scale with high probabilities around both the fixed point and the limit cycle. Convergence to the deterministic system is found in the thermodynamic limit.


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