scholarly journals Synchronous Multicentric Giant Cell Tumour of Distal Radius and Sacrum with Pulmonary Metastases

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Varun Sharma Tandra ◽  
Krishna Mohan Reddy Kotha ◽  
Moorthy Gadisetti Venkata Satyanarayana ◽  
Kali Varaprasad Vadlamani ◽  
Vyjayanthi Yerravalli
Keyword(s):  
Giant Cell ◽  
Distal Radius ◽  
Bone Grafting ◽  
Giant Cell Tumour ◽  
Pulmonary Metastases ◽  
Osteolytic Lesion ◽  
Bone Tumour ◽  
Cell Tumour ◽  
Primary Bone Tumour ◽  
Primary Bone

Giant cell tumour (GCT) is an uncommon primary bone tumour, and its multicentric presentation is exceedingly rare. We report a case of a 45-year-old female who presented to us with GCT of left distal radius. On the skeletal survey, osteolytic lesion was noted in her right sacral ala. Biopsy confirmed both lesions as GCT. Pulmonary metastasis was also present. Resection-reconstruction arthroplasty for distal radius and thorough curettage and bone grafting of the sacral lesion were done. Multicentric GCT involving distal radius and sacrum with primary sacral involvement is not reported so far to our knowledge.

scholarly journals Quality of life in patients with bone tumour

2018 ◽  
Vol 51 ◽  
pp. 02012
Author(s):  
Olga Shchelkova ◽  
Ekaterina Usmanova
Keyword(s):  
Quality Of Life ◽  
Bone Metastases ◽  
Social Functioning ◽  
Giant Cell ◽  
Giant Cell Tumour ◽  
Bone Tumour ◽  
Cell Tumour ◽  
Primary Bone ◽  
Primary Bone Tumours

Introduction – in the last decades, scientific research of health related quality of life (QoL) is developing fast worldwide. QoL concept pays attention to emotional experience of disease in patients, particularly to personal sense of possibility to satisfy actual needs and possibility of full social functioning in spite of disease specific limitations. The aim of the study was to reveal the basic aspects and personality factors of QoL in patients with bone tumour. Results: the study revealed that patients with bone metastases assess their health significantly worse than other patients. Besides, patients with osteosarcoma evaluate their general health higher than patients with giant cell tumour. Social functioning in patients with chondrosarcoma is higher than in patients with bone metastases and patients with giant cell tumour. Patients with chondrosarcoma have higher physical functioning and less restricted in daily activities than patients with bone metastases. Patients with bone metastases have the most intensive pain among all patients. Moreover, the study revealed personality significant influence on QoL related to bone tumour. Conclusion – patients with bone metastasis have lower QoL compared to patients with primary bone tumours. Patients with giant cell tumour have the worth quality of life among patients with primary bone tumours. Furthermore the results revealed differences in QoL parameters associated with personality characteristics in patients with bone tumour.

Functional results of wrist arthrodesis versus arthroplasty with proximal fibula following giant cell tumour excision of the distal radius

2018 ◽  
Vol 44 (4) ◽  
pp. 394-401 ◽  
Author(s):  
Huayi Qu ◽  
Wei Guo ◽  
Dasen Li ◽  
Yi Yang ◽  
Ran Wei ◽  
...  
Keyword(s):  
Grip Strength ◽  
Giant Cell ◽  
Distal Radius ◽  
Giant Cell Tumour ◽  
Functional Results ◽  
Cell Tumour ◽  
Musculoskeletal Tumor Society ◽  
Wrist Arthrodesis ◽  
Proximal Fibula ◽  
Radiocarpal Joint

Twenty-one patients underwent excision of a Campanacci grade III giant cell tumour of the distal radius and had reconstruction using a proximal fibula autograft. We compared the functional results of wrist arthrodesis versus arthroplasty. All 21 patients healed in an average of 8 months, and all have remained disease free. The Musculoskeletal Tumor Society 93, the Disabilities of the Arm, Shoulder, and Hand scores and the grip strength of the operated wrist compared with the contralateral wrist were 93%, 7, and 71% for the arthrodesis group and 83%, 17, and 40% for the arthroplasty group. Arthrodesis of the reconstructed radiocarpal joint provided better grip strength and functional outcomes than arthroplasty. Level of evidence: III

Extended intralesional curettage preferred over resection–arthrodesis for giant cell tumour of the distal radius

2019 ◽  
Vol 30 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Hasan Abuhejleh ◽  
Jay S. Wunder ◽  
Peter C. Ferguson ◽  
Marc H. Isler ◽  
Sophie Mottard ◽  
...  
Keyword(s):  
Giant Cell ◽  
Distal Radius ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Intralesional Curettage

scholarly journals Significance of EGFR/HER2 Expression and PIK3CA Mutations in Giant Cell Tumour of Bone Development

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Raja Amri ◽  
Slim Charfi ◽  
Mohamed Jemaà ◽  
Nabil Miled ◽  
Fathia Slimi ◽  
...  
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumour ◽  
Bone Development ◽  
Bone Tumour ◽  
Growth Factor Receptor ◽  
Kinase Domain ◽  
Cell Tumour ◽  
Pten Gene ◽  
Pik3ca Mutations ◽  
The Stability

Giant Cell Tumour of Bone (GCTB) is a rare bone tumour. Locally aggressive and recurrent, it might evolve into pulmonary metastases. Our present work is aimed at investigating the involvement of the epidermal growth factor receptor (ErbB) family and its downstream effectors in the development and recurrence of GCTB. For this purpose, we used a cohort of 32 GCTB patients and we evaluated the clinicohistological features and the expression of RANKL, EGFR, and HER2. The mutation status of KRAS, PI3KCA, and PTEN gene as potential oncogene involved in GCTB was also evaluated. We found a significant correlation between advanced histological stages, overexpression of EGFR/HER2, and tumour recurrence. Moreover, two mutations were found in the PIK3CA gene: a missense mutation, 1634A>C, detected for the first time in GCTB patients, without influencing the stability of the protein, and a frameshift mutation, c.1658_1659delGTinsC, causing the loss of the protein kinase domain. Altogether, these results suggest that overexpression of HER2/EGFR, Campanacci, and histological stages could be used as a novel prognostic marker for GCTB recurrence.

scholarly journals Reconstruction of Elbow by Free Fibular Graft in a Case of Osteoclastoma of Proximal Ulna: A Rare Case Report

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Kiran Kalaiah ◽  
S. G. Thejaswi ◽  
Marula Siddappa
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumour ◽  
English Literature ◽  
Bone Tumour ◽  
Cell Tumour ◽  
Fibular Graft ◽  
Range Of Movement ◽  
Proximal Ulna ◽  
Rare Case Report ◽  
Rare Location

Giant cell tumour is a benign aggressive bone tumour. Most commonly, it is seen in epiphysiometaphyseal region around knee and distal radius. Proximal ulna is a rare location for giant cell tumour. According to reports, only 4 such cases have been reported in English literature. We report one such case of giant cell tumour of proximal ulna. Patient presented with painless, progressive swelling around right elbow since 4 months. Proximal ulna along with tumour was resected and elbow was reconstructed using nonvascularized free fibular graft. At two years of follow-up, patient is tumour-free and has functional range of movement in elbow. We are reporting the case because of its rare location and for the indigenous treatment modality of using free fibular graft for elbow reconstruction.

Trans-Foveal Approach for Curettage and Bone Grafting of a Giant Cell Tumour in the Femoral Head

2016 ◽  
Vol 26 (6) ◽  
pp. 612-614
Author(s):  
Hannes A. Rüdiger ◽  
Krzystof Piasecki ◽  
Fabio Becce ◽  
Stéphane Cherix
Keyword(s):  
Femoral Head ◽  
Giant Cell ◽  
Bone Grafting ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Case Presentation ◽  
Surgical Access ◽  
Surgical Dislocation ◽  
Articular Cartilage Lesions

Background Surgical access to benign neoplastic lesions of the femoral head are associated with significant morbidity, including contamination of intra-osseous access tracks, articular cartilage lesions, avascular bone necrosis or tumour recurrence due to incomplete curettage. Case presentation We present a case of a 20-year-old female with a giant cell tumour in the femoral head, which was treated with curettage through a trans-foveal approach and bone grafting. This technique includes a surgical dislocation of the hip with trochanteric osteotomy. Results At the latest follow-up at 2 years, there was no evidence of local recurrence or avascular necrosis on MRI, and the patient was pain free and back to sports.

Beware the “giant cell tumour” of the distal radius

2009 ◽  
Vol 20 (2) ◽  
pp. 109-111 ◽  
Author(s):  
Robert U. Ashford ◽  
Judy Soper ◽  
Paul D. Stalley
Keyword(s):  
Giant Cell ◽  
Distal Radius ◽  
Giant Cell Tumour ◽  
Cell Tumour

Recurrent primary giant cell tumour of the proximal radius with pulmonary metastases

2008 ◽  
Vol 75 (6) ◽  
pp. 740-741
Author(s):  
Mickael Ropars ◽  
Pierre Siret ◽  
Rajiv Kaila ◽  
Helene Duval ◽  
Thierry Dréano
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumour ◽  
Pulmonary Metastases ◽  
Cell Tumour ◽  
Proximal Radius
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