scholarly journals Serum Cholesterol Reduction Efficacy of Biscuits with Added Plant Stanol Ester

Cholesterol ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Wantanee Kriengsinyos ◽  
Ajima Wangtong ◽  
Surat Komindr
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Double Blind ◽  
Plant Stanol Ester ◽  
Plant Stanols ◽  
Plant Stanol ◽  
Elevated Cholesterol ◽  
Plant Stanol Esters ◽  
Stanol Ester

This study’s aim was to test the low-density lipoprotein cholesterol- (LDL-c-) lowering efficacy of biscuits containing 2 g of plant stanols, which corresponded to 3.4 g of plant stanol esters. The biscuit is a new food format that can be consumed as a snack. In a double-blind, placebo-controlled parallel design study, 119 mildly to moderately hypercholesterolemic volunteers were randomized to plant stanol or control groups. Subjects were comparable in age, gender, lipid profiles, and body mass index. They consumed a control biscuit once a day for a two-week period, followed by a four-week intervention period that either had a plant stanol ester biscuit or a control. During the habitual diet, one biscuit per day was consumed at any time that subjects wished. Serum lipid profiles were measured at the first day of run-in, at baseline, and at the study’s end. Compared to the control, the total cholesterol (TC), LDL-c, and the LDL-to-high-density lipoprotein (LDL/HDL) ratio had serum reductions of 4.9%, 6.1%, and 4.3%, respectively, and were observed after 4 weeks of biscuit consumption with added plant stanols (P < 0.05). A significantly higher reduction in LDL-c (8.9%) and LDL/HDL ratio (11.4%) was measured in those taking a plant stanol biscuit with a meal compared to those who consumed a plant stanol biscuit without other food. In conclusion, incorporating plant stanols into a biscuit is an attractive, convenient, and acceptable way to modestly lower elevated cholesterol concentrations. For optimal efficacy, biscuits should be consumed with a meal as part of a healthy diet.

scholarly journals Plant Stanol Esters Reduce LDL (Low-Density Lipoprotein) Aggregation by Altering LDL Surface Lipids

2020 ◽  
Vol 40 (9) ◽  
pp. 2310-2321 ◽  
Author(s):  
Maija Ruuth ◽  
Lauri Äikäs ◽  
Feven Tigistu-Sahle ◽  
Reijo Käkelä ◽  
Harri Lindholm ◽  
...  
Keyword(s):  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Ester Group ◽  
Cholesterol Concentration ◽  
Plant Stanol Ester ◽  
Ldl Particles ◽  
Plant Stanol ◽  
Plant Stanol Esters ◽  
Stanol Ester

Objective: Plant stanol ester supplementation (2–3 g plant stanols/d) reduces plasma LDL (low-density lipoprotein) cholesterol concentration by 9% to 12% and is, therefore, recommended as part of prevention and treatment of atherosclerotic cardiovascular disease. In addition to plasma LDL-cholesterol concentration, also qualitative properties of LDL particles can influence atherogenesis. However, the effect of plant stanol ester consumption on the proatherogenic properties of LDL has not been studied. Approach and Results: Study subjects (n=90) were randomized to consume either a plant stanol ester-enriched spread (3.0 g plant stanols/d) or the same spread without added plant stanol esters for 6 months. Blood samples were taken at baseline and after the intervention. The aggregation susceptibility of LDL particles was analyzed by inducing aggregation of isolated LDL and following aggregate formation. LDL lipidome was determined by mass spectrometry. Binding of serum lipoproteins to proteoglycans was measured using a microtiter well-based assay. LDL aggregation susceptibility was decreased in the plant stanol ester group, and the median aggregate size after incubation for 2 hours decreased from 1490 to 620 nm, P =0.001. Plant stanol ester-induced decrease in LDL aggregation was more extensive in participants having body mass index<25 kg/m 2 . Decreased LDL aggregation susceptibility was associated with decreased proportion of LDL-sphingomyelins and increased proportion of LDL-triacylglycerols. LDL binding to proteoglycans was decreased in the plant stanol ester group, the decrease depending on decreased serum LDL-cholesterol concentration. Conclusions: Consumption of plant stanol esters decreases the aggregation susceptibility of LDL particles by modifying LDL lipidome. The resulting improvement of LDL quality may be beneficial for cardiovascular health. Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT01315964.

The Effects of Plant Stanol Ester in Different Subject Groups

2010 ◽  
Vol 6 (3) ◽  
pp. 18 ◽  
Author(s):  
Helena Gylling ◽  
Tatu A Miettinen ◽  
◽  
Keyword(s):  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Surrogate Marker ◽  
Density Lipoprotein ◽  
Serum Triglycerides ◽  
Primary Hypercholesterolaemia ◽  
Plant Stanol Ester ◽  
Reactive Protein ◽  
Plant Stanol ◽  
Stanol Ester

Different food products enriched with plant stanol esters have proved effective and safe as a dietary hypocholesterolaemic tool in about 60 published clinical studies during 15 years on the market. In addition to lowering low-density lipoprotein (LDL) cholesterol by 10% with a dose of 2g/day, plant stanol effectively reduces serum plant sterols and also, in some studies, serum triglycerides. It has been shown to be an effective dietary hypocholesterolaemic agent in adults and children with primary hypercholesterolaemia, in familial hypercholesterolaemia, in coronary subjects and in type 1 and type 2 diabetes. Plant stanol ester can be combined with statin to obtain more powerful serum total and LDL cholesterol reduction. This combination therapy inhibits both cholesterol synthesis and absorption. Plant stanol ester reduced the C-reactive protein (CRP) level in recent studies and, in contrast to ezetimibe, it does not change the LDL particle size. Plant stanol ester consumption tends to reduce the plant sterol contents of arterial wall, and in some, but not all, studies it improves endothelial function, a surrogate marker of pre-clinical atherosclerosis.

scholarly journals Cholesterol Lowering Effect of Plant Stanol Ester Yoghurt Drinks with Added Camelina Oil

Cholesterol ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Pia Salo ◽  
Päivi Kuusisto
Keyword(s):  
Ldl Cholesterol ◽  
Double Blind ◽  
Cholesterol Lowering ◽  
Plant Stanol Ester ◽  
Camelina Oil ◽  
Plant Stanols ◽  
Lowering Effect ◽  
Plant Stanol ◽  
Stanol Ester ◽  
Cholesterol Lowering Effect

The aim of this study was to investigate the effects of yoghurt minidrinks containing two doses of plant stanol ester either with or without added camelina oil on the serum cholesterol levels in moderately hypercholesterolemic subjects. In this randomised, double-blind, parallel group study, 143 subjects consumed a 65 mL minidrink together with a meal daily for four weeks. The minidrink contained 1.6 or 2.0 grams of plant stanols with or without 2 grams of alpha-linolenic acid-rich camelina oil. The placebo minidrink did not contain plant stanols or camelina oil. All plant stanol treated groups showed statistically significant total, LDL, and non-HDL cholesterol lowering relative to baseline and relative to placebo. Compared to placebo, LDL cholesterol was lowered by 9.4% (p<0.01) and 8.1% (p<0.01) with 1.6 g and 2 g plant stanols, respectively. With addition of Camelina oil, 1.6 g plant stanols resulted in 11.0% (p<0.01) and 2 g plant stanols in 8.4% (p<0.01) reduction in LDL cholesterol compared to placebo. In conclusion, yoghurt minidrinks with plant stanol ester reduced serum LDL cholesterol significantly and addition of a small amount of camelina oil did not significantly enhance the cholesterol lowering effect. This trial was registered with ClinicalTrials.gov NCT02628990.

scholarly journals Dietary plant stanol ester consumption improves immune function in asthma patients: results of a randomized, double-blind clinical trial1

2016 ◽  
Vol 103 (2) ◽  
pp. 444-453 ◽  
Author(s):  
Florence Brüll ◽  
Els De Smet ◽  
Ronald P Mensink ◽  
Anita Vreugdenhil ◽  
Anja Kerksiek ◽  
...  
Keyword(s):  
Immune Function ◽  
Double Blind ◽  
Plant Stanol Ester ◽  
Plant Stanol ◽  
Asthma Patients ◽  
Stanol Ester
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