scholarly journals Vitamin K Deficiency Embryopathy from Hyperemesis Gravidarum

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Andrew S. Lane ◽  
Jennifer L. Stallworth ◽  
Kacey Y. Eichelberger ◽  
Kenneth F. Trofatter
Keyword(s):  
Vitamin K ◽  
Enteral Feeding ◽  
Hyperemesis Gravidarum ◽  
Severe Form ◽  
Common Condition ◽  
Vitamin K Deficiency ◽  
Facial Profile ◽  
Prepregnancy Weight ◽  
K Deficiency ◽  
Nasal Hypoplasia

A 21-year-old primigravida had a pregnancy complicated by hyperemesis gravidarum (HG) beginning at 7-week gestation. Despite medical therapy, she lost 18% of her prepregnancy weight. Early ultrasound at 14 weeks demonstrated a flattened facial profile with nasal hypoplasia (Binder phenotype) consistent with vitamin K deficiency from HG. She had a percutaneous endoscopic gastrojejunostomy tube placed for enteral feeding at 15-week gestation. At repeated anatomy ultrasound at 21-week gestation, delivery, and postnatal pediatric genetics exam, nasal hypoplasia was consistent with vitamin K deficiency embryopathy from HG. Nausea and vomiting of pregnancy is a common condition. HG, the most severe form, has many maternal and fetal effects. Evaluation of vitamin K status could potentially prevent this rare and disfiguring embryopathy.

scholarly journals Intraperitoneal Hemorrhage in a Pregnant Woman with Hyperemesis Gravidarum: Vitamin K Deficiency as a Possible Cause

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Yosuke Baba ◽  
Hiroyuki Morisawa ◽  
Koyomi Saito ◽  
Hironori Takahashi ◽  
Kazuma Rifu ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Intestinal Obstruction ◽  
Vitamin K ◽  
Pain Treatment ◽  
Hyperemesis Gravidarum ◽  
Japanese Woman ◽  
Hemorrhagic Diathesis ◽  
Vitamin K Deficiency ◽  
Vitamin Deficiencies ◽  
K Deficiency

Hyperemesis gravidarum can cause various vitamin deficiencies. Vitamin K deficiency can lead to coagulopathy or hemorrhagic diathesis. A nulliparous Japanese woman with hyperemesis gravidarum at 105/7weeks was admitted with giant myoma, intestinal obstruction, and abdominal pain. Treatment for a degenerative myoma was instituted with intravenous antibiotics. The abdominal pain ameliorated, but intestinal obstruction persisted. At 166/7weeks, we performed laparotomy for release of intestinal obstruction, when intraabdominal bleeding of 110 mL existed. Blood tests revealed coagulopathy secondary to vitamin K deficiency. The coagulopathy responded to intravenous vitamin K injection. Coagulopathy due to vitamin K deficiency can occur with hyperemesis gravidarum, and coexisting intestinal obstruction and broad-spectrum antibiotics can aggravate the deficiency.

scholarly journals Vitamin K deficiency under enteral feeding: real or imagined threat

2021 ◽  
Vol 4 (4) ◽  
pp. 01-04
Author(s):  
Jochanan E. Naschitz ◽  
Natalia Zaigraykin ◽  
Elena Zlotover ◽  
Faisal Neime
Keyword(s):  
Vitamin K ◽  
Enteral Feeding ◽  
Hospital Care ◽  
Functional Form ◽  
Clotting Factors ◽  
Vitamin K Deficiency ◽  
Daily Vitamin ◽  
K Deficiency ◽  
Enteral Formulas

Patients receiving enteral feeding may develop vitamin K deficiency if the nutrition formula does not meet their daily vitamin K requirement. Vitamin K is essential for clotting factors II, VII, IX and X to be released in their functional form. Under vitamin K deficiency a coagulopathy may develop which is marked by prolongation of the prothrombin time (PT). There might be a need, unrecognized to-day, for monitoring the PT in patients receiving enteral feeding to unmask a latent coagulopathy. We assessed the prevalence of a prolonged PT in patients receiving enteral feeding for 3 months of more with one or a combination of the enteral formulas Osmolite®, Jevity®, Easymilk®. Twenty-three residents in long-term hospital care received solely enteral feeding for an average of 37 months, SD 21 months. The median daily vitamin K supplied by enteral feeding was 96.8 mcg (average 103.3 mcg, SD 28.8); this does not satisfy the 150 mcg of vitamin K required by the Food and Drug Administration. In 21 patients the PT-INR was 1-1.2 (normal). The PT was prolonged in two patients. In one of the latter, prolongation of PT-INR was not confirmed two days later. In the second case, the patient having repeatedly a PT-INR 1.4 (and a normal APTT), administration of vitamin K did not correct the PT. In conclusion, long-term vitamin K-deficient nutrition did not affect the vitamin K-dependent coagulation. This data may argue against the supposed need to monitor the PT in patients receiving long-term enteral nutrition.

Vitamin K deficiency in hyperemesis gravidarum as a potential cause of fetal intracranial hemorrhage and hydrocephalus

2007 ◽  
Vol 28 (1) ◽  
pp. 59-61 ◽  
Author(s):  
Yukie Kawamura ◽  
Kazuya Kawamata ◽  
Mitsuhisa Shinya ◽  
Michiyo Higashi ◽  
Masaki Niiro ◽  
...  
Keyword(s):  
Intracranial Hemorrhage ◽  
Vitamin K ◽  
Hyperemesis Gravidarum ◽  
Vitamin K Deficiency ◽  
K Deficiency

scholarly journals Major bleeding under enoxaparin treatment. An unexpected second offender

2021 ◽  
Vol 11 (3) ◽  
pp. 68-69
Author(s):  
Jochanan E Naschitz
Keyword(s):  
Ischemic Stroke ◽  
Vitamin K ◽  
Major Bleeding ◽  
Enteral Feeding ◽  
Left Ventricular ◽  
Mural Thrombus ◽  
Vitamin K Deficiency ◽  
Major Hemorrhage ◽  
Daily Dose ◽  
K Deficiency

Admitted to hospital with an ischemic stroke, a 63-year-old male was diagnosed with a left ventricular mural thrombus. Enoxaparin treatment was started. Over 6 weeks there were two episodes of major hemorrhage needing brief discontinuation of anticoagulation. A previously normal prothrombin time (PT) became prolonged upon which vitamin K deficiency was diagnosed. The deficiency was caused by enteral feeding using a formula which did not contain the required daily dose of vitamin K. A triple message emerges from this observation: theneed for monitoring the PT in patients receiving enteral feeding, more so in those receiving anticoagulant along with enteral feeding, and the appeal to fortify feeding formulas with vitamin K.

COAGULOPATHY SECONDARY TO VITAMIN K DEFICIENCY IN HYPEREMESIS GRAVIDARUM

1998 ◽  
Vol 92 (Supplement) ◽  
pp. 673-675
Author(s):  
Julian N. Robinson ◽  
Rini Banerjee ◽  
Mari-Paule Thiet
Keyword(s):  
Vitamin K ◽  
Hyperemesis Gravidarum ◽  
Vitamin K Deficiency ◽  
K Deficiency
Sign in / Sign up

Export Citation Format

Share Document