scholarly journals One-Year Results of Simultaneous Topography-Guided Photorefractive Keratectomy and Corneal Collagen Cross-Linking in Keratoconus Utilizing a Modern Ablation Software

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
A. M. Sherif ◽  
M. A. Ammar ◽  
Y. S. Mostafa ◽  
S. A. Gamal Eldin ◽  
A. A. Osman
Keyword(s):  
Photorefractive Keratectomy ◽  
Cross Linking ◽  
Safety Index ◽  
Interventional Study ◽  
Effective Option ◽  
Efficacy Index ◽  
One Year ◽  
Collagen Cross Linking ◽  
Corneal Collagen

Purpose.To evaluate effectiveness of simultaneous topography-guided photorefractive keratectomy and corneal collagen cross-linking in mild and moderate keratoconus.Methods. Prospective nonrandomized interventional study including 20 eyes of 14 patients with grade 1-2 keratoconus that underwent topography-guided PRK using a Custom Ablation Transition Zone (CATz) profile with 0.02% MMC application immediately followed by standard 3 mw/cm2UVA collagen cross-linking. Maximum ablation depth did not exceed 58 μm. Follow-up period: 12 months.Results.Progressive statistically significant improvement of UCVA from0.83±0.37logMAR preoperative, reaching0.25±0.26logMAR at 12 months (P<0.001). Preoperative BCVA (0.27±0.31logMAR) showed a progressive improvement reaching0.08±0.12logMAR at 12 months (P=0.02). MeanKmax reduced from48.9±2.8to45.4±3.1 D at 12 months (P<0.001), meanKmin reduced from45.9±2.8 D to44.1±3.2 D at 12 months (P<0.003), mean keratometric asymmetry reduced from3.01±2.03 D to1.25±1.2 D at 12 months (P<0.001). The safety index was 1.39 at 12 months and efficacy index 0.97 at 12 months.Conclusion. Combined topography-guided PRK and corneal collagen cross-linking are a safe and effective option in the management of mild and moderate keratoconus.Precis. To our knowledge, this is the first published study on the use of the CATz ablation system on the Nidek Quest excimer laser platform combined with conventional cross-linking in the management of mild keratoconus.

scholarly journals Safety and Visual Outcome of Visian Toric ICL Implantation after Corneal Collagen Cross-Linking in Keratoconus: Up to 2 Years of Follow-Up

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Rafic Antonios ◽  
Ali Dirani ◽  
Ali Fadlallah ◽  
Elias Chelala ◽  
Adib Hamade ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Visual Outcome ◽  
Cross Linking ◽  
Implantable Collamer Lens ◽  
Distance Visual Acuity ◽  
Uncorrected Distance Visual Acuity ◽  
Effective Option ◽  
Collagen Cross Linking ◽  
Corneal Collagen

Purpose. To evaluate the long-term safety and clinical outcome of phakic Visian toric implantable collamer lens (ICL) insertion after corneal collagen cross-linking (CXL) in progressive keratoconus.Methods. This was a retrospective study of 30 eyes (19 patients), with progressive keratoconus, who underwent sequential CXL followed by Visian toric ICL implantation after 6 months.Results. At baseline, 6 eyes had stage I, 14 eyes stage II, and 10 eyes stage III keratoconus graded by Amsler-Krumeich classification. At 6 months after CXL, onlyK(steep) andK(max) decreased significantly from baseline, with no change in visual acuity or refraction. Flattening in keratometric readings was stable thereafter. There was significant improvement in mean uncorrected distance visual acuity (1.57 ± 0.56 to 0.17 ± 0.06 logMAR,P<0.001) and mean corrected distance visual acuity (0.17 ± 0.08 to 0.11 ± 0.05 logMAR,P<0.001) at 12 months after ICL implantation that was maintained at the 2-year follow-up. Mean cylinder power and mean spherical equivalent (SE) also decreased significantly after ICL implantation. A small hyperopic shift in SE (+0.25 D) was observed at 2 years that did not alter visual outcomes.Conclusions. Visian toric ICL implantation following CXL is an effective option for improving visual acuity in patients with keratoconus up to 2 years.

scholarly journals Corneal collagen cross-linking in pediatric patients with keratoconus

2020 ◽  
Vol 148 (1-2) ◽  
pp. 70-75 ◽  
Author(s):  
Svetlana Stanojlovic ◽  
Vedrana Pejin ◽  
Tanja Kalezic ◽  
Jelica Pantelic ◽  
Borivoje Savic
Keyword(s):  
Visual Acuity ◽  
Pediatric Patients ◽  
Corneal Thickness ◽  
Cross Linking ◽  
Rubbing Behavior ◽  
Distant Visual Acuity ◽  
One Year ◽  
Collagen Cross Linking ◽  
Corneal Collagen

Introduction/Objective. The aim of this study was to report visual, refractive, and tomographic outcomes of corneal collagen cross-linking (CXL) in pediatric keratoconus. Methods. This retrospective study included 17 eyes of 12 patients with progressive keratoconus who underwent epithelium-off CXL at the age ? 18 years. Following data were analyzed at baseline and postoperatively at one, three, six, nine, 12 months for all the patients, and annually where available: uncorrected distant visual acuity (UDVA) and best spectacle-corrected distant visual acuity (CDVA), refraction and corneal tomography. Results. Mean UDVA improved significantly from 0.52 ? 0.38 at baseline to 0.24 ? 0.29 logarithm of minimum angle resolution (log MAR) at one year (p = 0.011) and remained stable at two-year follow-up (0.21 ? 0.34 log MAR). Mean CDVA was 0.15 ? 0.21 at baseline and 0.06 ? 0.13 log MAR at one year (p = 0.248). Maximum keratometry showed a significant flattening of 1.30 ? 1.99 D (p = 0.011) after a year and remained stable two years after CXL. Minimum keratometry significantly decreased with a mean change of 1.34 ? 1.37 (p = 0.001). Mean reduction of corneal thickness after CXL was 55.35 ? 64.42 ?m (P=0.003). After a year, seven (42%) eyes showed Kmax regression, nine (53%) stabilization, and one (5%) progression. Conclusion. In our study CXL effectively prevented progression of keratoconus in 95% of pediatric patients after a year, while improving UDVA and keratometry values. One patient with eye rubbing behavior showed signs of keratoconus progression after CXL treatment.

scholarly journals Implantable Collamer Lens for Correction of Refractive Errors in Patients with Keratoconus following Collagen Cross-Linking: One Year Follow-up

2014 ◽  
Vol 3 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Hassenien Safa Shuber
Keyword(s):  
Visual Acuity ◽  
Cross Linking ◽  
Refractive Errors ◽  
Implantable Collamer Lens ◽  
Uncorrected Visual Acuity ◽  
Efficacy Index ◽  
The Mean ◽  
One Year ◽  
Collagen Cross Linking

ABSTRACT Objective The purpose of this study is to assess the predictability, safety, efficacy and stability of correction of refractive errors in patients with keratoconus using Visian implantable collamer lens (ICL) following collagen cross-linking. Materials and methods This prospective, non-comparative study evaluated 20 eyes of 14 patients with keratoconus subjected to implantation of intraocular collamer lens at least 1 year following collagen cross-linking and stable refraction. Mean preoperative myopia was −8.43 ± 5.13 Diopters (D) (–3.5 to −20.0D and mean cylinder was −2.19 ± 1.28D (0.0 to −4.5D). The preoperative spherical equivalent (SE) was −9.52 ± 5.33D (–3.75 to −21.25D). During the 12 months follow-up, uncorrected visual acuity, best corrected visual acuity, refraction, intraocular pressure and vaulting are measured. Results At 12 months postoperatively, 90% of eye had refractive cylinder of <1.0D with (p = 0.003) and 20 (100%) eyes was within ±0.75D of sphere at 1 year (r2 = 0.99) and (p = 0.0085). The mean postoperative BCVA in decimal was 0.498 ± 0.232, while the mean preoperative BCVA was 0.484 ± 0.285. The safety index at 12 months was 1.02. The mean postoperative UCVA in decimal was 0.498 ± 0.232 and the mean preoperative BCVA is 0.484 ± 0.29 and the efficacy index at 12 months was 1.01. Conclusion Implantation of Visian Intraocular collamer lens is predictable, safe and effective way to correct refractive error in patients with keratoconus following collagen cross-linking. How to cite this article Shuber HS. Implantable Collamer Lens for Correction of Refractive Errors in Patients with Keratoconus following Collagen Cross-Linking: One Year Follow-up. Int J Kerat Ect Cor Dis 2014;3(1):29-35.

Corneal collagen cross-linking with and without simultaneous intrastromal corneal ring segment implantation: One-year pilot study

2019 ◽  
pp. 112067211988787 ◽  
Author(s):  
Indra Prasad Sharma ◽  
Ramendra Bakshi ◽  
Monica Chaudhry
Keyword(s):  
Visual Acuity ◽  
Confidence Interval ◽  
Randomized Study ◽  
Cross Linking ◽  
Intrastromal Corneal Ring ◽  
Ring Segment ◽  
One Year ◽  
Collagen Cross Linking ◽  
Corneal Collagen

Aim: The aim of this study was to assess and compare the visual, refractive, and topographic outcomes of keratoconic eyes treated with corneal collagen cross-linking combined with and without same day intrastromal corneal ring segment over the first 12 months. Methods: This prospective randomized study analyzed 38 eyes of 30 consecutive keratoconus patients aged 26.21 ± 6.97 (range = 15–41) years. A total of 20 eyes were treated with collagen cross-linking alone, and 18 eyes underwent collagen cross-linking combined with simultaneous femtosecond laser-assisted intrastromal corneal ring segment. Visual acuity, manifest refraction, and corneal topography (using a rotating Scheimpflug topographer) were assessed and compared between the two groups at baseline, 6, and 12 months. Results: On an average follow-up duration of 12.2 ± 0.50 (range = 11–13) months, both collagen cross-linking alone and collagen cross-linking with simultaneous intrastromal corneal ring segment implantation were effective. However, collagen cross-linking plus intrastromal corneal ring segment resulted in an additional improvement of uncorrected distance visual acuity of 0.16 (95% confidence interval = 0.01 to 0.32) logarithm of the minimum angle of resolution units (p = 0.035), cylindrical power by 1.16 D (95% confidence interval = 0.25 to 2.06, p = 0.014), and spherical equivalent by 1.40 D (95% confidence interval = −2.71 to −0.08, p = 0.038) at 1 year. During the study period, no serious intraoperative or postoperative complications were noted in either group. Conclusion: One-year follow-up results suggest that collagen cross-linking with simultaneously combined intrastromal corneal ring segment implantation could yield an additive visual and refractive outcome. The combined procedure is safe and merits consideration for the treatment of progressive keratoconus to achieve better visual rehabilitation.

scholarly journals One-year follow-up of accelerated transepithelial corneal collagen cross-linking for progressive pediatric keratoconus

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Mi Tian ◽  
Weijun Jian ◽  
Ling Sun ◽  
Yang Shen ◽  
Xiaoyu Zhang ◽  
...  
Keyword(s):  
Cross Linking ◽  
One Year ◽  
Collagen Cross Linking ◽  
Corneal Collagen

scholarly journals Outcomes of Corneal Collagen Cross-linking for Keratoconus the Effect of Cone Location

2013 ◽  
Vol 2 (1) ◽  
pp. 16-19 ◽  
Author(s):  
Vinay Agrawal
Keyword(s):  
Mean Shift ◽  
Cross Linking ◽  
Significant Shift ◽  
Central Cone ◽  
The Difference ◽  
One Year ◽  
D 12 ◽  
Collagen Cross Linking ◽  
Corneal Collagen

ABSTRACT Aim One-year outcome of corneal collagen cross-linking (CXL) for keratoconus with reference to topographic cone location. Materials and methods Clinical audit of the results of CXL were used. Three hundred and seventy-eight eyes of 225 patients with preoperative and 12-month completed follow-up were included. Cone location was defined by cone location magnitude index (CLMI) using the Keratron scout topography system. The eyes were divided into two groups–central with cone location within 3 mm zone of the topography map and paracentral with cone location between the 3 and 5 mm zones. Results The overall group showed a mean flattening of the CLMI of 1.67 D [preoperative 53.35 ± 5.63 D, 12 months 51.69 ± 4.67 (p = 0.095)]. The flattening in central cone group was 2.67 D [preoperative 54.01 ± 5.3819, at 12 months to 51.341 ± 4.588 (p = 0.016)]. In paracentral cone group the flattening was lesser at 1.73 D [preoperative apex K 52.805 ± 6.382, at 12 months 51.03 ± 4.82 (p = 0.006)]. The difference between groups was statistically significant (p < 0.001). The central cone group showed no significant shift in cone position [preoperative 1.0059 ± 0.24, at 12 months 0.986 ± 0.206 (p = 0.45)]. The paracentral cone group showed a significant mean shift of 1.05 mm in cone location [preoperative 2.224 ± 0.440, at 12 months 1.196 ± 0.529 (p = 0.001)]. Conclusion Cone location has an impact on the results of corneal cross-linking. The paracentral cones show a significant shift toward the center of the cornea and the central cones show a larger flattening. How to cite this article Agrawal V. Outcomes of Corneal Collagen Cross-linking for Keratoconus the Effect of Cone Location. Int J Kerat Ect Cor Dis 2013;2(1):16-19.

scholarly journals One-Year Follow-Up of Changes in Corneal Densitometry After Accelerated (45 mW/cm2) Transepithelial Corneal Collagen Cross-Linking for Keratoconus

Cornea ◽  
2016 ◽  
Vol 35 (11) ◽  
pp. 1434-1440 ◽  
Author(s):  
Yang Shen ◽  
Weijun Jian ◽  
Ling Sun ◽  
Meng Li ◽  
Tian Han ◽  
...  
Keyword(s):  
Cross Linking ◽  
Corneal Densitometry ◽  
One Year ◽  
Collagen Cross Linking ◽  
Corneal Collagen

scholarly journals The Effects of Epithelium-off Corneal Collagen Cross-linking on Peripheral Corneal Keratometry, Pachymetry as well as Scheimpflug Imaging Calculated Corneal Indices in Keratoconus

2014 ◽  
Vol 3 (3) ◽  
pp. 113-117
Author(s):  
Adam Muzychuk ◽  
Victor Penner ◽  
Guillermo Rocha ◽  
Ahmed Al-Ghoul
Keyword(s):  
Case Series ◽  
Cross Linking ◽  
Collagen Crosslinking ◽  
Post Procedure ◽  
Scheimpflug Imaging ◽  
Corneal Collagen Crosslinking ◽  
One Year ◽  
Collagen Cross Linking ◽  
Corneal Collagen

ABSTRACT Purpose To utilize Scheimpflug imaging to describe corneal changes in keratoconic patients undergoing collagen cross- linking. Study type Case series. Study design Retrospective chart review at two sites: Calgary, Alberta and Brandon, Manitoba, Canada. All patients were diagnosed with keratoconus and had undergone corneal collagen crosslinking. All patients had pre- and post-procedure imaging done with Oculus Pentacam. Results Sixty-one eyes of 48 patients with 6 months follow- up and 36 eyes of 27 patients with one year follow-up were included. Average age was 27 ± 12 years (15-48 years). Fifty- one males and 10 females were studied. At 1 year follow-up, all Pentacam indices were found to improve: ISV −4.44 ± 18.6 (p = 0.16), IVA −0.07 ± 0.27 (p = 0.12), KI −0.009 ± 0.082 (p = 0.49), CKI −0.012 ± 0.027 (p = 0.01), IHA −3.87 ± 23.3 (p = 0.33) and IDH −0.062 ± 0.308 (p = 0.24). Keratometry measurements were flatter at the pupil centre by 0.87 ± 2.53 D (p = 0.05). Kmax and Kmin were flatter by 0.58 ± 1.37 D (p = 0.02) and 0.33 ± 1.70 D (p = 0.25) respectively. Pupil center pachymetry was thinner by 12.9 ± 21.1 µm (p = 0.0006) at 6 months, as were the corneal apex and thinnest local by 12.9 ± 22.3 µm (p = 0.001) and 21.8 ± 54.6 µm (p = 0.05) respectively. However, all central pachymetry readings were not statistically different from baseline at the one year measurements. Peripheral corneal measurements at 6 mm diameter were no different from baseline at 6 months, however, were significantly thicker at the 1 year follow-up. Conclusion The data, in this study, points to a more uniform cornea post corneal collagen crosslinking. The inferior cornea becomes flatter and superior cornea steeper with less variation when comparing the corneal curvatures. The peripheral cornea becomes thicker at 1 year post-procedure. Collagen cross- linking stabilizes the cornea. How to cite this article Penner V, Muzychuk A, Al-Ghoul A, Rocha G. The Effects of Epithelium-off Corneal Collagen Crosslinking on Peripheral Corneal Keratometry, Pachymetry as well as Scheimpflug Imaging Calculated Corneal Indices in Keratoconus. Int J Kerat Ect Cor Dis 2014;3(3):113-117.

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