scholarly journals Cardiovascular Risk Factors in Subclinical Hypothyroidism: A Case Control Study in Nepalese Population

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Rajendra KC ◽  
Saroj Khatiwada ◽  
Kishun Deo Mehta ◽  
Pratikshya Pandey ◽  
Madhab Lamsal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Subclinical Hypothyroidism ◽  
Ldl Cholesterol ◽  
Case Control Study ◽  
Density Lipoprotein ◽  
Case Control ◽  
Hs Crp ◽  
Hypothyroid Patients ◽  
Control Study

Objectives. To assess cardiovascular risk factors in Nepalese population with subclinical hypothyroidism as compared to age and sex matched controls.Materials and Methods. A case control study was conducted among 200 subjects (100 subclinical hypothyroid and 100 euthyroid) at B.P. Koirala Institute of Health Sciences, Dharan, Nepal. Demographic and anthropometric variables including systolic and diastolic blood pressure (BP) were taken. Blood samples were assayed for serum free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and high sensitivity C reactive protein (hs-CRP).Results. Subclinical hypothyroid patients had significantly higher diastolic BP, total cholesterol, LDL cholesterol, and hs-CRP than controls. The odds ratio of having hypercholesterolemia (>200 mg/dL), low HDL cholesterol (<40 mg/dL), undesirable LDL-cholesterol (>100 mg/dL), high hs-CRP (>1 mg/L), and high diastolic BP (>80 mmHg) and being overweight (BMI ≥ 23 Kg/m2) in subclinical hypothyroidism was 2.29 (95% CI; 1.2–4.38,p=0.011), 1.73 (95% CI; 0.82–3.62,p=0.141), 3.04 (95% CI; 1.66–5.56,p<0.001), 2.02 (95% CI; 1.12–3.64,p=0.018), 3.35 (95% CI; 1.72–6.55,p<0.001), and 0.9 (95% CI; 0.48–1.67,p=0.753), respectively, as compared to controls.Conclusion. Subclinical hypothyroid patients are associated with higher risk for cardiovascular disease than euthyroid subjects.

scholarly journals SAT0077 CARDIOVASCULAR RISK ASSESSMENT WITH CAROTID ULTRASONOGRAPHY IN ADDITION TO THE TRADITIONAL CARDIOVASCULAR RISK FACTORS IN RHEUMATOID ARTHRITIS PATIENTS: A CASE CONTROL STUDY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 973-973
Author(s):  
R. Gonzalez Mazario ◽  
J. J. Fragio-Gil ◽  
P. Martinez Calabuig ◽  
E. Grau García ◽  
M. De la Rubia Navarro ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Disease Duration ◽  
Case Control Study ◽  
Case Control ◽  
Healthy Controls ◽  
Carotid Ultrasonography ◽  
Control Study

Background:Cardiovascular disease (CV) is the most frequent cause of death in rheumatoid arthritis (RA) patients. It is well known that RA acts as an independent cardiovascular risk factor.Objectives:To assess the CV risk in RA patients using carotid ultrasonography (US) additionally to the traditional CV risk factors.Methods:A prospective transversal case control study was performed, including adult RA patients who fulfilled ACR/EULAR 2010 criteria and healthy controls matched according to CV risk factors. Population over 75 years old, patients with established CV disease and/or chronic kidney failure (from III stage) were excluded. The US evaluator was blinded to the case/control condition and evaluated the presence of plaques and the intima-media thickness. Statistical analysis was performed with R (3.6.1 version) and included a multivariate variance analysis (MANOVA) and a negative binomial regression adjusted by confounding factors (age, sex and CV risk factors).Results:A total of 200 cases and 111 healthy controls were included in the study. Demographical, clinical and US data are exposed in table 1. Not any difference was detected in terms of CV risk factors between the cases and controls. In both groups a relationship between age, BMI and high blood pressure was detected (p<0.001).Table 1.Table 2.RA basal characteristicsDisease duration (years)16,98 (11,38)Erosions (X-Ray of hands/feet)163 (81,5%)Seropositive (RF/anti-CCP)146 (73%)Extra-articular symptoms44 (22%)Intersticial difusse lung disease10 (5%)Rheumatoid nodules14 (7%)Prednisone use103 (51,5%)Median dose of Prednisone last year (mg)2,34 (2,84)sDMARDsMethotrexate104 (52%)Leflunomide29 (14,5%)Hydroxycloroquine9 (4,5%)bDMARDs89 (44,5%) TNFi41 (20,5%) Abatacept15 (7,5%) IL6i22 (11%) RTX11 (5,5%)JAKi26 (13%) Baricitinib11 (5,5%) Tofacitinib15 (7,5%)DAS 28-ESR3,1 (2,3, 3,9)SDAI7,85 (4,04, 13,41)HAQ0,88 (0,22, 1,5)RF (U/mL)51 (15, 164,25)Anti-CCP (U/mL)173 (22, 340)Patients showed higher intima-media (both right and left) thickness compared to controls (p<0.006). Moreover it was also related to the disease duration and DAS28 score (p<0.001). A higher plaque account was noted in cases(p<0.004) and it was also related to the disease duration (p<0.001).Conclusion:RA implies a higher CV risk. Traditional CV risk factors explains only partially the global risk. These findings support that RA acts as an independent cardiovascular risk factor.Disclosure of Interests:None declared

Elastic aortic properties in cystic fibrosis adults without cardiovascular risk factors: A case‐control study

2019 ◽  
Vol 36 (6) ◽  
pp. 1118-1122 ◽  
Author(s):  
Enrico Vizzardi ◽  
Edoardo Sciatti ◽  
Ivano Bonadei ◽  
Elisa Menotti ◽  
Francesco Prati ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cystic Fibrosis ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Serum Levels of TWEAK and Scavenger Receptor CD163 in Type 1 Diabetes Mellitus: Relationship with Cardiovascular Risk Factors. A Case-Control Study

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e43919 ◽  
Author(s):  
Gemma Llauradó ◽  
José-Miguel González-Clemente ◽  
Elsa Maymó-Masip ◽  
David Subías ◽  
Joan Vendrell ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 1 Diabetes ◽  
Cardiovascular Risk ◽  
Case Control Study ◽  
Scavenger Receptor ◽  
Serum Levels ◽  
Case Control ◽  
Control Study
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