scholarly journals Increasing the Time Interval between PCV Chemotherapy Cycles as a Strategy to Improve Duration of Response in Low-Grade Gliomas: Results from a Model-Based Clinical Trial Simulation

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Pauline Mazzocco ◽  
Jérôme Honnorat ◽  
François Ducray ◽  
Benjamin Ribba
Keyword(s):  
Treatment Efficacy ◽  
In Silico ◽  
Therapeutic Strategies ◽  
Clinical Trial Simulation ◽  
Time Interval ◽  
Low Grade ◽  
Low Grade Gliomas ◽  
Before And After ◽  
Duration Of Response ◽  
Pcv Chemotherapy

Background. We previously developed a mathematical model capturing tumor size dynamics of adult low-grade gliomas (LGGs) before and after treatment either with PCV (Procarbazine, CCNU, and Vincristine) chemotherapy alone or with radiotherapy (RT) alone.Objective. The aim of the present study was to present how the model could be used as a simulation tool to suggest more effective therapeutic strategies in LGGs. Simulations were performed to identify schedule modifications that might improve PCV chemotherapy efficacy.Methods. Virtual populations of LGG patients were generated on the basis of previously evaluated parameter distributions. Monte Carlo simulations were performed to compare treatment efficacy acrossin silicoclinical trials.Results. Simulations predicted that RT plus PCV would be more effective in terms of duration of response than RT alone. Additional simulations suggested that, in patients treated with PCV chemotherapy, increasing the interval between treatment cycles up to 6 months from the standard 6 weeks can increase treatment efficacy. The predicted median duration of response was 4.3 years in LGGs treated with PCV cycles given every 6 months versus 3.1 years in patients treated with the classical regimen.Conclusion. The present study suggests that, in LGGs, mathematical modeling could facilitate clinical research by helping to identify,in silico, potentially more effective therapeutic strategies.

Dynamic history of low-grade gliomas before and after temozolomide treatment

2007 ◽  
Vol 61 (5) ◽  
pp. 484-490 ◽  
Author(s):  
Damien Ricard ◽  
Gentian Kaloshi ◽  
Alexandra Amiel-Benouaich ◽  
Julie Lejeune ◽  
Yannick Marie ◽  
...  
Keyword(s):  
Low Grade ◽  
Low Grade Gliomas ◽  
Before And After ◽  
History Of

scholarly journals P17.09 * PCV CHEMOTHERAPY IMMEDIATELY FOLLOWED BY RADIOTHERAPY IN DIFFUSE LOW GRADE GLIOMAS - ABOUT A SERIES OF 12 PATIENTS

2014 ◽  
Vol 16 (suppl 2) ◽  
pp. ii89-ii89
Author(s):  
M. Blonski ◽  
C. Lacroix ◽  
P. N. Thi-Lambert ◽  
G. Gauchotte ◽  
K. Hassani ◽  
...  
Keyword(s):  
Low Grade ◽  
Low Grade Gliomas ◽  
Pcv Chemotherapy

scholarly journals OS06.6 Optimized radiotherapy protocols delay the malignant transformation of low-grade gliomas in-silico

2017 ◽  
Vol 19 (suppl_3) ◽  
pp. iii12-iii12
Author(s):  
A. Henares-Molina ◽  
S. Benzekry ◽  
P. Lara ◽  
M. García-Rojo ◽  
V. Pérez-García ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
In Silico ◽  
Low Grade ◽  
Low Grade Gliomas

scholarly journals Expression of lncRNAs in Low-Grade Gliomas and Glioblastoma Multiforme: An In Silico Analysis

PLoS Medicine ◽  
2016 ◽  
Vol 13 (12) ◽  
pp. e1002192 ◽  
Author(s):  
Brian J. Reon ◽  
Jordan Anaya ◽  
Ying Zhang ◽  
James Mandell ◽  
Benjamin Purow ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
In Silico ◽  
In Silico Analysis ◽  
Low Grade ◽  
Low Grade Gliomas ◽  
Silico Analysis

scholarly journals Seizure burden pre- and postresection of low-grade gliomas as a predictor of tumor progression in low-grade gliomas

2018 ◽  
Vol 6 (3) ◽  
pp. 209-217 ◽  
Author(s):  
Fernando Santos-Pinheiro ◽  
Mingjeong Park ◽  
Diane Liu ◽  
Lawrence N Kwong ◽  
Savannah Cruz ◽  
...  
Keyword(s):  
Seizure Frequency ◽  
Tumor Recurrence ◽  
Surgical Intervention ◽  
Tumor Resection ◽  
Frequency Change ◽  
Low Grade ◽  
Low Grade Gliomas ◽  
Before And After ◽  
Early Tumor ◽  
Early Tumor Recurrence

Abstract Background Low-grade gliomas (LGGs) are slow-growing, infiltrative tumors frequently associated with seizures. Predicting which patients will develop early tumor recurrence based on clinical indicators following initial surgical intervention remains a challenge. Seizure recurrence following surgery may be an early indicator of tumor recurrence, especially in patients presenting with increase in seizure frequency. Methods This study analyzed 148 patients meeting inclusion criteria (age >18 years, LGG diagnosis, at least 1 seizure event recorded before and after initial surgical intervention). All patients were treated at the Brain and Spine Center at The University of Texas MD Anderson Cancer Center from January 2000 to March 2013. Seizure frequency in a 6-month period before and after tumor resection was categorized as none, 1, few (2 to 3 seizures) or several (>3 seizures). Immediately postoperative seizures (up to 48 hours from surgery) were not included in the analysis. Results A total of 116 (78.4%) patients had seizures at initial presentation and most (95%) were started on antiepileptic drugs (AEDs). We found 2 clinical variables with a significant impact on progression-free survival (PFS): Higher seizure frequency during the 6-month postoperative period and seizure frequency increase between the 6-month pre- and the 6-month postoperative periods were both correlated to higher risk of early tumor recurrence (P = .007 and P = .004, respectively). Conclusion Seizure frequency following surgical resection of LGGs and the seizure frequency change between the 6-month preoperative and postoperative periods may serve as clinical predictors of early tumor recurrence in patients with LGGs who are also afflicted by seizures.

scholarly journals Prolonged response without prolonged chemotherapy: a lesson from PCV chemotherapy in low-grade gliomas

2010 ◽  
Vol 12 (10) ◽  
pp. 1078-1082 ◽  
Author(s):  
M. Peyre ◽  
S. Cartalat-Carel ◽  
D. Meyronet ◽  
D. Ricard ◽  
A. Jouvet ◽  
...  
Keyword(s):  
Low Grade ◽  
Low Grade Gliomas ◽  
Pcv Chemotherapy ◽  
Prolonged Response

Prolonged response without prolonged chemotherapy: A lesson from PCV chemotherapy in low-grade gliomas.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. e12519-e12519
Author(s):  
M. Peyre ◽  
S. Cartalat-Carel ◽  
D. Meyronet ◽  
M. Sunyach ◽  
E. Jouanneau ◽  
...  
Keyword(s):  
Low Grade ◽  
Low Grade Gliomas ◽  
Pcv Chemotherapy ◽  
Prolonged Response

A mathematical model of diffuse low-grade gliomas treated with PCV chemotherapy.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 2065-2065
Author(s):  
F. Ducray ◽  
M. Peyre ◽  
D. Ricard ◽  
B. Čajavec-Bernard ◽  
E. Grenier ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Low Grade ◽  
Low Grade Gliomas ◽  
Pcv Chemotherapy

scholarly journals Radiation protraction schedules for low-grade gliomas: a comparison between different mathematical models

2019 ◽  
Vol 16 (161) ◽  
pp. 20190665
Author(s):  
I. Budia ◽  
A. Alvarez-Arenas ◽  
T. E. Woolley ◽  
G. F. Calvo ◽  
J. Belmonte-Beitia
Keyword(s):  
Tumour Growth ◽  
Therapeutic Strategy ◽  
Clinical Implications ◽  
Time Interval ◽  
Low Grade ◽  
Spatial Effects ◽  
Glioma Patient ◽  
Tumour Control ◽  
Low Grade Gliomas ◽  
Growth Laws

We optimize radiotherapy (RT) administration strategies for treating low-grade gliomas. Specifically, we consider different tumour growth laws, both with and without spatial effects. In each scenario, we find the optimal treatment in the sense of maximizing the overall survival time of a virtual low-grade glioma patient, whose tumour progresses according to the examined growth laws. We discover that an extreme protraction therapeutic strategy, which amounts to substantially extending the time interval between RT sessions, may lead to better tumour control. The clinical implications of our results are also presented.

scholarly journals Serum endocan levels before and after surgery on low-grade gliomas

2017 ◽  
Vol 8 (1) ◽  
pp. 32 ◽  
Author(s):  
Taner Tanriverdi ◽  
Rahsan Kemerdere ◽  
BerrinB Inal ◽  
Odhan Yuksel ◽  
HumeyraO Emre ◽  
...  
Keyword(s):  
Low Grade ◽  
Low Grade Gliomas ◽  
Before And After
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