scholarly journals Metabolomic Profiling in Perinatal Asphyxia: A Promising New Field

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Niamh M. Denihan ◽  
Geraldine B. Boylan ◽  
Deirdre M. Murray
Keyword(s):  
Biomarker Discovery ◽  
Perinatal Asphyxia ◽  
Biospecimen Collection ◽  
Metabolomic Profiling ◽  
Current State ◽  
Hypoxic Environment ◽  
Omic Technology ◽  
Important Field ◽  
Multidisciplinary Staff ◽  
Comprehensive Study

Metabolomics, the latest “omic” technology, is defined as the comprehensive study of all low molecular weight biochemicals, “metabolites” present in an organism. As a systems biology approach, metabolomics has huge potential to progress our understanding of perinatal asphyxia and neonatal hypoxic-ischaemic encephalopathy, by uniquely detecting rapid biochemical pathway alterations in response to the hypoxic environment. The study of metabolomic biomarkers in the immediate neonatal period is not a trivial task and requires a number of specific considerations, unique to this disease and population. Recruiting a clearly defined cohort requires standardised multicentre recruitment with broad inclusion criteria and the participation of a range of multidisciplinary staff. Minimally invasive biospecimen collection is a priority for biomarker discovery. Umbilical cord blood presents an ideal medium as large volumes can be easily extracted and stored and the sample is not confounded by postnatal disease progression. Pristine biobanking and phenotyping are essential to ensure the validity of metabolomic findings. This paper provides an overview of the current state of the art in the field of metabolomics in perinatal asphyxia and neonatal hypoxic-ischaemic encephalopathy. We detail the considerations required to ensure high quality sampling and analysis, to support scientific progression in this important field.

Establishment of the Principle of Professional Development in the State Personnel Policy of the Russian Federation: development of communication skills

Communicology ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 54-62 ◽  
Author(s):  
F.I. Sharkov ◽  
T.N. Lugovsky
Keyword(s):  
Professional Development ◽  
Personnel Management ◽  
Communication Skills ◽  
Russian Federation ◽  
Civil Servants ◽  
Current State ◽  
Modern Methods ◽  
The Russian Federation ◽  
Rapid Transformation ◽  
Comprehensive Study

This article gives a detailed description of the principle of a comprehensive study of the current state of the management system of civil servants’ professional, describes the development of practical measures and recommendations for its optimization, given the effectiveness of improving the professional development of civil servants. The relevance of this article is based on the need to develop a science-based approach to the rapid transformation of the civil service using modern methods of personnel management for the growth of potential and professionalism of civil servants.

scholarly journals Metabolic Evaluation of Urine from Patients Diagnosed with High Grade (HG) Bladder Cancer by SPME-LC-MS Method

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2194
Author(s):  
Kamil Łuczykowski ◽  
Natalia Warmuzińska ◽  
Sylwia Operacz ◽  
Iga Stryjak ◽  
Joanna Bogusiewicz ◽  
...  
Keyword(s):  
Thin Film ◽  
Bladder Cancer ◽  
High Performance ◽  
Biomarker Discovery ◽  
Solid Phase ◽  
Biological Fluids ◽  
Reversed Phase ◽  
Control Group ◽  
Metabolic Evaluation ◽  
Metabolomic Profiling

Bladder cancer (BC) is a common malignancy of the urinary system and a leading cause of death worldwide. In this work, untargeted metabolomic profiling of biological fluids is presented as a non-invasive tool for bladder cancer biomarker discovery as a first step towards developing superior methods for detection, treatment, and prevention well as to further our current understanding of this disease. In this study, urine samples from 24 healthy volunteers and 24 BC patients were subjected to metabolomic profiling using high throughput solid-phase microextraction (SPME) in thin-film format and reversed-phase high-performance liquid chromatography coupled with a Q Exactive Focus Orbitrap mass spectrometer. The chemometric analysis enabled the selection of metabolites contributing to the observed separation of BC patients from the control group. Relevant differences were demonstrated for phenylalanine metabolism compounds, i.e., benzoic acid, hippuric acid, and 4-hydroxycinnamic acid. Furthermore, compounds involved in the metabolism of histidine, beta-alanine, and glycerophospholipids were also identified. Thin-film SPME can be efficiently used as an alternative approach to other traditional urine sample preparation methods, demonstrating the SPME technique as a simple and efficient tool for urinary metabolomics research. Moreover, this study’s results may support a better understanding of bladder cancer development and progression mechanisms.

scholarly journals Current State of “Omics” Biomarkers in Pancreatic Cancer

2021 ◽  
Vol 11 (2) ◽  
pp. 127 ◽  
Author(s):  
Beste Turanli ◽  
Esra Yildirim ◽  
Gizem Gulfidan ◽  
Kazim Yalcin Arga ◽  
Raghu Sinha
Keyword(s):  
Pancreatic Cancer ◽  
Personalized Medicine ◽  
Biomarker Discovery ◽  
Survival Rates ◽  
Postoperative Recurrence ◽  
Molecular Biomarkers ◽  
Background Information ◽  
Current State ◽  
Pancreatic Cancer Screening ◽  
The Future

Pancreatic cancer is one of the most fatal malignancies and the seventh leading cause of cancer-related deaths related to late diagnosis, poor survival rates, and high incidence of metastasis. Unfortunately, pancreatic cancer is predicted to become the third leading cause of cancer deaths in the future. Therefore, diagnosis at the early stages of pancreatic cancer for initial diagnosis or postoperative recurrence is a great challenge, as well as predicting prognosis precisely in the context of biomarker discovery. From the personalized medicine perspective, the lack of molecular biomarkers for patient selection confines tailored therapy options, including selecting drugs and their doses or even diet. Currently, there is no standardized pancreatic cancer screening strategy using molecular biomarkers, but CA19-9 is the most well known marker for the detection of pancreatic cancer. In contrast, recent innovations in high-throughput techniques have enabled the discovery of specific biomarkers of cancers using genomics, transcriptomics, proteomics, metabolomics, glycomics, and metagenomics. Panels combining CA19-9 with other novel biomarkers from different “omics” levels might represent an ideal strategy for the early detection of pancreatic cancer. The systems biology approach may shed a light on biomarker identification of pancreatic cancer by integrating multi-omics approaches. In this review, we provide background information on the current state of pancreatic cancer biomarkers from multi-omics stages. Furthermore, we conclude this review on how multi-omics data may reveal new biomarkers to be used for personalized medicine in the future.

scholarly journals Data preprocessing workflow for exhaled breath analysis by GC/MS using open sources

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Rosa Alba Sola Martínez ◽  
José María Pastor Hernández ◽  
Gema Lozano Terol ◽  
Julia Gallego-Jara ◽  
Luis García-Marcos ◽  
...  
Keyword(s):  
Biomarker Discovery ◽  
Data Preprocessing ◽  
Exhaled Breath ◽  
Sample Collection ◽  
Clinical Tool ◽  
Chronic Respiratory Diseases ◽  
Current State ◽  
Exhaled Breath Analysis ◽  
High Prevalence ◽  
Volatile Organic

AbstractThe noninvasive diagnosis and monitoring of high prevalence diseases such as cardiovascular diseases, cancers and chronic respiratory diseases are currently priority objectives in the area of health. In this regard, the analysis of volatile organic compounds (VOCs) has been identified as a potential noninvasive tool for the diagnosis and surveillance of several diseases. Despite the advantages of this strategy, it is not yet a routine clinical tool. The lack of reproducible protocols for each step of the biomarker discovery phase is an obstacle of the current state. Specifically, this issue is present at the data preprocessing step. Thus, an open source workflow for preprocessing the data obtained by the analysis of exhaled breath samples using gas chromatography coupled with single quadrupole mass spectrometry (GC/MS) is presented in this paper. This workflow is based on the connection of two approaches to transform raw data into a useful matrix for statistical analysis. Moreover, this workflow includes matching compounds from breath samples with a spectral library. Three free packages (xcms, cliqueMS and eRah) written in the language R are used for this purpose. Furthermore, this paper presents a suitable protocol for exhaled breath sample collection from infants under 2 years of age for GC/MS.

scholarly journals Making Meaningful Clinical Use of Biomarkers

2017 ◽  
Vol 12 ◽  
pp. 117727191771523 ◽  
Author(s):  
Matthew J Selleck ◽  
Maheswari Senthil ◽  
Nathan R Wall
Keyword(s):  
Biomarker Discovery ◽  
Therapeutic Monitoring ◽  
Clinical Use ◽  
Current State

This review discusses the current state of biomarker discovery for the purposes of diagnostics and therapeutic monitoring. We underscore relevant challenges that have defined the gap between biomarker discovery and meaningful clinical use. We highlight recent advancements in and propose a way to think about future biomarker development.

FINANCIAL STATUS AND PROSPECTS OF ECONOMIC DEVELOPMENT OF THE OUTSOURCING ENTERPRISE

2018 ◽  
Author(s):  
Olga Batrak ◽  
◽  
Nataliia Flentei ◽  
Keyword(s):  
Economic Development ◽  
National Economy ◽  
External Environment ◽  
External Factors ◽  
Financial Status ◽  
Financial Condition ◽  
Current State ◽  
New Ideas ◽  
Internal And External Factors ◽  
Comprehensive Study

The current state of the national economy means that businesses need to constantly look for ways to improve their efficiency and find new ideas to address their shortcomings. The problem of improving the financial condition of the enterprise and finding ways to improve the financial condition of the enterprise is primarily related to the mechanism for assessing the financial condition of the enterprise. The study of the financial condition of the enterprise gives an advantage to the business entity among competitors, allows to identify shortcomings in the activities of the enterprise and to form methods to improve its activities. Both internal and external factors have a significant impact on the financial condition of the enterprise. Since the internal and external environment is constantly changing, so business is characterized by uncertainty. The article considers the specifics of the analysis of the financial condition and prospects of economic development of the outsourcing company. The author generalizes the concept of "financial condition of the enterprise" and substantiates the importance of a comprehensive study of its evaluation indicators. Based on the analysis of the financial condition of Corplex LLC identified promising ways of economic development of the studied outsourcing company.

The Psychology of Pandemics

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Steven Taylor
Keyword(s):  
Psychological Factors ◽  
Disease Outbreaks ◽  
Annual Review ◽  
Publication Date ◽  
Prolonged Grief ◽  
Psychological Phenomena ◽  
Current State ◽  
Health Authorities ◽  
Important Field ◽  
Mitigation Methods

This article reviews the current state of knowledge and promising new directions concerning the psychology of pandemics. Pandemics are disease outbreaks that spread globally. Historically, psychological factors have been neglected by researchers and health authorities despite evidence that pandemics are, to a large extent, psychological phenomena whereby beliefs and behaviors influence the spreading versus containment of infection. Psychological factors are important in determining ( a) adherence to pandemic mitigation methods (e.g., adherence to social distancing), ( b) pandemic-related social disruption (e.g., panic buying, racism, antilockdown protests), and ( c) pandemic-related distress and related problems (e.g., anxiety, depression, posttraumatic stress disorder, prolonged grief disorder). The psychology of pandemics has emerged as an important field of research and practice during the coronavirus 2019 (COVID-19) pandemic. As a scholarly discipline, the psychology of pandemics is fragmented and diverse, encompassing various psychological subspecialties and allied disciplines, but is vital for shaping clinical practice and public health guidelines for COVID-19 and future pandemics. Expected final online publication date for the Annual Review of Clinical Psychology, Volume 18 is May 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

A Survey on Recent Recommendation Systems for the Tourism Industry

2020 ◽  
pp. 205-237
Author(s):  
S. Ranjith ◽  
P. Victer Paul
Keyword(s):  
User Satisfaction ◽  
Recommendation System ◽  
Recommendation Systems ◽  
Tourism Industry ◽  
User Preferences ◽  
Reference List ◽  
Current State ◽  
Recent Recommendation ◽  
Important Field ◽  
Preference Criteria

Data mining is an important field that derives insights from the data and recommendation systems. Recommendation systems have become common in recent years in the field of tourism. These are widely used as a tool that can input various selection criteria and user preferences and yields travel recommendations to tourists. User's style and preferences should be constructed accurately so as to supply most relevant suggestions. Researchers proposed various types of tourism recommendation systems (TRS) in order to improve the accuracy and user satisfaction. In this chapter, the authors studied the current state of tourism recommendation system models and discussed their preference criteria. As a part of that, the authors studied various important preference factors in TRS and categorized them based on their likeness. This chapter reports TRS model future directions and compiles a comprehensive reference list to assist researchers.

How Clinical Trial Data Sharing Platforms Can Advance the Study of Biomarkers

2019 ◽  
Vol 47 (3) ◽  
pp. 369-373 ◽  
Author(s):  
Rebecca Li ◽  
Ida Sim
Keyword(s):  
Clinical Trial ◽  
Data Sharing ◽  
Biomarker Discovery ◽  
Clinical Trial Data ◽  
Trial Data ◽  
Data Types ◽  
Current State ◽  
Biomarker Research ◽  
Diverse Data

Although data sharing platforms host diverse data types the features of these platforms are well-suited to facilitating biomarker research. Given the current state of biomarker discovery, an innovative paradigm to accelerate biomarker discovery is to utilize platforms such as Vivli to leverage researchers' abilities to integrate certain classes of biomarkers.

scholarly journals Current state and perspectives of Space Weather science in Italy

2020 ◽  
Vol 10 ◽  
pp. 6
Author(s):  
Christina Plainaki ◽  
Marco Antonucci ◽  
Alessandro Bemporad ◽  
Francesco Berrilli ◽  
Bruna Bertucci ◽  
...  
Keyword(s):  
Space Weather ◽  
Weather Forecasting ◽  
Space Missions ◽  
Weather Data ◽  
Space Weather Forecasting ◽  
Current State ◽  
Space Agency ◽  
New Instrumentation ◽  
Important Field ◽  
Italian Space Agency

Italian teams have been involved many times in Space Weather observational campaigns from space and from the ground, contributing in the advancing of our knowledge on the properties and evolution of the related phenomena. Numerous Space Weather forecasting and now-casting modeling efforts have resulted in a remarkable add-on to the overall progress in the field, at both national and international level. The Italian Space Agency has participated several times in space missions with science objectives related to Space Weather; indeed, an important field for the Italian scientific and industrial communities interested in Heliophysics and Space Weather, is the development of new instrumentation for future space missions. In this paper, we present a brief state-of-the-art in Space Weather science in Italy and we discuss some ideas on a long-term plan for the support of future scientific research in the related disciplines. In the context of the current roadmap, the Italian Space Agency aims to assess the possibility to develop a national scientific Space Weather data centre to encourage synergies between different science teams with interest in the field and to motivate innovation and new mission concept development. Alongside with the proposed recommendations, we also discuss how the Italian expertise could complement international efforts in a wider international Space Weather context.

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