scholarly journals Adenocarcinoma with BAC Features Presented as the Nonsolid Nodule Is Prone to Be False-Negative on18F-FDG PET/CT

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Hu-bing Wu ◽  
Lijuan Wang ◽  
Quan-shi Wang ◽  
Yan-jian Han ◽  
Hong-sheng Li ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Detection Rate ◽  
False Negative ◽  
General Linear Model ◽  
Lesion Size ◽  
Blood Pool ◽  
Pet Ct ◽  
Blood Pool Activity ◽  
18F Fdg ◽  
Fdg Pet Ct

Purpose. The present study investigated which type of adenocarcinoma with BAC features was prone to be false-negative on 18F-FDG PET/CT.Materials and Methods. A retrospective study was performed on 51 consecutive patients with localized adenocarcinoma with BAC features. CT and PET were assessed for lesion size, GGO percentage, and SUVmax. Lesions with FDG uptake the same as or more than mediastinal blood-pool activity were considered as PET-positive.Results. Of the 51 cases, 19.6% presented as pure GGO nodules, 31.4% as mixed nodules, and 49.0% as solid nodules. None of the pure GGO nodules was 18F-FDG avid, compared with 37.5% of mixed nodules and 96.0% of solid nodules (χ2=31.55,P=0.000). In the mixed nodule group, SUVmax was negatively correlated with GGO percentage (r=-0.588;P=0.021). The positive detection rate of 18F-FDG PET/CT was 50.0%, 55.6%, and 100% in tumors 1.1–2.0 cm, 2.1–3.0 cm, and >3.0 cm in diameter, respectively (χ2=5.815,P=0.055). General linear model factor analysis showed that the GGO was an important factor contributing to false-negative PET/CT results (F=23.992,P=0.000), but lesion size was not (F=0.602,P=0.866).Conclusions. The present study indicated that the adenocarcinoma with BAC features presented as nonsolid nodule is prone to be false negative on 18F-FDG PET/CT.

scholarly journals 18F-FDG-PET/CT Evaluation of Indeterminate Adrenal Masses in Noncancer Patients

2021 ◽  
Author(s):  
Xin He ◽  
Elaine M Caoili ◽  
Anca M Avram ◽  
Barbra S Miller ◽  
Tobias Else
Keyword(s):  
Fdg Pet ◽  
False Negative ◽  
Blood Pool ◽  
Adrenal Tumors ◽  
Negative Results ◽  
False Negative Results ◽  
Pet Ct ◽  
Adrenal Masses ◽  
18F Fdg ◽  
Fdg Pet Ct

Abstract Context Adrenal tumors in noncancer patients are common. Objective Evaluate performance of 18F-fluorodeoxyglucose positron emission tomography computed tomography (18F-FDG-PET/CT) in distinguishing between benign and malignant adrenal tumors. Design Retrospective chart review 2010-2019. Setting Academic institution. Patients One hundred and seventeen noncancer patients, defined as having no history of cancer or with cancer in remission for ≥5 years, completed 18F-FDG-PET/CT to evaluate adrenal masses, with pathologic diagnoses or imaging follow-up (≥12 months). Intervention 18F-FDG-PET/CT of 117 indeterminate adrenal masses. Main Outcome Measures Receiver operator characteristic curve of the ratios of adrenal lesion standardized uptake value (SUV)max to liver SUVmean and of adrenal lesion SUVmax to aortic arch blood pool SUVmean were constructed. Results Seventy benign and 47 malignant masses (35 adrenocortical carcinomas [ACCs], 12 adrenal metastases) were identified. Malignant masses had higher median liver SUV and blood pool SUV ratios than benign masses (6.2 and 7.4 vs 1.4 and 2.0, P < .001). Median liver and blood pool SUV ratios of ACC (6.1 and 7.3, respectively) and metastases (6.7 and 7.7, respectively) were higher than those of than adenomas (1.4 and 2.2, P < .05 for all comparisons). Optimal liver SUV ratio to discern between benign and malignant masses was 2.5, yielding 85% sensitivity, 90% specificity, and 7 false negative results (including 3 ACCs). Optimal blood pool SUV ratio was 3.4, yielding 83% sensitivity, 90% specificity, and 8 false negative results (including 4 ACCs). Conclusion When used in conjunction with other clinical assessments, 18F-FDG-PET/CT can be a valuable tool in evaluating adrenal masses in noncancer patients.

scholarly journals The role of 18F-FDG PET/CT in the management of large-vessel vasculitis: applications and limitations in clinical practice

2012 ◽  
pp. 249-254
Author(s):  
Maria V. Mattoli ◽  
Giorgio Treglia ◽  
Lucia Leccisotti ◽  
Alessandro Giordano
Keyword(s):  
Clinical Practice ◽  
Fdg Pet ◽  
False Negative ◽  
Large Vessel Vasculitis ◽  
Large Vessel ◽  
Metabolic Imaging ◽  
Small Vessel Vasculitis ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Introduction: 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) plays a key role in oncology, and it is now being used increasingly to diagnose, characterize, and monitor disease activity in inflammatory disorders, including vasculitis. Unfortunately, its role in the management of vasculitis is still not well-defined, and clinicians are often unsure how this metabolic imaging technique should be used in these diseases, although its usefulness in diagnosing large-vessel vasculitis has been clearly demonstrated. Materials and methods: We reviewed the literature about the use of PET/CT in the management of vasculitis in an attempt to identify the applications and the limitations of this technique in clinical practice. Results and discussion: Our literature review revealed that 18F-FDG PET/CT is a useful tool for diagnosing vasculitis (especially when the symptoms of the disease are non-specific); guiding biopsy procedures (areas with high glucose consumption); evaluating disease extension; and monitoring treatment responses. The main limitations of this method are the relatively low spatial resolution of the tomograph, which can lead to false-negative results in the presence of small-vessel vasculitis, and risk of false positive results, especially those related to the presence of atherosclerosis and to post-treatment vascular remodeling.

Diagnosis of infective endocarditis by 18F-FDG-PET/CT, presentation of a false negative result

2018 ◽  
Vol 150 (6) ◽  
pp. 247-248
Author(s):  
Beatriz Colina Andrés ◽  
Maite Arbulu Tapia ◽  
Miguel Ángel Goenaga Sánchez
Keyword(s):  
Infective Endocarditis ◽  
Fdg Pet ◽  
False Negative ◽  
False Negative Result ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Fever of unknown origin: Importance of 18F-FDG PET/CT in the diagnosis of a late infectious complication after aneurysm bypass

VASA ◽  
2011 ◽  
Vol 40 (5) ◽  
pp. 418-421 ◽  
Author(s):  
Goudard ◽  
Pierret ◽  
Dusaud ◽  
Falzone ◽  
Tourtier ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Secondary Infection ◽  
False Negative ◽  
Artery Aneurysm ◽  
Low Grade ◽  
Popliteal Artery Aneurysm ◽  
Popliteal Aneurysm ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Persistent blood flow in aneurysmal sac after bypass-exclusion is well documented in the literature. Aneurysm enlargement, local compressive symptoms and even sac rupture are commonly described complications. Late secondary infection of popliteal artery aneurysm (PAA) following ligation and venous bypass is exceptional. We report the case of late PAA infection six years after bypass-exclusion in a 75 year-old man which was diagnosed by 18F-FDG PET/CT. The patient was successfully treated by aneurysm resection and antibiotics. The diagnosis of popliteal aneurysm infection is often clinical, echographic and sonographic, but computed tomography scan can be false negative in chronic low-grade infection. 18F-FDG PET/CT is able to accurately diagnose and localize infection with high sensibility and specificity.

False negative scintigraphy with 99mTc-sestamibi in parathyroid carcinoma with associated brown tumors. Contributions of 18F-FDG-PET/CT

2011 ◽  
Vol 30 (3) ◽  
pp. 174-179
Author(s):  
A. Santiago Chinchilla ◽  
C. Ramos Font ◽  
M.A. Muros de Fuentes ◽  
M. Navarro-Pelayo Láinez ◽  
H. Palacios Gerona ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Parathyroid Carcinoma ◽  
False Negative ◽  
Pet Ct ◽  
Brown Tumors ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
99Mtc Sestamibi

Characteristics and Detection Rate of Thyroidal Incidentaloma using 18F-FDG PET-CT

2008 ◽  
Vol 8 (1) ◽  
pp. 38
Author(s):  
Kang Young Rhee ◽  
Gun Koh ◽  
Sun Kuk Kim ◽  
Jin Chul Koh ◽  
Haeng Soo Kim ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Detection Rate ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Diagnostic and prognostic value of 99mTc-Tektrotyd scintigraphy and 18F-FDG PET/CT in a single-center cohort of neuroendocrine tumors

2021 ◽  
Author(s):  
Jelena Saponjski ◽  
Djuro Macut ◽  
Nebojša Petrovic ◽  
Sanja Ognjanovic ◽  
Bojana Popovic ◽  
...  
Keyword(s):  
False Positive ◽  
Fdg Pet ◽  
False Negative ◽  
Progression Free Survival ◽  
True Positive ◽  
True Negative ◽  
Free Survival ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

IntroductionThe aim was to assess the diagnostic value of 99mTc-Tektrotyd scintigraphy (TCT) and positron emission tomography/computed tomography using F-18 fluorodeoxyglucose (18F-FDG PET/CT) in the detection and follow-up of neuroendocrine tumors (NETs), and their predictive value for disease progression.Material and methodsIn this retrospective cohort, TCT and 18F-FDG PET/CT were performed in 90 patients (37 men, 53 women, mean age 52.7 ±15.1), with NET. Correlation of Ki67 and tumor grade versus Krenning score and SUVmax was assessed, Kaplan-Meier analysis was used for progression-free survival (PFS), and Cox regression analysis was performed to identify the association between progression-related factors and PFS.ResultsOut of 90, true positive TCT was detected in 56 (62.2%) patients, true negative in 19 (21.1%), false positive in 4 (4.4%), false negative in 11 (12.2%), while 18F-FDG PET/CT was true positive in 69 (76.7%) patients, true negative in 10 (11.1%), false positive in 5 (5.5%), false negative in 6 (6.7%). Mean 18F-FDG PET/CT SUVmax was 6.8 ±6.2. Diagnostic sensitivity of TCT was 83.6%, specificity 82.6%, accuracy 83.3% vs. 18F-FDG PET/CT sensitivity was 92.0%, specificity 66.7%, accuracy 87.8%. A significant correlation between Ki67 and SUVmax was found in positive 18F-FDG PET/CT findings, unlike the correlation between Ki67 and Krenning score. Median PFS was 25 months (95% CI: 18.2–31.8), in 18F-FDG PET/CT positive patients 23 months (95% CI: 16.3–29.7) and 18F-FDG PET/CT negative 26 months (p = 0.279). Progression-free survival predictors were SUVmax and Krenning score.ConclusionsIn our study, TCT and 18F-FDG PET/CT have high diagnostic accuracy in detection of NET. Higher Krenning score on TCT and SUVmax in positive 18F-FDG PET/CT findings are predictors of disease progression. 99mTc-Tektrotyd scintigraphy and 18F-FDG PET/CT can be useful complementary tools in management of patients with NETs and in predicting patients’ outcome.

scholarly journals Implications of False Negative and False Positive Diagnosis in Lymph Node Staging of NSCLC by Means of 18F-FDG PET/CT

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e78552 ◽  
Author(s):  
Shaolei Li ◽  
Qingfeng Zheng ◽  
Yuanyuan Ma ◽  
Yuzhao Wang ◽  
Yuan Feng ◽  
...  
Keyword(s):  
Lymph Node ◽  
False Positive ◽  
Fdg Pet ◽  
False Negative ◽  
Lymph Node Staging ◽  
Positive Diagnosis ◽  
False Positive Diagnosis ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct
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