scholarly journals Isolated Central Nervous System Relapse in Chronic Myeloid Leukemia

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Juliana Gomez ◽  
Victor Duenas
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Blast Crisis ◽  
Bone Marrow Involvement ◽  
Central Nervous System Relapse ◽  
The Central Nervous System ◽  
Cytogenetic Remission

Chronic myeloid leukemia is a myeloproliferative disorder that has three distinguished phases: chronic, accelerated, and blastic. In extremely rare cases, the blast phase can affect the central nervous system without concomitant bone marrow involvement. We report the case of a patient with chronic myeloid leukemia who, despite having achieved complete cytogenetic remission in the bone marrow for several years, experienced a blast crisis of the central nervous system following an episode of infectious meningoencephalitis.

scholarly journals Isolated central nervous system blast crisis in a case of chronic myeloid leukemia on dasatinib

2018 ◽  
Vol 07 (03) ◽  
pp. 170-187 ◽  
Author(s):  
P.K Kiran ◽  
Girish V. Badarke ◽  
C.N Suresh ◽  
B.J Srinivas ◽  
Radheshyam Naik
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Blast Crisis

Isolated Central Nervous System Blast Crisis of Chronic Myeloid Leukemia with Dasatinib Therapy

2021 ◽  
Vol 67 (02/2021) ◽  
Author(s):  
Yi Dong ◽  
Jia Wang ◽  
Yuanyuan Shen ◽  
Qing Zhang ◽  
Zhimin Zhai ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Blast Crisis

scholarly journals An Atypical Initial Presentation of Chronic Myeloid Leukemia with Central Nervous System and Lymph Node Blast Crises

2016 ◽  
Vol 9 (2) ◽  
pp. 415-421 ◽  
Author(s):  
Khadega A. Abuelgasim ◽  
Saeed Alshieban ◽  
Nada A. Almubayi ◽  
Ayman Alhejazi ◽  
Abdulrahman R. Jazieh
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Chronic Myeloid Leukemia ◽  
Peripheral Blood ◽  
Myeloid Leukemia ◽  
Single Agent ◽  
Chronic Phase ◽  
Current Evidence ◽  
Molecular Response

We describe the case of a young man with therapy-naive chronic myeloid leukemia who did not initially have any peripheral blood or bone marrow excess blasts but presented with extramedullary myeloid blast crises involving the central nervous system and multiple lymph nodes. Conventional cytogenetic tests were positive for t(9;22)(q34:q11) as well as for trisomy 8, 14 and 21 and del(16q). The patient’s peripheral blood and bone marrow were positive for the BCR-ABL oncogene when analyzed by fluorescence in situ hybridization and polymerase chain reaction. He achieved good clinical, radiological, cytogenetic and molecular response to acute myeloid leukemia induction chemotherapy combined with 16 doses of triple intrathecal chemotherapy and oral dasatinib (second-generation tyrosine kinase inhibitor) treatment. Due to his poor general condition, he was treated with 24 Gy of whole-brain radiation therapy, as allogeneic stem cell transplantation was not feasible. Although extramedullary CNS blast crises are usually associated with a very poor outcome, our patient remains in complete cytogenetic and molecular remission, on single-agent dasatinib, 4 years after the diagnosis with no current evidence of active extramedullary disease. This suggests that dasatinib has a role in controlling not only chronic-phase chronic myeloid leukemia, but also its CNS blast crisis.

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