scholarly journals Sustainable Utilization of Traditional Chinese Medicine Resources: Systematic Evaluation on Different Production Modes

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Xiwen Li ◽  
Yuning Chen ◽  
Yunfeng Lai ◽  
Qing Yang ◽  
Hao Hu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Medicinal Plant ◽  
Pesticide Residues ◽  
Large Scale ◽  
Plant Disease ◽  
Supply And Demand ◽  
Systematic Evaluation ◽  
Sustainable Utilization ◽  
Market Demand

The usage amount of medicinal plant rapidly increased along with the development of traditional Chinese medicine industry. The higher market demand and the shortage of wild herbal resources enforce us to carry out large-scale introduction and cultivation. Herbal cultivation can ease current contradiction between medicinal resources supply and demand while they bring new problems such as pesticide residues and plant disease and pests. Researchers have recently placed high hopes on the application of natural fostering, a new method incorporated herbal production and diversity protecting practically, which can solve the problems brought by artificial cultivation. However no modes can solve all problems existing in current herbal production. This study evaluated different production modes including cultivation, natural fostering, and wild collection to guide the traditional Chinese medicine production for sustainable utilization of herbal resources.

scholarly journals Can Traditional Chinese Medicine Diagnosis Be Parameterized and Standardized? A Narrative Review

Healthcare ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 177
Author(s):  
Luís Carlos Matos ◽  
Jorge Pereira Machado ◽  
Fernando Jorge Monteiro ◽  
Henry Johannes Greten
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Functional Status ◽  
Control Measures ◽  
Systematic Evaluation ◽  
Diagnostic Tools ◽  
Functional Evaluation ◽  
Diagnostic Systems ◽  
Mechanical Pulse ◽  
Proof Of Efficacy

The integration of Traditional Chinese Medicine (TCM) in Western health systems and research requires a rational communicable theory, scientific proof of efficacy and safety, and quality control measures. The existence of clear definitions and the diagnosis standardization are critical factors to establish the patient’s vegetative functional status accurately and, therefore, systematically apply TCM therapeutics such as the stimulation of reflex skin areas known as acupoints. This science-based conceptualization entails using validated methods, or even developing new systems able to parameterize the diagnosis and assess TCM related effects by objective measurements. Traditionally, tongue and pulse diagnosis and the functional evaluation of action points by pressure sensitivity and physical examination may be regarded as essential diagnostic tools. Parameterizing these techniques is a future key point in the objectification of TCM diagnosis, such as by electronic digital image analysis, mechanical pulse diagnostic systems, or the systematic evaluation of acupoints’ electrophysiology. This review aims to demonstrate and critically analyze some achievements and limitations in the clinical application of device-assisted TCM diagnosis systems to evaluate functional physiological patterns. Despite some limitations, tongue, pulse, and electrophysiological diagnosis devices have been reported as a useful tool while establishing a person’s functional status.

scholarly journals Efficacy and Safety of Sophora flavescens (Kushen) Based Traditional Chinese Medicine in the Treatment of Ulcerative Colitis: Clinical Evidence and Potential Mechanisms

2020 ◽  
Vol 11 ◽  
Author(s):  
Mingjun Chen ◽  
Yuxuan Ding ◽  
Zhanqi Tong
Keyword(s):  
Ulcerative Colitis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Large Scale ◽  
Remission Rate ◽  
Chinese Herb ◽  
Biomedical Literature ◽  
Network Pharmacology ◽  
Aminosalicylic Acid ◽  
Acid Therapy

Background: Radix Sophorae flavescentis (Kushen), a Chinese herb, is widely used in the treatment of ulcerative colitis (UC) with damp-heat accumulation syndrome (DHAS) according to traditional Chinese medicine (TCM) theory.Objective: The aim of this study was to illuminate the clinical efficacy and potential mechanisms of Kushen-based TCM formulations in the treatment of UC with DHAS.Materials and Methods: A systematic literature search was performed in the PubMed, EMBASE, Chinese Biomedical Literature database, China National Knowledge Infrastructure database, Chongqing VIP Information database, and Wanfang database for articles published between January 2000 and July 2020 on randomized controlled trials (RCTs) that used Kushen-based TCM formulations in the treatment of UC with DHAS. A network pharmacology approach was conducted to detect the potential pathways of Kushen against UC with DHAS.Results: Eight RCTs with a total of 983 subjects were included in the meta-analysis. Compared with the control subjects (5-aminosalicylic acid therapy), those who received Kushen-based TCM formulations for the treatment of UC showed a significantly higher clinical remission rate (RR = 1.20, 95% CI: [1.04, 1.38], p = 0.02) and lower incidence of adverse events (RR = 0.63, 95% CI [0.39, 1.01], p = 0.06). A component-target-pathway network was constructed, indicating five main components (quercetin, luteolin, matrine, formononetin, and phaseolin), three major targets (Interleukin-6, Myc proto-oncogene protein, and G1/S-specific cyclin-D1) and one key potential therapeutic pathway (PI3K-Akt signaling) of Kushen against UC with DHAS.Conclusion: Kushen-based TCM formulations provide good efficacy and possess great potential in the treatment of UC. Large-scale and high-quality clinical trials and experimental verification should be considered for further confirmation of the efficacy of Kushen-based formulations.

scholarly journals Predicting the Drug Safety for Traditional Chinese Medicine through a Comparative Analysis of Withdrawn Drugs Using Pharmacological Network

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Mengzhu Xue ◽  
Shoude Zhang ◽  
Chaoqian Cai ◽  
Xiaojuan Yu ◽  
Lei Shan ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Natural Products ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Drug Safety ◽  
Large Scale ◽  
Drug Candidate ◽  
Topology Analysis ◽  
Drug Safety Surveillance ◽  
Approved Drugs

As the major issue to limit the use of drugs, drug safety leads to the attrition or failure in clinical trials of drugs. Therefore, it would be more efficient to minimize therapeutic risks if it could be predicted before large-scale clinical trials. Here, we integrated a network topology analysis with cheminformatics measurements on drug information from the DrugBank database to detect the discrepancies between approved drugs and withdrawn drugs and give drug safety indications. Thus, 47 approved drugs were unfolded with higher similarity measurements to withdrawn ones by the same target and confirmed to be already withdrawn or discontinued in certain countries or regions in subsequent investigations. Accordingly, with the 2D chemical fingerprint similarity calculation as a medium, the method was applied to predict pharmacovigilance for natural products from an in-house traditional Chinese medicine (TCM) database. Among them, Silibinin was highlighted for the high similarity to the withdrawn drug Plicamycin although it was regarded as a promising drug candidate with a lower toxicity in existing reports. In summary, the network approach integrated with cheminformatics could provide drug safety indications effectively, especially for compounds with unknown targets or mechanisms like natural products. It would be helpful for drug safety surveillance in all phases of drug development.

scholarly journals Detection of Herb-Symptom Associations from Traditional Chinese Medicine Clinical Data

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Yu-Bing Li ◽  
Xue-Zhong Zhou ◽  
Run-Shun Zhang ◽  
Ying-Hui Wang ◽  
Yonghong Peng ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Clinical Data ◽  
Multiple Testing ◽  
Large Scale ◽  
Individualized Medicine ◽  
Correlation Method ◽  
Data Sets ◽  
Chi Square ◽  
Positive Correlations

Background. Traditional Chinese medicine (TCM) is an individualized medicine by observing the symptoms and signs (symptoms in brief) of patients. We aim to extract the meaningful herb-symptom relationships from large scale TCM clinical data.Methods. To investigate the correlations between symptoms and herbs held for patients, we use four clinical data sets collected from TCM outpatient clinical settings and calculate the similarities between patient pairs in terms of the herb constituents of their prescriptions and their manifesting symptoms by cosine measure. To address the large-scale multiple testing problems for the detection of herb-symptom associations and the dependence between herbs involving similar efficacies, we propose a network-based correlation analysis (NetCorrA) method to detect the herb-symptom associations.Results. The results show that there are strong positive correlations between symptom similarity and herb similarity, which indicates that herb-symptom correspondence is a clinical principle adhered to by most TCM physicians. Furthermore, the NetCorrA method obtains meaningful herb-symptom associations and performs better than the chi-square correlation method by filtering the false positive associations.Conclusions. Symptoms play significant roles for the prescriptions of herb treatment. The herb-symptom correspondence principle indicates that clinical phenotypic targets (i.e., symptoms) of herbs exist and would be valuable for further investigations.

scholarly journals Traditional Chinese Medicine Reduces the Incidence of Chemotherapy-Induced Stroke: A Five-Year Nationwide Population-Based Cohort Study From Taiwan

2021 ◽  
Vol 12 ◽  
Author(s):  
Chien-Chen Huang ◽  
Yu-Cih Yang ◽  
Iona MacDonald ◽  
Ching-Yuan Lai ◽  
Cheng-Hao Tu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Large Scale ◽  
Population Based ◽  
Incidence Rates ◽  
First Year ◽  
Subdistribution Hazard ◽  
Stroke Incidence ◽  
Kaplan Meier

Background: Chemotherapy is suspected to be a risk factor for stroke in patients with cancer, athough the results from large-scale studies are controversial. Few strategies are available for reducing the stroke-related risks.Methods: We analyzed stroke incidence rates in Taiwan’s Longitudinal Health Insurance database 2000 (LHID2000) for patients aged ≥20 years with newly-diagnosed cancer between Jan 1, 2000 and Dec 31, 2006, who did or did not receive chemotherapy. Moreover, we compared stroke incidence rates among chemotherapy users who did or did not use traditional Chinese medicine. All study participants were followed-up for 5 years or until they had a stroke.Results: In adjusted Kaplan-Meier analysis, the incidence of stroke was higher within the first year of cancer diagnosis among chemotherapy recipients compared with those who did not receive chemotherapy (31.1 vs. 9.75; adjusted subdistribution hazard ratio [sHR] 2.21; 95% confidence interval [CI], 1.52–3.20; p < 0.001). This between-group difference persisted at 4 years of follow-up (13.6 vs. 5.42; adjusted sHR 1.94; 95% CI, 1.53–2.46; p < 0.001). Similarly, the 5-year incidence rate of stroke was significantly lower among chemotherapy recipients using TCM vs. non-TCM users (0.19 vs. 0.46; adjusted sHR 0.45; 95% CI, 0.26–0.79; p < 0.001), as was the mortality rate (adjusted sHR 0.55; 95% CI, 0.44–0.68; p < 0.001).Conclusion: These Taiwanese data suggest that chemotherapy is a risk factor for stroke and that the use of TCM can significantly mitigate this risk. TCM also appears to reduce the mortality risk associated with chemotherapy.

scholarly journals Comparative transcriptome analysis of roots at different development stages reveals the mechanism of root expansion of Callerya speciosa Champ.

2019 ◽  
Author(s):  
Shaochang Yao ◽  
Zuzai Lan ◽  
Rongshao Huang ◽  
Yong Tan ◽  
Jinyuan Gu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Medicinal Plant ◽  
Root Formation ◽  
Comparative Transcriptome ◽  
Development Stages ◽  
Tuberous Roots ◽  
Perennial Shrub ◽  
Underlying Mechanisms ◽  
Fibrous Roots

Abstract Background Callerya speciosa Champ., a perennial shrub medicinal plant of Fabaceae, is one of the most commonly used in traditional Chinese medicine and food that has been widely cultivated in South China. The tuberous roots of C. speciosa transferred from fibrous roots but few fibrous roots can transfer into tuberous roots. To date, the underlying mechanisms for tuberous root formation and development of C. speciosa have not yet been elucidated.

scholarly journals AMFormulaS: an intelligent retrieval system for traditional Chinese medicine formulas

2021 ◽  
Vol 21 (S2) ◽  
Author(s):  
Yidi Cui ◽  
Bo Gao ◽  
Lihong Liu ◽  
Jing Liu ◽  
Yan Zhu
Keyword(s):  
Statistical Analysis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Search Engine ◽  
Large Scale ◽  
Retrieval System ◽  
Small Scale ◽  
Efficient Retrieval ◽  
Efficient Information ◽  
Retrieval Engine

Abstract Background Formula is an important means of traditional Chinese medicine (TCM) to treat diseases and has great research significance. There are many formula databases, but accessing rich information efficiently is difficult due to the small-scale data and lack of intelligent search engine. Methods We selected 38,000 formulas from a semi-structured database, and then segmented text, extracted information, and standardized terms. After that, we constructed a structured formula database based on ontology and an intelligent retrieval engine by calculating the weight of decoction pieces of formulas. Results The intelligent retrieval system named AMFormulaS (means Ancient and Modern Formula system) was constructed based on the structured database, ontology, and intelligent retrieval engine, so the retrieval and statistical analysis of formulas and decoction pieces were realized. Conclusions AMFormulaS is a large-scale intelligent retrieval system which includes a mass of formula data, efficient information extraction system and search engine. AMFormulaS could provide users with efficient retrieval and comprehensive data support. At the same time, the statistical analysis of the system can enlighten scientific research ideas and support patent review as well as new drug research and development.

scholarly journals The Efficacy of Heat-Clearing (Qingre) and Detoxifying (Jiedu) Traditional Chinese Medicine Gargle for Chemotherapy-Induced Oral Mucositis: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhixian Lin ◽  
Jiangfeng Chen ◽  
Sunya Han
Keyword(s):  
Systematic Review ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Oral Mucositis ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Systematic Evaluation ◽  
Cochrane Library ◽  
Randomized Controlled ◽  
Randomized Controlled Studies

Objective: Chemotherapy-induced oral mucositis (CIOM) is an extremely serious complication of cancer. In China, the heat-clearing (Qingre) and detoxifying (Jiedu) traditional Chinese medicine QRJD-TCM gargle has been widely used to treat CIOM. To date, no systematic evaluation has been conducted on the clinical efficacy of QRJD-TCM gargle in treating CIOM. The objective of this systematic review and meta-analysis was to evaluate the efficacy of QRJD-TCM gargle in the treatment of CIOM.Methods: Relevant randomized controlled trials (RCTs) comparing QRJD-TCM gargle with conventional Western medicine mouthwash (CWMM) for CIOM were confirmed by systematically searching PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Chinese Scientific Journal Database, Wanfang Database, and Sinomed until October 20, 2020. Two researchers independently assessed the risk of bias according to the Cochrane risk-of-bias criteria. Excel 2010 was used in setting up a database of extracted information, and RevMan 5.3.0 was used in analyzing included trial data. The composition of the QRJD-TCM gargle was evaluated.Results: A total of 25 articles were included in this meta-analysis. Results showed that compared with CWMM, QRJD-TCM gargle can reduce the incidence of CIOM (OR = 0.23, 95% CI [0.18, 0.29], p < 0.00001) and severity of CIOM (grade I–II: OR = 0.36, 95%CI [0.28, 0.46], p < 0.00001; grade III–IV: OR = 0.15, 95%CI [0.09, 0.28], p < 0.00001). In addition, QRJD-TCM gargle improved the effective rate of CIOM (OR = 15.91, 95% CI [7.93, 31.89], p < 0.00001).Conclusion: QRJD-TCM gargle is effective in preventing and treating CIOM. However, more standard, double-blind, and multicenter randomized controlled studies are needed to further confirm the efficacy of QRJD-TCM gargle in the prevention and treatment of CIOM.

Special Feature

2007 ◽  
Vol 11 (17n18) ◽  
pp. 1168-1197
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Medicinal Plant ◽  
Western Medicine ◽  
Cancer Care ◽  
Animal Species ◽  
Scientific Basis ◽  
Chinese Medicinal Plant

The Scientific Basis of Chinese Medicine and Cancer Care: A Western Medicine Perspective. Kampo Treatment for Cancer. A Chinese Medicinal Plant to Combat Cancer. Using Endangered Animal Species in Traditional Chinese Medicine.

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