scholarly journals Erratum to “Localized and Sustained Delivery of Erythropoietin from PLGA Microspheres Promotes Functional Recovery and Nerve Regeneration in Peripheral Nerve Injury”

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Wei Zhang ◽  
Yuan Gao ◽  
Yan Zhou ◽  
Jianheng Liu ◽  
Licheng Zhang ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Nerve Injury ◽  
Functional Recovery ◽  
Peripheral Nerve Injury ◽  
Sustained Delivery ◽  
Plga Microspheres

scholarly journals Localized and Sustained Delivery of Erythropoietin from PLGA Microspheres Promotes Functional Recovery and Nerve Regeneration in Peripheral Nerve Injury

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Wei Zhang ◽  
Yuan Gao ◽  
Yan Zhou ◽  
Jianheng Liu ◽  
Licheng Zhang ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Intraperitoneal Injection ◽  
Sustained Delivery ◽  
Plga Microspheres ◽  
Neuroprotective Effects ◽  
Injury Recovery ◽  
Daily Intraperitoneal Injection

Erythropoietin (EPO) has been demonstrated to exert neuroprotective effects on peripheral nerve injury recovery. Though daily intraperitoneal injection of EPO during a long period of time was effective, it was a tedious procedure. In addition, only limited amount of EPO could reach the injury sites by general administration, and free EPO is easily degradedin vivo. In this study, we encapsulated EPO in poly(lactide-co-glycolide) (PLGA) microspheres. Bothin vitroandin vivorelease assays showed that the EPO-PLGA microspheres allowed sustained release of EPO within a period of two weeks. After administration of such EPO-PLGA microspheres, the peripheral nerve injured rats had significantly better recovery compared with those which received daily intraperitoneal injection of EPO, empty PLGA microspheres, or saline treatments. This was supported by the functional, electrophysiological, and histological evaluations of the recovery done at week 8 postoperatively. We conclude that sustained delivery of EPO could be achieved by using EPO-PLGA microspheres, and such delivery method could further enhance the recovery function of EPO in nerve injury recovery.

scholarly journals Erythropoietin Accelerates Functional Recovery After Peripheral Nerve Injury

2008 ◽  
Vol 90 (8) ◽  
pp. 1644-1653 ◽  
Author(s):  
John C Elfar ◽  
Justin A Jacobson ◽  
J Edward Puzas ◽  
Randy N Rosier ◽  
Michael J Zuscik
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Functional Recovery ◽  
Peripheral Nerve Injury

Regeneration and functional recovery following peripheral nerve injury

2004 ◽  
Vol 1 (2) ◽  
pp. 177-185 ◽  
Author(s):  
Francisco J. Rodríguez ◽  
Antoni Valero-Cabré ◽  
Xavier Navarro
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Functional Recovery ◽  
Peripheral Nerve Injury

Sustained IGF-1 delivery ameliorates effects of chronic denervation and improves functional recovery after peripheral nerve injury

Biomaterials ◽  
2021 ◽  
pp. 121244
Author(s):  
Philip J. Hanwright ◽  
Chenhu Qiu ◽  
Jennifer Rath ◽  
Yang Zhou ◽  
Nicholas von Guionneau ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Functional Recovery ◽  
Peripheral Nerve Injury ◽  
Chronic Denervation

scholarly journals Functional Recovery via Preregenerated Nerve Graft in Rat Sciatic Nerve Injury Model

Neurosurgery ◽  
2019 ◽  
Vol 66 (Supplement_1) ◽  
Author(s):  
Umang Khandpur ◽  
Ying Yan ◽  
Wilson Zachary Ray ◽  
Matthew R MacEwan
Keyword(s):  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Functional Recovery ◽  
Peripheral Nerve Injury ◽  
Muscle Force ◽  
Nerve Graft ◽  
Tissue Loss ◽  
Limb Amputation ◽  
Percent Recovery

Abstract INTRODUCTION Patients who have experienced major tissue loss with peripheral nerve injury (eg, limb amputation) may be offered composite tissue allotransplantation (CTA). The return of sensory ability and cosmetic component of CTAs make them an attractive alternative to prosthetic devices. Unfortunately, robust reinnervation especially over great distances remains an issue for hand allotransplants. In this study, we introduce a preregenerated nerve graft to shorten the distance and therefore time to terminal tissue reinnervation, which could improve the utility of CTAs. METHODS A total of 18 rats weighing 250 to 300 gm each were randomized into 1 of 3 groups: baseline, fresh, or preregenerated. The baseline group underwent sham surgery to obtain baseline functional data. The fresh and preregenerated groups both underwent grafting of the sciatic nerve but the preregenerated group utilized 8-wk preregenerated grafts. At postperative week 8 from distal neurorrhaphy, both groups underwent terminal functional testing via EMG and evoked muscle force. RESULTS The preregenerated group had significantly greater mean EMG (P < .05) and maximum tetanic muscle force values (P < .05) than the fresh group. Mean percent recovery in EMG for the fresh group was 21.95% compared with 81.79% in the preregenerated group. Mean percent recovery in muscle force was 9.46% and 33.15%, respectively. CONCLUSION The results of this study provide a novel approach to enhance final functional recovery after peripheral nerve injury. The current practice of constructing a nerve stump may be improved by grafting a nerve segment at the time of injury and allowing it to preregenerate into local musculature so that if a CTA is later performed, an expedited and more robust reinnervation could be accomplished.

Use of the CatWalk gait analysis system to assess functional recovery in rodent models of peripheral nerve injury – a systematic review

2020 ◽  
Vol 345 ◽  
pp. 108889
Author(s):  
Johannes Heinzel ◽  
Gregor Längle ◽  
Viola Oberhauser ◽  
Thomas Hausner ◽  
Jonas Kolbenschlag ◽  
...  
Keyword(s):  
Systematic Review ◽  
Peripheral Nerve ◽  
Gait Analysis ◽  
Nerve Injury ◽  
Functional Recovery ◽  
Peripheral Nerve Injury ◽  
Rodent Models ◽  
Analysis System
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