scholarly journals Mixed Germ Cell Tumor of Testis with Isolated Scapular Metastasis: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Dipti Rani Samanta ◽  
Chaitali Bose ◽  
Roopesh Krishnappa ◽  
Saumyaranjan Mishra ◽  
Sulagna Mohanty ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Serum Markers ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
Mixed Germ Cell Tumor ◽  
Nonseminomatous Germ Cell Tumor ◽  
Poorly Differentiated

Bone metastasis is a rare entity in germ cell tumor of testis and is a poor prognostic site. It is usually associated with synchronous metastasis at other sites. Till now very few cases of isolated bone metastasis of germ cell tumor of testis have been reported but none have reported scapular metastasis. We are reporting a case of nonseminomatous germ cell tumor of right testis that was operated eight months ago and now presented with isolated scapular metastasis. Histopathology of the scapular tissue revealed rhabdomyosarcoma or poorly differentiated synovial sarcoma. Immunohistochemistry with serum markers concluded it to be metastatic germ cell tumor. To the best of our knowledge this is the first reported case of scapular metastasis of testicular germ cell tumor. This case is being reported here due to dilemmatic way of presentation and also to emphasize that histopathology may sometimes misguide and immunohistochemistry is necessary in such cases.

scholarly journals Metastatic Mixed Germ Cell Tumor Presented With Hemoptysis- A Case Report

2020 ◽  
Vol 3 (1) ◽  
pp. 01-03
Author(s):  
Sardar Islam
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
X Ray ◽  
Node Metastasis ◽  
Mixed Germ Cell Tumor ◽  
Rare Combination ◽  
Systemic Metastasis

A 35 year’s old male presented with right testicular swelling for last six month. He developed hemoptysis and mild dyspnea for 2 weeks. Ultrasonography revealed testicular malignancy with multiple heterogenecity. CT scan of the abdomen did not reveal any lymph node metastasis. His X-ray chest showed extensive pulmonary metastasis. All three tumor markers were raised. Histology was suggestive of mixed germ cell tumor with a rare combination of Seminoma and Choriocarcinoma. Because of this rare combination of 2 varieties of testicular germ cell tumor and advanced systemic metastasis we presented this case.

scholarly journals Nephroblastoma Arising from Primary Testicular Germ Cell Tumor: A Case Report and Literature Review

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Houda Alatassi ◽  
Brittany E. O’Bryan ◽  
Jamie C. Messer ◽  
Zhenglong Wang
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Embryonal Carcinoma ◽  
Lung Metastases ◽  
English Literature ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
Mixed Germ Cell Tumor

Adult extrarenal nephroblastoma is a very rare tumor. Nephroblastoma arising from primary testicular germ cell tumor is exceedingly rare. To our knowledge, only three cases have been reported in the English literature. We report a case of a 19-year-old man who presented with a large right testicle. Image studies showed a large retroperitoneal mass along with liver and lung metastases. Orchiectomy demonstrated a mixed germ cell tumor composed of yolk sac tumor, embryonal carcinoma, and mature and immature teratoma with a significant portion of nephroblastoma. The patient received chemotherapy and no recurrence was noted during six months of followup. WT-1 expression was also studied due to the lack of consistency of its expression in testicular nephroblastoma in the literature. We also present a discussion and review of the literature due to its rarity, which indicate an adverse prognosis for patients with nephroblastoma components receiving standard chemotherapeutical regimes for testicular germ cell tumors.

Clinical significance of amyloid precursor protein in patients with testicular germ cell tumor.

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Germ Cell ◽  
Clinical Significance ◽  
Germ Cell Tumor ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Precursor Protein ◽  
Testicular Germ Cell ◽  
Nonseminomatous Germ Cell Tumor ◽  
Yolk Sac Tumors

Testicular cancer is a relatively rare cancer that accountsfor approximately 1–1.5% of male cancers, and 90–95%of these cancers are testicular germ cell tumors (TGCTs)[1]. TGCTs can be classified into two major histologicalcategories, namely, seminomatous germ cell tumor (SGCT)and nonseminomatous germ cell tumor (NGCT). NGCTs,which include yolk sac tumors, embryonal cell carcinomas,teratomas, and choriocarcinomas, are different from SGCTswith regard to clinical characteristics and therapy required.Amyloid precursor protein (APP) is a type 1transmembrane protein that is considered to play a key rolein Alzheimer’s disease. It has multiple isoforms attributableto alternative splicing and is expressed in various types ofhuman cells. APP695 predominantly exists in the neuronswhereas other isoforms such as the APP751 and APP770are expressed in nonneuronal cells [2]. The biological roleof APP is not well understood. APP and its cleaved formshave been suggested to mediate various functions, includingcell adhesion [3], cell signaling [4], and cell growth [5–7].These functions are important in carcinogenesis, and APPexpression may be involved in the development of variouscancers [8–13].We have previously shown that APP is a primaryandrogen-responsive gene that promotes the growth of2 Advances in Urologyprostate cancer cells [14]. In the present study, we investigatedAPP immunoreactivity (IR) and APP mRNA expression inTGCTs and evaluated its clinical significance.

Testicular germ cell tumor with pineal metastases

Neurosurgery ◽  
1990 ◽  
pp. 688 ◽  
Author(s):  
B Delahunt ◽  
H H Teoh ◽  
V Balakrishnan ◽  
J N Nacey ◽  
S P Clark
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell

666 A NOVEL RISK STRATIFICATION SYSTEM FOR CHEMOTHERAPY FAILURE IN TESTICULAR GERM CELL TUMOR

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Jessica Lubahn ◽  
Nicholas Cost ◽  
Mehrad Adibi ◽  
Adam Romman ◽  
Ganesh Raj ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
Stratification System ◽  
Risk Stratification System

scholarly journals A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility

2011 ◽  
Vol 20 (15) ◽  
pp. 3109-3117 ◽  
Author(s):  
Peter A. Kanetsky ◽  
Nandita Mitra ◽  
Saran Vardhanabhuti ◽  
David J. Vaughn ◽  
Mingyao Li ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
Tumor Susceptibility ◽  
Independent Locus
Sign in / Sign up

Export Citation Format

Share Document