scholarly journals Obesity and Metabolic Phenotypes (Metabolically Healthy and Unhealthy Variants) Are Significantly Associated with Prevalence of Elevated C-Reactive Protein and Hepatic Steatosis in a Large Healthy Brazilian Population

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Sameer Shaharyar ◽  
Lara L. Roberson ◽  
Omar Jamal ◽  
Adnan Younus ◽  
Michael J. Blaha ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
High Sensitivity ◽  
Abdominal Ultrasound ◽  
Normal Weight ◽  
C Reactive Protein ◽  
Cvd Risk ◽  
Reactive Protein ◽  
Metabolically Healthy Obese ◽  
Metabolically Healthy ◽  
Relationship Of

Background. Among the obese, the so-called metabolically healthy obese (MHO) phenotype is thought to confer a lower CVD risk as compared to obesity with typical associated metabolic changes. The present study aims to determine the relationship of different subtypes of obesity with inflammatory-cardiometabolic abnormalities.Methods. We evaluated 5,519 healthy, Brazilian subjects (43±10years, 78% males), free of known cardiovascular disease. Those with <2 metabolic risk factors (MRF) were considered metabolically healthy, and those with BMI ≥ 25 kg/m2and/or waist circumference meeting NCEP criteria for metabolic syndrome as overweight/obese (OW). High sensitivity C reactive protein (hsCRP) was measured to assess underlying inflammation and hepatic steatosis (HS) was determined via abdominal ultrasound.Results. Overall, 40% of OW individuals were metabolically healthy, and 12% normal-weight had ≥2 MRF. The prevalence of elevated CRP (≥3 mg/dL) and HS in MHO versus normal weight metabolically healthy group was 22% versus 12%, and 40% versus 8% respectively (P<0.001). Both MHO individuals and metabolically unhealthy normal weight (MUNW) phenotypes were associated with elevated hsCRP and HS.Conclusion. Our study suggests that MHO and MUNW phenotypes may not be benign and physicians should strive to treat individuals in these subgroups to reverse these conditions.

Abstract 179: Vascular Inflammation and Hepatic Steatosis among the Overweight Metabolically Healthy Individuals and Normal Weight with Cardiometabolic Risk Factor Clustering

2013 ◽  
Vol 33 (suppl_1) ◽  
Author(s):  
Sameer Shaharyar ◽  
Adil Karim ◽  
Michael J Blaha ◽  
Shozab S Ali ◽  
Omar Jamal ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Vascular Inflammation ◽  
High Sensitivity ◽  
Abdominal Ultrasound ◽  
Normal Weight ◽  
Cvd Risk ◽  
Reactive Protein ◽  
Cardiometabolic Disorders ◽  
Metabolically Healthy ◽  
Hs Crp

BACKGROUND Emerging literature has elucidated a new phenotype, metabolically healthy overweight/obese (MHO) who have a similar CVD risk to normal weight individuals. The aim of the study was to compare the relative risk of both phenotypes with subclinical inflammatory-cardiometabolic disorders. METHODS We evaluated 6,464 healthy non diabetic Brazilian subjects (43±10 years, 79% males). Those with <2 metabolic risk factors (MRF)were considered metabolically healthy and those with BMI≥25 kg/m2 as overweight (OW). High sensitivity C reactive protein (hs-CRP) was measured to assess degree of underlying inflammation and hepatic steatosis (HS) was determined via abdominal ultrasound. RESULTS Overall, 52% OW individuals were metabolically normal, and 11% normal-weight had≥2 MRF. The respective prevalence for elevated CRP (≥ 3 mg/dl) was 28% vs 16%, p<0.0001) and 71% vs 28% for HS, respectively. As compared to those with normal weight/metabolically benign, the highest risk of elevated CRP & HS was noted among those with overweight/metabolically unhealthy individuals (table). Both MHO individuals & normal weight metabolically unhealthy participants had similar association with elevated CRP & HS. CONCLUSION Our study highlights that healthy overweight/obesity & normal weight metabolically unhealthy phenotypes are not entirely benign and efforts are needed to reverse these conditions.

Abstract P292: Severe Obesity is Associated with Dramatic Increase in Cardiovascular Disease Risk Factor Prevalence: Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Robert Kaplan ◽  
Larissa M Avilés-Santa ◽  
Christina M Parrinello ◽  
Sheila Castañeda ◽  
Arlene L Hankinson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Class Ii ◽  
Normal Weight ◽  
Class Iii ◽  
C Reactive Protein ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Total N ◽  
Reactive Protein ◽  
Class Iii Obesity

Introduction: Prevalence of severe obesity is increasing, especially among the young Hispanic population. Methods: In the HCHS/SOL cohort of 18-74 year old US Hispanics, we examined gradients across BMI and age in CVD risk factors. Results: Approximately one in five males (total N = 6,547) and one in ten females (total N=9,797) met criteria for class II obesity (BMI 35 - 40 kg/m 2 ) or class III obesity (BMI ≥ 40 kg/m 2 ). The prevalence of hypertension, diabetes, and elevated C-reactive protein rose with each successive class of overweight/obesity. In contrast, the prevalence of elevated levels of total cholesterol, LDL-c and triglycerides increased across normal weight, overweight (BMI 25 - 30 kg/m 2 ), and class I obese (BMI 30 - 35 kg/m 2 ) groups, but did not increase in frequency across class I, class II, and class III obesity groups. The Figure depicts isolines that identify age- specific subgroups of the normal-weight and class II - III obese groups that had the same estimated prevalence of CVD risk factors, with 95 percent confidence intervals. Among young adults with class II or III obesity, the prevalence of hypertension, diabetes, and the combination of three or more CVD risk factors was similar to that among normal-weight individuals (BMI 18.5 - 25 kg/m 2 ) who were 15 to 30 years older. Among young obese individuals, the prevalence of low HDL-c levels and high C-reactive protein levels exceeded that among the oldest adults in the cohort. CVD risk factors had stronger, more consistent gradients across the BMI categories among men than among women. Conclusion: Class II and III obesity, defined as BMI ≥ 35 kg/m 2 , are common in the Hispanic/Latino population. Young adults with these severe forms of obesity have dramatically increased frequency of cardiometabolic risk factors. The age-related accumulation of multiple CVD risk factors, such as is typically seen in normal-weight individuals, is accelerated by 1-2 decades in severly overweight women and by 2-3 decades in severely overweight men.

Relationship of C-reactive protein with components of the metabolic syndrome in normal-weight and overweight elderly

2005 ◽  
Vol 15 (4) ◽  
pp. 270-278 ◽  
Author(s):  
Tiny Hoekstra ◽  
Johanna M. Geleijnse ◽  
Evert G. Schouten ◽  
Frans J. Kok ◽  
Cornelis Kluft
Keyword(s):  
Metabolic Syndrome ◽  
Normal Weight ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Metabolic Syndrome ◽  
Relationship Of

Relationship of high-sensitivity C-reactive protein to prognosis and other prognostic markers in outpatients with heart failure

2007 ◽  
Vol 153 (6) ◽  
pp. 1048-1055 ◽  
Author(s):  
Jonathan D. Windram ◽  
Puan H. Loh ◽  
Alan S. Rigby ◽  
Ian Hanning ◽  
Andrew L. Clark ◽  
...  
Keyword(s):  
Heart Failure ◽  
Prognostic Markers ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Relationship Of

scholarly journals The Use of High Sensitivity C-Reactive Protein in Cardiovascular Disease Detection

2018 ◽  
Vol 21 ◽  
pp. 496-503 ◽  
Author(s):  
Ana Rita Castro ◽  
Sara Oliveira Silva ◽  
Sandra Clara Soares
Keyword(s):  
Vascular Inflammation ◽  
Life Quality ◽  
High Sensitivity ◽  
Medical Community ◽  
Concentration Limit ◽  
C Reactive Protein ◽  
High Concentration ◽  
Cvd Risk ◽  
Plaque Instability ◽  
Reactive Protein

Cardiovascular diseases (CVDs) are responsible for a high mortality rate worldwide. One of the most common causes of CVDs is vascular inflammation associated to atherosclerosis. Inflammatory biomarkers are used to assist the detection of CVDs and monitor their evaluation, prognosis and therapy implementation. C-reactive protein (CRP) is an acute phase protein produced after stimulation by pro-inflammatory cytokines. CRP is a biomarker of the inflammatory reaction and an important mediator of atherosclerosis. Given it actively contributes to the development of the atherosclerotic plaque, instability and subsequent clot formation it is also considered a CVD risk factor. Since 2010, the plasma concentration of hsCRP (high sensitivity CRP) has been used as a biomarker for disease prognosis in patients with intermediate risk for CVDs. It could be useful to establish a high concentration limit of hsCRP that can be used by clinicians for diagnosis of acute myocardial infarction, cardio embolic or ischemic stroke, and hypertrophic cardiomyopathy. The end cost/effectiveness of hsCRP screening is still an area of controversy but it is a priority to make the medical community aware of the positive relation between high hsCRP and CVDs to improve median survival and life quality of the patients.

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