scholarly journals High-Grade Leiomyosarcoma Arising in a Previously Replanted Limb

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Tiffany J. Pan ◽  
Liron Pantanowitz ◽  
Kurt R. Weiss
Keyword(s):  
Viral Infections ◽  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Traumatic Amputation ◽  
Chronic Injury ◽  
First Case ◽  
Grade 3 ◽  
Prior Trauma

Sarcoma development has been associated with genetics, irradiation, viral infections, and immunodeficiency. Reports of sarcomas arising in the setting of prior trauma, as in burn scars or fracture sites, are rare. We report a case of a leiomyosarcoma arising in an arm that had previously been replanted at the level of the elbow joint following traumatic amputation when the patient was eight years old. He presented twenty-four years later with a 10.8 cm mass in the replanted arm located on the volar forearm. The tumor was completely resected and pathology examination showed a high-grade, subfascial spindle cell sarcoma diagnosed as a grade 3 leiomyosarcoma with stage pT2bNxMx. The patient underwent treatment with brachytherapy, reconstruction with a free flap, and subsequently chemotherapy. To the best of our knowledge, this is the first case report of leiomyosarcoma developing in a replanted extremity. Development of leiomyosarcoma in this case could be related to revascularization, scar formation, or chronic injury after replantation. The patient remains healthy without signs of recurrence at three-year follow-up.

Malignant spindle cell tumors of the posterior fossa in children: case series and review of management

2021 ◽  
pp. 1-11
Author(s):  
Michael J. Gigliotti ◽  
Christine Mau ◽  
Charles S. Specht ◽  
Cynthia Lawson ◽  
Sarah McNutt ◽  
...  
Keyword(s):  
Literature Review ◽  
Posterior Fossa ◽  
Ewing Sarcoma ◽  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma ◽  
Presenting Symptoms ◽  
Spindle Cell Tumors

OBJECTIVE The WHO Classification of Tumours of the Central Nervous System (2016) classifies nonmeningothelial malignant spindle cell tumors involving the extraaxial tissues of the posterior fossa as melanocytic tumors and malignant mesenchymal tumors (sarcomas). The objective of this study was to conduct a review of the literature pertaining to the management strategies of posterior fossa malignant spindle cell tumors in the pediatric population. METHODS The authors performed an institutional search of their pathology database for patients younger than 18 years of age who presented with posterior fossa malignant spindle cell tumors. A literature review was also performed using the PubMed database, with “posterior fossa” or “spindle cell tumors” or “Ewing sarcoma” or “high-grade” or “spindle cell sarcoma” or “leptomeningeal melanocytoma” as keywords. The database search was restricted to pediatric patients (age ≤ 18 years). Parameters reported from the literature review included patient age, tumor location, presenting symptoms, treatment modalities (resection, chemotherapy, and/or radiotherapy), leptomeningeal spread at or after the time of treatment, and follow-up length and resulting outcome. RESULTS The authors report 3 rare cases of posterior fossa malignant spindle cell tumors, including Ewing sarcoma in a 13-year-old male; high-grade spindle cell sarcoma, not otherwise specified in a 10-year-old male; and primary leptomeningeal melanocytoma in a 16-year-old female. All 3 patients underwent resection and radiotherapy and either chemotherapy or targeted immunotherapy. At the last follow-up, all patients were alive with either resolution or stable disease. CONCLUSIONS A review of these 3 cases and the existing literature support managing patients with intracranial malignant spindle cell tumors with multimodal therapy that can include a combination of resection, radiotherapy, and chemotherapy or immunotherapy to prolong progression-free and overall survival.

INTRAARTERIAL CISPLATIN AND CAFFEINE WITH/WITHOUT DOXORUBICIN FOR MUSCULOSKELETAL HIGH-GRADE SPINDLE-CELL SARCOMA

1994 ◽  
Author(s):  
H TSUCHIYA ◽  
K TOMITA ◽  
H YASUTAKE ◽  
Y TAKAGI ◽  
S KATSUO ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma

scholarly journals Manifestation of Pleomorphic Undifferentiated Aortic Sarcoma with Splenic Infarction: A Case Report

2020 ◽  
Vol 13 (2) ◽  
pp. 1002-1005
Author(s):  
Varun Kaushal ◽  
Behzad Amoozgar ◽  
Nabonita Barua ◽  
Shankar Chhetri ◽  
Bhaveshkumar Garsondiya
Keyword(s):  
Poor Prognosis ◽  
Spindle Cell ◽  
Tumor Resection ◽  
Splenic Infarction ◽  
Spindle Cell Sarcoma ◽  
Shortness Of Breath ◽  
Major Vein ◽  
Aortic Sarcoma ◽  
Ct And Mri

Aortic spindle cell sarcoma is a rare neoplasm with poor prognosis that is often found incidentally due to its adverse effects. CT and MRI with contrast are useful imaging modalities, but a tissue biopsy is the gold standard for diagnosis. Tumor resection is the ultimate treatment followed by chemotherapy. Our case was an adult female who presented mainly for shortness of breath, and further imaging workup demonstrated a soft tumor juxtaposed to a major vein with compressive effect. The patient’s tumor was resected, and the pathology result confirmed undifferentiated aortic sarcoma. The patient’s condition improved and she was discharged with outpatient oncology follow-up and possible treatment.

The transvenous retrograde pressure cooker technique for the curative embolization of high-grade brain arteriovenous malformations

2020 ◽  
pp. neurintsurg-2020-016566
Author(s):  
Masaomi Koyanagi ◽  
Pascal John Mosimann ◽  
Hannes Nordmeyer ◽  
Markus Heddier ◽  
Juergen Krause ◽  
...  
Keyword(s):  
Arteriovenous Malformations ◽  
High Grade ◽  
Transvenous Embolization ◽  
Cure Rate ◽  
Brain Arteriovenous Malformations ◽  
Long Term Follow Up ◽  
Occlusion Rate ◽  
Grade 3

BackgroundTransvenous embolization of brain arteriovenous malformations (AVMs) can be curative. We aimed to evaluate the cure rate and safety of the transvenous retrograde pressure cooker technique (RPCT) using coils and n-butyl-2-cyanoacrylate as a venous plug.MethodsAll AVM patients treated via transvenous embolization between December 2004 and February 2017 in a single center were extracted from our database. Inclusion criteria were: inability to achieve transarterial cure alone; AVM < 3 cm; and single main draining vein. Outcome measures were immediate and 90 days' angiographic AVM occlusion rate, and morbidity and mortality at 30 days and 12 months, according to the modified Rankin Scale (mRS) score.ResultsFifty-one patients (20 women; median age 47 years) were included. A majority (71%) were high grade (3 to 5 in the Spetzler–Martin classification). AVMs were deeply seated in 30 (59%) and cortical in 21 patients (41%). Thirty-three patients were previously embolized transarterially (65%). All patients but one were cured within a single session with the RPCT (96%). Cure was confirmed on follow-up digital subtraction angiography at 3 months in 82% of patients. Three patients experienced intracranial hemorrhage (6%), one requiring surgical evacuation. There were no deaths. One treatment-related major permanent deficit was observed (2.0%). Mean mRS before treatment, at 30 days, and 12 months after RPCT was 1.5, 1.5, and 1.3, respectively.ConclusionsThe retrograde pressure cooker technique can be curative in carefully selected high-grade AVMs. Long-term follow-up and prospective studies are needed to confirm our results.

scholarly journals Histochemical and ultrastructural study of an elastofibroma dorsi coexisting with a high grade spindle cell sarcoma

10.4081/884 ◽  
2009 ◽  
Vol 48 (2) ◽  
pp. 173 ◽  
Author(s):  
M Alberghini ◽  
P Bacchini ◽  
G Pignatti ◽  
MC Maltarello ◽  
L Zanella ◽  
...  
Keyword(s):  
Ultrastructural Study ◽  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma ◽  
Elastofibroma Dorsi

scholarly journals Well-Differentiated Extraskeletal Osteosarcoma Arising from the Retroperitoneum That Recurred as Anaplastic Spindle Cell Sarcoma

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Hiromasa Arai ◽  
Yasushi Rino ◽  
Teppei Nishii ◽  
Norio Yukawa ◽  
Nobuyuki Wada ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Tumor Resection ◽  
Large Mass ◽  
Japanese Woman ◽  
Spindle Cell Sarcoma ◽  
Histopathological Diagnosis ◽  
High Grade ◽  
Extraskeletal Osteosarcoma ◽  
Cell Sarcoma ◽  
Well Differentiated

Extraskeletal osteosarcoma is an uncommon high-grade malignant soft tissue sarcoma. Well-differentiated extraskeletal osteosarcoma is thought to have a better prognosis than classical extraskeletal osteosarcoma, but dedifferentiation after recurrence has also been reported. We present a case of a primary retroperitoneal extraskeletal osteosarcoma in a 62-year-old Japanese woman. Abdominal CT revealed a large mass with diffuse calcification in the right retroperitoneal space and tumor resection was performed. The histopathological diagnosis was well-differentiated retroperitoneal extraskeletal osteosarcoma. She was followed up by CT every 6 months without adjuvant radiotherapy and chemotherapy for 31 months until anaplastic high-grade spindle cell sarcoma recurred in the retroperitoneum. Our case is the seventh reported description of well-differentiated extraskeletal sarcoma, and the first to arise in the retroperitoneum and recur as an entirely dedifferentiated spindle cell sarcoma.

scholarly journals Giant ovarian cystadenocarcinoma in an adult patient, a rare finding in modern times

2019 ◽  
Vol 2019 (7) ◽  
Author(s):  
Gabriel Alejandro Molina ◽  
Alison Nicole Izurieta ◽  
Miguel Angel Moyon ◽  
William G Aguayo ◽  
Fernando X Moyon ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Broad Spectrum ◽  
Late Stage ◽  
Diagnostic Techniques ◽  
High Grade ◽  
Clinical Behavior ◽  
Rare Finding ◽  
Modern Times ◽  
First Case

Abstract Ovarian cancer (OC) is one of the most commonly diagnosed cancers among women. Regretfully due to its a broad spectrum of clinical behavior and challenging diagnosis most cases are diagnosed at a late stage. On rare occasions, these tumors can grow to massive sizes if left untreated, worsening the prognosis of the patient. Thanks to the advancement of medicine and diagnostic techniques, these rare cases are less frequent. Timely detection and surgery could avoid all these potentially troublesome scenarios. We report the case of a 64-year-old female with a giant 13 kg high-grade papillary serous ovarian cystadenocarcinoma, the tumor grew during a four year period and was adequately treated with surgery and is under close follow up with the oncologist. To our knowledge, this is the first case of a giant ovarian cystadenocarcinoma ever reported in Ecuador.

scholarly journals Gemcitabine and docetaxel in relapsed and unresectable high-grade osteosarcoma and spindle cell sarcoma of bone

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
E. Palmerini ◽  
R. L. Jones ◽  
E. Marchesi ◽  
A. Paioli ◽  
M. Cesari ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma ◽  
High Grade Osteosarcoma
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