scholarly journals Tracheal Diverticulum: A Unique Case with Intraoperative Morphologic Assessment

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Rohini Chennuri ◽  
Pavithra Dissanayake ◽  
Urjeet A. Patel ◽  
Gabor Tarjan
Keyword(s):  
Rare Case ◽  
Case Reports ◽  
Past Medical History ◽  
Minor Salivary Glands ◽  
Imaging Studies ◽  
Significant Past Medical History ◽  
Unique Case ◽  
Radiologic Findings ◽  
Tracheal Diverticulum ◽  
Cystic Cavity

There are rare case reports of tracheal diverticula or paratracheal air cysts. These cases, however, were reported mostly as incidental sonographic or radiologic findings without histologic confirmation. Furthermore, the handful of studies that describe this entity histopathologically report only cases in patients with prior respiratory symptoms. Here, we report a rare case of an asymptomatic 60-year-old female with no significant past medical history who presented with primary hyperparathyroidism. She was found to have an incidental right paraesophageal air-filled diverticulum with multiple thin septations on her imaging studies. She was taken to surgery and the histologic examination of the specimen revealed multiloculated cystic cavity lined by respiratory-type columnar epithelium with lymphocytic infiltrate and minor salivary glands within the surrounding stroma, rendering the diagnosis of tracheal diverticula.

scholarly journals Rare Case of Rapidly Worsening REM Sleep Induced Bradycardia

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Ayyappa S. Duba ◽  
Suneetha Jasty ◽  
Ankit Mahajan ◽  
Vijay Kodadhala ◽  
Raza Khan ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Rare Case ◽  
Sinoatrial Node ◽  
Past Medical History ◽  
Sinus Arrest ◽  
Dual Chamber ◽  
Significant Past Medical History ◽  
Sleep Study ◽  
Dual Chamber Pacemaker ◽  
Over Time

Sinoatrial arrest also known as sinus pause occurs when sinoatrial node of the heart transiently ceases to generate the electrical impulse necessary for the myocardium to contract. It may last from 2.0 seconds to several minutes. Etiologies of sinoatrial arrest can be complex and heterogeneous. During rapid eye movement (REM) sleep, sinus arrests unrelated to apnea or hypopnea are very rare and only a few cases have been reported. Here we report a case of 36-year-old male with no significant past medical history who presented to our hospital after a syncopal episode at night. Physical examination showed no cardiac or neurological abnormalities and initial EKG and neuroimaging were normal. Overnight telemonitor recorded several episodes of bradyarrhythmia with sinus arrest that progressively lengthened over time. Sleep study was done which confirmed that sinus arrests occurred more during REM sleep and are unrelated to apnea or hypopnea. Electrophysiology studies showed sinus nodal dysfunction with no junctional escape, subsequently a dual chamber pacemaker placed for rapidly worsening case of REM sleep induced bradycardia.

scholarly journals Giant haemorrhagic retroperitoneal mesothelial cyst: a rare case report

2017 ◽  
Vol 5 (10) ◽  
pp. 4626
Author(s):  
Sandesh Deolekar ◽  
Bibekananda Mahapatra ◽  
Sridevi Murali ◽  
Karna Chheda ◽  
Naseem Khan ◽  
...  
Keyword(s):  
Rare Case ◽  
Unusual Case ◽  
Abdominal Discomfort ◽  
Mesenteric Cyst ◽  
Past Medical History ◽  
Significant Past Medical History ◽  
Mesothelial Cyst ◽  
Rare Case Report ◽  
Specific Symptoms ◽  
Cystic Mesothelioma

A peritoneal cystic mesothelioma is a very rare mesenteric cyst of mesothelial origin. The size of this lesion usually ranges between a few centimetres and 10 cm. It is usually asymptomatic, but occasionally presents with various, non-specific symptoms. We present a 24-years-old woman with vague abdominal discomfort and associated distension for 6 months, with generalized weakness with no significant past medical history. This is an unusual case of a giant peritoneal mesothelioma which is hemorrhagic nature which could be the first such case reported. 

Linezolid Induced Skin Reactions in a Multi Drug Resistant Infective Endocarditis Patient: A Rare Case

2020 ◽  
Vol 15 (3) ◽  
pp. 222-226 ◽  
Author(s):  
Asha K. Rajan ◽  
Ananth Kashyap ◽  
Manik Chhabra ◽  
Muhammed Rashid
Keyword(s):  
Case Report ◽  
Infective Endocarditis ◽  
Rare Case ◽  
Case Reports ◽  
Multidrug Resistant ◽  
The Body ◽  
Prior History ◽  
Skin Reactions ◽  
Rare Case Report ◽  
Multiple Drugs

Rationale: Linezolid (LNZ) induced Cutaneous Adverse Drug Reactions (CADRs) have rare atypical presentation. Till date, there are very few published case reports on LNZ induced CADRs among the multidrug-resistant patients suffering from Infective Endocarditis (MDR IE). Here, we present a rare case report of LNZ induced CARs in a MDR IE patient. Case report: A 24-year-old female patient was admitted to the hospital with chief complaints of fever (101°C) associated with rigors, chills, and shortness of breath (grade IV) for the past 4 days. She was diagnosed with MDR IE, having a prior history of rheumatic heart disease. She was prescribed LNZ 600mg IV BD for MDR IE, against Staphylococcus coagulase-negative. The patient experienced flares of cutaneous reactions with multiple hyper-pigmented maculopapular lesions all over the body after one week of LNZ therapy. Upon causality assessment, she was found to be suffering from LNZ induced CADRs. LNZ dose was tapered gradually and discontinued. The patient was prescribed corticosteroids along with other supportive care. Her reactions completely subsided and infection got controlled following 1 month of therapy. Conclusion: Healthcare professionals should be vigilant for rare CADRs, while monitoring the patients on LNZ therapy especially in MDR patients as they are exposed to multiple drugs. Moreover, strengthened spontaneous reporting is required for better quantification.

scholarly journals Hyperhomocysteinemia in a Patient with Moyamoya Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Durga Shankar Meena ◽  
Gopal Krishana Bohra ◽  
Mahadev Meena ◽  
Bharat Kumar Maheshwari
Keyword(s):  
Cerebrovascular Disease ◽  
Moyamoya Disease ◽  
Cerebral Angiography ◽  
Rare Case ◽  
Homocysteine Level ◽  
Case Reports ◽  
Circle Of Willis

Moyamoya disease is a chronic progressive cerebrovascular disease characterized by bilateral occlusion or stenosis of arteries around circle of Willis. We report a case of 18-year-old female presented with recurrent episodes of headache and vertigo. On cerebral angiography, the patient was diagnosed to have moyamoya disease. On further evaluation, thrombophilia profile showed increased homocysteine level. The patient was treated conservatively with cobalamin and aspirin and advised for revascularization. According to the literature, there are few case reports of moyamoya disease with thrombotic disorders. Hence, we are reporting this interesting and rare case.

scholarly journals Vestibular neuritis caused by severe acute respiratory syndrome coronavirus 2 infection diagnosed by serology: Case report

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110132
Author(s):  
Alexandra Halalau ◽  
Madalina Halalau ◽  
Christopher Carpenter ◽  
Amr E Abbas ◽  
Matthew Sims
Keyword(s):  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Medical History ◽  
Cranial Nerve ◽  
Respiratory Illness ◽  
Vestibular Neuritis ◽  
Past Medical History ◽  
Significant Past Medical History ◽  
Eighth Cranial Nerve ◽  
Male Physician

Vestibular neuritis is a disorder selectively affecting the vestibular portion of the eighth cranial nerve generally considered to be inflammatory in nature. There have been no reports of severe acute respiratory syndrome coronavirus 2 causing vestibular neuritis. We present the case of a 42-year-old Caucasian male physician, providing care to COVID-19 patients, with no significant past medical history, who developed acute vestibular neuritis, 2 weeks following a mild respiratory illness, later diagnosed as COVID-19. Physicians should keep severe acute respiratory syndrome coronavirus 2 high on the list as a possible etiology when suspecting vestibular neuritis, given the extent and implications of the current pandemic and the high contagiousness potential.

scholarly journals CSF3R T618I, SETBP1 G870S, SRSF2 P95H, and ASXL1 Q780* tetramutation co-contribute to myeloblast transformation in a chronic neutrophilic leukemia

2021 ◽  
Author(s):  
Yi Qian ◽  
Yan Chen ◽  
Xiaoming Li
Keyword(s):  
Alpha Interferon ◽  
Past Medical History ◽  
Variant Allele Frequency ◽  
Significant Past Medical History ◽  
Chronic Neutrophilic Leukemia ◽  
Hypercellular Marrow ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing ◽  
Stat Pathway

AbstractChronic neutrophilic leukemia (CNL) is a rare but serious myeloid malignancy. In a review of reported cases for WHO-defined CNL, CSF3R mutation is found in about 90% cases and confirmed as the molecular basis of CNL. Concurrent mutations are observed in CSF3R-mutated CNL patients, including ASXL1, SETBP1, SRSF2, JAK2, CALR, TET2, NRAS, U2AF1, and CBL. Both ASXL1 and SETBP1 mutations in CNL have been associated with a poor prognosis, whereas, SRSF2 mutation was undetermined. Our patient was a 77-year-old man and had no significant past medical history and symptoms with leukocytosis. Bone marrow (BM) aspirate and biopsy revealed a markedly hypercellular marrow with prominent left-shifted granulopoiesis. Next-generation sequencing (NGS) of DNA from the BM aspirate of a panel of 28 genes, known to be pathogenic in MDS/MPN, detected mutations in CSF3R, SETBP1, and SRSF2, and a diagnosis of CNL was made. The patient did not use a JAK-STAT pathway inhibitor (ruxolitinib) but started on hydroxyurea and alpha-interferon and developed pruritus after 4 months of diagnosis and nasal hemorrhage 1 month later. Then, the patient was diagnosed with CNL with AML transformation and developed intracranial hemorrhage and died. We repeated NGS and found that three additional mutations were detected: ASXL1, PRKDC, MYOM2; variant allele frequency (VAF) of the prior mutations in CSF3R, SETBP1, and SRSF2 increased. The concurrence of CSF3RT618I, ASXL1, SETBP1, and SRSF2 mutation may be a mutationally detrimental combination and contribute to disease progression and AML transformation, as well as the nonspecific treatment of hydroxyurea and alpha-interferon, but the significance and role of PRKDC and MYOM2 mutations were not undetermined.

scholarly journals Paraneoplastic polymyositis presenting as a clinically occult breast cancer

2017 ◽  
Vol 99 (2) ◽  
pp. e40-e43 ◽  
Author(s):  
N Merali ◽  
M Yousuff ◽  
V Pronisceva ◽  
A Poddar
Keyword(s):  
Paraneoplastic Syndrome ◽  
Rare Case ◽  
Primary Tumour ◽  
Imaging Studies ◽  
Occult Breast Cancer ◽  
Symptom Stability ◽  
Underlying Malignancy ◽  
Neurological Presentation ◽  
Complete History ◽  
Metaplastic Breast Carcinoma

Paraneoplastic syndrome affects less than 1% of cancer patients. Diagnosis of paraneoplastic syndrome with neurological presentation requires screening for an underlying malignancy, including a complete history, physical examination and imaging studies. Treatment often results in symptom stability, rather than improvement. Paraneoplastic polymyositis can precede or instantaneously occur at diagnosis or treatment of a primary tumour, while neurological symptoms can persist even following cancer treatment. We report a rare case of metaplastic breast carcinoma with an unusual presentation of paraneoplastic polymyositis.

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