scholarly journals Helicobacter pyloriAntibody Titer and Gastric Cancer Screening

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Hiroshi Kishikawa ◽  
Kayoko Kimura ◽  
Sakiko Takarabe ◽  
Shogo Kaida ◽  
Jiro Nishida
Keyword(s):  
Gastric Cancer ◽  
Cancer Screening ◽  
High Risk ◽  
Antibody Titer ◽  
Positive Antibody ◽  
Group A ◽  
Gastric Cancer Screening ◽  
H Pylori ◽  
Group B ◽  
Group D

The “ABC method” is a serum gastric cancer screening method, and the subjects were divided based onH. pyloriserology and atrophic gastritis as detected by serum pepsinogen (PG): Group A [H. pylori(−) PG (−)], Group B [H. pylori(+) PG (−)], Group C [H. pylori(+) PG (+)], and Group D [H. pylori(−) PG (+)]. The risk of gastric cancer is highest in Group D, followed by Groups C, B, and A. Groups B, C, and D are advised to undergo endoscopy, and the recommended surveillance is every three years, every two years, and annually, respectively. In this report, the reported results with respect to further risk stratification by anti-H. pyloriantibody titer in each subgroup are reviewed: (1) high-negative antibody titer subjects in Group A, representing posteradicated individuals with high risk for intestinal-type cancer; (2) high-positive antibody titer subjects in Group B, representing active inflammation with high risk for diffuse-type cancer; and (3) low-positive antibody titer subjects in Group C, representing advanced atrophy with increased risk for intestinal-type cancer. In these subjects, careful follow-up with intervals of surveillance of every three years in (1), every two years in (2), and annually in (3) should be considered.

scholarly journals Seroprevalence of Helicobacter pylori infection and gastric mucosal atrophy in Bhutan, a country with a high prevalence of gastric cancer

2013 ◽  
Vol 62 (10) ◽  
pp. 1571-1578 ◽  
Author(s):  
Seiji Shiota ◽  
Varocha Mahachai ◽  
Ratha-korn Vilaichone ◽  
Thawee Ratanachu-ek ◽  
Lotay Tshering ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Negative Group ◽  
Mucosal Atrophy ◽  
Gastric Mucosal Atrophy ◽  
High Prevalence ◽  
Group A ◽  
H Pylori ◽  
Group B ◽  
Group D

Gastric cancer is the second leading cause of cancer-related mortality in the world. Recently, serum Helicobacter pylori antibodies and pepsinogen (PG) have been used for gastric cancer screening. The incidence of gastric cancer in Bhutan is reported to be quite high compared with that in neighbouring countries. In this study, 381 subjects from three areas of Bhutan were assessed for gastric mucosal atrophy and serological parameters. Anti-H. pylori IgG, PG I, PG II and cytotoxin-associated gene A (CagA) antibodies were measured using ELISA. Subjects were classified into four groups according to H. pylori and PG seropositivity: Group A (H. pylori-negative/PG-negative), Group B (H. pylori-positive/PG-negative), Group C (H. pylori-positive/PG-positive) and Group D (H. pylori-negative/PG-positive). The prevalence of H. pylori in the 381 subjects was 71.1 % (271/381), with high infection rates found in rural areas. The PG I/II ratio was significantly inversely correlated with the atrophy score in the antrum and the corpus (P<0.001). Multivariate analysis showed that the PG status was significantly associated with the presence of atrophy in the corpus. The prevalence of the PG-positive status was significantly higher among H. pylori-positive subjects than among H. pylori-negative subjects (P<0.001). Based on the ABC method, Group B was the most dominant, followed by Group A, Group C and Group D. The high incidence of gastric cancer in Bhutan can be attributed to the high prevalence of H. pylori infection and gastric mucosal atrophy.

scholarly journals A case of initial H. pylori infection in an adult, found by blood test for gastric cancer screening

2017 ◽  
Vol 90 (1) ◽  
pp. 90-91
Author(s):  
Yurika Ikegami ◽  
Tomoyuki Yada ◽  
Koichi Ito ◽  
Yoshiyuki Itakura ◽  
Naomi Uemura
Keyword(s):  
Gastric Cancer ◽  
Cancer Screening ◽  
Blood Test ◽  
Gastric Cancer Screening ◽  
H Pylori

scholarly journals Cost-effectiveness ofHelicobacter pyloriscreening followed by eradication treatment for employees in Japan

2018 ◽  
Vol 146 (14) ◽  
pp. 1834-1840 ◽  
Author(s):  
A. Kowada
Keyword(s):  
Gastric Cancer ◽  
Cost Effectiveness ◽  
Cancer Screening ◽  
High Risk ◽  
Sensitivity Analyses ◽  
High Risk Population ◽  
Lifetime Horizon ◽  
Risk Population ◽  
Life Years ◽  
H Pylori

AbstractGastric cancer is the third leading cause of cancer death worldwide. Gastric cancer screening using upper gastrointestinal series, endoscopy and serological testing has been performed in population-based (employee-based and community-based) and opportunistic cancer screening in Japan. There were 45 531 gastric cancer deaths in 2016, with the low screening and detection rates.Helicobacter pylori(H. pylori) screening followed by eradication treatment is recommended in high-risk population settings to reduce gastric cancer incidence. The aim of this study was to evaluate the cost-effectiveness ofH. pyloriscreening followed by eradication treatment for a high-risk population in the occupational health setting. Decision trees and Markov models were developed for two strategies;H. pyloriantibody test (HPA) screening and no screening. Targeted populations were hypothetical cohorts of employees aged 20, 30, 40, 50 and 60 years using a company health payer perspective on a lifetime horizon. Per-person costs and effectiveness (quality-adjusted life-years) were calculated and compared. HPA screening yielded greater benefits at the lower cost than no screening. One-way and probabilistic sensitivity analyses using Monte-Carlo simulation showed strong robustness of the results.H. pyloriscreening followed by eradication treatment is recommended to prevent gastric cancer for employees in Japan, on the basis of cost-effectiveness.

Gastric cancer screening of a high-risk population in Japan using serum pepsinogen and barium digital radiography

2005 ◽  
Vol 96 (10) ◽  
pp. 713-720 ◽  
Author(s):  
Hiroshi Ohata ◽  
Masashi Oka ◽  
Kimihiko Yanaoka ◽  
Yasuhito Shimizu ◽  
Chizu Mukoubayashi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Screening ◽  
High Risk ◽  
Digital Radiography ◽  
High Risk Population ◽  
Serum Pepsinogen ◽  
Risk Population ◽  
Gastric Cancer Screening

scholarly journals The Effect of Oral Administration of Pistacia Atlantica Kurdica Gum on the Eradication of Helicobacter Pylori in Patients with Dyspepsia: A Randomized Clinical Trial

2016 ◽  
Vol 9 (2) ◽  
pp. 256 ◽  
Author(s):  
Hamidollah Afrasiabian ◽  
Mohammad Hadi Imanieh ◽  
Mohammad Ali Nejati ◽  
Alireza Salehi
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Demographic Situation ◽  
Significant Difference ◽  
Before And After ◽  
Group A ◽  
H Pylori ◽  
Group B ◽  
Group D ◽  
Common Infections

<p><em>H. pylori</em><strong> </strong>infection is one of the most common infections in the world so that the aim of this study was to evaluate the antimicrobial <em>P. Atlantica Kurdica</em> gum in the eradication of <em>H. pylori</em>. This study is a randomized clinical trial; Patients with positive Urea Breath Test and symptoms of dyspepsia were entered. Patients were randomly divided into four groups. Group A: three drugs including 500 mg of Amoxicillin twice a day (bd), Clarithromycin 500 mg bd and Omeprazole 20 mg (bd) and Group B: Group A drugs plus the capsule containing 1 g of powdered <em>P. Atlantica Kurdica </em>gum (bd). In Group C: the capsule containing 1 g of powdered <em>P. Atlantica Kurdica</em> gum (bd) and Group D: this group took placebo-containing capsule (bd) for 14 days respectively. Dyspeptic symptoms before and after healing period and the UBT results two days before the start of treatment and 30 days after the completion were compared in 4 groups. Patients were not statistically significant difference from each other in the four groups regarding the demographic situation. Moreover, <em>H. pylori</em> eradication rate was 19/24 in Group A, 18/24 in Group B, 10/23 in Group C and 2/24 in Group D. Relieving symptoms of dyspepsia in Groups B and C were significantly higher than in Group D (P=0.025 and p=0.006 respectively). <em>P. Atlantica Kurdica</em> significantly led to the treatment of dyspepsia symptoms and <em>H. pylori</em> eradication.</p>

Sign in / Sign up

Export Citation Format

Share Document