scholarly journals Polymorphisms of Leptin (-2548 G/A) and Leptin Receptor (Q223R) Genes in Iranian Women with Breast Cancer

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Reza Mahmoudi ◽  
Bahareh Noori Alavicheh ◽  
Mohammad Amin Nazer Mozaffari ◽  
Mohammad Fararouei ◽  
Mohsen Nikseresht
Keyword(s):  
Breast Cancer ◽  
Significant Contribution ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Serum Levels ◽  
Serum Leptin ◽  
Increased Risk ◽  
Pcr Rflp ◽  
The Mean ◽  
Larger Sample

Recent studies have shown that polymorphisms in leptin and leptin receptor genes are associated with increased risk for breast cancer. This study aimed at investigating -2548 G/A polymorphism in leptin gene and Q223R polymorphism in leptin receptor gene in patients with breast cancer. The study included 45 women with breast cancer and 41 healthy women. PCR-RFLP was used to determine the genotype of the subjects in terms of -2548 G/A polymorphism in leptin gene and Q223R polymorphism in leptin receptor gene. Serum levels of leptin were also measured by ELISA. For -2548 G/A polymorphism, the genotypes were homozygous AA (OR = 1.13;p=0.8) and heterozygous GA (OR = 0.41;p=0.2) and for Q223R polymorphism, the genotypes were homozygous RR (OR = 6.7;p=0.09) and heterozygous QR (OR = 8.3;p=0.06). The mean serum level of leptin was 33.22 ± 21.35 ng/mL in patients and 29.49 ± 23.27 ng/mL in the normal participants (p=0.3). Although, despite the magnitude of the associations, the results suggested no statistically significant contribution of -2548 G/A polymorphism (in leptin gene), Q223R polymorphism (in leptin receptor gene), and serum leptin levels in predicting the risk of breast cancer, further studies with larger sample size are suggested.

Relationships among serum leptin, leptin receptor gene polymorphisms, and breast cancer in Korea

2006 ◽  
Vol 237 (1) ◽  
pp. 137-142 ◽  
Author(s):  
Hee-Yeon Woo ◽  
Hyosoon Park ◽  
Chang-Seok Ki ◽  
Yong Lai Park ◽  
Won Gil Bae
Keyword(s):  
Breast Cancer ◽  
Gene Polymorphisms ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Serum Leptin ◽  
Receptor Gene Polymorphisms

The Roles of Serum Leptin Concentration and Polymorphism in Leptin Receptor Gene at Codon 109 in Breast Cancer

Oncology ◽  
2007 ◽  
Vol 72 (1-2) ◽  
pp. 75-81 ◽  
Author(s):  
Chien-Liang Liu ◽  
Yuan-Ching Chang ◽  
Shih-Ping Cheng ◽  
Schu-Rern Chern ◽  
Tsen-Long Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Serum Leptin

scholarly journals The Trend in Distribution of Q223R Mutation of Leptin Receptor Gene in Amoebic Liver Abscess Patients from North India: A Prospective Study

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Anil Kumar Verma ◽  
Vineet Ahuja ◽  
Jaishree Paul
Keyword(s):  
Liver Abscess ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Rflp Analysis ◽  
North India ◽  
Amoebic Liver Abscess ◽  
Fisher Exact Test ◽  
Exact Test ◽  
Pcr Rflp ◽  
A Prospective Study

Host genetic susceptibility is an important risk factor in infectious diseases. We explored the distribution of Q223R mutation in leptin receptor gene of amoebic liver abscess (ALA) patients of North India. A total of 55 ALA samples along with 102 controls were subjected to PCR-RFLP analysis. The frequency of allele “G” (coding for arginine) was in general high in Indian population irrespective of the disease. Our results of Fisher exact test shows that heterozygous mutant (QQ versus QR,P=0.049) and homozygous mutant (QQ versus RR,P=0.004) were significantly associated with amoebic liver abscess when compared with homozygous wild (QQ).

Role of serum leptin levels and leptin receptor gene polymorphisms in systemic lupus erythematosus

2020 ◽  
Vol 39 (11) ◽  
pp. 3465-3472
Author(s):  
Abd EL-Moaty Ali Afifi ◽  
Reham M. Shaat ◽  
Ola Mohamed Gharbia ◽  
M. Elhanafy ◽  
Al Shimaa Goda Hasan
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Gene Polymorphisms ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Systemic Lupus ◽  
Serum Leptin ◽  
Receptor Gene Polymorphisms

scholarly journals Association of Prolactin and Its Receptor Gene Regions with Familial Breast Cancer

2006 ◽  
Vol 91 (4) ◽  
pp. 1513-1519 ◽  
Author(s):  
Annika Vaclavicek ◽  
Kari Hemminki ◽  
Claus R. Bartram ◽  
Kerstin Wagner ◽  
Barbara Wappenschmidt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Variation ◽  
Receptor Gene ◽  
Academic Research ◽  
Nucleotide Polymorphisms ◽  
Promoter Regions ◽  
Increased Risk ◽  
Human Mammary Tumors ◽  
Variant Alleles

Context: The contribution of prolactin (PRL) through its receptor (PRLR) to the pathogenesis and progression of human mammary tumors has received recent attention. Objective: We investigated whether genetic variation in the PRL and PRLR genes is associated with the risk of breast cancer (BC). Design: We conducted a case-control study with a total of seven single nucleotide polymorphisms (SNPs). Setting: The study was conducted at an academic research laboratory and university clinics. Patients and Other Participants: A total of 441 German familial, unrelated BC cases and 552 controls matched by age, ethnicity, and geographical region participated in the study. Intervention(s): There were no interventions. Main Outcome Measures(s): SNP genotype and haplotype distributions and haplotype interactions were correlated with the risk of BC. Results: Two SNPs (rs1341239 and rs12210179) within the PRL promoter regions were significantly associated with increased risk in homozygotes for the variant alleles [odds ratio (OR), 1.67 and 95% confidence interval (CI), 1.11–2.50; and OR, 2.09 and 95% CI, 1.23–3.52, respectively]. The PRL haplotype containing the variant alleles of the promoter SNPs increased significantly the risk of BC (OR 1.42, 95%CI 1.07–1.90). A PRLR haplotype was associated with a significant decrease in BC risk (OR 0.69, 95% CI 0.54–0.89). An increasing number of PRL and PRLR risk haplotypes led to a significant trend of increasing risk for BC (χ2 = 12.15; P = 0.007). Conclusions: Genetic variation in the PRL and PRLR genes was shown to influence BC risk. Additional studies are needed to further clarify the role of the PRL and PRLR genes in the risk of BC.

scholarly journals Polymorphism of the IL13 gene may be associated with Uterine leiomyomas in Slovenian women

2016 ◽  
Vol 19 (2) ◽  
pp. 51-60 ◽  
Author(s):  
J Krsteski ◽  
S Jurgec ◽  
M Pakiž ◽  
I But ◽  
U Potočnik
Keyword(s):  
Tumor Biology ◽  
Serum Levels ◽  
Uterine Leiomyomas ◽  
Nucleotide Polymorphisms ◽  
First Sexual Intercourse ◽  
Pelvic Tumors ◽  
Increased Risk ◽  
Pcr Rflp ◽  
History Of ◽  
First Time

AbstractUterine leiomyomas (ULM) are a common cause of solid pelvic tumors in women. Their etiopathogenesis remains unclear. Interleukins (ILs) and their receptors can influence tumor biology of ULM. The aim of this study was to evaluate single nucleotide polymorphisms (SNPs) exhibited in the genes IL4 (rs2070874), IL4R (rs1801275), IL12RB1 (rs11575934), IL12B (rs6887695), IL13 (rs20541) and IL23R (rs7517847) as risk factors for ULM in Slovenian women and to identify associations between corresponding clinical parameters and the analyzed SNPs. In addition, solitary and multiple ULM were compared to identify clinical and/or genetic parameters influencing their occurrence. We conducted a case-control study that included 181 women with leiomyomas and 133 control subjects. Genotyping of selected SNPs was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and high resolution melting (HRM) techniques. The TT genotype of rs20541 (IL13) was significantly associated with decreased risk of ULM compared to both the CC and CT genotypes [p = 0.018; odds ratio (OR) = 0.184; 95% confidence interval (95% CI) = 0.048-0.7121. Using genetic and clinical data to develop a predictive model with logistic regression, we found that adenomyosis, higher age at diagnosis, family history of ULM occurrence, earlier menarche, lower number of pregnancies and lower age at first sexual intercourse, the G allele and genotypes AG and GG of rs1801275 (IL4R) were associated with an increased risk of multiple ULM occurrence. We also found an association between rs20541 (IL13) and 17ß-estradiol serum levels in patients with multiple ULM (p 0.003). Our study showed, for the first time, that rs20541 (IL13) may contribute to susceptibility of ULM development and that rs1801275 (IL4R) can predispose patients to develop multiple ULM.

scholarly journals The Impact ofLEPG-2548A andLEPRGln223Arg Polymorphisms on Adiposity, Leptin, and Leptin-Receptor Serum Levels in a Mexican Mestizo Population

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Efraín Chavarria-Avila ◽  
Mónica Vázquez-Del Mercado ◽  
Eduardo Gomez-Bañuelos ◽  
Sandra-Luz Ruiz-Quezada ◽  
Jorge Castro-Albarran ◽  
...  
Keyword(s):  
Body Fat ◽  
Fat Mass ◽  
Leptin Receptor ◽  
Serum Levels ◽  
Normal Weight ◽  
Body Fat Mass ◽  
Western Mexico ◽  
Pcr Rflp ◽  
Obese Subjects ◽  
The Impact

The polymorphisms in leptin (LEPG-2548A) and leptin-receptor (LEPRGln223Arg) seem to influence obesity and lipid metabolism among others. The aim of this study was to investigate the effect of these polymorphisms on adiposity, leptin (sLeptin), and leptin-receptor (sLeptin-receptor) serum concentrations as well as inflammation markers. We included 382 adults originally from Western Mexico. They were genotyped by PCR-RFLP. Obese individuals showed higher sLeptin (58.2±31.35 ng/mL) but lower sLeptin-receptor (12.6±3.74 ng/mL) levels than normal weight ones (17.6±14.62 ng/mL,17.4±4.62 ng/mL, resp.),P<0.001. Obese subjects carriers of Arg/Arg genotype had more (P=0.016) sLeptin-receptor (14.7±4.96 ng/mL) and less (P=0.004) sLeptin (44.0±28.12 ng/mL) levels than Gln/Gln genotype (11.0±2.92 ng/mL,80.3±33.24 ng/mL, resp.). Body fat mass was lower (Pfrom 0.003 to 0.045) for A/A (36.5%±6.80) or Arg/Arg (36.8%±6.82) genotypes with respect to G/G (41.3%±5.52) and G/A (41.6%±5.61) or Gln/Gln (43.7%±4.74) and Gln/Arg (41.0%±5.52) genotypes carriers. Our results suggest thatLEP-2548A andLEPR223Arg could be genetic markers of less body fat mass accumulation in obese subjects from Western Mexico.

Associations among Lipids, Leptin, and Leptin Receptor Gene Gin223Arg Polymorphisms and Breast Cancer in China

2008 ◽  
Vol 126 (1-3) ◽  
pp. 38-48 ◽  
Author(s):  
Cun-Zhi Han ◽  
Li-Li Du ◽  
Jie-Xian Jing ◽  
Xian-Wen Zhao ◽  
Fu-Guo Tian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Leptin Receptor ◽  
Receptor Gene
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