scholarly journals High Prevalence of Infertility among Women with Graves’ Disease and Hashimoto’s Thyroiditis

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Alessandra Quintino-Moro ◽  
Denise E. Zantut-Wittmann ◽  
Marcos Tambascia ◽  
Helymar da Costa Machado ◽  
Arlete Fernandes
Keyword(s):  
Autoimmune Diseases ◽  
Hashimoto’S Thyroiditis ◽  
Cross Sectional Study ◽  
Hashimoto's Thyroiditis ◽  
Graves Disease ◽  
Cross Sectional ◽  
Unprotected Sexual Intercourse ◽  
High Prevalence ◽  
History Of ◽  
Endocrinology Clinic

Objectives. To evaluate the prevalence of infertility in women with Graves’ disease (GD) or Hashimoto’s thyroiditis (HT) and associated factors.Material and Methods. This cross-sectional study was conducted at the Endocrinology Clinic for Thyroid Autoimmune Diseases, with 193 women aged 18–50 years with GD and 66 women aged 18–60 years with HT. The women were interviewed to obtain data on their gynecological and obstetric history and family history of autoimmune diseases. Their medical records were reviewed to determine the characteristics of the disease and to confirm association with other autoimmune diseases. Infertility was defined as 12 months of unprotected sexual intercourse without conception.Results. The prevalence of infertility was 52.3% in GD and 47.0% in HT. Mean age at diagnosis was 36.5 years and 39.2 years, in GD and HT, respectively. The mean number of pregnancies was lower in women who were 35 years old or younger at diagnosis and was always lower following diagnosis of the disease, irrespective of age. The only variable associated with infertility was a shorter time of the disease in HT.Conclusions. The prevalence of infertility was high in women with GD and HT and affected the number of pregnancies in young women.

scholarly journals Autoimmune comorbidities in Hashimoto’s thyroiditis: different patterns of association in adulthood and childhood/adolescence

2017 ◽  
Vol 176 (2) ◽  
pp. 133-141 ◽  
Author(s):  
R M Ruggeri ◽  
F Trimarchi ◽  
G Giuffrida ◽  
R Certo ◽  
E Cama ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Hashimoto’S Thyroiditis ◽  
Skin Diseases ◽  
Connective Tissue Diseases ◽  
Cross Sectional Study ◽  
Hashimoto's Thyroiditis ◽  
Cross Sectional ◽  
Autoimmune Thyroid ◽  
Adult Age

Objective Hashimoto’s thyroiditis (HT), the most common autoimmune thyroid disease at any age, is often associated with other autoimmune diseases. The present study was aimed to describe the type and frequency of non-thyroidal autoimmune diseases (NTADs) in HT patients and to delineate the clinical pattern of diseases clustering in pediatric/adolescent and adult age. Design Cross-sectional study. Methods 1053 newly diagnosed HT patients (500 adults (467 F, mean age 40.2 ± 13.7 years) and 553 children/adolescents (449 F, mean age 11.1 ± 3.0 years)) were evaluated for common NTADs by means of careful recording of medical history, physical examination and assessment of selected autoantibody profiles. Results The prevalence of associated NTADs was significantly higher in adults than that in pediatric/adolescent HT patients (P < .0001). In addition, the number of adult patients suffering from two or more associated NTADs was significantly higher than that of children/adolescent (P < 0.0001). A female prevalence was evident in both cohorts, but was significant in the adults (P < 0.0001). The epidemiological distribution of NTADs was strongly different in the two cohorts, the most frequent associated diseases being arthropathies and connective tissue diseases in adults and type 1 diabetes and coeliac disease in children/adolescents. Skin diseases were represented with similar prevalence in both cohorts, vitiligo being the most common. Conclusions Age at HT presentation may influence autoimmune diseases clustering, favoring the association of specific NTADs in different ages of life. Moreover, the association between HT and NTADs increases with age and occurs most frequently in adults.

scholarly journals The prevalence of autoimmune diseases in patients with multiple sclerosis: A cross-sectional study in Qom, Iran, in 2018

2021 ◽  
Author(s):  
Nazanin Ershadinia ◽  
Nader Mortazavinia ◽  
Sepideh Babaniamansour ◽  
Mahdi Najafi-Nesheli ◽  
Parto Babaniamansour ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Autoimmune Disease ◽  
Autoimmune Diseases ◽  
Hashimoto’S Thyroiditis ◽  
Cross Sectional Study ◽  
Hashimoto's Thyroiditis ◽  
Sectional Study ◽  
Cross Sectional ◽  
Duration Of Disease

Background: Multiple sclerosis (MS) is one of the most common autoimmune diseases worldwide and various autoimmune comorbidities are reported with MS. The objective of this study is to estimate the prevalence of the autoimmune diseases’ comorbidity in patients with MS. Methods: In this cross-sectional study, we investigated a group of patients with MS in terms of age, gender, duration of MS, presence of simultaneous autoimmune diseases, such as Graves’ disease, Hashimoto’s thyroiditis, type 1 diabetes mellitus (DM), and systemic lupus erythematous (SLE). Results: This study included 1215 patients with MS, of which 70.8% were women. The mean age of participants was 33.70 ± 27.63 years. 55 patients (4.5%) had at least one autoimmune disease. The most common comorbidity was for Hashimoto’s thyroiditis (30 patients). The frequency of simultaneous autoimmune disease was higher in women. Mean age (P = 0.01), mean duration of MS (P = 0.03), and mean age on MS diagnosis (P = 0.02) were significantly higher in simultaneous MS and other autoimmune diseases. Conclusion: Our study revealed that the probability of autoimmune diseases co-occurrence in patients with MS could be higher in older patients, in longer duration of disease, and also in patients with higher age at time of MS diagnosis.

scholarly journals Relationship Between Thyroid Cancer and Hashimoto's Disease

2021 ◽  
Author(s):  
Marcelo Ramiro Montúfar Silva ◽  
Jessica Paola Cevallos Montalvo ◽  
Byron Mauricio Sánchez Andino ◽  
María Johanna Jima Sanchez ◽  
Cecilia Alejandra García Ríos
Keyword(s):  
Thyroid Cancer ◽  
Hashimoto’S Thyroiditis ◽  
Cross Sectional Study ◽  
Hashimoto's Thyroiditis ◽  
Cross Sectional ◽  
Palabras Clave ◽  
Laboratory Results ◽  
History Of ◽  
Clinical Records ◽  
The Relationship

Introduction: Globally, Ecuador ranks fifth among the countries with the highest incidence of thyroid carcinoma in women, below Korea, Brazil, Italy and New Celedonia. The aim of this research was to mention the relationship between thyroid cancer and Hashimoto's thyroiditis at Pablo Arturo Suárez Hospital in Quito in the years 2014 to 2017. Methodology: A cross sectional study was conducted. The data were taken from the clinical records in the statistical service, 105 cases of thyroid cancer were found.  In the laboratory results 21 patients had anti TPO and/or anti TG positive antibodies. Conclusion: 20% of patients with thyroid cancer had a history of Hashimoto's thyroiditis. Keywords: thyroid cancer, Hashimoto's thyroiditis, autoimmune thyroiditis. RESUMEN Introducción: A nivel mundial el Ecuador ocupa el quinto lugar entre los países con mayor incidencia de carcinoma de tiroides en mujeres, por debajo de Corea, Brasil, Italia y Nueva Celedonia. Objetivo: El objetivo de la presente investigación fue mencionar la relación entre cáncer de tiroides y tiroiditis de Hashimoto en el Hospital Pablo Arturo Suárez de la ciudad de Quito en los años 2014 a 2017. Metodología: se desarrolló un estudio de tipo transversal los datos se tomaron de los expedientes clínicos en el servicio de estadística, donde se encontró 105 casos de estudios histopatológicos compatibles con neoplasia tiroidea. Resultados: En los resultados de laboratorio se evidenció que 21 pacientes tuvieron anticuerpos anti TPO y/o anti TG positivos. Conclusión: El 20% de pacientes con cáncer de tiroides tuvieron antecedente de enfermedad autoinmune tiroidea. Palabras clave: cáncer de tiroides, tiroiditis de Hashimoto, tiroiditis autoinmune.

scholarly journals Prevalence of MDR organism (MDRO) carriage in children and their household members in Siem Reap Province, Cambodia

2020 ◽  
Vol 2 (4) ◽  
Author(s):  
Shweta R Singh ◽  
Bunsoth Mao ◽  
Konstantin Evdokimov ◽  
Pisey Tan ◽  
Phana Leab ◽  
...  
Keyword(s):  
Final Analysis ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Middle Income ◽  
E Coli ◽  
Middle Income Countries ◽  
Siem Reap ◽  
High Prevalence ◽  
Significant Public Health ◽  
History Of

Abstract Background The rising incidence of infections caused by MDR organisms (MDROs) poses a significant public health threat. However, little has been reported regarding community MDRO carriage in low- and middle-income countries. Methods We conducted a cross-sectional study in Siem Reap, Cambodia comparing hospital-associated households, in which an index child (age: 2–14 years) had been hospitalized for at least 48 h in the preceding 2–4 weeks, with matched community households on the same street, in which no other child had a recent history of hospitalization. Participants were interviewed using a survey questionnaire and tested for carriage of MRSA, ESBL-producing Enterobacterales (ESBL-E) and carbapenemase-producing Enterobacterales (CPE) by culture followed by antibiotic susceptibility testing. We used logistic regression analysis to analyse associations between collected variables and MDRO carriage. Results Forty-two pairs of households including 376 participants with 376 nasal swabs and 290 stool specimens were included in final analysis. MRSA was isolated from 26 specimens (6.9%). ESBL-producing Escherichia coli was detected in 269 specimens (92.8%) whereas ESBL-producing Klebsiella pneumoniae was isolated from 128 specimens (44.1%), of which 123 (42.4%) were co-colonized with ESBL-producing E. coli. Six (2.1%) specimens tested positive for CPE (4 E. coli and 2 K. pneumoniae). The prevalence ratios for MRSA, ESBL-producing E. coli and ESBL-producing K. pneumoniae carriage did not differ significantly in hospital-associated households and hospitalized children compared with their counterparts. Conclusions The high prevalence of ESBL-E across both household types suggests that MDRO reservoirs are common in the community. Ongoing genomic analyses will help to understand the epidemiology and course of MDRO spread.

scholarly journals Study of the health status of geriatric age group in Chitwan district of Nepal

2015 ◽  
Vol 5 (1) ◽  
pp. 11-17
Author(s):  
L Subedi ◽  
R B Sah
Keyword(s):  
Health Status ◽  
Well Being ◽  
Cross Sectional Study ◽  
Living Alone ◽  
Age Group ◽  
Cross Sectional ◽  
High Prevalence ◽  
Health Related ◽  
History Of ◽  
Mental Well Being

Retirement, change in housing, illness or death of spouse greatly affect the physical and mental well-being of the geriatric person. This study aims to find out the health status of geriatric age group in chitwan district of Nepal. A cross sectional study was carried out among 300 geriatric people where 15.7% of the geriatric were living alone, 50.3 % and 39.7% of geriatrics gave history of regular use of tobacco and alcohol respectively. Co-morbidities were found in 63% of geriatrics who suffered from 2 or more diseases. In Total 44% were found to have Ophthalmic problems, 23% were found to have ENT problems, 5.33% were found to mental disorders, 33% were found to have CVS problems, 43% were found to have GI problems, 15.67 % were found to have Metabolic disorder. The study highlighted a high prevalence of morbidity and health related problems in geriatric age groups.DOI: http://dx.doi.org/10.3126/jcmc.v5i1.12560

Prevalence and Determinants of Malnutrition Among Reproductive Aged Women of Rural Bangladesh

2009 ◽  
Vol 22 (1) ◽  
pp. 110-117 ◽  
Author(s):  
Abul Hasnat Milton ◽  
Wayne Smith ◽  
Bayzidur Rahman ◽  
Bashir Ahmed ◽  
S.M. Shahidullah ◽  
...  
Keyword(s):  
Rural Women ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Health Consequences ◽  
Cross Sectional ◽  
High Prevalence ◽  
Pregnancy Status ◽  
History Of ◽  
Reproductive Aged Women ◽  
Special Priority

Malnutrition among the rural Bangladeshi women of reproductive age is still very high. This high prevalence attributes to a range of adverse health consequences on the women and their offspring. A total of 2341 women aged between 20 and 45 years residing in the study area were interviewed in this cross-sectional study. Information on socioeconomic variables, nutritional status, and pregnancy-related history was obtained using interviewer administered questionnaire. A total of 34% of the reproductive aged rural women suffer from malnutrition. A multivariate analysis shows association between malnutrition and monthly household income, history of taking oral contraceptive, current pregnancy status, and history of breastfeeding. The final regression model shows a statistically significant decreasing trend in malnutrition status with increasing income ( P for trend <.001). The economic and health consequences of malnutrition in this group of women are enormous. National nutritional program should target this women group for any intervention with a special priority.

Traumatismo dento-alveolar em escolares de uma ONG em Salvador-Bahia: uma abordagem epidemiológica

2019 ◽  
Vol 9 ◽  
pp. 173
Author(s):  
Tatiana Frederico de Almeida ◽  
Carolina Silva Cervino Garcia
Keyword(s):  
Young People ◽  
Cross Sectional Study ◽  
Older Children ◽  
Cross Sectional ◽  
Children And Young People ◽  
Oral Health Problem ◽  
The Family ◽  
High Prevalence ◽  
History Of ◽  
Dentoalveolar Trauma

Introdução: O traumatismo dento-alveolar em vários locais do mundo tem alta prevalência na dentição decídua e permanente de crianças e jovens, com cerca de um terço destes sendo afetados. Objetivo: descrever a prevalência e gravidade de traumatismo dento-alveolar em crianças e jovens de 03 a 18 anos, assim como fatores associados. Metodologia: Foi realizado estudo transversal no Centro de Integração Familiar em Salvador, Bahia, que atende cerca de 400 crianças e jovens. Foram registradas informações sociodemográficas e história do trauma. O estudo foi realizado com uma amostra de 357 escolares. Resultados: A amostra tinha idade média de 8,3 anos. A prevalência do traumatismo foi de 15,69%, sendo a fratura de esmalte o agravo mais frequentemente encontrado, e sua etiologia principal a queda. Conclusão: O trauma acometeu o sexo feminino, as crianças mais velhas, de cor branca/outras, com overjet acentuado e com mais de dois irmãos. É necessária maior divulgação de informações de prevenção deste problema de saúde bucal.AbstractIntroduction: Dento-alveolar trauma in many places around the world has a high prevalence in deciduous and permanent dentition of children and young people, with about one third of them being affected. Objective: To describe the prevalence and severity of dentoalveolar trauma in children and young people from 03 to 18 years old, as well as associated factors. Methodology: A cross-sectional study was conducted at the Family Integration Center in Salvador, Bahia, which serves about 400 children and young people. Sociodemographic information and history of trauma were recorded. The study was conducted with a sample of 357 students. Results: The sample had a mean age of 8.3 years. The prevalence of trauma was 15.69%, with the enamel fracture being the most frequently encountered injury, and its main etiology being the fall. Conclusion: The trauma affected females, older children, white/others people, with severe overjet and with more than two siblings. More information on prevention of this oral health problem is needed.

Syphilis and HIV Infection among Displaced Pregnant Women in Rural Mozambique

1994 ◽  
Vol 5 (2) ◽  
pp. 117-123 ◽  
Author(s):  
H A Cossa ◽  
S Gloyd ◽  
R G Vaz ◽  
E Folgosa ◽  
E Simbine ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Pregnant Women ◽  
Hiv Transmission ◽  
Perinatal Transmission ◽  
Anal Intercourse ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Hiv Seroprevalence ◽  
High Prevalence ◽  
History Of

A cross-sectional study was conducted among displaced pregnant women in Mozambique to determine the prevalence and correlates of HIV infection and syphilis. Between September 1992 and February 1993, 1728 consecutive antenatal attendees of 14 rural clinics in Zambézia were interviewed, examined, and tested for HIV and syphilis antibodies. The seroprevalence of syphilis and HIV were 12.2% and 2.9%, respectively. Reported sexual abuse was frequent (8.4%) but sex for money was uncommon. A positive MHA-TP result was significantly associated with unmarried status, history of past STD, HIV infection, and current genital ulcers, vaginal discharge, or genital warts. Significant correlates of HIV seropositivity included anal intercourse, history of past STD, and syphilis. In summary, displaced pregnant women had a high prevalence of syphilis but a relatively low HIV seroprevalence suggesting recent introduction of HIV infection in this area or slow spread of the epidemic. A syphilils screening and treatment programme is warranted to prevent perinatal transmission and to reduce the incidence of chancres as a cofactor for HIV transmission.

scholarly journals Pathogenic NOTCH3 Variants Are Frequent Among the Korean General Population

2021 ◽  
Vol 7 (6) ◽  
pp. e639
Author(s):  
Chul-Hoo Kang ◽  
Young Mee Kim ◽  
Yang-Ji Kim ◽  
Su-Jeong Hong ◽  
Do Yoon Kim ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Genome Project ◽  
Jeju Island ◽  
Cross Sectional ◽  
Genome Database ◽  
Pathogenic Variants ◽  
Number Of Patients ◽  
High Prevalence ◽  
History Of ◽  
Reference Genome Database

ObjectiveThis study aimed to determine the frequency of pathogenic NOTCH3 variants among Koreans.MethodsIn this cross-sectional study, we queried for pathogenic NOTCH3 variants in 2 Korean public genome databases: the Korean Reference Genome Database (KRGDB) and the Korean Genome Project (Korea1K). In addition, we screened the 3 most common pathogenic NOTCH3 variants (p.Arg75Pro, p.Arg544Cys, and p.Arg578Cys) for 1,000 individuals on Jeju Island, where the largest number of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) have been reported in Korea.ResultsThe pathogenic NOTCH3 variant (p.Arg544Cys) was found in 0.12% of sequences in the KRGDB, and 3 pathogenic variants (p.Arg75Pro, p.Arg182Cys, and p.Arg544Cys) were present in 0.44% of the Korea1K database. Of the 1,000 individuals on Jeju Island, we found 2 cysteine-altering NOTCH3 variants (p.Arg544Cys variant in 9 and p.Arg578Cys in 1 individual) in 1.00% of the participants (95% confidence interval: 0.48%–1.83%). The presence of cysteine-altering NOTCH3 variants was significantly associated with a history of stroke (p < 0.001).DiscussionPathogenic NOTCH3 variants are frequently found in the general Korean population. Such a high prevalence of pathogenic variants could threaten the brain health of tens of thousands to hundreds of thousands of older adults in Korea.

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