scholarly journals Pleomorphic Invasive Ductal Carcinoma of the Breast in a Patient with Huntington’s Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Sami Shousha
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Giant Cells ◽  
Tumour Cells ◽  
Neural Cells ◽  
Carcinoma Of The Breast ◽  
Nuclear Pleomorphism ◽  
Abnormal Mitoses

A pleomorphic invasive ductal carcinoma developed in a patient with Huntington’s disease. The tumour showed marked nuclear pleomorphism and contained large number of bizarre tumour giant cells and abundant abnormal mitoses. Tumour cells showed nuclear vesicles and inclusions similar to those described in nuclei of neural cells in patients with Huntington’s disease. The case suggests that, in some patients, tumour morphology may reflect specific individual features.

Coexistent adenomyoepithelioma and invasive ductal carcinoma of the breast: presentation as separate tumors

2008 ◽  
Vol 41 (4) ◽  
pp. 238-242 ◽  
Author(s):  
Naoto Kuroda ◽  
Nokiaki Fujishima ◽  
Masahiko Ohara ◽  
Takashi Hirouchi ◽  
Keiko Mizuno ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Carcinoma Of The Breast

scholarly journals ROS1 Expression in Invasive Ductal Carcinoma of the Breast Related to Proliferation Activity

2013 ◽  
Vol 54 (3) ◽  
pp. 650 ◽  
Author(s):  
Minseob Eom ◽  
Sayamaa Lkhagvadorj ◽  
Sung Soo Oh ◽  
Airi Han ◽  
Kwang Hwa Park
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Carcinoma Of The Breast ◽  
Proliferation Activity

scholarly journals Staging performance of whole-body DWI, PET/CT and PET/MRI in invasive ductal carcinoma of the breast

2017 ◽  
Vol 51 (1) ◽  
pp. 281-288 ◽  
Author(s):  
Onofrio Antonio Catalano ◽  
Dania Daye ◽  
Alberto Signore ◽  
Carlo Iannace ◽  
Mark Vangel ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Whole Body ◽  
Carcinoma Of The Breast ◽  
Pet Ct

Reduced Expression of PTEN Protein and Its Prognostic Implications in Invasive Ductal Carcinoma of the Breast

Oncology ◽  
2005 ◽  
Vol 68 (4-6) ◽  
pp. 398-404 ◽  
Author(s):  
Shinichi Tsutsui ◽  
Hiroshi Inoue ◽  
Kazuhiro Yasuda ◽  
Kosuke Suzuki ◽  
Hidefumi Higashi ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Carcinoma Of The Breast ◽  
Pten Protein ◽  
Prognostic Implications

scholarly journals Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles for cholesterol delivery in Huntington’s disease

2020 ◽  
Author(s):  
Giulia Birolini ◽  
Marta Valenza ◽  
Ilaria Ottonelli ◽  
Alice Passoni ◽  
Monica Favagrossa ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neurodegenerative Disorder ◽  
Polymeric Nanoparticles ◽  
Cholesterol Biosynthesis ◽  
Hybrid Nanoparticles ◽  
Neural Cells ◽  
Peripheral Tissues ◽  
Brain Cholesterol ◽  
The Brain

AbstractSupplementing brain cholesterol is emerging as a potential treatment for Huntington’s disease (HD), a genetic neurodegenerative disorder characterized, among other abnormalities, by inefficient brain cholesterol biosynthesis. However, delivering cholesterol to the brain is challenging due to the bloodbrain barrier (BBB), which prevents it from reaching the striatum, especially, with therapeutically relevant doses.Here we describe the distribution, kinetics, release, and safety of novel hybrid polymeric nanoparticles made of PLGA and cholesterol which were modified with an heptapeptide (g7) for BBB transit (hybrid-g7-NPs-chol). We show that these NPs rapidly reach the brain and target neural cells. Moreover, deuterium-labeled cholesterol from hybrid-g7-NPs-chol is released in a controlled manner within the brain and accumulates over time, while being rapidly removed from peripheral tissues and plasma. We confirm that systemic and repeated injections of the new hybrid-g7-NPs-chol enhanced endogenous cholesterol biosynthesis, prevented cognitive decline, and ameliorated motor defects in HD animals, without any inflammatory reaction.In summary, this study provides insights about the benefits and safety of cholesterol delivery through advanced brain-permeable nanoparticles for HD treatment.

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