scholarly journals Genomic Changes in an Attenuated ZB Strain of Foot-and-Mouth Disease Virus Serotype Asia1 and Comparison with Its Virulent Parental Strain

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Aiguo Xin ◽  
Mingwang Zhu ◽  
Zhenqi Peng ◽  
Qi Hu ◽  
Chenhong Shi ◽  
...  
Keyword(s):  
Disease Virus ◽  
Molecular Basis ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Coding Region ◽  
Common Amino Acid ◽  
Genomic Changes ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

The molecular basis of attenuation of foot-and-mouth disease virus (FMDV) serotype Asia1 ZB strain remains unknown. To understand the genetic changes of attenuation, we compared the entire genomes of three different rabbit-passaged attenuated ZB strains (ZB/CHA/58(att), ZBRF168, and ZBRF188) and their virulent parental strains (ZBCF22 and YNBS/58). The results showed that attenuation may be brought about by 28 common amino acid substitutions in the coding region, with one nucleotide point mutation in the 5′-untranslated region (5′-UTR) and another one in the 3′-UTR. In addition, a total of 21 nucleotides silent mutations had been found after attenuation. These substitutions, alone or in combination, may be responsible for the attenuated phenotype of the ZB strain in cattle. This will contribute to elucidation of attenuating molecular basis of the FMDV ZB strain.

Capsid coding region diversity of re-emerging lineage C foot-and-mouth disease virus serotype Asia1 from India

2015 ◽  
Vol 160 (7) ◽  
pp. 1751-1759 ◽  
Author(s):  
Saravanan Subramaniam ◽  
Jajati K. Mohapatra ◽  
Biswajit Das ◽  
Gaurav K. Sharma ◽  
Jitendra K. Biswal ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Coding Region ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

Antiviral potential of ivermectin against foot-and-mouth disease virus, serotype O, A and Asia-1

2021 ◽  
pp. 104914
Author(s):  
Zahra Naeem ◽  
Sohail Raza ◽  
Saba Afzal ◽  
Ali Ahmad Sheikh ◽  
Muhammad Muddassir Ali ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

A recombinant protein-based ELISA for detecting antibodies to foot-and-mouth disease virus serotype Asia 1

2009 ◽  
Vol 159 (1) ◽  
pp. 112-118 ◽  
Author(s):  
Young-Joon Ko ◽  
Hye-Young Jeoung ◽  
Hyang-Sim Lee ◽  
Byung-Sik Chang ◽  
Seung-Min Hong ◽  
...  
Keyword(s):  
Recombinant Protein ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth ◽  
Serotype Asia 1

scholarly journals Factors Required for the Uridylylation of the Foot-and-Mouth Disease Virus 3B1, 3B2, and 3B3 Peptides by the RNA-Dependent RNA Polymerase (3Dpol) In Vitro

2005 ◽  
Vol 79 (12) ◽  
pp. 7698-7706 ◽  
Author(s):  
Arabinda Nayak ◽  
Ian G. Goodfellow ◽  
Graham J. Belsham
Keyword(s):  
Rna Polymerase ◽  
Disease Virus ◽  
Rna Synthesis ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Coding Region ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Positive Strand Rna

ABSTRACT The 5′ terminus of picornavirus genomic RNA is covalently linked to the virus-encoded peptide 3B (VPg). Foot-and-mouth disease virus (FMDV) is unique in encoding and using 3 distinct forms of this peptide. These peptides each act as primers for RNA synthesis by the virus-encoded RNA polymerase 3Dpol. To act as the primer for positive-strand RNA synthesis, the 3B peptides have to be uridylylated to form VPgpU(pU). For certain picornaviruses, it has been shown that this reaction is achieved by the 3Dpol in the presence of the 3CD precursor plus an internal RNA sequence termed a cis-acting replication element (cre). The FMDV cre has been identified previously to be within the 5′ untranslated region, whereas all other picornavirus cre structures are within the viral coding region. The requirements for the in vitro uridylylation of each of the FMDV 3B peptides has now been determined, and the role of the FMDV cre (also known as the 3B-uridylylation site, or bus) in this reaction has been analyzed. The poly(A) tail does not act as a significant template for FMDV 3B uridylylation.

Evidence of recombination in a new isolate of foot-and-mouth disease virus serotype Asia 1

2009 ◽  
Vol 139 (1) ◽  
pp. 117-121 ◽  
Author(s):  
Kwang-Nyeong Lee ◽  
Jae-Ku Oem ◽  
Jong-Hyeon Park ◽  
Su-Mi Kim ◽  
Seo-Yong Lee ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth ◽  
Serotype Asia 1

scholarly journals Emergence of novel lineage of foot‐and‐mouth disease virus serotype Asia1 BD‐18 (G‐IX) in Bangladesh

2019 ◽  
Vol 67 (2) ◽  
pp. 486-493 ◽  
Author(s):  
M. Rahmat Ali ◽  
A. S. M. Rubayet Ul Alam ◽  
Md. Al Amin ◽  
Mohammad Anwar Siddique ◽  
Munawar Sultana ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth
Sign in / Sign up

Export Citation Format

Share Document