scholarly journals Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Rade Grbic ◽  
Dijana J Miric ◽  
Bojana Kisic ◽  
Ljiljana Popovic ◽  
Vojkan Nestorovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Sequential Analysis ◽  
Bone Cells ◽  
Redox Status ◽  
Oxidative Stress Markers ◽  
Total Vitamin ◽  
Baseline Serum ◽  
Stress Markers ◽  
Systemic Oxidative Stress

In bacterial bone infections, excessively formed oxidants may result in local and systemic oxidative stress. Vitamin C is the major extracellular nonenzymatic antioxidant, also implicated in bone cells metabolism and viability. The physiological functions of vitamin C largely depend on its redox status. We sequentially assessed oxidative stress markers, hydroperoxides and malondialdehyde (MDA), total antioxidant activity (AOA), total vitamin C, ascorbic acid (Asc), and oxidized/reduced vitamin C ratio in 137 patients with acute osteomyelitis (OM). Compared to 52 healthy controls, in OM group baseline serum hydroperoxides, MDA and oxidized/reduced vitamin C ratio were higher whilst Asc and AOA were lower (P < 0.05, resp.). On the other side, total vitamin C levels in patients and controls were similar(P > 0.05), thereby suggesting a relative rather than absolute vitamin C deficiency in OM. During the follow-up, oxidative stress markers, AOA, and oxidizedreduced vitamin C ratio were gradually returned to normal, while there was no apparent change of total vitamin C concentrations. Persistently high values of oxidized/reduced vitamin C ratio and serum MDA were found in subacute OM. In conclusion, acute OM was associated with enhanced systemic oxidative stress and the shift of vitamin C redox status towards oxidized forms.

scholarly journals Significance of Elevated Blood Metal Ion Levels in Patients with Metal-on-Metal Prostheses: An Evaluation of Oxidative Stress Markers

2010 ◽  
Vol 4 (1) ◽  
pp. 221-227 ◽  
Author(s):  
Cathy Tkaczyk ◽  
Alain Petit ◽  
John Antoniou ◽  
David J Zukor ◽  
Maryam Tabrizian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metal Ion ◽  
Biological Effects ◽  
Redox Status ◽  
Heme Oxygenase 1 ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Systemic Oxidative Stress ◽  
Metal On Metal ◽  
Significant Difference

It is widely known that cobalt and chromium ions can enhance the production of reactive oxygen species, known to be damaging to cells by disturbing their redox status and then generating oxidative stress. The aim of the present study was to determine if increased metal ion levels induce a state of oxidative stress in patients with metal-on-metal (MM) hip arthroplasty. Results indicated that there was no significant difference in the concentration of oxidative stress markers (total antioxidants, peroxides, and nitrated proteins) in the patients with MM bearings compared to patients without prostheses. The activity antioxidant enzymes was stable (catalase and glutathione peroxidase) or slightly decreased (superoxide dismutase and heme oxygenase-1) over time. This work is the first to determine the biological effects of metal ions released from MM hip implants with regards to mid-term systemic oxidative stress and showed that the increased levels of Co and Cr ions are not associated with significant oxidative stress damage in the plasma of patients with these implants.

Relationship between atherogenic index and oxidative stress among patients presented with coronary artery disease in a tertiary care hospital

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 2807-2813
Author(s):  
Resmi C R ◽  
Kedari G S R ◽  
Deepa P K
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Vitamin C ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Enzymatic Antioxidants ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Lipid Parameters ◽  
And Oxidative Stress

CAD is recognized as a multifactorial disease that is influenced by environmental and genetic factors. This study aimed to evaluate the levels of lipid parameters, oxidative stress and antioxidant markers in subjects with CAD compared to their age & sex matched controls and to analyze the relationship between atherogenic Index and oxidative stress among them 62 clinically proved CAD patients and 62 healthy age and sex matched subjects without CAD were selected for this study. 5 ml of fasting venous blood was collected from all the subjects and investigations such as FPG, lipid profile, oxidative markers Malondialdehyde (MDA), F2 isoprostanes (F2iso) and antioxidants glutathione S-transferase (GST), superoxide dismutase (SOD), vitamin-C, vitamin-E were performed. This study showed that levels of lipid parameters total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-c) and AI were significantly higher whereas high density lipoprotein cholesterol (HDL-c) were significantly low in CAD patients compared to normal controls. Oxidative stress markers MDA and F2 Isoprostanes level were significantly high, whereas enzymatic antioxidants GST and SOD and non-enzymatic antioxidants Vitamin-C and Vitamin-E levels were significantly low in CAD patients. Oxidative stress markers were found to significantly influence the AI. Results of this study showed that oxidative stress markers F2iso and MDA and antioxidants GST, VIT-C and VIT-E are found to influence the atherogenic index significantly.

Beyond lowering circulating LDL: Apheresis-induced changes of systemic oxidative stress markers by four different techniques

2009 ◽  
Vol 10 (5) ◽  
pp. 34-38 ◽  
Author(s):  
Steffi Kopprasch ◽  
Juergen Graessler ◽  
Stefan R. Bornstein ◽  
Peter E.H. Schwarz ◽  
Sergey Tselmin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Stress Markers ◽  
Ldl Apheresis ◽  
Stress Markers ◽  
Systemic Oxidative Stress ◽  
Induced Changes

Treatment of hyperthyroidism reduces systemic oxidative stress, as measured by markers of RNA and DNA damages

2021 ◽  
Author(s):  
Camilla B Larsen ◽  
Kamilla Ryom Riis ◽  
Kristian Hillert Winther ◽  
Emil List Larsen ◽  
Christina Ellervik ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Urinary Excretion ◽  
Geometric Mean ◽  
Nodular Goiter ◽  
Whole Body ◽  
Oxidative Stress Markers ◽  
Toxic Nodular Goiter ◽  
Stress Markers ◽  
Systemic Oxidative Stress ◽  
Rna And Dna

Abstract Background Whole-body oxidative stress can be estimated by the urine excretion of oxidized guanosine species, 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), derived from RNA and DNA, respectively. These oxidative stress markers are not well explored in thyroid disorders. Methods Urinary excretion of 8-oxoGuo and 8-oxodG was measured in 51 hyperthyroid patients (toxic nodular goiter (TNG), n=30; Graves’ disease (GD), n=21) before or shortly after initiation of therapy and when stable euthyroidism had been achieved for at least 12 months. Results Adjusting for age, the baseline urinary excretion of oxidative stress markers correlated positively with plasma thyroxine (8-oxoGuo: p=0.002; 8-oxodG: p=0.021) and was significantly higher in GD than in TNG patients (p=0.001 for both oxidative stress markers). Restoration of euthyroidism significantly affected the excretion of the oxidative stress markers. In TNG, 8-oxoGuo decreased from geometric mean 2.11 nmol/mmol creatinine (95%CI:1.85-2.39) to 1.91 nmol/mmol (95%CI:1.67-2.19), p=0.001, while 8-oxodG decreased from 1.65 nmol/mmol (95%CI:1.41-1.93) to 1.48 nmol/mmol (95%CI:1.27-1.74), p=0.026. In GD, 8-oxoGuo decreased from 2.25 nmol/mmol (95%CI:1.95-2.59) to 1.79 nmol/mmol (95%CI:1.63-1.97), p=0.0003, while 8-oxodG decreased from 2.02 nmol/mmol (95%CI:1.73-2.38) to 1.54 nmol/mmol (95%CI:1.31-1.81), p=0.001. In the euthyroid state, there were no differences between groups. Conclusion Restoration of euthyroidism in patients with hyperthyroidism significantly decreased the systemic oxidative stress load by 10-25%. Our findings may help to explain the higher morbidity and mortality linked to hyperthyroid diseases, as shown in observational studies.

scholarly journals Vitamin C and fibre consumption from fruits and vegetables improves oxidative stress markers in healthy young adults

2011 ◽  
Vol 107 (8) ◽  
pp. 1119-1127 ◽  
Author(s):  
Helen Hermana M. Hermsdorff ◽  
Kiriaque B. F. Barbosa ◽  
Ana Carolina P. Volp ◽  
Blanca Puchau ◽  
Josefina Bressan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Young Adults ◽  
Vitamin C ◽  
Fruits And Vegetables ◽  
Vitamin Supplement ◽  
Oxidative Stress Markers ◽  
Cross Sectional ◽  
Supplement Use ◽  
Stress Markers ◽  
Gpx Activity

The aim of the present cross-sectional study was to assess the potential relationships between fruit and vegetable (FV) consumption and some oxidative stress markers in young adults, with particular emphasis on fibre and vitamin C intake. The study enrolled 246 healthy subjects (eighty-eight men and 158 women), with a mean age of 22 (sd3) years and a mean BMI of 21·9 (sd2·8) kg/m2. Dietary intake, anthropometry, blood pressure, lifestyle features and blood biochemical data were assessed with validated procedures. Those subjects in the highest tertile (T) of FV consumption ( ≥ 705 g/d) had statistically lower oxidised LDL (ox-LDL) concentrations as well as higher plasma total antioxidant capacity (TAC) and glutathione peroxidase (GPx) activity (Pfor trend < 0·05), after adjusting for sex, age, energy intake, physical activity, smoking, BMI, vitamin supplement use and other confounding factors. Moreover, plasma ox-LDL concentrations showed a decreasing trend and TAC an increasing trend across tertiles of fibre (T3: ≥ 14 g/d) and vitamin C (T3: ≥ 150 mg/d) from FV intake, while GPx activity was positively associated with vitamin C intake (Pfor trend < 0·05). In conclusion, greater FV consumption was independently associated with reduced ox-LDL as well as increased TAC and GPx activity in healthy young adults, with dietary fibre and vitamin C from FV clearly being implicated in this beneficial relationship.

Oxidative stress markers and apoptosis in the prostate of diabetic rats and the influence of vitamin C treatment

2012 ◽  
Vol 113 (7) ◽  
pp. 2223-2233 ◽  
Author(s):  
Marina Guimarães Gobbo ◽  
Daniele Lisboa Ribeiro ◽  
Sebastião Roberto Taboga ◽  
Eduardo Alves de Almeida ◽  
Rejane Maira Góes
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Diabetic Rats ◽  
Oxidative Stress Markers ◽  
Stress Markers

scholarly journals The Protective Role of Vitamin C and Chitosan Against Paraquat-induced Oxidative Stress in Muscles of Common Carp (Cyprinus carpio)

2016 ◽  
Vol 74 (4) ◽  
pp. 149-158 ◽  
Author(s):  
Zeinab Sharifinasab ◽  
Mahdi Banaee ◽  
Mohammad Mohiseni ◽  
Ahmad Noori
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Common Carp ◽  
Total Antioxidant Status ◽  
Protective Role ◽  
Normal Diet ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Total Antioxidant ◽  
C Complex

Abstract The purpose of this study was to examine the effects of antioxidants, including vitamin C, chitosan or a combination of both, on oxidative stress markers in muscles, as edible tissues of fish, exposed to paraquat. Fish exposed to 0.02 mg/L paraquat for 21 days were fed different diets: a normal diet, a diet containing chitosan (1000 mg/kg diet), a diet with vitamin C (1000 mg/kg diet) or both vitamin C and chitosan. Oxidative stress markers, including the activity of catalase, total antioxidant and malondialdehyde (MDA), as well as biochemical parameters including the activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine phosphokinase (CPK), lactate dehydrogenase (LDH) and acetylcholinesterase (AChE), were measured in muscles. Fish exposure to paraquat increased LDH, CPK, catalase and MDA activity significantly, while it significantly decreased AST, ALT and AChE activity and total antioxidant capacity in muscles. Administration of vitamin C, combined with chitosan, to fish exposed to paraquat was effective in regulating AChE, AST, ALT, LDH, CPK and catalase activity. A significant increase in the total antioxidant status and a significant decrease in MDA levels were observed in fish fed chitosan-vitamin C complex. In conclusion, it is suggested that combined supplementation with vitamin C and chitosan may improve the detoxification system in the muscles of fish and protect common carp from paraquat toxicity.

scholarly journals Association of Changes in Body Composition with Changes in Systemic Oxidative Stress Following Weight Loss Program in Obese Adults Attending Obesity Clinic, Hospital Universiti Sains Malaysia

2014 ◽  
Vol 6 (1) ◽  
pp. 60-64
Author(s):  
Md Rizman Md Lazin @ Md Lazim ◽  
Rahimah Zakaria ◽  
Rohana Abdul Jalil ◽  
Wan Suriati Wan Nik ◽  
Che Badariah Abdul Aziz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Weight Loss ◽  
Body Composition ◽  
Weight Loss Program ◽  
Oxidative Stress Markers ◽  
Obese Adults ◽  
Stress Markers ◽  
Systemic Oxidative Stress ◽  
Clinic Hospital ◽  
Obesity Clinic

The main objective of the present study was to evaluate the association of changes in body composition with changes in systemic oxidative stress markers among obese adults participating in a weight loss program. Thirty four obese adults were recruited from the Obesity Clinic, Hospital Universiti Sains Malaysia (USM) to voluntarily participate in a weight loss program comprising of physical exercise and dietary modification. Levels/activities of oxidative stress markers were measured before and after the program. Mean body weight, body mass index (BMI), waist circumference (WC), hip circumference (HC) and percentage of body fat mass decreased significantly while mean body lean mass and body water increased significantly after the weight loss program. Plasma glutathione peroxidase (GPx) activity and 4- hydroxynonenal (4-HNE) concentration increased significantly while other enzymatic antioxidant activities such as catalase (CAT) and superoxide dismutase (SOD) were not significantly increased. The ratio of reduced glutathione (GSH) to oxidized glutathione (GSSG) was significantly decreased. There was no significant association between changes in body composition and changes in systemic oxidative stress markers among obese adults. In conclusion, changes in body composition were not associated with changes in systemic oxidative stress markers among obese adults.

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