scholarly journals Database Constraints Applied to Metabolic Pathway Reconstruction Tools

2014 ◽  
Vol 2014 ◽  
pp. 1-12
Author(s):  
Jordi Vilaplana ◽  
Francesc Solsona ◽  
Ivan Teixido ◽  
Anabel Usié ◽  
Hiren Karathia ◽  
...  
Keyword(s):  
Molecular Networks ◽  
Medium Size ◽  
Biological Applications ◽  
Data Link ◽  
Pathway Reconstruction ◽  
Metabolic Pathway Reconstruction ◽  
Database Constraints ◽  
Standard Configuration ◽  
The Individual ◽  
Data Mining Application

Our group developed two biological applications,Biblio-MetReSandHomol-MetReS, accessing the same database of organisms with annotated genes.Biblio-MetReSis a data-mining application that facilitates the reconstruction of molecular networks based on automated text-mining analysis of published scientific literature.Homol-MetReSallows functional (re)annotation of proteomes, to properly identify both the individual proteins involved in the process(es) of interest and their function. It also enables the sets of proteins involved in the process(es) in different organisms to be compared directly. The efficiency of these biological applications is directly related to the design of the shared database. We classified and analyzed the different kinds of access to the database. Based on this study, we tried to adjust and tune the configurable parameters of the database server to reach the best performance of the communication data link to/from the database system. Different database technologies were analyzed. We started the study with a public relationalSQLdatabase,MySQL.Then, the same database was implemented by aMapReduce-based database namedHBase.The results indicated that the standard configuration ofMySQLgives an acceptable performance for low or medium size databases. Nevertheless, tuning database parameters can greatly improve the performance and lead to very competitive runtimes.

scholarly journals Conceptualizing Competences in E-Services Adoption and Assimilation in SMEs

2010 ◽  
pp. 225-238
Author(s):  
Ada Scupola
Keyword(s):  
Medium Size ◽  
Web Based ◽  
Management Level ◽  
Individual Level ◽  
System A ◽  
Conceptual Skills ◽  
Reservation System ◽  
The Individual ◽  
And Control ◽  
Business To Business

This article investigates the competences deemed necessary both at top managerial and individual levels for the successful adoption and assimilation of business-to-business e-services in small and medium size enterprises. To this end, an in-depth case study of a business-to-business e-service system, a Web-based travel reservation system, was conducted. The results show that three main competences, namely vision, value and control, are important at top management level for the primary adoption of e-services. For secondary adoption and assimilation, three categories of competences were identified as being important either to have or to develop at the individual level, namely technical, interpersonal and conceptual skills.

scholarly journals Oak Species Quercus robur L. and Quercus petraea Liebl. Identification Based on UHPLC-HRMS/MS Molecular Networks

Metabolites ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 684
Author(s):  
Gaëlle Buche ◽  
Cyril Colas ◽  
Laëtitia Fougère ◽  
Emilie Destandau
Keyword(s):  
Quercus Robur ◽  
Quercus Petraea ◽  
Molecular Network ◽  
Molecular Networks ◽  
Venn Diagram ◽  
Pedunculate Oak ◽  
Pure Species ◽  
Wide Range ◽  
Fragmentation Patterns ◽  
The Individual

Two species of oak are dominant in French forests: pedunculate oak (Quercus robur L.) and sessile oak (Quercus petraea Liebl.). Their differentiation is not straightforward but is essential to better understand their respective molecular content in order to better valorize them. Thus, to improve oak species identification, an untargeted UHPLC-HRMS/MS method associated with a two-step data treatment was developed to analyze a wide range of specialized metabolites enabling the comparison of both species of oak extracts. Pooled extracts from sessile and pedunculate oaks, composed of extracts from several trees of pure species from various origins, were compared using first the Venn diagram, as a quick way to get an initial idea of how close the extracts are, and then using a molecular network to visualize, on the one hand, the ions shared between the two species and, on the other hand, the compounds specific to one species. The molecular network showed that the two species shared common clusters mainly representative of tannins derivatives and that each species has specific molecules with similar fragmentation patterns, associated in specific clusters. This methodology was then applied to compare these two pooled extracts to unknown individuals in order to determine the species. The Venn diagram allowed for the quick presumption of the species of the individual and then the species could be assigned more precisely with the molecular network, at the level of specific clusters. This method, developed for the first time, has several interests. First, it makes it possible to discriminate the species and to correctly assign the species of unknown samples. Moreover, it gave an overview of the metabolite composition of each sample to better target oak tree utilization and valorization.

Franchising and Information Technology

2011 ◽  
pp. 118-139
Author(s):  
Ye-Sho Cehn ◽  
Robert Justis ◽  
P. Pete Chong
Keyword(s):  
Small Business ◽  
Small Businesses ◽  
Small Business Administration ◽  
Medium Size ◽  
Local Distribution ◽  
Small Business Development ◽  
Business Opportunity ◽  
The Individual ◽  
The Right ◽  
The U.S

According to Justis and Judd (1998), franchising is defined as “a business opportunity by which the owner (producer or distributor) of a service or a trademarked product grants exclusive rights to an individual for the local distribution and/or sale of the service or product, and in return receives a payment or royalty and conformance to quality standards. The individual or business granting the business rights is called the franchisor, and the individual or business granted the right to operate in accordance with the chosen method to produce or sell the product or service is called the franchisee.” Although the business of the franchisor is usually larger than the “satellite small businesses” of the franchisees, most franchisors manage mostly small and medium-size enterprises (Stanworth, Price, and Purdy, 2001). The U.S. Small Business Administration (SBA) recognizes this fact and sponsors various seminars in franchising, for example, business plan and raising capital, through regional Small Business Development Centers (Thomas and Seid, 2000). In addition, SBA sets up programs specifically designed for franchises (for example, Franchise Registry Web site: www.franchiseregistry.com) to streamline the review process for SBA loan applications (Sherman, 1999) and provide special incentives for franchisees to open locations in economically depressed areas (Thomas and Seid, 2000).

A Pipeline for Metabolic Pathway Reconstruction in Plant Orphan Species

2020 ◽  
pp. 367-380
Author(s):  
Cristina López-Hidalgo ◽  
Mónica Escandón ◽  
Luis Valledor ◽  
Jesus V. Jorrin-Novo
Keyword(s):  
Metabolic Pathway ◽  
Pathway Reconstruction ◽  
Metabolic Pathway Reconstruction

scholarly journals Intranasal Vaccine Using P10 Peptide Complexed within Chitosan Polymeric Nanoparticles as Experimental Therapy for Paracoccidioidomycosis in Murine Model

2020 ◽  
Vol 6 (3) ◽  
pp. 160
Author(s):  
Samuel Rodrigues Dos Santos Junior ◽  
Francenya Kelley Lopes da Silva ◽  
Lucas Santos Dias ◽  
Ana Camila Oliveira Souza ◽  
Marcelo Valdemir de Araujo ◽  
...  
Keyword(s):  
Polymeric Nanoparticles ◽  
Paracoccidioides Brasiliensis ◽  
Physicochemical Characteristics ◽  
Fungal Species ◽  
Experimental Therapy ◽  
Medium Size ◽  
Biological Applications ◽  
Dispersion Index ◽  
Fungal Load ◽  
Intranasal Vaccine

Paracoccidioidomycosis (PCM) is a granulomatous fungal disease caused by the dimorphic fungal species of Paracoccidioides, which mainly affects the lungs. Modern strategies for the treatment and/or prevention of PCM are based on a Th1-type immune response, which is important for controlling the disease. One of the most studied candidates for a vaccine is the P10 peptide, derived from the 43 kDa glycoprotein of Paracoccidioides brasiliensis. In order to improve its immune modulatory effect, the P10 peptide was associated with a chitosan-conjugated nanoparticle. The nanoparticles presented 220 nm medium size, poly dispersion index (PDI) below 0.5, zeta potential of +20 mV and encapsulation efficiency around 90%. The nanoparticles’ non-toxicity was verified by hemolytic test and cell viability using murine macrophages. The nanoparticles were stable and presented physicochemical characteristics desirable for biological applications, reducing the fungal load and the usual standard concentration of the peptide from 4 to 20 times.

Influence of the Exhaust System on Performance of a 4-Cylinder Supercharged Engine

1998 ◽  
Vol 120 (4) ◽  
pp. 855-860 ◽  
Author(s):  
F. Trenc ◽  
F. Bizjan ◽  
A. Hribernik
Keyword(s):  
Pressure Pulse ◽  
Exhaust System ◽  
Medium Size ◽  
Advantages And Disadvantages ◽  
Available Energy ◽  
Good Utilization ◽  
The Individual ◽  
Radial Turbines ◽  
Manifold System ◽  
Four Cylinders

Twin entry radial turbines are mostly used to drive compressors of small and medium size 6-cylinder diesel engines where the available energy of the undisturbed exhaust pulses can be efficiently used to drive the turbine of a turbocharger. Three selected cylinders feed two separated manifold branches and two turbine inlets and prevent negative interaction of pressure waves and its influence on the scavenging process of the individual cylinders. In the case of a four-stroke, 4-cylinder engine, two selected cylinders, directed by the firing order, can be connected to one (of the two) separated manifold branches that feeds one turbine entry. Good utilization of the pressure pulse energy, together with typically longer periods of reduced exhaust flow can lead to good overall efficiency of the “two-pulse” system. Sometimes this system can be superior to the single manifold system with four cylinders connected to one singleentry turbine. The paper describes advantages and disadvantages of the above described exhaust systems applied to a turbocharged and aftercooled 4-cylinder Diesel engine. Comparisons supported by the analyses of the numerical and experimental results are also given in the presented paper.

scholarly journals Leveraging Heterogeneous Network Embedding for Metabolic Pathway Prediction

2020 ◽  
Author(s):  
Abdur Rahman M. A. Basher ◽  
Steven J. Hallam
Keyword(s):  
Metabolic Pathway ◽  
Software Package ◽  
Genomic Sequence ◽  
Dimensional Space ◽  
Reference Database ◽  
Sequence Information ◽  
Layered Architecture ◽  
Pathway Reconstruction ◽  
Pathway Prediction ◽  
Metabolic Pathway Reconstruction

AbstractMetabolic pathway reconstruction from genomic sequence information is a key step in predicting regulatory and functional potential of cells at the individual, population and community levels of organization. Although the most common methods for metabolic pathway reconstruction are gene-centric e.g. mapping annotated proteins onto known pathways using a reference database, pathway-centric methods based on heuristics or machine learning to infer pathway presence provide a powerful engine for hypothesis generation in biological systems. Such methods rely on rule sets or rich feature information that may not be known or readily accessible. Here, we present pathway2vec, a software package consisting of six representational learning based modules used to automatically generate features for pathway inference. Specifically, we build a three layered network composed of compounds, enzymes, and pathways, where nodes within a layer manifest inter-interactions and nodes between layers manifest betweenness interactions. This layered architecture captures relevant relationships used to learn a neural embedding-based low-dimensional space of metabolic features. We benchmark pathway2vec performance based on node-clustering, embedding visualization and pathway prediction using MetaCyc as a trusted source. In the pathway prediction task, results indicate that it is possible to leverage embeddings to improve pathway prediction outcomes.Availability and implementationThe software package, and installation instructions are published on github.com/[email protected]

scholarly journals Trust as catalyst for the organizational performance. A focus on a medium-size IT Romanian company

2017 ◽  
Vol 11 (1) ◽  
pp. 770-778
Author(s):  
Raluca Badea
Keyword(s):  
Social Capital ◽  
Organizational Performance ◽  
Quantitative Research ◽  
Social Economy ◽  
Primary Component ◽  
Medium Size ◽  
Core Element ◽  
The Social ◽  
The Individual ◽  
High Level

Abstract In an environment where the shift from knowledge to social economy forces the company to identify a new sustainable approach to attire, motivate and retain employees, partners and shareholders, social capital and its elements seem to be the key. The focus of the article is to prove the contribution that trust, in its entirety, as primary component of the social capital, has on the organizational performance of the company. The centric piece of the paper is based on a quantitative research conducted in a medium size IT company and it is designed to support the hypotheses per which a high level of trust will positively influence the overall business results. Regardless if it’s societal trust, market trust, relationship trust or selftrust, the respondents are requested to assess its multiple dimensions as these are translated into the company’s principles and values, the leaders’ strategy to improve the life of the shareholders, the company’s brands and their impact on the consumers, the relationship between individual and his/her peers and managers, as well as the individual’s aspirational behavior to be a trusted colleague/employee. Analyzing the results of the questionnaire, trust as core element of the social capital appears to be a main factor that drives the competitive advantage, designed to boost the employees’ energy, increase the sustainability for the company, irreversibly gain the confidence of stakeholders and eventually act a catalyst for the individual and organizational performance. The in-progress results of this paper represent significant key findings that trigger a more advance research, at a larger scale, by evaluating other companies, with similar employees’ profile to confirm the magnitude of this influence and convince the business leaders to continue supporting the creation and leverage of social capital in general and strive to generate, build and maintain trust as a must have asset.

THE BIGGER THE SYSTEM, THE NARROWER AND MORE SPECIALIZED THE INTERFACE WITH INDIVIDUALS

PEDIATRICS ◽  
1979 ◽  
Vol 63 (4) ◽  
pp. 611-611
Author(s):  
John Gall
Keyword(s):  
Remote Sensing ◽  
Social Security ◽  
Vital Signs ◽  
Medium Size ◽  
Social Security Number ◽  
Professional Activities ◽  
Driver's License ◽  
Large Systems ◽  
The Individual ◽  
The Relationship

In very large systems, the relationship is not with the individual at all but with his Social Security number, his driver's license, or some other paper phantom. In systems of medium size, some residual awareness of the individual may still persist. A hopeful indication was recently observed by the author in a medium-sized hospital. Taped to the wall of the nurses' station, just above the Vital Signs Remote Sensing Console, which enables the nurses to record whether the patient is breathing and even to take his pulse without actually going down the hall to see him, was the following hand-lettered reminder: THE CHART IS NOT THE PATIENT. Unfortunately, this slogan, with its humanistic implications, turned out to be misleading. The nurses were neither attending nor making notations in the charts. They were in the hospital auditorium, taking a course in interdisciplinary function (Interdisciplinary function may be defined as the art of correlating one's own professional activities more and more with those of other professionals while actually doing less and less.)

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