scholarly journals Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic Hg/Whole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Andréia Ávila Soares de Oliveira ◽  
Marilesia Ferreira de Souza ◽  
André van Helvoort Lengert ◽  
Marcelo Tempesta de Oliveira ◽  
Rossana Batista de Oliveira Godoy Camargo ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Whole Blood ◽  
Fish Consumption ◽  
Multivariate Analyses ◽  
Mercury Species ◽  
Icp Ms ◽  
Total Hg ◽  
Pcr Assays ◽  
Plasma Compartment

This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1,GSTT1,GSTP1,GCLM, andGCLC) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg). Subjects (n=88), exposed to MeHg from fish consumption, were enrolled in the study. Hg species in the plasma compartment were determined by LC-ICP-MS, whereas genotyping was performed by PCR assays. Mean total Hg levels in plasma (THgP) and whole blood (THgB) were10±4.2and37±21, whereas mean evels of plasmatic MeHg (MeHgP), inorganic Hg (IHgP), and HgP/HgB were4.3±2.9,5.8±2.3 µg/L, and0.33±0.15, respectively.GSTM1andGCLCpolymorphisms influence THgP and MeHgP (multivariate analyses,P<0.050). Null homozygotes forGSTM1showed higher THgP and MeHgP levels compared to subjects withGSTM1(THgPβ=0.22,P=0.035; MeHgPβ=0.30,P=0.050) and persons carrying at least one T allele forGCLChad significant higher MeHgP (β=0.59,P=0.046). Also, polymorphicGCLMsubjects had lower THgP/THgB than those with the nonvariant genotype. Taken together, data of this study suggest that GSH-related polymorphisms may change the metabolism of MeHg by modifying the distribution of mercury species iin plasma compartment and the HgP/HgB partitioning.

Biomonitoring of 29 trace elements in whole blood from inhabitants of Cotonou (Benin) by ICP-MS

2017 ◽  
Vol 43 ◽  
pp. 38-45 ◽  
Author(s):  
Brice Yedomon ◽  
Alain Menudier ◽  
Florence Lecavelier Des Etangs ◽  
Ludovic Anani ◽  
Benjamin Fayomi ◽  
...  
Keyword(s):  
Trace Elements ◽  
Whole Blood ◽  
Icp Ms

scholarly journals Mercury determination and speciation analysis in surface waters

2012 ◽  
Vol 10 (4) ◽  
pp. 1175-1182 ◽  
Author(s):  
Elisaveta Mladenova ◽  
Ivanka Dakova ◽  
Dimiter Tsalev ◽  
Irina Karadjova
Keyword(s):  
Surface Waters ◽  
Inductively Coupled Plasma ◽  
Mechanical Stability ◽  
Solid Phase ◽  
Chemical Vapor ◽  
Speciation Analysis ◽  
Regeneration Ability ◽  
Mercury Species ◽  
Icp Ms ◽  
Relative Standard

AbstractA sorbent L-cysteine grafted silica gel has been evaluated for separation and enrichment of dissolved inorganic i-Hg(II) and methylmercury CH3Hg(I) from surface waters at sub-µg L−1 concentrations. Chemical parameters for mercury species enrichment and separation have been optimized. Analytical schemes for the determination of Hg species, using selective column solid phase extraction (SPE) with continuous flow chemical vapor generation atomic absorption spectrometry (CF-CVG-AAS) or inductively coupled plasma-mass spectrometry (ICP-MS) were developed. Possibilities for on-site SPE enrichment were demonstrated as well. The limits of quantification were 1.5 and 5 ng L−1 for dissolved i-Hg(II) and CH3Hg(I) by CF-CVG-AAS and 1 and 2.5 ng L−1 by ICP-MS with relative standard deviations between 7–12% and 7–14%, respectively. The chemically modified SPE sorbent has demonstrated high regeneration ability, chemical and mechanical stability, acceptable capacity and good enrichment factors. Results for total dissolved mercury were in reasonable agreement with those from independent analyses by direct ICP-MS determinations for river waters and for estuarine water certified reference material.

Headspace In-Tube Microextraction and GC-ICP-MS Determination of Mercury Species in Petroleum Hydrocarbons

2018 ◽  
Vol 32 (10) ◽  
pp. 10493-10501 ◽  
Author(s):  
Zuzana Gajdosechova ◽  
Enea Pagliano ◽  
Andre Zborowski ◽  
Zoltan Mester
Keyword(s):  
Petroleum Hydrocarbons ◽  
Mercury Species ◽  
Icp Ms

Separation of Fe from whole blood matrix for precise isotopic ratio measurements by MC-ICP-MS: a comparison of different approaches

2003 ◽  
Vol 18 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Anna Stenberg ◽  
Dimitry Malinovsky ◽  
Ilia Rodushkin ◽  
Henrik Andrén ◽  
Christer Pontér ◽  
...  
Keyword(s):  
Whole Blood ◽  
Isotopic Ratio ◽  
Icp Ms

scholarly journals Analysis of whole blood by ICP-MS equipped with a high temperature total sample consumption system

2017 ◽  
Vol 32 (1) ◽  
pp. 78-87 ◽  
Author(s):  
Águeda Cañabate ◽  
Esperanza García-Ruiz ◽  
Martín Resano ◽  
José-Luis Todolí
Keyword(s):  
High Temperature ◽  
Whole Blood ◽  
Inductively Coupled Plasma ◽  
Total Sample ◽  
Sample Introduction ◽  
Element Analysis ◽  
Inductively Coupled ◽  
System P ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

In this work, the performance of a high temperature torch Integrated Sample Introduction System (hTISIS) using inductively coupled plasma mass spectrometry (ICP-MS) for the multi-element analysis of whole blood is evaluated.

scholarly journals Determination of organic and inorganic mercury species in water and sediment samples by HPLC on-line coupled with ICP-MS

Talanta ◽  
2009 ◽  
Vol 80 (1) ◽  
pp. 207-211 ◽  
Author(s):  
José Soares dos Santos ◽  
Miguel de la Guárdia ◽  
Augustin Pastor ◽  
Maria Lúcia Pires dos Santos
Keyword(s):  
Inorganic Mercury ◽  
Mercury Species ◽  
Sediment Samples ◽  
Water And Sediment ◽  
Icp Ms ◽  
On Line ◽  
Water And Sediment Samples

scholarly journals Comparison of Commercial Extraction Systems and PCR Assays for Quantification of Epstein-Barr Virus DNA Load in Whole Blood

2012 ◽  
Vol 50 (4) ◽  
pp. 1384-1389 ◽  
Author(s):  
R. Germi ◽  
J. Lupo ◽  
T. Semenova ◽  
S. Larrat ◽  
N. Magnat ◽  
...  
Keyword(s):  
Whole Blood ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Pcr Assays ◽  
Epstein Barr
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