scholarly journals Evaluation of Prothrombin Time and Activated Partial Thromboplastin Time in Hypertensive Patients Attending a Tertiary Hospital in Calabar, Nigeria

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Nnamani Nnenna Adaeze ◽  
Anthony Uchenna Emeribe ◽  
Idris Abdullahi Nasiru ◽  
Adamu Babayo ◽  
Emmanuel K. Uko
Keyword(s):  
Blood Pressure ◽  
Prothrombin Time ◽  
Partial Thromboplastin Time ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Activated Partial Thromboplastin Time ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Duration Of Illness ◽  
Normotensive Subjects

Introduction. Several biomedical findings have established the effects of hypertension on haemostasis and roles of blood coagulation products in the clinical course of hypertension.Methods. This cross-sectional study aimed at determining effects of hypertension on prothrombin time (PT) and activated partial thromboplastin time (APTT) in hypertensive patients in comparison with normotensive subjects attending a tertiary hospital in Calabar. Forty-two (42) hypertensive patients and thirty-nine (39) normotensive control subjects were investigated for PT and APTT using Quick one-stage methods.Results. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) correlated positively with APTT (r=0.3072,r=0.4988;P<0.05) in hypertensive patients. DBP, SBP, PT, and APTT were significantly higher in hypertensive patients when compared to normotensive subjects (P<0.05). DBP correlated negatively with duration of illness (r=-0.3097;P<0.05) in hypertensive patients and positively with age of normotensive subjects (r=0.3523;P<0.05).Conclusion. The results obtained indicated that measurements of PT and APTT may serve as indices for evaluating hemostatic abnormalities in hypertensive patients and guide for antihypertensive therapy. However, to have better understanding of hemostatic activities in hypertension, it is recommended to conduct D-dimer, platelet factors, and protein assays.

scholarly journals Coagulation Impairment in Type 2 Diabetes Mellitus

2015 ◽  
Vol 10 (1) ◽  
pp. 26-29 ◽  
Author(s):  
Fayeza Karim ◽  
Qazi Shamima Akter ◽  
Shamima Jahan ◽  
Afruza Khanom ◽  
Samira Haque ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Prothrombin Time ◽  
Partial Thromboplastin Time ◽  
Cross Sectional Study ◽  
Activated Partial Thromboplastin Time ◽  
Diabetic Patients ◽  
Cross Sectional

Background: Complication of diabetes mellitus (DM) includes coagulation impairment. Hypercoagulable state in patient with DM may accelerate thromboembolic risk for cardiovascular disease (CVD).Objective: To assess Prothrombin Time and Activated Partial Thromboplastin Time in type 2 diabetes mellitus for observing their coagubility status.Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2013 to June 2014. One hundred male patients with type 2 diabetes mellitus aged 40-60 years and one hundred age, BMI matched healthy subjects were included as control in this study. Patients were selected from BIRDEM, Dhaka. Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT) were estimated by auto analyzer. For statistical analysis unpaired student’t test was used.Results: In this study PT and APTT were significantly (P<0.001) lower in diabetes mellitus than those of control group.Conclusion: From this study, it may be concluded that diabetic patients are prone to develop coagulation impairment.Bangladesh Soc Physiol. 2015, June; 10(1): 26-29

scholarly journals PEMERIKSAAN PROTHROMBIN TIME DAN ACTIVATED PARTIAL THROMBOPLASTIN TIME DENGAN HUMACLOT VA SERTA SYSMEX CA 500

2016 ◽  
Vol 18 (3) ◽  
pp. 147
Author(s):  
Misnah Misnah ◽  
Agus Alim Abdullah ◽  
Mansyur Arif ◽  
Burhanuddin Bahar
Keyword(s):  
Prothrombin Time ◽  
Partial Thromboplastin Time ◽  
Pearson Correlation ◽  
Clinical Pathology ◽  
Cross Sectional Study ◽  
Activated Partial Thromboplastin Time ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Correlation Test ◽  
Pearson Correlation Test

Prothrombin Time (PT) and an activated Partial Thromboplastin Time (aPTT) are routine coagulation tests used for pre-operative screening. The analytical step as one of the laboratory test’s stage that plays the role in the determination of the test is influenced by several factors, one of them is choosing its proper devices. The aim of this study was to know the correlation of the PT and aPTT test’s result using Humaclot VA and Sysmex CA 500 devices. A cross sectional study has been done at the Clinical Pathology Laboratory of Wahidin Sudirohusodo Hospital Makassar started from May 2009 until June 2009. The data were analyzed with T and Pearson’s Correlation test. From the 50 samples were obtained the percentage of the corresponding frequency of the PT results between Humaclot VA and Sysmex CA 500 about 84%, whereas the frequency of the corresponding results aPPT between Humaclot VA and Sysmex CA 500 is 76%, the Pearson correlation test for PT=0.58, and aPTT=0.38. There were found the suitability of PT, aPTT of Humaclot VA with CA 500 and both tools have a positive correlation.

Analisis Faktor Determinan yang berhubungan dengan Kepatuhan Rekomendasi Modifikasi Gaya Hidup Pasien Hipertensi

2020 ◽  
Vol 7 (2) ◽  
pp. 256-263
Author(s):  
Abdul Qodir
Keyword(s):  
Blood Pressure ◽  
Lifestyle Modification ◽  
Multivariate Logistic Regression Analysis ◽  
Cross Sectional Study ◽  
Lifestyle Modifications ◽  
Chi Square ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Consecutive Sampling ◽  
Knowledge Practice

Penatalaksanaan farmakologis dan non farmakologis dipercaya dapat mengontrol tekanan darah dan mencegah komplikasi, tetapi banyak pasien hipertensi tekanan darahnya tidak terkontrol. Hal tersebut dikarenakan kepatuhan yang buruk dalam melaksanakan rekomendasi gaya hidup. Penelitian ini bertujuan untuk menganalisis determinan faktor yang berhungan dengan kepatuhan melaksanakan rekomendasi modifikasi gaya hidup. Penelitian ini menggunakan metode cross-sectional di pukesmas dinoyo Kota Malang tahun 2019. Teknik pengambilan sampel menggunakan Consecutive Sampling. Kuesioner yang digunakan meliputi : karakteristik demografi, pengetahuan dan rekomendasi mofifikasi gaya hidup pasien hipertensi. Hubungan antara rekomendasi modifikasi gaya hidup dengan variabel independen dianalisis menggunakan uji chi square dan analisis regresi logistik. 140 pasien hipertensi berpartisipasi dalam penelitian ini (60 laki-laki, 80 wanita). Prevalensi kepatuhan adalah 28,6 %. Tingkat pengetahuan berhubungan signifikan  dengan kepatuhan melaksanakan rekomendasi gaya hidup (p=0,00). Jenis kelamin, usia, dan tingkat pendidikan tidak mempunyai hubungan signifikan dengan kepatuhan rekomendasi modifikasi gaya hidup (p= 0,06; p=0,21; p=0,87). Pengetahuan mempunyai hubungan yang signifikan dengan kepatuhan rekomendasi modifikasi gaya hidup. Management of pharmacological and non-pharmacological is believed to control blood pressure and prevent complications,  but many hypertensive patients have uncontrolled blood pressure. This is due to poor adherence to recommended lifestyle modifications. This study was aimed to determine the factors associated with adherence to recommended lifestyle modifications of hypertensive patients. A cross-sectional study was conducted in Pukesmas Dinoyo Malang in 2019. Consecutive Sampling was used to select study subjects. The questionnaire included information about demographic characteristics, knowledge, practice of lifestyle-modification measures. Associations between adherence to lifestyle modification and independent variables were analyzed using chi square and multivariate logistic regression analysis. 140 hypertensive patients participated in the study (60 men, 80 women). The prevalence of adherence was 28.6%. The level of knowledge was significant associated with adherence to recommended lifestyle modifications (p = 0.00). Genders , age, and educational level were no significant associated with to recommended lifestyle modifications (p= 0.06; p=0.21; p=0.87). Knowledge was significant associated with adherence to recommended lifestyle modifications of hypertensive patients.

scholarly journals Socio-demographic, Clinical Characteristics and Status of Hypertension Control among Rural Hypertensive Patients

1970 ◽  
Vol 6 (1) ◽  
pp. 5-9
Author(s):  
NU Ahmed ◽  
M Rahman ◽  
MDU Islam ◽  
SY Ali ◽  
AM Hossain ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Control ◽  
Clinical Characteristics ◽  
Pressure Control ◽  
Cross Sectional Study ◽  
Hypertension Control ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Education And Awareness ◽  
Males And Females

Hypertension is an important independent predictor of cardiovascular disease, cerebrovascular accidents and death. The prevalence of cardiovascular diseases and hypertension is rapidly increasing in developing countries. A cross sectional study was conducted among 103 hypertensive patients during December 2009 to June 2010 in Goshair Hat Upazilla of Shariatpur District to determine the socio-demographic, clinical characteristics and status of control of hypertension in rural population. Respondents were distributed more or less equally among males and females. The mean ± SD and median age of the respondents were calculated as 59.97 ± 11.12 years, with 64% of them were included in the age group of 51 to 70 years. More than half of the respondents were housewives (51.5%), which were followed by businessmen (21.4%). Every three of five patients were over weight, while 22.3% respondents were obese. One third of the respondents were also diabetic (33%). None of the 103 patients had achieved the target for SBP (Systolic blood pressure) control (<140mm of Hg) and only 21.4% of the patients had achieved the target for DBP (Diastolic blood pressure) control (<90 mm of Hg). Again none of the diabetic hypertensive patients had achieved the target for SBP control (<130mm of Hg) and only one patient had achieved the target for DBP control (<80 mm of Hg). Overall five patients were found to have uncontrolled and severe hypertension (BP >180/110 mm of Hg), all of whom were female. From this study control of hypertension was found poor among rural hypertensive population. For effectively combating the burden of hypertension in this population, education and awareness about hypertension needs to be given priority. Key words: Hypertension; socio-demographic characteristics; rural area; control of blood pressure DOI: 10.3329/fmcj.v6i1.7402 Faridpur Med. Coll. J. 2011;6(1): 05-09

scholarly journals ASSOCIATION OF POSTPRANDIAL BLOOD SUGAR WITH HYPERCOAGULABILITY IN COMPARISON TO FASTING BLOOD SUGARS IN DIABETIC AND HEALTHY PATIENTS: A CROSS-SECTIONAL STUDY

2017 ◽  
Vol 10 (7) ◽  
pp. 378
Author(s):  
Sri Ramulu Kadiyala ◽  
Karthik Rao ◽  
Nr Rao ◽  
Ram Bhat ◽  
Jayaprakash Rao ◽  
...  
Keyword(s):  
Blood Sugar ◽  
Partial Thromboplastin Time ◽  
Cross Sectional Study ◽  
Activated Partial Thromboplastin Time ◽  
Postprandial Blood Glucose ◽  
Healthy Controls ◽  
Sectional Study ◽  
Normal Range ◽  
Cross Sectional

Objective: The aim of this study was to find the association of postprandial blood glucose with hypercoagulability in comparison to fasting blood sugars(FBS) in diabetic and healthy patients.Methods: The present study involved a total of 156 patients, of which 78 were taken as cases (diabetics) and other 78 as controls (non-diabetics). Laboratory analysis included prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen assay done along with fasting, and postprandial sugars.Results: Platelets in diabetics and healthy controls were in normal range. Decrease in PT and partial thromboplastin time was noted in diabetics compared to non-diabetic controls. Fibrinogen levels were increased in cases compared to controls. Changes in PT values were more significant with postprandial blood sugar (PPBS) levels when compared to FBS levels, and APTT follows the same pattern with more in PPBS levels and FBS levels in diabetics. PPBS showed elevated fibrinogen when compared to FBS in diabetics as well as non-diabetics.Conclusion: Type 2 diabetes mellitus is a hypercoagulable state as proven by the following results of our study.

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