scholarly journals Synthesis and Antimicrobial Activity of New Schiff Base Compounds Containing 2-Hydroxy-4-pentadecylbenzaldehyde Moiety

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Gadada Naganagowda ◽  
Reinout Meijboom ◽  
Amorn Petsom
Keyword(s):  
Schiff Base ◽  
Acid Hydrazide ◽  
Heterocyclic Amines ◽  
Antibacterial And Antifungal Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Carboxylic Acid Hydrazide ◽  
Antibacterial And Antifungal ◽  
C Nmr

Various novel Schiff base compounds have been synthesized by reaction of 2-hydroxy-4-pentadecylbenzaldehyde with substituted benzothiophene-2-carboxylic acid hydrazide and different substituted aromatic or heterocyclic amines in the presence of acetic acid in ethanol. The structures of all these compounds were confirmed by elemental analysis, IR, 1H-NMR, 13C-NMR, and mass spectral data and have been screened for antibacterial and antifungal activity.

scholarly journals Synthesis and Antimicrobial Screening of Some Novel 2, 5-Disubstituted 1, 3, 4-oxadiazole Derivatives

2011 ◽  
Vol 8 (s1) ◽  
pp. S149-S154 ◽  
Author(s):  
P. Panneerselvam ◽  
G. Geete Ganesh
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Antibacterial And Antifungal Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
E Coli ◽  
H Nmr ◽  
Oxadiazole Derivatives ◽  
Antibacterial And Antifungal ◽  
New Compounds

The syntheses of series of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives are described. A total of twelve new compounds were synthesized and characterized by IR,1H-NMR and Mass spectral data. All newly synthesized compounds were screened for their antimicrobial activityi.e. antibacterial activity againstS. aureusandE. coliand antifungal activity against fungusA. nigar. CompoundsG5andG7exhibited significant both antibacterial and antifungal activity whileG2,G10andG3,G9showed antibacterial and antifungal activity respectively. These compounds were 2, 5-disubstituted 1, 3, 4-oxadiazole moiety at position two and five showed reasonable antibacterial and antifungal activity.

scholarly journals Microwave Assisted Synthesis of New 1-{2, 4-Dihydroxy-5-[5-(aryl)-1-pyridine/pyrimidine-4-carbonyl)-4, 5-dihydro-1H-pyrazol-3-yl]-phenyl}-3-(aryl)-propenones and their Antibacterial Activity

2009 ◽  
Vol 6 (2) ◽  
pp. 323-331
Author(s):  
D. Ashok ◽  
K. Aravind
Keyword(s):  
Antibacterial Activity ◽  
Microwave Irradiation ◽  
Spectral Data ◽  
Acid Hydrazide ◽  
Microwave Assisted Synthesis ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Microwave Assisted ◽  
C Nmr

A series of 1-{2, 4-dihydroxy-5-[5-(aryl)-1-pyridine/pyrimidine-4-carbonyl)-4, 5-dihydro-1H-pyrazol-3-yl]-phenyl}-3-(aryl)-propenones (2a-h) have been synthesized from 1-[2,4-dihydroxy-5-(aryl acryloyl)phenyl]-aryl propenones(1a-h)by Micheal addition with isoniazide/pyrazinic acid hydrazide under microwave irradiation and classical heating. The synthesized compounds were characterized by IR,1H-NMR,13C-NMR and Mass spectral data. All the compounds were screened for their Antibacterial activity.

scholarly journals An Efficient and Clean Synthesis of Thiophenyl Thiazole Depended Novel Triazolo[4,3-a]Quinoxaline Derivatives

2015 ◽  
Vol 51 ◽  
pp. 125-134
Author(s):  
Haresh G. Kathrotiya ◽  
Sagar P. Gami ◽  
Yogesh T. Naliapara
Keyword(s):  
Schiff Base ◽  
Elemental Analysis ◽  
Room Temperature ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Clean Synthesis ◽  
Quinoxaline Derivatives ◽  
Ft Ir ◽  
C Nmr

A simple and efficient approach for the synthesis of thiophenyl thiazole based triazolo [4,3-a] quinoxaline derivatives is described. In this methodology, 3-hydrazinyl-N-(4-(thiophen-2-yl) thiazol-2-yl) quinoxalin-2-amine derivatives treated with various aromatic aldehyde to form Schiff base which on treatment with iodobenzene diacetate in dichloromethane at room temperature to furnish title compounds. The synthesized compounds were characterized by 1H NMR, 13C NMR, FT-IR, elemental analysis, and mass spectral data

scholarly journals Synthesis Characterization and Antimicrobial Activity Studies of Some Transition Metal Complexes Derived from 3-Chloro-N′-[(1E)-(2-hydroxy phenyl)methylene]-6-methoxy-1-benzothiophene-2-carbohydrazide

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Vivekanand D. Biradar ◽  
B. H. M. Mruthyunjayaswamy
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Esr Spectra ◽  
Mass Spectral Data ◽  
Tetrahedral Geometry ◽  
Donor Ligand ◽  
Mass Spectral ◽  
E Coli ◽  
H Nmr

A series of new coordination complexes of Cu(II), Co(II), Ni(II), Zn(II), Hg(II), Mn(II), and Fe(III) with the Schiff base 3-chloro-N′-[(1E)-(2-hydroxy phenyl)methylene]-6-methoxy-1-benzothiophene-2-carbohydrazide (HL) have been synthesized and characterized by elemental analysis, electrical conductivity measurements, IR spectra,1H NMR, mass spectral data, electronic spectra, magnetic susceptibility, ESR spectra, TGA, and Powder XRD data. The Schiff base behaves as tridentate ONO donor ligand and forms the complexes of the type ML2(metal-ligand) stoichiometry for Cu(II), Co(II), Ni(II), and Mn(II) complexes and ML stoichiometry for Zn(II), Hg(II), and Fe(III) complexes. All the complexes are colored and nonelectrolytes. It is found that Cu(II), Co(II), Ni(II), Mn(II) and Fe(III) complexes have exhibited octahedral geometry whereas Zn(II) and Hg(II) complexes exhibited tetrahedral geometry. The ligand and its metal complexes have been screened for their antibacterial activity againstE. coliandS. aureusand antifungal activity againstA. nigerandA. flavus.

scholarly journals Synthesis of New Bicyclic Hydroxamic Acids with Cytotoxic Activity

2018 ◽  
Vol 61 (4) ◽  
Author(s):  
Iker S. Escalona-Torres ◽  
Francisco Yuste ◽  
Rubén Sánchez-Obregón
Keyword(s):  
Cytotoxic Activity ◽  
Nitro Group ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Hydroxamic Acids ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
C Nmr

Six new bicyclic hydroxamic acids were synthesized through an uncommon nitro group rearrangement between β-nitrostyrenes and dimedone. The structures of all the new synthesized compounds were confirmed using a combination of FTIR, <sup>1</sup>H NMR, <sup>13</sup>C NMR and mass spectral data. Likewise, the cytotoxic activity of the obtained products was evaluated in six different cancer cell lines. Two compounds showed significant potency on two cancer cell lines with IC50 between 9.31±0.1 and 23.38±0.9 μM.

scholarly journals A Novel and Efficient Synthesis of [1,2,3]-Triazolyl Substituted Benzo[c]Coumarins and Evaluation of their Antimicrobial Activity

2016 ◽  
Vol 70 ◽  
pp. 1-11
Author(s):  
Neha N. Gohil ◽  
Kaushik N. Kundaliya ◽  
Dinkar I. Brahmbhatt
Keyword(s):  
Antimicrobial Activity ◽  
Fungal Pathogens ◽  
Sodium Acetate ◽  
Efficient Synthesis ◽  
Mass Spectral Data ◽  
Pyridinium Bromide ◽  
Mass Spectral ◽  
H Nmr ◽  
Anti Fungal ◽  
C Nmr

A series of novel [1,2,3]-triazolyl substituted benzo [c] coumarins have been synthesized by reacting various 3-coumarinoyl methyl pyridinium bromide salts with 1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl) ethanones in the presence of sodium acetate in refluxing acetic acid. The structures of the synthesized compounds have been elucidated by IR,1H-NMR,13C-NMR and Mass spectral data. All the synthesized compounds have been screened for theirinvitroanti-bacterial and anti-fungal activities. Some of the compounds have been found to be active against some bacterial and fungal pathogens compared to standard drugs.

scholarly journals Synthesis and In Vitro Antibacterial and Antifungal Evaluation of Quinoline Analogue Azetidin and Thiazolidin Derivatives

2014 ◽  
Vol 39 ◽  
pp. 195-210 ◽  
Author(s):  
Shraddha M. Prajapati ◽  
Rajesh H. Vekariya ◽  
Kinjal D. Patel ◽  
Shyamali N. Panchal ◽  
Hitesh D. Patel ◽  
...  
Keyword(s):  
Gram Negative Bacteria ◽  
Aspergillus Clavatus ◽  
Dilution Technique ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Antibacterial And Antifungal ◽  
Broth Dilution

A library of quinoline analog two novel series of azetidin (SH1-5) and thiazolidin (SHa-e) derivatives were designed and synthesized with simple and eco-friendly methodologies. The structures of the compounds were elucidated with the aid of elemental analysis, IR, 1H-NMR and mass spectral data. These novel synthesized compounds were evaluated for antibacterial activity against two gram-positive bacteria (Staphylococcus aureus, Staphylococcus pyogenus) and two gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli). The title compounds were also studied for their antifungal activity with Candida albicans, Aspergillus niger, Aspergillus clavatus using the broth dilution technique. Most of the compounds were the best bio-active desired antibacterial analog with less MIC value against different tested strains.

Lactaran Sesquiterpen Velleral Dari Kulit Batang Tumbuhan Drymis beccariana Gibbs. (Winteraceae) yang Bersifat Sitotoksik dan Antimikroba

2012 ◽  
Vol 8 (1) ◽  
Author(s):  
Bimo Budi Santoso ◽  
Darma Santi ◽  
Markus H. Langsa ◽  
Rina Mogea
Keyword(s):  
Bioactive Compound ◽  
Stem Bark ◽  
Artemia Salina ◽  
Leukemia Cells ◽  
Antibacterial And Antifungal Activity ◽  
H Nmr ◽  
Potential Source ◽  
Staphyloccocus Aureus ◽  
Antibacterial And Antifungal ◽  
C Nmr

<em>Isolation guided by brine-shrimp ( Artemia salina) bioassay from the stem bark of .Drymis beccariana Gibbs. led to isolate a bioactive compound called Velleral (<strong>1</strong>) ((3aS,8aS)-2,2,8-trimethyl-3,3a.6.8a-tetrahydro-1H-azulene-5,6-dicarbaldehyde).The structure of this compound was elucidated based on physical and spectroscopic data (UV, IR, , <sup>1</sup>H NMR, <sup>13</sup>C-NMR and&nbsp; GC-MS). This compound showed significant active in the&nbsp; A. salina bioassay with IC<sub>50</sub> 2.92 &micro;g/mL and &nbsp;exhibited siginificant cytotoxicity against&nbsp; murine P-388 leukemia cells with IC<sub>50</sub> 3,39 &mu;g /mL.Moreover, the compound exhibited antibacterial and antifungal activity especially against&nbsp; Staphyloccocus aureus&nbsp; ATCC 25923 and Candida albians respectively. This result indicates that stem bark of D. beccariana is a potential source of bioactive compounds</em><em>.</em>

scholarly journals Synthesis and Biological Activity of Some 3,4-Dihydro-4-(4-substituted aryl)-6-(naptho[2,1-b]furan-2-yl pyrimidine-2(1H)-one Derivatives

2012 ◽  
Vol 9 (1) ◽  
pp. 175-180 ◽  
Author(s):  
Sanjeevan S. Gaikwad ◽  
Venkat S. Suryawanshi ◽  
Kishan S. Lohar ◽  
Dhanaji V. Jadhav ◽  
Narayan D. Shinde
Keyword(s):  
Biological Activity ◽  
Potassium Hydroxide ◽  
Alcoholic Solution ◽  
Significant Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
Reflux Temperature

A series of new oxopyrimidine were prepared by cyclocondensation route with various substituted chalcones in presence of alcoholic solution of potassium hydroxide at reflux temperature. The synthesized oxopyrimidine derivatives were characterized by means of their IR,1H NMR, mass spectral data and elemental analysis. The synthesized oxopyrimidines derivatives were evaluated for antibacterial and antifungal activities, some of them were found to possess significant activity.

Synthesis, antiviral, cytotoxicity and antitumor evaluations of A4 type of porphyrin derivatives

2015 ◽  
Vol 19 (06) ◽  
pp. 753-768 ◽  
Author(s):  
Ahmed A. Fadda ◽  
Rasha E. El-Mekawy ◽  
Ahmed I. El-Shafei
Keyword(s):  
Spectral Data ◽  
Moderate Degree ◽  
Tumor Cell Lines ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Porphyrin Derivatives ◽  
Hiv 1 ◽  
C Nmr ◽  
Hsv 1

This manuscript describes the synthesis of a new series of porphyrin structures 4a–4m, 7, 9, 12 and 14. These structures were investigated against two types of viruses such as HIV-1 and HSV-1. Also they were screened for their antitumor activity. Among all tested compounds, it was found that compound 4b showed a high activity against HIV-1 and HSV-1 and against four different tumor cell lines. Most of the tested compounds showed a moderate degree of a potent antimicrobial activity. The structure of these compounds was confirmed on the basis of their analytical and spectral data such as UV-vis, IR, 13 C NMR, 1 H NMR spectroscopy and mass spectral data.

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