scholarly journals Prevalence of Congenital Anomalies: A Community-Based Study in the Northwest of Iran

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Hossein Mashhadi Abdolahi ◽  
Mohammad Hassan Kargar Maher ◽  
Farzaneh Afsharnia ◽  
Saeed Dastgiri
Keyword(s):  
Birth Defects ◽  
Rural Areas ◽  
Congenital Anomalies ◽  
Prevalence Rate ◽  
Heart Diseases ◽  
Similar Rate ◽  
Western Region ◽  
Mortality And Morbidity ◽  
Live Births ◽  
Northwest Of Iran

Background. Congenital anomalies are responsible for a remarkable proportion of mortality and morbidity in newborns. The aim of this study was to document the epidemiological features of congenital anomalies in rural areas, northwest of Iran. Method. The study population included live births born between 2004 and 2012 in rural areas of Tabriz district. All health records of the children under 8 years were assessed retrospectively. Results. Of 22500 live births, 254 cases were identified with a primary diagnosis of congenital anomalies giving a prevalence rate of 112.89 per 10 000 births (95% CI: 99.08 to 126.69). Anomalies of the nervous system were the most common defects, accounting for 24% of birth defects followed by the heart diseases anomalies. The highest prevalence rate for birth defects was observed in the south-western region with 386 per 10 000 births (95% CI: 215 to 556) compared to the similar rate in the north-western region with 15 per 10 000 births (95% CI: −14 to 45). Conclusion. The considerable geographic disparities in the prevalence of congenital anomalies in the region might be attributed to the highly polluted industrial zone in the area (including air and water pollution, etc.). This needs further etiological investigations in the region.

scholarly journals Prevalence and time trend of congenital heart defects: a registry-based study in Iran

2021 ◽  
Author(s):  
Hossein Molapour ◽  
Saeed Dastgiri ◽  
Elham Davtalabesmaeili
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Anomalies ◽  
Prevalence Rate ◽  
Congenital Heart ◽  
Time Trend ◽  
Heart Defects ◽  
Live Births ◽  
Registry System ◽  
Methodological Improvement ◽  
Northwest Of Iran

Introduction: Conclusion Congenital heart defects (CHD) are one of the most common types of congenital anomalies affecting one percent of births every year. The aim of this study was to report the prevalence and time trend of CHD in the northwest of Iran between 2000 and 2019. Methods: Since 2000, infants born with birth defects have been registered in Tabriz Registry of Congenital Anomalies (TRoCA). For this study, the information and data of newborns with CHD (1084) were collected using the TRoCA registry system. Results: Over two decades the prevalence rate of CHD in the northwest of Iran was 3.7 per 1000 live births (95 percent CI: 34.9 to 39.4). The prevalence rate of CHD during the first decade (2000-09) and the second (2010-19) were estimated 2.8 (95 percent CI: 2.5 to 2.9) and 5.9 (95 percent CI: 5.4 to 6.4) per 1000 live births, respectively. Conclusion: The prevalence rate of CHD in Iran showed an increasing trend indicating methodological improvement in the facilities and diagnosis techniques. It would therefore seem essential to concentrate on the primary prevention activities to reduce the burden of these defects. Keywords: Congenital heart defects, Prevalence, Congenital heart anomalies, Epidemiology

Incidence of congenital heart diseases in children born at Eastern Regional Referral Hospital, Monggar

2016 ◽  
Vol 2 (1) ◽  
pp. 1-4
Author(s):  
Purushotam Bhandari ◽  
Kezang Wangmo
Keyword(s):  
Birth Defects ◽  
Congenital Heart ◽  
Septal Defect ◽  
Heart Diseases ◽  
Referral Hospital ◽  
Congenital Heart Diseases ◽  
Regional Referral Hospital ◽  
True Incidence ◽  
Live Births ◽  
Eastern Regional

Introduction: Congenital heart diseases are the commonest birth defects worldwide. While the true incidence of congenital heart diseases is known in many countries, it has not been studied in Bhutan. Methods: Neonates born at the Eastern Regional Referral Hospital, Monggar in the year 2010 were screened for congenital heart diseases at birth by echocardiography and clinical examination including pulse oximetry. Results: The majority of the study subjects were natives of eastern districts of Bhutan. The incidence of congenital heart diseases was found to be 68 per 1000 live births, with Atrial Septal Defect being the commonest lesion. Conclusions: The overall incidence of congenital heart disease is higher than what is reported in other countries although the incidence of serious lesions was similar to what is reported elsewhere.

scholarly journals Pregnancy outcomes from the global pharmacovigilance database on interferon beta-1b exposure

2020 ◽  
Vol 13 ◽  
pp. 175628642091031 ◽  
Author(s):  
Kerstin Hellwig ◽  
Fernando Duarte Caron ◽  
Eva-Maria Wicklein ◽  
Aasia Bhatti ◽  
Alessandra Adamo
Keyword(s):  
Cohort Study ◽  
Health Status ◽  
Spontaneous Abortion ◽  
Birth Defects ◽  
Pregnancy Outcomes ◽  
Congenital Anomalies ◽  
Interferon Beta ◽  
Live Births ◽  
Congenital Birth Defects ◽  
Pharmacovigilance Database

Background: The goal of the present cohort study was to review outcomes of patients exposed to interferon beta-1b during pregnancy. Methods: Pregnancy cases with exposure to interferon beta-1b reported to Bayer’s pharmacovigilance (PV) database from worldwide sources from January 1995 through February 2018 were retrieved for evaluation. Only cases where pregnancy outcomes were unknown at the time of reporting (i.e. prospective cases) were included in the analysis of this retrospective cohort study. Results: As of February 2018, 2581 prospective pregnancies exposed to interferon beta-1b were retrieved from the database; 1348 pregnancies had documented outcomes. The majority of outcomes [1106 cases (82.0%)] were live births. Health status was known for 981 live births (no known health status for 125). Most of the prospective pregnancies with known outcomes corresponded to live births with no congenital anomalies [896 cases (91.3%)]. Spontaneous abortion occurred in 160 cases (11.9%). Congenital birth defects were observed in 14/981 live births with known health status [1.4%, 95% confidence interval (CI) 0.78–2.38]. No consistent pattern in the type of birth defect was identified. Rates of both spontaneous abortion and birth defects were not higher than the general population. Conclusions: These PV data, the largest sample of interferon beta-1b-exposed patients reported to date, suggest no increase in risk of spontaneous abortion or congenital anomalies in women exposed during pregnancy.

scholarly journals Pattern of congenital heart diseases in Western Rajasthan: an echocardiographic study

2020 ◽  
Vol 8 (4) ◽  
pp. 1385
Author(s):  
Anil Baroopal ◽  
Rohit Mathur ◽  
Sanjeev Sanghvi ◽  
J. P. Soni
Keyword(s):  
Congenital Heart ◽  
Septal Defect ◽  
Heart Diseases ◽  
Female Ratio ◽  
Mortality And Morbidity ◽  
Live Births ◽  
Medical College ◽  
Echocardiographic Study ◽  
Study Population ◽  
Male To Female

Background: Congenital heart disease (CHD) accounts for nearly one third of all major congenital anomalies. Globally the prevalence of CHD is 1.01 to 17.5 per 1000 live births. In India it is 1.3 to 26.4 per 1000 study population. CHD is an important cause of mortality and morbidity representing a global health burden. Early diagnosis and treatment may lead to improved prognosis in patients suffering from CHD. The aim of this study was to assess the pattern of CHD in Western Rajasthan, India by echocardiography.Methods: This was a retrospective study carried out at Dr. S. N. Medical College and attached group of hospitals in Jodhpur, Rajasthan, India. The study period was from July 2014 to June 2017. Records of all patients undergoing transthoracic echocardiography from newborn to 25 years of age were analyzed for age, sex and CHD findings.Results: In the study period, a total of 24,914 patients underwent echocardiography, of which 877 patients were identified as having CHD. Prevalence of CHD was 35.20 per 1000 study population. Amongst the total diagnosed CHD cases, 489 (55.76%) patients were male, with male to female ratio of 1.2:1. CHDs were diagnosed more commonly between 1 month and 1 year of age (41.28%). The commonest type of acyanotic CHD in the present study was ventricular septal defect (21.44%) and cyanotic CHD was tetralogy of Fallot (18.24%).Conclusions: Prevalence of CHD in Western Rajasthan, India was 35.20 per 1000 study population. Profile of CHDs in the present study was similar to that in published literature.

scholarly journals Maternal Age-Associated Congenital Anomalies Among Newborns: A Retrospective Study in Latvia

Medicina ◽  
2013 ◽  
Vol 49 (1) ◽  
pp. 6 ◽  
Author(s):  
Irisa Zīle ◽  
Anita Villeruša
Keyword(s):  
Retrospective Study ◽  
Live Birth ◽  
Congenital Anomalies ◽  
Prevalence Rate ◽  
Maternal Age ◽  
Birth Prevalence ◽  
Live Births ◽  
Medical Birth Register ◽  
Study Results ◽  
The Mean

Background and Objective. In Latvia, the mean age of women giving birth increased from 27.3 in 2000 to 29.0 years in 2010 during the last 11 years. The aim of this study was to report on major congenital anomalies of newborns at birth by the maternal age and to compare the mean maternal age by different diagnosis subgroups and maternal and neonatal characteristics. Material and Methods. A cross-sectional retrospective study with the data from the Medical Birth Register (2000–2010) was carried out. The live birth prevalence rate was calculated for the subgroups of major congenital anomalies per 10 000 live births by the maternal age. Results. The live birth prevalence rate of major congenital anomalies during the period 2000– 2010 was 211.4 per 10 000 live births. The prevalence rate increased depending on the maternal age. Congenital heart defects, limb defects, and urinary system anomalies were the most common anomalies. The study results showed an age-related risk of abdominal wall defects, orofacial clefts, and chromosomal anomalies. There were significantly higher proportions of preterm births, newborns with low birth weight, and complications during pregnancy among mothers aged 35 years and more. Conclusions. The data on congenital anomalies from the Latvian Medical Birth Register can be used for the assessment of epidemiology of congenital anomalies. The results of this retrospective study showed a decrease in the live birth prevalence rate of major congenital anomalies despite an increase in the mean age of mothers in Latvia.

scholarly journals Congenital Anomalies among the Babies of Diabetic Mothers with Uncontrolled Blood Sugar -A Study in a Tertiary Hospital

2017 ◽  
Vol 29 (1) ◽  
pp. 26-31
Author(s):  
Kazi Taslima
Keyword(s):  
Blood Sugar ◽  
Birth Defects ◽  
Congenital Anomalies ◽  
Heart Diseases ◽  
Tertiary Hospital ◽  
Diabetic Control ◽  
Renal Anomalies ◽  
Uncontrolled Diabetes ◽  
Minor Anomalies ◽  
Diabetic Mothers

Diabetes mellitus is a silent killer which affects at any stage of life. Worldwide incidence of major malformation among the offspring of diabetic mothers ranges from 5-10%. Though 65-75% of birth defects are multifactorial, poor diabetic control in pregnancy predisposes congenital malformation. The aim of this retrospective study is to see the actual picture of congenital anomalies among the babies of uncontrolled diabetic mothers. Cases are taken from the hospital records of the patients who delivered congenitally abnormal babies & were admitted in SCABU of BIRDEM during the period of January, 2006 to December, 2010. After going through all records, patients were divided into DM/GDM/ND groups and different variables are studied. Among the patients (163), 57 (35%) were DM, 38 were (23.3%) GDM and 68 (41.7%) were ND. Major congenital anomalies were found 82.45% in DM and 71.05% in GDM and 83.82% in ND patients. Rests were minor anomalies. Among the anomalies maximum were congenital heart diseases, then CNS anomalies, then renalanomalies and then others. In this study congenital anomalies were found 1.4 times more in DM patients. Among DM and GDM patients maximum had uncontrolled blood sugar. Neonatal mortality was higher in DM and GDM groups. Both cardiac and CNS abnormalities were 1.2 times higher in diabetic groups. Renal anomalies were 2.8 times higher. Limb abnormalities were 7.15 times higher in diabetic groups. So it is concluded that pregnancy with uncontrolled diabetes increases the risk of birth defects, mainly CVS, CNS and Renal system related.Medicine Today 2017 Vol.29(1): 26-31

Congenital Anomalies Among Singleton Live Births in a Tertiary Care Teaching Hospital

2011 ◽  
Vol 3 (11) ◽  
pp. 358-360
Author(s):  
Manikanta Reddy. V Manikanta Reddy. V ◽  
◽  
Senthil Kumar. S Senthil Kumar. S ◽  
Sanjeeva Reddy. N Sanjeeva Reddy. N
Keyword(s):  
Teaching Hospital ◽  
Congenital Anomalies ◽  
Tertiary Care ◽  
Tertiary Care Teaching Hospital ◽  
Live Births ◽  
Care Teaching

Demographic Factors Associated with Congenital Malformations Among Young Infants in Fallujah Maternity and Children Hospital, Fallujah City, Iraq

2020 ◽  
pp. 1-5
Author(s):  
Samira T.Abdulghani ◽  
Samira T.Abdulghani
Keyword(s):  
Developing Countries ◽  
Congenital Anomalies ◽  
Prevalence Rate ◽  
Gestational Hypertension ◽  
Heart Defects ◽  
Demographic Factors ◽  
Cross Sectional ◽  
Factors Associated ◽  
Young Infants ◽  
History Of

Background: Congenital anomalies are a major cause of infant morbidity and mortality in developing countries including our country. Registries and data on these anomalies are still primitive and poorly collated. In this study we aimed to assess the important demographic factors associated with the development of congenital anomalies. Methods: This was a cross-sectional hospital-based study involving 880 infants in the 1st year of life registered in the birth defect unit in Fallujah Maternity and Children Hospital in the period between 1st of January 2017 to the 31st of December 2019. The prevalence rate, the pattern of anomalies and the factors associated with their occurrence were determined. Results: The prevalence rate of the group enrolled in this study was 31/1000 total births, congenital heart defects was the commonest followed by central nervous system anomalies, 58% of the infants were males, 65% had ≥ 2.5 kg birth weight & 95% were singletons. Family history of congenital anomalies was found in 31.25% of cases. The largest group of mothers (55.7%) were 21-30 years old & 92.5% of fathers were less than 45 years old. Parental consanguinity reported in 64.3% of the total cases. Only 4.5% of mothers reported history of fever during pregnancy, and none of them had history of exposure to x-ray or teratogenic drug use. Gestational hypertension was reported in 10% of the total (880) mothers, hypertension and diabetes mellitus in 0.3%, while hepatitis C, hepatitis B, toxoplasmosis and epilepsy, each was reported in only one mother (0.1% of the total). Regarding the outcome of pregnancy, 66.6% were live births, 24.2% were abortions and 9.2% were stillbirths. History of previous abortions was reported in 22% of cases. Urban residents accounted for 63% of the families of congenitally abnormal infants while 37% were rural. Conclusion: Congenital anomalies are still a major cause for concern and tension in Fallujah society, there is serious need to establish a surveillance and good statistical system for congenital anomalies and efforts should be made to raise awareness of their occurrence and the associated risk factors in Iraq and other developing countries.

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