scholarly journals Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Giovanni Tarantino ◽  
Carmine Finelli ◽  
Franco Scopacasa ◽  
Fabrizio Pasanisi ◽  
Franco Contaldo ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Fatty Acids ◽  
Coronary Artery ◽  
Free Fatty Acids ◽  
Disease Risk ◽  
Oxidative Capacity ◽  
Obese Patients ◽  
Potential Marker ◽  
Artery Disease ◽  
Circulating Levels

The present study shows low circulating levels of SIRT4 in obese patients with nonalcoholic fatty liver disease mirroring its reduced mitochondrial expression in an attempt to increase the fat oxidative capacity and then the mitochondrial function in liver and in muscle. SIRT4 modulates the metabolism of free fatty acids reducing their high circulating levels but, unfortunately, increasing ROS production. Great concentration of free fatty acids, released by adipose tissue, coupled with oxidative stress, directly results in endothelial dysfunction, early atherosclerosis, and coronary artery disease risk factor.

scholarly journals Impact of free fatty acids on prognosis in coronary artery disease patients under different glucose metabolism status

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Jing-Lu Jin ◽  
Ye-Xuan Cao ◽  
Hui-Hui Liu ◽  
Hui-Wen Zhang ◽  
Yuan-Lin Guo ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Fatty Acids ◽  
Coronary Artery ◽  
Glucose Metabolism ◽  
Free Fatty Acids ◽  
Cox Model ◽  
Stable Coronary Artery Disease ◽  
P Value ◽  
Significant Difference ◽  
Artery Disease

Abstract Background The aim of the present study is to examine the effects of free fatty acids (FFAs) on major cardiovascular events (MACEs) in patients with stable coronary artery disease (CAD) and different glucose metabolism status. Methods In this study, we consecutively enrolled 5443 patients from March 2011 to May 2015. Patients were categorized according to both status of glucose metabolism status [diabetes mellitus (DM), pre-diabetes (Pre-DM), normal glycaemia regulation (NGR)] and FFAs levels. All subjects were followed up for the occurrence of the MACEs. Results During a median of 6.7 years’ follow-up, 608 MACEs occurred. A twofold higher FFAs level was independently associated with MACEs after adjusting for confounding factors [Hazard Ratio (HR): 1.242, 95% confidence interval (CI) 1.084–1.424, p value = 0.002]. Adding FFAs to the Cox model increased the C-statistic by 0.015 (0.005–0.027). No significant difference in MACEs was observed between NGR and Pre-DM groups (p > 0.05). When patients were categorized by both status of glucose metabolism and FFAs levels, medium and high FFAs were associated with significantly higher risk of MACEs in Pre-DM [1.736 (1.018–2.959) and 1.779 (1.012–3.126), all p-value < 0.05] and DM [2.017 (1.164–3.494) and 2.795 (1.619–4.824), all p-value < 0.05]. Conclusions The present data indicated that baseline FFAs levels were associated with the prognosis in DM and Pre-DM patients with CAD, suggesting that FFAs may be a valuable predictor in patients with impaired glucose metabolism.

scholarly journals Multivessel coronary artery disease, free fatty acids, oxidized LDL and its antibody in myocardial infarction

2014 ◽  
Vol 13 (1) ◽  
pp. 111 ◽  
Author(s):  
Olga Gruzdeva ◽  
Evgenya Uchasova ◽  
Yulia Dyleva ◽  
Ekaterina Belik ◽  
Victoria Karetnikova ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Fatty Acids ◽  
Coronary Artery ◽  
Free Fatty Acids ◽  
Oxidized Ldl ◽  
Multivessel Coronary Artery Disease ◽  
Artery Disease ◽  
Disease Free
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