scholarly journals Changes in Cardiopulmonary Reserve and Peripheral Arterial Function Concomitantly with Subclinical Inflammation and Oxidative Stress in Patients with Heart Failure with Preserved Ejection Fraction

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Damien Vitiello ◽  
François Harel ◽  
Rhian M. Touyz ◽  
Martin G. Sirois ◽  
Joel Lavoie ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Blood Flow ◽  
Ejection Fraction ◽  
Arterial Blood Flow ◽  
Preserved Ejection Fraction ◽  
Arterial Blood ◽  
Patients With Heart Failure ◽  
Peripheral Arterial ◽  
And Oxidative Stress

Background. Changes in cardiopulmonary reserve and biomarkers related to wall stress, inflammation, and oxidative stress concomitantly with the evaluation of peripheral arterial blood flow have not been investigated in patients with heart failure with preserved ejection fraction (HFpEF) compared with healthy subjects (CTL).Methods and Results. Eighteen HFpEF patients and 14 CTL were recruited. Plasma levels of inflammatory and oxidative stress biomarkers were measured at rest. Brain natriuretic peptide (BNP) was measured at rest and peak exercise. Cardiopulmonary reserve was assessed using an exercise protocol with gas exchange analyses. Peripheral arterial blood flow was determined by strain gauge plethysmography. Peak VO2(12.0±0.4versus19.1±1.1 mL/min/kg,P<0.001) and oxygen uptake efficiency slope (1.55±0.12versus2.06±0.14,P<0.05) were significantly decreased in HFpEF patients compared with CTL. BNP at rest and following stress, C-reactive-protein, interleukin-6, and TBARS were significantly elevated in HFpEF. Both basal and posthyperemic arterial blood flow were not significantly different between the HFpEF patients and CTL.Conclusions. HFpEF exhibits a severe reduction in cardiopulmonary reserve and oxygen uptake efficiency concomitantly with an elevation in a broad spectrum of biomarkers confirming an inflammatory and prooxidative status in patients with HFpEF.

Abstract 500: Basal Peripheral Arterial Blood Flow Increases Concomitantly with Decreased Cardiopulmonary Reserve and Biomarkers Activation in Patients with Heart Failure and Preserved Ejection Fraction

2013 ◽  
Vol 33 (suppl_1) ◽  
Author(s):  
Damien Vitiello ◽  
François Harel ◽  
Rhian M Touyz ◽  
Martin G Sirois ◽  
Joel Lavoie ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Blood Flow ◽  
Arterial Blood Flow ◽  
Subclinical Inflammation ◽  
Preserved Ejection Fraction ◽  
Arterial Function ◽  
Arterial Blood ◽  
Peripheral Arterial ◽  
And Oxidative Stress

Background The underlying pathophysiology of heart failure with preserved ejection fraction (HFpEF) remains poorly understood. Changes in peripheral arterial function concomitantly with the evaluation of cardiopulmonary reserve and biomarkers related to wall stress, extra-cellular matrix turnover (ECM), subclinical inflammation and oxidative stress have not been investigated in patients with HFpEF nor compared with age-matched healthy volunteers (HV). We hypothesized that patients with HFpEF would have impairments in cardiac reserve with reduced peripheral arterial function associated with broad-spectrum biomarkers activation. Methods Eighteen male and female HFpEF patients (aged 70 ± 9 yr) NYHA class II and III were recruited. Data from patients were compared with those from 14 age and sex matched HV. A maximal exercise testing with gas exchange analysis was completed on a treadmill using a RAMP protocol and heart rate recovery (HRR) was measured at 1 and 2 minutes following exercise. Peripheral arterial function was assessed using near infrared radionuclide plethysmography. Biomarkers included BNP, NT-proBNP, hsCRP, TBARS, 8-epi-prostaglandin F2α, MMP 1, 2, 9 and TIMP 1, 2, 3, 4) were analyzed. Results Selected data are presented in the Table 1 and 2. Conclusions Compared to healthy volunteers, patients with HFpEF demonstrated a significant decrease in aerobic capacity but an increase in basal peripheral arterial blood flow, subclinical inflammation and oxidative stress. The increase in resting arterial blood flow may be a compensatory mechanism for the decrease in cardiac reserve and the pro-inflammatory/oxidant milieu in these patients.

scholarly journals EFFECT OF UROCORTIN 2 AND 3 ON FOREARM ARTERIAL BLOOD FLOW IN PATIENTS WITH HEART FAILURE

2013 ◽  
Vol 61 (10) ◽  
pp. E647 ◽  
Author(s):  
Sowmya Venkatasubramanian ◽  
Duncan Philp ◽  
Audrey White ◽  
Ninian Lang
Keyword(s):  
Heart Failure ◽  
Blood Flow ◽  
Arterial Blood Flow ◽  
Arterial Blood ◽  
Patients With Heart Failure

scholarly journals Effect of combination antihypertensive therapy, including renin-angiotensin-aldosterone system inhibitors, on oxidative stress and arterial remodeling in hypertensive patients with heart failure with preserved ejection fraction

2021 ◽  
Vol 26 (5) ◽  
pp. 4158
Author(s):  
Z. M. Akhilgova ◽  
A. P. Roitman ◽  
N. G. Rakova ◽  
A. V. Bugrov ◽  
E. A. Pavlovskaya ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Ejection Fraction ◽  
Endothelial Function ◽  
Left Atrial ◽  
Arterial Remodeling ◽  
Preserved Ejection Fraction ◽  
Triple Combination Therapy ◽  
Hypertensive Patients ◽  
Patients With Heart Failure

Aim. To study the effect of triple combination therapy on oxidative stress and arterial remodeling in hypertensive patients with heart failure with preserved ejection fraction (HFpEF).Material and methods. The study involved 76 people with diagnosed HFpEF. After a comprehensive examination, patients were randomized into two equal groups: first group — patients who received perindopril 10 mg, indapamide 2,5mg and amlodipine 5 mg; second — patients who received losartan 100 mg, indapamide 2,5 mg, amlodipine 5 mg. Before and 16 weeks after the therapy initiation, cardiac ultrasound, assessment of endothelial function with estimating endothelium-dependent vasodilation, assessment of vascular stiffness by photoplethysmography and compression oscillometry were carried out. The plasma concentration of oxidative stress marker 8-isoprostane was studied.Results. During the follow-up period, a significant improvement in endothelial function was noted: in the first group — from 8,1% to 11,4% (p=0,001), in the second — from 5,8% to 8,3% (p=0,0007). In both groups, there was an improvement in microvessel elasticity: a significant decrease in specific peripheral vascular resistance, as well as a significant decrease in total peripheral resistance in the first group (p<0,002) and a tendency to decrease in the second one (p>0,05). There was a significant increase in the stiffness of the aorta and muscular arteries in both groupsю In the first group, a stiffness index decreased from 10,38 m/s to 8,33 m/s (p<0,0001), in the second — from 10,6 m/s to 9,3 m/s (p<0,01). In addition, resistance index in the first group decreased from 71,5% to 60% (p<0,0001), while in the second — from 68% to 60% (p=0,006). Also, both groups showed a significant decrease in the left atrial diastolic dimension and the left atrial volume index. A decrease in the 8-isoprostane plasma levels was noted, which indicates a decrease in oxidative stress.Conclusion. Oxidative stress, which develops due to chronic systemic inflammation, plays a key role in the pathogenesis of HFpEF. The results obtained show an improved endothelial function as a result of decrease in oxidative stress, which is accompanied by an improvement in vessel wall elasticity, thereby slowing down the heart failure progression.

scholarly journals Reduced peripheral arterial blood flow with preserved cardiac output during submaximal bicycle exercise in elderly heart failure

2009 ◽  
Vol 11 (1) ◽  
pp. 48 ◽  
Author(s):  
Chirapa Puntawangkoon ◽  
Dalane W Kitzman ◽  
Stephen B Kritchevsky ◽  
Craig A Hamilton ◽  
Barbara Nicklas ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Flow ◽  
Cardiac Output ◽  
Arterial Blood Flow ◽  
Bicycle Exercise ◽  
Arterial Blood ◽  
Peripheral Arterial

Estimating exercise PaCO2 in patients with heart failure with preserved ejection fraction

2021 ◽  
Author(s):  
Bryce N. Balmain ◽  
Andrew R. Tomlinson ◽  
James P. MacNamara ◽  
Satyam Sarma ◽  
Benjamin D. Levine ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Dead Space ◽  
Blood Gases ◽  
Constant Load ◽  
Peak Exercise ◽  
Preserved Ejection Fraction ◽  
Arterial Blood Gases ◽  
Arterial Blood ◽  
Patients With Heart Failure

Heart failure with preserved ejection fraction (HFpEF) patients exhibit cardiopulmonary abnormalities that could affect the predictability of exercise PaCO2 from the Jones (PJCO2) equation (PJCO2=5.5+0.9xPETCO2-2.1xVT). Since the dead space to tidal volume (VD/VT) calculation also includes PaCO2 measurements, estimates of VD/VT from PJCO2 may also be affected. Because using noninvasive estimates of PaCO2 and VD/VT could save patient discomfort, time, and cost, we examined whether PETCO2 and PJCO2 can be used to estimate PaCO2 and VD/VT in 13 HFpEF patients. PETCO2 was measured from expired gases measured simultaneously with radial arterial blood gases at rest, constant-load (20W), and peak exercise. VD/VT[art] was calculated using the Enghoff modification of the Bohr equation, and estimates of VD/VT were calculated using PETCO2 (VD/VT[ET]) and PJCO2 (VD/VT[J]) in place of PaCO2. PETCO2 was similar to PaCO2 at rest (-1.46±2.63, P=0.112) and peak exercise (0.66±2.56, P=0.392), but overestimated PaCO2 at 20W (-2.09±2.55, P=0.020). PJCO2 was similar to PaCO2 at rest (-1.29±2.57, P=0.119) and 20W (-1.06±2.29, P=0.154); but, underestimated PaCO2 at peak exercise (1.90±2.13, P=0.009). VD/VT[ET] was similar to VD/VT[art] at rest (-0.01±0.03, P=0.127) and peak exercise (0.01±0.04, P=0.210), but overestimated VD/VT[art] at 20W (-0.02±0.03, P=0.025). Although VD/VT[J] was similar to VD/VT[art] at rest (-0.01±0.03, P=0.156) and 20W (-0.01±0.03, P=0.133), VD/VT[J] underestimated VD/VT[art] at peak exercise (0.03±0.04, P=0.013). Exercise PETCO2 and VD/VT[ET] provide better estimates of PaCO2 and VD/VT[art] than PJCO2 and VD/VT[J] does at peak exercise. Thus, estimates of PaCO2 and VD/VT should only be used if sampling arterial blood during CPET is not feasible.

scholarly journals Prevalence of peripheral arterial disease in patients with heart failure with preserved ejection fraction

Clinics ◽  
2019 ◽  
Vol 74 ◽  
Author(s):  
Giuliano Reolon da Cunha ◽  
Roberto José Brugnarotto ◽  
Victória Armendaris El Halal ◽  
Márcio Garcia Menezes ◽  
Eduardo Bartholomay ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Preserved Ejection Fraction ◽  
Patients With Heart Failure ◽  
Peripheral Arterial
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