scholarly journals Cytotoxicity Potentials of Eleven Bangladeshi Medicinal Plants

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Amina Khatun ◽  
Mahmudur Rahman ◽  
Tania Haque ◽  
Md. Mahfizur Rahman ◽  
Mahfuja Akter ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Reducing Sugars ◽  
Artemia Salina ◽  
Vincristine Sulphate ◽  
Different Types ◽  
Litsea Glutinosa ◽  
Ethnomedicinal Uses ◽  
First Time ◽  
Different Parts ◽  
Carcinoma Tumor

Various forms of cancer are rising all over the world, requiring newer therapy. The quest of anticancer drugs both from natural and synthetic sources is the demand of time. In this study, fourteen extracts of different parts of eleven Bangladeshi medicinal plants which have been traditionally used for the treatment of different types of carcinoma, tumor, leprosy, and diseases associated with cancer were evaluated for their cytotoxicity for the first time. Extraction was conceded using methanol. Phytochemical groups like reducing sugars, tannins, saponins, steroids, gums, flavonoids, and alkaloids were tested using standard chromogenic reagents. Plants were evaluated for cytotoxicity by brine shrimp lethality bioassay usingArtemia salinacomparing with standard anticancer drug vincristine sulphate. All the extracts showed potent to moderate cytotoxicity ranging from LC502 to 115 µg/mL. The highest toxicity was shown byHygrophila spinosaseeds (LC50=2.93 µg/mL) and the lowest byLitsea glutinosaleaves (LC50=114.71 µg/mL) in comparison with standard vincristine sulphate (LC50=2.04 µg/mL). Among the plants, the plants traditionally used in different cancer and microbial treatments showed highest cytotoxicity. The results support their ethnomedicinal uses and require advanced investigation to elucidate responsible compounds as well as their mode of action.

scholarly journals Broad-spectrum survey of medicinal plants as a potential source of anticancer agents

2022 ◽  
Vol 21 (1) ◽  
pp. 1-40
Author(s):  
K Saranya ◽  
◽  
V Manivasagan ◽  
K Gopi ◽  
K Karthik ◽  
...  
Keyword(s):  
Cell Division ◽  
Side Effects ◽  
Medicinal Plants ◽  
Broad Spectrum ◽  
Anticancer Agents ◽  
Cancer Treatments ◽  
Potential Source ◽  
African Populations ◽  
Different Types ◽  
Different Parts

Cancer is an abnormal and uncontrolled growth of cells that spreads through cell division. There are different types of medicines available to treat cancers, but no drug is found to be fully effective and safe for humans. The major problem involved in the cancer treatments is the toxicity of the established drug and their side effects. Medicinal plants are used as folk medicines in Asian and African populations for thousands of years. 60% of the drugs for treating cancer are derived from plants. More than 3000 plants have anticancer activity. The present review aims at the study of a broad spectrum survey of plants having anticancer components for different type of cancers. This article consists of 364 medicinal plants and their different parts as potential Source of Anticancer Agents.

scholarly journals Language choice, language alternation and code-switching in the Mercator-Hondius Atlas

2016 ◽  
Vol 6 (1) ◽  
pp. 35-45
Author(s):  
Aleksi Mäkilähde
Keyword(s):  
Present Article ◽  
Language Choice ◽  
Code Switching ◽  
Switching Patterns ◽  
Language Alternation ◽  
Different Types ◽  
First Editions ◽  
Linguistic Approach ◽  
First Time ◽  
Different Parts

The atlas of Gerardus Mercator (Gerard de Cremer), or the Atlas sive cosmographicae meditationes de fabrica mundi et fabricati figura, is one of first modern atlases and one of the most famous of those compiled in the Netherlands. The first (unfinished) edition was published in 1595, but the copperplates were later acquired by Jodocus Hondius (Joost de Hondt) and his business associates. The revised Mercator-Hondius Atlas was published for the first time in 1606 with added maps and texts. The texts printed on verso of the maps were written by Petrus Montanus (Pieter van den Berg), who was a brother-in-law of Hondius and a Latin teacher. Many subsequent editions of the atlas were produced in the years that followed. The first editions were in Latin, but versions in European vernaculars such as French, German and Italian were produced later as well. The present article focuses on the multilingual nature of the Mercator-Hondius Atlas (1613, editio quarta) by discussing language choice, language alternation and code-switching patterns in different parts of the atlas. The dominant language of the descriptive texts is Latin, but there are also switches into many other languages, including Greek (written in Greek script) and several vernaculars. Furthermore, the map pages tend to indicate the names of different types of area (e.g. cities, seas, and oceans) in different languages. The aim of the present article is to provide a preliminary exploration of the possibilities of approaching the atlas with the aid of concepts and ideas derived from modern code-switching studies. I demonstrate how these concepts can be used to describe the language choice patterns in the text and discuss some of the challenges the data poses for a linguistic approach.

scholarly journals Tetracarpidium conophorum (African walnut) Hutch. & Dalziel: Ethnomedicinal uses and its therapeutic activities

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Ayeni E. Ayodeji ◽  
Nuhu Aliyu
Keyword(s):  
Medicinal Plants ◽  
Healthcare Management ◽  
African Countries ◽  
Pharmacological Activities ◽  
The Family ◽  
The World ◽  
Edible Seed ◽  
Therapeutic Activities ◽  
Ethnomedicinal Uses ◽  
Different Parts

The use of medicinal plants to cure many ailments has been a tradition in different parts of the world. Tetracarpidium conophorum (African walnut) belongs to the family Euphorbiaceae. It is an edible seed that is widely cultivated for its delicacy. All parts of the plant have been used ethnomedically. This article reviewed the ethnomedicinal, nutritional, phytochemical and some pharmacological activities of T. conophorum, because medicinal plants are our hope in achieving sustainable global statutory of health for all and a last resort in healthcare management in African countries. This review reveals previous findings and other pharmacological benefits of the African walnut towards its potential as food and drug development.

Probabilistic Assessment of Reliability and Risk Values by Certification Results

2020 ◽  
pp. 52-67
Author(s):  
Vladimir A. Lapin ◽  
Erken S. Aldakhov ◽  
S. D. Aldakhov ◽  
A. B. Ali
Keyword(s):  
Seismic Risk ◽  
Housing Stock ◽  
Seismic Resistance ◽  
Probabilistic Assessment ◽  
Quantitative Estimates ◽  
Different Types ◽  
Reduce Risk ◽  
First Time ◽  
Structural Solutions ◽  
Practical Recommendations

For the first time in Almaty full passport of apartment stock of multiapartment building was carried out. The structure of the housing stock was revealed with the allocation of groups of buildings according to structural solutions and assessment of their seismic resistance. Based on the results of certification, quantitative estimates of failure probability values for different types of buildings were obtained. Formulas for estimation of quantitative value of seismic risk are obtained. The number of deaths in the estimated zem-shakes was estimated. The results of the assessments will be used for practical recommendations to reduce risk and expected losses in possible earthquakes.

Status of Family Fissidentaceae in Gujarat

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
D.G. Shah ◽  
D.N. Mehta ◽  
R.V. Gujar
Keyword(s):  
Distinct Species ◽  
The State ◽  
The Other ◽  
Land Plants ◽  
Reproductive Structures ◽  
The Family ◽  
The Status ◽  
Vegetative Characters ◽  
First Time ◽  
Different Parts

Bryophytes are the second largest group of land plants and are also known as the amphibians of the plant kingdom. 67 species of bryophytes have been reported from select locations across the state of Gujrat. The status of family fissidentaceae which is a large moss family is being presented in this paper. Globally the family consists of 10 genera but only one genus, Fissidens Hedw. has been collected from Gujarat. Fissidens is characterized by a unique leaf structure and shows the presence of three distinct lamina, the dorsal, the ventral and the vaginant lamina. A total of 8 species of Fissidens have been reported from the state based on vegetative characters as no sporophyte stages were collected earlier. Species reported from the neighboring states also showed the absence of sporophytes. The identification of different species was difficult due to substantial overlap in vegetative characters. Hence a detailed study on the diversity of members of Fissidentaceae in Gujarat was carried out between November 2013 and February 2015. In present study 8 distinct species of Fissidens have been collected from different parts of the state. Three species Fissidens splachnobryoides Broth., Fissidens zollingerii Mont. and Fissidens curvato-involutus Dixon. have been identified while the other five are still to be identified. Fissidens zollingerii Mont. and Fissidens xiphoides M. Fleisch., which have been reported as distinct species are actually synonyms according to TROPICOS database. The presence of sexual reproductive structures and sporophytes for several Fissidens species are also being reported for the first time from the state.

The Small State Challenge

2018 ◽  
Author(s):  
Jack Corbett ◽  
Wouter Veenendaal
Keyword(s):  
Comparative Politics ◽  
Institutional Design ◽  
Small States ◽  
Small State ◽  
Informal Politics ◽  
Different Types ◽  
Approach Method ◽  
Key Terms ◽  
First Time

Chapter 1 introduces the main arguments of the book; outlines the approach, method, and data; defines key terms; and provides a chapter outline. Global theories of democratization have systematically excluded small states, which make up roughly 20 per cent of countries. These cases debunk mainstream theories of why democratization succeeds or fails. This book brings small states into the comparative politics fold for the first time. It is organized thematically, with each chapter tackling one of the main theories from the democratization literature. Different types of data are examined—case studies and other documentary evidence, interviews and observation. Following an abductive approach, in addition to examining the veracity of existing theory, each chapter is also used to build an explanation of how democracy is practiced in small states. Specifically, we highlight how small state politics is shaped by personalization and informal politics, rather than formal institutional design.

scholarly journals MiRNA Expression in Neuroendocrine Neoplasms of Frequent Localizations

2021 ◽  
Vol 7 (3) ◽  
pp. 38
Author(s):  
Alexandra Korotaeva ◽  
Danzan Mansorunov ◽  
Natalya Apanovich ◽  
Anna Kuzevanova ◽  
Alexander Karpukhin
Keyword(s):  
Mirna Expression ◽  
Malignant Tumors ◽  
Neuroendocrine Neoplasms ◽  
Specific Expression ◽  
Clinical Biomarkers ◽  
Different Types ◽  
Functional Features ◽  
First Time ◽  
Potential Biomarkers

Neuroendocrine neoplasms (NEN) are infrequent malignant tumors of a neuroendocrine nature that arise in various organs. They occur most frequently in the lungs, intestines, stomach and pancreas. Molecular diagnostics and prognosis of NEN development are highly relevant. The role of clinical biomarkers can be played by microRNAs (miRNAs). This work is devoted to the analysis of data on miRNA expression in NENs. For the first time, a search for specificity or a community of their functional characteristics in different types of NEN was carried out. Their properties as biomarkers were also analyzed. To date, more than 100 miRNAs have been characterized as differentially expressed and significant for the development of NEN tumors. Only about 10% of the studied miRNAs are expressed in several types of NEN; differential expression of the remaining 90% was found only in tumors of specific localizations. A significant number of miRNAs have been identified as potential biomarkers. However, only a few miRNAs have values that characterized their quality as markers. The analysis demonstrates the predominant specific expression of miRNA in each studied type of NEN. This indicates that miRNA’s functional features are predominantly influenced by the tissue in which they are formed.

scholarly journals Flavonoid Glycosides with a Triazole Moiety for Marine Antifouling Applications: Synthesis and Biological Activity Evaluation

Marine Drugs ◽  
2020 ◽  
Vol 19 (1) ◽  
pp. 5
Author(s):  
Daniela Pereira ◽  
Catarina Gonçalves ◽  
Beatriz T. Martins ◽  
Andreia Palmeira ◽  
Vitor Vasconcelos ◽  
...  
Keyword(s):  
Qsar Model ◽  
Quantitative Structure Activity Relationship ◽  
Artemia Salina ◽  
Flavonoid Glycosides ◽  
Antifouling Activity ◽  
Antifouling Coatings ◽  
Marine Industry ◽  
Low Toxicity ◽  
Polymethoxylated Flavones ◽  
First Time

Over the last decades, antifouling coatings containing biocidal compounds as active ingredients were used to prevent biofouling, and eco-friendly alternatives are needed. Previous research from our group showed that polymethoxylated chalcones and glycosylated flavones obtained by synthesis displayed antifouling activity with low toxicity. In this work, ten new polymethoxylated flavones and chalcones were synthesized for the first time, including eight with a triazole moiety. Eight known flavones and chalcones were also synthesized and tested in order to construct a quantitative structure-activity relationship (QSAR) model for these compounds. Three different antifouling profiles were found: three compounds (1b, 11a and 11b) exhibited anti-settlement activity against a macrofouling species (Mytilus galloprovincialis), two compounds (6a and 6b) exhibited inhibitory activity against the biofilm-forming marine bacteria Roseobacter litoralis and one compound (7b) exhibited activity against both mussel larvae and microalgae Navicula sp. Hydrogen bonding acceptor ability of the molecule was the most significant descriptor contributing positively to the mussel larvae anti-settlement activity and, in fact, the triazolyl glycosylated chalcone 7b was the most potent compound against this species. The most promising compounds were not toxic to Artemia salina, highlighting the importance of pursuing the development of new synthetic antifouling agents as an ecofriendly and sustainable alternative for the marine industry.

scholarly journals Second-order neutrosophic boundary-value problem

2021 ◽  
Author(s):  
Sandip Moi ◽  
Suvankar Biswas ◽  
Smita Pal(Sarkar)
Keyword(s):  
Differential Equation ◽  
Boundary Value Problem ◽  
Differential Calculus ◽  
Boundary Value ◽  
Second Order ◽  
Numerical Examples ◽  
Different Types ◽  
First Time

AbstractIn this article, some properties of neutrosophic derivative and neutrosophic numbers have been presented. This properties have been used to develop the neutrosophic differential calculus. By considering different types of first- and second-order derivatives, different kind of systems of derivatives have been developed. This is the first time where a second-order neutrosophic boundary-value problem has been introduced with different types of first- and second-order derivatives. Some numerical examples have been examined to explain different systems of neutrosophic differential equation.

scholarly journals The Volatile Phytochemistry of Seven Native American Aromatic Medicinal Plants

Plants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1061
Author(s):  
Sims K. Lawson ◽  
Prabodh Satyal ◽  
William N. Setzer
Keyword(s):  
Native American ◽  
Medicinal Plants ◽  
Essential Oil ◽  
Essential Oils ◽  
Palmitic Acid ◽  
Methyl Salicylate ◽  
Chromatographic Techniques ◽  
Germacrene D ◽  
First Time ◽  
Gaultheria Procumbens

As part of our evaluation of essential oils derived from Native American medicinal plants, we have obtained the essential oils of Agastache foeniculum (Pursch) Kuntze (Lamiaceae), Gaultheria procumbens L. (Ericaceae), Heliopsis helianthoides (L.) Sweet (Asteraceae), Liatris spicata (L.) Willd. (Asteraceae), Pycnanthemum incanum (L.) Michx. (Lamiaceae), Smallanthus uvedalia (L.) Mack. ex Mack. (Asteraceae), and Verbena hastata L. (Verbenaceae) by hydrodistillation. The essential oils were analyzed by gas chromatographic techniques. The essential oil of A. foeniculum was dominated by estragole (88–93%), while methyl salicylate (91%) dominated the G. procumbens essential oil. Germacrene D was the major component in H. helianthoides (42%) and L. spicata (24%). 1,8-Cineole (31%) and α-terpineol (17%) were the main compounds in P. incanum essential oil. The essential oil of S. uvedalia showed α-pinene (24%), perillene (15%), and β-caryophyllene (17%) as major components. Verbena hastata essential oil was rich in 1-octen-3-ol (up to 29%) and palmitic acid (up to 22%). Four of these essential oils, H. helianthoides, L. spicata, P. incanum, and V. hastata, are reported for the first time. Additionally, the enantiomeric distributions of several terpenoid components have been determined.

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