scholarly journals Erratum to “A Minimal-Invasive Metabolic Test Detects Malignant Hyperthermia Susceptibility in a Patient after Sevoflurane-Induced Metabolic Crisis”

2014 ◽  
Vol 2014 ◽  
pp. 1-1
Author(s):  
Frank Schuster ◽  
Stephan Johannsen ◽  
Norbert Roewer ◽  
Martin Anetseder
Keyword(s):  
Malignant Hyperthermia ◽  
Minimal Invasive ◽  
Malignant Hyperthermia Susceptibility ◽  
Metabolic Crisis ◽  
Metabolic Test

scholarly journals A Minimal-Invasive Metabolic Test Detects Malignant Hyperthermia Susceptibility in a Patient after Sevoflurane-Induced Metabolic Crisis

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Frank Schuster ◽  
Stephan Johannsen ◽  
Norbert Roewer
Keyword(s):  
Malignant Hyperthermia ◽  
Intramuscular Injection ◽  
Diagnostic Procedures ◽  
Minimal Invasive ◽  
Malignant Hyperthermia Susceptibility ◽  
Inhalation Anesthetics ◽  
Life Threatening ◽  
Life Threatening Complication ◽  
Metabolic Test

Malignant hyperthermia is a rare but life-threatening complication of general anesthesia in predisposed patients usually triggered by potent inhalation anesthetics and/or the depolarizing muscle relaxant succinylcholine. The authors present a case of delayed sevoflurane-induced malignant hyperthermia in a 21-year-old male patient that was sufficiently treated by discontinuation of trigger agent application and dantrolene infusion. After surviving an MH episode diagnostic procedures are indicated to increase patient safety. In the presented case, the use of a novel minimal-invasive metabolic test with intramuscular injection of halothane and caffeine successfully confirmed MH susceptibility and hence might be an alternative for invasive in vitro contracture testing in selected cases.

An In-Vivo Metabolic Test for Detecting Malignant Hyperthermia Susceptibility in Humans: A Pilot Study

2008 ◽  
Vol 107 (3) ◽  
pp. 909-914 ◽  
Author(s):  
Frank Schuster ◽  
Thomas Metterlein ◽  
Sabrina Negele ◽  
Peter Kranke ◽  
Ralf M. Muellenbach ◽  
...  
Keyword(s):  
Pilot Study ◽  
Malignant Hyperthermia ◽  
Malignant Hyperthermia Susceptibility ◽  
Metabolic Test

Malignant hyperthermia susceptibility: utilization of genetic results in an electronic medical record to increase safety

2020 ◽  
Vol 21 (17) ◽  
pp. 1207-1215
Author(s):  
Jordan F Baye ◽  
Natasha J Petry ◽  
Shauna L Jacobson ◽  
Michelle M Moore ◽  
Bethany Tucker ◽  
...  
Keyword(s):  
Decision Support ◽  
Malignant Hyperthermia ◽  
Clinical Decision Support ◽  
Perioperative Complications ◽  
Implementation Strategies ◽  
Clinical Decision ◽  
Lessons Learned ◽  
Malignant Hyperthermia Susceptibility ◽  
Alert System ◽  
Genotyping Platform

Aim: This manuscript describes implementation of clinical decision support for providers concerned with perioperative complications of malignant hyperthermia susceptibility. Materials & methods: Clinical decision support for malignant hyperthermia susceptibility was implemented in 2018 based around our pre-emptive genotyping platform. We completed a brief descriptive review of patients who underwent pre-emptive testing, focused particularly on RYR1 and CACNA1S genes. Results: To date, we have completed pre-emptive genetic testing on more than 10,000 patients; 13 patients having been identified as a carrier of a pathogenic or likely pathogenic variant of RYR1 or CACNA1S. Conclusion: An alert system for malignant hyperthermia susceptibility – as an extension of our pre-emptive genomics platform – was implemented successfully. Implementation strategies and lessons learned are discussed herein.

Prediction of Malignant Hyperthermia Susceptibility by Clinical Signs

1987 ◽  
Vol 66 (4) ◽  
pp. 547-550 ◽  
Author(s):  
Ronald D. Miller ◽  
MARILYN GREEN LARACH ◽  
HENRY ROSENBERG ◽  
DAVID R. LARACH ◽  
A. MICHAEL BROENNLE
Keyword(s):  
Malignant Hyperthermia ◽  
Clinical Signs ◽  
Malignant Hyperthermia Susceptibility

In Vitro Diagnosis of Malignant Hyperthermia Susceptibility with Ryanodine-Induced Contractures in Human Skeletal Muscles

1996 ◽  
Vol 82 (6) ◽  
pp. 1230-1236 ◽  
Author(s):  
Frank Wappler ◽  
Norbert Roewer ◽  
Andreas Kochling ◽  
Jens Scholz ◽  
Markus Steinfath ◽  
...  
Keyword(s):  
Malignant Hyperthermia ◽  
Skeletal Muscles ◽  
Malignant Hyperthermia Susceptibility ◽  
Human Skeletal Muscles ◽  
In Vitro Diagnosis
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