scholarly journals Using Celecoxib for the Suppression of Preterm Labor Instead of Magnesium Sulfate

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Najmieh Saadati ◽  
Farideh Moramezi ◽  
Maria Cheraghi ◽  
Laila Sokhray

We aimed to use celecoxib to suppress preterm labor instead magnesium sulfate (MgSO4) to prevent preterm labor.Methods.It was a randomized clinical trial study, which was done on 600 pregnant women. All subjects were divided into two groups by simple random sampling. One group was given 4 grams of MgSO4intravenously and second group was given 100 mg of celecoxib orally every 12 hours for at least 2 days. The data were entered and analyzed using SPSS 11 and performed usingt-test and chi-square test.Results.The finding of this study has shown that preterm labor may be prevented in 75.7% of subjects who had received celecoxib and there were no significant difference between two groups in frequency of history of preterm labor (P=1), frequencies of nulliparity (P=0.99), duration of drug use and arrest contraction (P=0.29), delivery before 48 hours (P=0.20), and mean gestational age in lack of response to treatment (P=0.24).Conclusions.Result has shown that celecoxib was similar to MgSO4as a medication to prevent preterm labor; it was recommended to be prescribe to prevent preterm labor, because it was cheaper than magnesium sulfate.

2020 ◽  
Vol 10 (1) ◽  
pp. 12
Author(s):  
Nahid Shahbazian ◽  
Najmieh Saadati ◽  
Mina Mahdavi

Introduction: Fetal and neonatal complications are more common in premature than full term pregnancy. Treatment of preterm labor and postpone delivery increases neonatal survival and better quality of life and reduces health care costs for premature infants. This study aimed to compare the effects of Nifedipine and Magnesium sulfate in arresting preterm labor and to adverse the effects of these drugs. Materials and Methods: This randomized and clinical trial study was performed on 100 pregnant women who were hospitalized for preterm labor pain. The participants were pregnant women with the gestational age of 28 to 34 weeks and with a single pregnancy and symptoms of preterm were studied. They were randomly divided into two equal groups. After not suppressing the pain by fluid therapy, in the first group Magnesium sulfate infused injection (N=50) was performed, while in the second group, oral Nifedipine were given. The research uses SPSS software (version 20) statistical software issue 20 to analyze the result of tests with descriptive statistical methods including independent T test and chi square test. Results: Mean maternal age, gestational age, parity converted Magnesium sulfate and Nifedipine group had no significant difference in statistical analysis. Delivery was delayed more than 48 hours in 48% (24 person) of cases in the Magnesium sulfate group and in 72% (36 person) in Nifedipine group (p=0.03). A statistically significant difference in response to treatment was more in group of Nifedipine. Conclusion: The results showed that Nifedipine is more effective than Magnesium sulfate in postponing delivery (more than 48 hours), producing minimal side effect, having adequate price and applying an easy use method. Therefore, Nifedipine, as a tocolytic, can be a good substitute for Magnesium sulfate in preterm labor treatment.


2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Sadrakh Tompodung ◽  
Harold F. Tambajong ◽  
Diana Lalenoh

Abstract: Endotracheal intubation needs a muscle relaxant to permit the pipe to get easily into the trachea. Injury of the respiratory tract during this procedure can be avoided by being cognizant of the onsets of action of certain muscle relaxants. Rocuronium is a non-depolarization muscle relaxant with intermediate duration of action and fewer side effects. This study aimed to find out the onset of action of rocuronium. This was an observational study conducted in the operation rooms of Prof. Dr. R.D. Kandou Hospital from November 2012 to January 2013. Samples were patients with ASA 1-2, aged 18 40 years who had been selected by using simple random sampling methods. Midazolam 0,7 mg/kg BW and fentanyl 2 µg/kg BW were used as premedication agents; propofol 2 mg/kg BW as an anaesthetic induction agent; and rocuronium 0,6 mg/kg BW as the muscle relaxant. The rocuronium’s onset of action was measured by using TOF-Watch after the injection of rocuronium until the percentage of muscle relaxation was 0. The results showed that the onset of action in 17 samples (14 females and 3 males) was 151 seconds. The onset of action in females was 65 seconds shorter than in males. A correlation test (P = 0.857) and the chi-square test (P = 0.434) showed no significant correlation between age and the onset of action. There was a significant difference (P < 0.05) between the onset of action and sex showed by the t-test (P = 0.023) and the chi-square test (P = 0.035). Conclusion: The average onset of action of rocuronium was 2 minutes and 31 seconds, with  females having a shorter onset of action of rocuronium. Keywords: onset of action, rocuronium.     Abstrak: Pemasangan pipa trakea memerlukan obat pelumpuh otot untuk memudahkan pipa ini masuk ke saluran napas. Cedera saluran napas akibat pemasangan pipa trakea dapat dihindari dengan mengetahui mula kerja (onset of action) dari obat pelumpuh otot. Rokuronium merupakan obat pelumpuh otot jenis non-depolarisasi dengan lama kerja sedang tanpa efek samping bagi tubuh. Penelitian ini bertujuan untuk mengetahui mula kerja rokuronium dan dilakukan di ruang operasi Rumah Sakit Prof Dr. R.D. Kandou Manado sejak bulan Nopember 2012 hingga Januari 2013. Sampel ialah pasien dengan ASA 1-2, berusia 18-40 tahun, yang dipilih secara simple random sampling. Pasien dipremedikasi dengan midazolam 0,7 mg/kg BB dan fentanil 2 µg/kg BB, diinduksi dengan propofol 2 mg/kg BB dan kemudian diberikan rokuronium 0,6 mg/kg BB secara intra vena. Mula kerja rokuronium diukur antara selesai penyuntikan hingga persentase kelumpuhan otot pada TOF-watch mencapai 0. Hasil penelitian memperlihatkan pada 17 sampel (14 orang perempuan dan 3 orang laki-laki), rerata mula kerja rokuronium 151 detik. Mula kerja rokuronium pada perempuan 65 detik lebih singkat daripada laki-laki. Hasil uji korelasi (P = 0,857) dan uji chi-square (P = 0,434) memperlihatkan tidak terdapat korelasi bermakna antara usia dan mula kerja rokuronium. Terdapat perbedaan bermakna (P < 0,05) antara mula kerja rokuronium dan jenis kelamin yang ditunjukkan dengan uji t (P = 0,023) dan uji chi-square (P = 0,035). Simpulan: Rerata mula kerja rokuronium dengan dosis 0,6 mg/kg BB untuk kedua jenis kelamin 2 menit 31 detik. Perempuan mempunyai mula kerja rokuronium lebih singkat daripada laki-laki. Kata kunci: mula kerja, rokuronium.


2014 ◽  
Vol 2 (3) ◽  
pp. 286
Author(s):  
Tifani Lasianjayani ◽  
Santi Martini

ABSTRACTHypertension is a disease that causes morbidity and mortality about 20–50% of all deaths. In the worldwide, about 927 people suffer hypertension and that number will be increase to 29,2 in 2025. Obesity and smoking are one of risk factors to hypertension incidence. The purpose of this research was to analayze the relationship between obesity and smoking to hypertension incidence. The cross sectional design is used in this research and involved 75 samples who ware selected from cardiology’s patients at Haji Hospital Surabaya by simple random sampling on May 2014. The variables are sex, obesity, and smoking behavior. In the smoking behavior data, the history of smoking, filters used, smoking periode, total cigarette, and types of cigarette are used. In this research, crosstabulation with Chi Square test is used on data analysis. There are 45 people (60%) had hypertension and 64,4% from sample with hypertension was women. The result of this research showed that there was a significant relationship between obesity and hypertension (p = 0,014) with coeffisient contingension about 0,299. Otherwise, there was no a significant relationship between history of smoking (p = 0,211), filters used (p = 0,378), smoking periode (p = 1,000), smoker criteria (p = 0,848), and types of cigarette (p = 0,673) to hypertension incidence. The conclution of this research was only obesity which had a relationship with hypertension incidence.Keywords: hypertension, sex, obesity, smoking behavior


2021 ◽  
Vol 3 (1) ◽  
pp. 85
Author(s):  
Noza Loviana ◽  
Ninik Darsini ◽  
Aditiawarman Aditiawarman

AbstrakLatar Belakang: Secara global, persalinan preterm menjadi penyebab utama kematian neonatus usia dini 0-7 hari pertama kehidupan dengan menimbulkan dampak morbiditas yang tinggi juga. Indonesia menempati urutan negara ke 5 estimasi persalinan preterm tertinggi di dunia. Beberapa faktor yang dapat berpengaruh terhadap persalinan preterm yaitu idiopatik, iatrogenik, sosio-demografi, maternal dan genetik. Penelitian ini bertujuan untuk melihat hubungan antara usia ibu, pendidikan ibu, pekerjaan ibu dan riwayat persalinan preterm terhadap kejadian persalinan prterm di RSUD Dr. Soetomo Surabaya. Metode: Metode penelitian ini adalah analitik observasional dengan rancang bangun case control. Jumlah populasi sebanyak 1311 orang pada periode 1 Januari - 31 Desember 2018. Sampel dibagi dalam dua kelompok yaitu kelompok kasus (ibu yang bersalin preterm) dan kelompok kontrol (ibu yang bersalin tidak preterm) sebanyak masing-masing kelompok 137 orang yang disesuaikan dengan kriteria inklusi dan eksklusi dan berdasarkan teknik pengambilan sampel yaitu simpel random sampling. Variabel independen terdiri dari usia ibu, pendidikan, pekerjaan dan riwayat persalinan preterm sedangkan variabel dependen adalah persalinan preterm. Analisis data bivariat menggunankan uji Chi-Square test dengan taraf signifikansi α = 0,05 (95% CI). Hasil: Hasil uji Chi-Square menunjukkan bahwa tidak ada hubungan bermakna antara usia ibu bersalin (nilai p = 0,259), pendidikan  (nilai p = 1), pekerjaan (nilai p = 0,225) dan riwayat persalinan preterm (nilai p = 0,191) dengan kejadian persalinan preterm. Kesimpulan: Faktor risiko seperti usa ibu bersalin, pendidikan ibu, pekerjaan ibu dan riwayat persalinan preterm tidak memiliki hubungan terhadap kejadian persalinan preterm. Abtract Background : Globally, preterm labor is the main cause of neonatal mortality in the first 0-7 days of life with a high impact of morbidity. Indonesia ranks 5th in the highest estimate of preterm labor in the world. Several factors that can influence preterm labor are idiopathic, iatrogenic, socio-demographic, maternal and genetic. This study aims to look at the relationship between maternal age, maternal education, maternal occupation and a history of preterm labor against the incidence of prenatal labor in RSUD Dr. Soetomo Surabaya. Method : The method of this study is observational analytic with a case-control design. The total population is 1311 people in the period January 1 - December 31, 2018. Samples were divided into two groups, namely the case group (preterm maternity) and the control group (mothers who were not preterm) as many as 137 groups each according to the inclusion criteria and exclusion and based on sampling techniques, namely simple random sampling. Independent variables consisted of maternal age, education, occupation and a history of preterm labor while the dependent variable was preterm labor. Bivariate data analysis used the Chi-Square test with a significance level of α = 0.05 (95% CI). Results : The Chi-Square test results showed that there was no significant relationship between maternal age (p = 0.259), education (p = 1), employment (p = 0.225) and preterm labor history (p = 0.191) with the incidence of preterm labor. Conclusion: Risk factors such as maternal age, maternal education, maternal occupation and a history of preterm labor have no relationship to the incidence of preterm labor.  


2014 ◽  
Vol 2 (3) ◽  
pp. 286
Author(s):  
Tifani Lasianjayani ◽  
Santi Martini

ABSTRACTHypertension is a disease that causes morbidity and mortality about 20–50% of all deaths. In the worldwide, about 927 people suffer hypertension and that number will be increase to 29,2 in 2025. Obesity and smoking are one of risk factors to hypertension incidence. The purpose of this research was to analayze the relationship between obesity and smoking to hypertension incidence. The cross sectional design is used in this research and involved 75 samples who ware selected from cardiology’s patients at Haji Hospital Surabaya by simple random sampling on May 2014. The variables are sex, obesity, and smoking behavior. In the smoking behavior data, the history of smoking, filters used, smoking periode, total cigarette, and types of cigarette are used. In this research, crosstabulation with Chi Square test is used on data analysis. There are 45 people (60%) had hypertension and 64,4% from sample with hypertension was women. The result of this research showed that there was a significant relationship between obesity and hypertension (p = 0,014) with coeffisient contingension about 0,299. Otherwise, there was no a significant relationship between history of smoking (p = 0,211), filters used (p = 0,378), smoking periode (p = 1,000), smoker criteria (p = 0,848), and types of cigarette (p = 0,673) to hypertension incidence. The conclution of this research was only obesity which had a relationship with hypertension incidence.Keywords: hypertension, sex, obesity, smoking behavior


2020 ◽  
Vol 4 (2) ◽  
pp. 163-171
Author(s):  
Dadan Ramadhan ◽  
Lilies Setiartiti

This research is quantitative. The population of this research was all of Micro Enterprises in Kulon Progo Regency. The sample of this research were 156 micro-entrepreneurs in the Kulonprogo district. This research used a simple random sampling technique to get the data. The researcher used a questionnaire as the instrument, which tested both its validity and its reliability. The data analysis technique used in this research is the Chi-Square test. The result showed, the majority of respondents had knowledge (79,5%), and the ability of financial literacy (80,8%) was categorized in the high-level category. There was a no different level of financial literacy for the micro-entrepreneur in Kulon Progo Regency based on the gender.


2018 ◽  
Vol 2 (3) ◽  
pp. 237
Author(s):  
Aditya Faisal Rakhman ◽  
Taufiqurrahman Taufiqurrahman

Background: Wasting prevalence in Indonesia is never been decreased for years. Wasting caused by many factors such as skipping breakfast and inappropriate selection of snacks that contribute to children’s level of nutritional intake adequacy.Objectives: The purpose of this research was to analyze correlation between skipping breakfast and selection of snack among elementary school children. Method: This was an analytical observational research with case control design conducted in three elementary schools in Sembung Village, Gresik. The sample size was 22 students in each group, which taken using a simple random sampling technique at student of 3rd, 4th and 5th grade. Data was collected by interviewing the respondent with structured questionnaire. Nutritional status was classified with BMI/Age using WHO-MGRS standard. Association among variables were analyzed using Chi-Square test. (α=0.05). Result: The result showed that 68.2% respondent from cases used skipping breakfast while 27.3% respondent from control used to skip breakfast. 22.7% respondent in cases used to consume high nutritional value snack food while 72.7% respondent in control used to consume high nutritional value snack food. Chi-Square test showed there was an association between breakfast habits and the selection of snack with wasting (p=0.007; OR=5.714) (p=0.001; OR=9.067).Conclusion: Skipping breakfast habits and the selection of snack had a correlation with wasting incident in village children.ABSTRAKLatar Belakang: Prevalensi wasting di Indonesia tidak pernah mengalami penurunan yang signifikan selama tahun ke tahun. Kejadian wasting dipengaruhi oleh beberapa faktor seperti kebiasaan sarapan dan pemilihan makanan jajanan yang mampu berkontibusi terhadap tingkat kecukupan energi dan zat gizi anak.Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan antara kebiasaan melewatkan sarapan dan kebiasan memilih jajanan makanan kejadian wasting pada anak sekolah dasar di pedesaan.Metode: Penelitian observasional analitik dengan desain case control ini dilakukan di 3 sekolah dasar di Desa Sembung Kecamatan Wringinanom Kabupaten Gresik. Besar sampel penelitian ini adalah 22 sampel untuk masing -masing kelompok yang berasal dari kelas III, IV dan V dan diambil secara simple random sampling. Pengambilan data dilakukan dengan cara wawancara pada anak dengan kuisioner tersktutur. Klasifikasi berdasarkan pada nilai tabel z-score IMT/U WHO-MGRS.  Analisis data dilakukan dengan menggunakan uji chi-square (α=0,05)Hasil: Hasil penelitian menunjukkan bahwa 68,2% responden kelompok kasus, terbiasa melewatkan sarapan sedangkan 27,3% responden kelompok kontrol terbiasa melewatkan sarapan. 22,7% responden kelompok kasus terbiasa membeli makanan jajan bernilai gizi tinggi sedangkan 72,7% responden kelompok kontrol terbiasa membeli makanan jajan bernilai gizi tinggi. Hasil Uji Chi-Square menunjukkan ada hubungan antara kebiasaan sarapan dan pemilihan makanan jajanan dengan kejadian wasting (p= 0,007 OR: 5,714) (p= 0,001 OR: 9,067).Kesimpulan: Kebiasaan melewatkan sarapan dan pemilihan makanan jajanan berhubungan dengan kejadian wasting pada anak pedesaan.


2017 ◽  
Vol 24 (3) ◽  
pp. 11-19
Author(s):  
Metha Fahriani ◽  
Reli Aprilawanti

Preterm labor is dangerous because of the potential increase of about 65-67% of perinatal mortality. The purpose of this study was to determine the relationship between  maternal age and incidence of anemia in preterm parturition in                       dr. M. Yunus Hospital Bengkulu. This type of research was Analytic Survey with study design Case Control with a ratio of 1: 1. The population in this study was mothers who numbered 1,434 people delivering mothers were taken by Total Sampling as many as 53 people (50%) mothers who have parturition premature for cases and  Systematic Random Sampling as many as 53 people (50%) mothers who did not experience parturition premature to control which totaled 106. The computerized data analysis using chi-square test. The results showed that of the 53 mothers who are 36 premature parturition with age 20 or 35 years and 30 people suffering from anemia. Of the 53 mothers who no premature parturition are 16 age 20 or 35 years and 15 suffer from anemia. There is a relationship between age and preterm parturition in the CI Midwifery dr. M. Yunus Hospital Bengkulu with the medium category. There is a relationship between anemia and preterm parturition in the CI Midwifery dr. M. Yunus Hospital Bengkulu with the closeness of the relationship that are in the weak category. It was expected to health worker, especially mid wifery in midwifery room to perform counseling about anemia and the importance  of  control  when  pregnant.Keywords :  age, anemia, premature partus


2017 ◽  
Vol 24 (11) ◽  
pp. 1749-1754
Author(s):  
Muhammad Abdullah ◽  
Zaheer Ahmed ◽  
Hassan Fareed

The aim on the study was to compare the efficancy of salmeterol and formoterolin persistent asthama. Study Design: Randomized-Controlled-Trial(RCT). Setting: Departmentof Medicine, Allied Hospital, Faisalabad. Period: June 2014 to December 2014. Methodology:Patients of both genders with ages between 18 and 70 years having persistent bronchial asthmawhile Pregnant or lactating mothers, patients with upper or lower respiratory tract infections,acute asthma exacerbations within 4 weeks of first visit, Oral corticosteroids within 4 weeks ordepot steroids within 12 weeks of first visit and Smoking history of more than 10 pack yearswere excluded from study. Patients were randomly divided into two groups (Group A & GroupB) using computer generated random number table. Salmeterol/Fluticasone combination wasgiven to group A with a dose of 50/250μg, 2 actuations with ABEL SPACER DEVICE twice aday for a period of 24 weeks. Formoterol/Budesonide combination was given to group B with adose of 400/6μg with Rotahaler twice a day. Follow up was done by patient’s outdoor visits at6th,12th,18h and 24th week. Results: 180 patients were enrolled in the study. 79 (44%) weremales and 101 (56%) were females. Mean age of study population was 45.25+13.382 years.Patients in Group B experienced lesser number of exacerbations than patients in Group B.Group B showed better response to treatment than Group A using chi square test. (P-Value0.001). Conclusion: It has been concluded that budesonide/Formoterol is more effective incontrolling asthma symptoms than fluticasone/Salmeterol.


2021 ◽  
Vol 6 (1) ◽  
pp. 43
Author(s):  
Mardiyah Ibrahim ◽  
Tasnim Tasnim ◽  
Nurmiaty Nurmiaty

Saat ini motivasi dan kinerja bidan masih dianggap kurang, disamping itu terjadi masa tunggu kerja yang lebih lama dari para lulusan Diploma III Kebidanan dikarenakan jumlah lulusan banyak yang belum lulus ujian kompetensi. Penelitian ini bertujuan untuk menganalisis hubungan tingkat kelulusan ujian kompetensi dan motivasi terhadap kinerja bidan lulusan Akademi Kebidanan Konawe. Populasi dalam penelitian ini sebanyak 115 orang. Besar sampel sebanyak 89 responden yang diambil dengan cara simple random sampling. Data dikumpulkan dengan kuisioner, kemudian di analisis menggunakan uji chi square dan koefisien phi. Hasil penelitian menunjukkan bahwa ada hubungan yang lemah antara tingkat kelulusan uji kompetensi bidan dengan motivasi dimana diperoleh X2 hitung > X2 tabel (5,994 > 3,841), dan (Φ) sebesar 0,289. Ada hubungan yang lemah antara tingkat kelulusan uji kompetensi bidan dengan kinerja bidan dimana diperoleh nilai X2 hitung > X2 tabel (6,303 > 3,841), dan (Φ) sebesar 0,283, sedangkan hubungan antara motivasi dengan kinerja bidan memiliki hubungan yang sangat kuat. diperoleh nilai X2 hitung > X2 tabel (55,101 > 3,841), dan (Φ) sebesar 0,881. Oleh karena itu, perlu terus di upayakan peningkatan motivasi bidan dalam bekerja yang salah satu caranya adalah dengan pemberian penghargaan bagi bidan prestasi.Currently, the motivation and performance of midwives are still considered lacking. There is a longer employment waiting period than the Diploma III obstetrics graduates because the number of graduates has not passed the competency exam. This research aims to analyse the relationship of competency exam graduation rate and motivation to the performance of The Graduate midwife of the Konawe Academy. The population in this study was 115 people. A large sample of 89 respondents was taken using simple random sampling. Data is collected with a questionnaire, then in analysis using Chi-square test and phi coefficient. The results showed that there was a weak relationship between the graduation rate of the competency test midwife with the motivation where the X2 calculated > X2 table (5.994 > 3.841), and (Φ) amounted to 0.289. There is a weak relationship between the graduation rate of the midwife competence test with the performance of midwives where the value of X2 count > X2 table (6.303 > 3.841), and (Φ) amounting to 0.283. In contrast, the relationship between the motivation with the performance of midwives has very Strong. The retrieved X2 count value of > X2 table (55.101 > 3.841), and (Φ) amounting to 0.881. Therefore, it is necessary to continue to increase the motivation of midwives in working that one way is to give appreciation to midwives’ achievement.


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