scholarly journals Bullosis Diabeticorum: Rare Presentation in a Common Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Vineet Gupta ◽  
Neha Gulati ◽  
Jaya Bahl ◽  
Jaswinder Bajwa ◽  
Naveen Dhawan
Keyword(s):  
Sudden Onset ◽  
Common Disease ◽  
Type I ◽  
Rare Presentation ◽  
Diabetic Vasculopathy ◽  
Diabetes Mellitus Type I ◽  
Uncontrolled Diabetes ◽  
History Of ◽  
Skin Biopsies ◽  
Bullosis Diabeticorum

A 27-year-old African American male presented with a sudden onset of blisters. He had a past medical history of uncontrolled diabetes mellitus type I, diabetic vasculopathy, and neuropathy. The physical examination revealed nonerythematous skin denudations on both elbows and lateral aspect of arm bilaterally. Investigations which included skin biopsies confirmed the diagnosis of bullosis diabeticorum. The bullae were treated with hydrotherapy and healed with no complications in 4 weeks. We present this case to illustrate the rare occurrence of diabetic bulla in a diabetic patient especially with poor glycemic control. The case is also a reminder of the importance of diabetes screening in nondiabetic patients who are diagnosed with diabetic bulla.

scholarly journals Pantoea agglomerans Bacteremia: Is It Dangerous?

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Ikwinder Preet Kaur ◽  
Sindhura Inkollu ◽  
Amulya Prakash ◽  
Haresh Gandhi ◽  
Mohsin Sheraz Mughal ◽  
...  
Keyword(s):  
Diabetic Ketoacidosis ◽  
Opportunistic Infections ◽  
Blood Cultures ◽  
Pantoea Agglomerans ◽  
Type I ◽  
Case Presentation ◽  
Diabetes Mellitus Type I ◽  
Uncontrolled Diabetes ◽  
Chest X Ray ◽  
Rule Out

Introduction. Pantoea agglomerans, an anaerobic Gram-negative bacillus, is a rare cause of opportunistic infections affecting premature infants to seniors. We present a 34-year-old man who was presented for the management of diabetic ketoacidosis and developed Pantoea agglomerans bacteremia after one week of hospitalization. Case Presentation. A 34-year-old African-American male with uncontrolled diabetes mellitus type I and recurrent skin infections was admitted with diabetic ketoacidosis. He had left upper extremity abscess, preliminary wound cultures were positive for Gram-positive cocci, and an initial set of blood cultures were negative. He was started empirically on vancomycin. One week after admission, he started having chills followed by a recurrent increase in body temperature to 102 degrees Fahrenheit. The wound was healing, without active infection. Chest X-ray and CT scan of abdomen and pelvis to rule out infection were negative. Repeat blood cultures showed P. agglomerans in both the tubes. The patient was successfully treated with intravenous ceftriaxone, and he recovered fully without any complication. Discussion. Pantoea agglomerans is a bacteria associated with plants; however, it can infect humans and vertebrate animals. The outcome seems favourable with the institution of appropriate antibiotics even in immunocompromised patients.

scholarly journals Estimating the Levels of Autoantibodies to NMDA And Dopamine Receptors in Children with Diabetes Mellitus Type I, Subject to the Condition Severity

Medicina ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 41-48
Author(s):  
Yu. V. Bykov ◽  
◽  
V. A. Baturin ◽  
T. I. Uglova ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Nmda Receptors ◽  
Children And Adolescents ◽  
Dopamine Receptors ◽  
Type I Diabetes ◽  
Enzyme Linked Immunosorbent Assay ◽  
Type I ◽  
Diabetes Mellitus Type I ◽  
History Of

Type I Diabetes Mellitus (DM) is among the most common endocrinological diseases in adolescents. The purpose of this study was to research the level of autoantibodies (AAT) to NMDA receptors and Type 2 dopamine receptors (DAR2) in children with varying severity condition of Type I Diabetes. We examined 38 children and adolescents aged 2 to 17 years. In order to determine the levels of AAT to NMDA receptors and dopamine receptors (DR2) in blood serum, we applied the enzyme-linked immunosorbent assay (ELISA). We found higher levels of AAT to NMDA receptors and dopamine receptors (DAR2) in children with chronic Type I Diabetes against the background of diabetic ketoacidosis (DKA), as compared to children with the diabetes onset or compensation of the disease. The increased levels of AAT to NMDA and dopamine receptors (DAR2) were found in children and adolescents against the background of a long history of the disease and frequent hospitalization to the intensive care unit.

scholarly journals A case of diabetic myonecrosis: A rare complication of a common disease

2019 ◽  
Vol 7 ◽  
pp. 2050313X1882346
Author(s):  
Rami Alkhoury
Keyword(s):  
Diabetes Mellitus ◽  
Rare Complication ◽  
Diabetic Control ◽  
Serum Glucose ◽  
Sudden Onset ◽  
Common Disease ◽  
Diabetic Patients ◽  
History Of ◽  
Uncommon Condition

Diabetes mellitus is a growing concern in today’s population and a common cause of significant morbidity and mortality in those affected. Diabetic myonecrosis is an uncommon condition that can be seen in uncontrolled, long-standing diabetic patients who complain of localized, sudden-onset muscle pain. We present a 57-year-old woman with type 2 diabetes mellitus who presented to the emergency department with left-sided pelvic pain for the past 2 months. The pain had progressively gotten worse with a significant reduction in the range of motion of her left hip. Magnetic resonance imaging imaging revealed focal enhancement, edema, and enlargement of the left iliacus muscle. Assessment of serum glucose and hemoglobin A1c revealed a history of poor diabetic control, eventually giving rise to a diagnosis of diabetic myonecrosis. She was discharged with a new diabetic regimen, pain control, and outpatient physical therapy.

scholarly journals Estimating the Levels of Autoantibodies to NMDA and Dopamine Receptors in Children with Diabetes Mellitus Type I, Subject to the Condition Severity

Medicina ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 73-80
Author(s):  
Yu. V. Bykov ◽  
◽  
V. A. Baturin ◽  
T. A. Uglova ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Nmda Receptors ◽  
Children And Adolescents ◽  
Dopamine Receptors ◽  
Type I Diabetes ◽  
Enzyme Linked Immunosorbent Assay ◽  
Type I ◽  
Diabetes Mellitus Type I ◽  
History Of

Type I Diabetes Mellitus (DM) is among the most common endocrinological diseases for adolescents. The purpose was to study the level of autoantibodies (AAT) to NMDA receptors and Type 2 dopamine receptors (DAR2) in children with varying severity of Type I Diabetes. We examined 38 children and adolescents aged 2 to 17 years. In order to determine the levels of AAT to NMDA receptors and dopamine receptors (DR2) in blood serum, we applied the enzyme-linked immunosorbent assay (ELISA). We found higher levels of AAT to NMDA receptors and dopamine receptors (DAR2) in children with chronic Type I Diabetes against the background of diabetic ketoacidosis (DKA), as compared to children with the diabetes onset or compensation of the disease. The increased levels of AAT to NMDA and dopamine receptors (DAR2) were found in children and adolescents against the background of a long history of the disease and frequent hospitalization to the intensive care unit.

Acute-onset isolated bilateral palatal palsy in an adolescent

2021 ◽  
Vol 14 (9) ◽  
pp. e243467
Author(s):  
Avinash Shekhar Jaiswal ◽  
Rajeev Kumar ◽  
Prem Sagar ◽  
Rakesh Kumar
Keyword(s):  
Sudden Onset ◽  
Acute Onset ◽  
Age Group ◽  
Rare Presentation ◽  
Limb Weakness ◽  
Aggressive Management ◽  
History Of ◽  
Gag Reflex ◽  
Nasal Regurgitation ◽  
Rule Out

A 16-year-old patient presented with sudden-onset difficulty in swallowing food especially for liquids with nasal regurgitation and rhinolalia with no history of fever and limb weakness. Examination revealed bilateral palatal palsy with absence of gag reflex. Other neurological examinations were normal. Investigations were done to rule out any known pathology leading to such a presentation. The symptoms were attributed to an idiopathic acute-onset-acquired bilateral palatal palsy, in the absence of any identifiable cause. This is a rare presentation in adolescent age with no case reported in the literature so far in this age group. Medical management was started and patient showed complete improvement within 2 weeks of his symptoms. Early diagnosis and aggressive management of this condition lead to a favourable prognosis.

The diagnosis of metabolic storage disease in skin biopsies (a light-, electronmicroscopic, and analytical study)

1978 ◽  
Vol 36 (2) ◽  
pp. 648-649
Author(s):  
W. Jurecka ◽  
W. Gebhart ◽  
H. Lassmann
Keyword(s):  
Storage Disease ◽  
Hunter Syndrome ◽  
Histochemical Demonstration ◽  
Sweat Glands ◽  
Type I ◽  
Storage Material ◽  
Scheie Syndrome ◽  
Storage Products ◽  
Skin Biopsies ◽  
Type V

Diagnosis of metabolic storage disease can be established by the determination of enzymes or storage material in blood, urine, or several tissues or by clinical parameters. Identification of the accumulated storage products is possible by biochemical analysis of isolated material, by histochemical demonstration in sections, or by ultrastructural demonstration of typical inclusion bodies. In order to determine the significance of such inclusions in human skin biopsies several types of metabolic storage disease were investigated. The following results were obtained.In MPS type I (Pfaundler-Hurler-Syndrome), type II (Hunter-Syndrome), and type V (Ullrich-Scheie-Syndrome) mainly “empty” vacuoles were found in skin fibroblasts, in Schwann cells, keratinocytes and macrophages (Dorfmann and Matalon 1972). In addition, prominent vacuolisation was found in eccrine sweat glands. The storage material could be preserved in part by fixation with cetylpyridiniumchloride and was also present within fibroblasts grown in tissue culture.

Pneumomediastinum: A Rare Presentation of Inflicted Injuries in Infants

2020 ◽  
Author(s):  
Adam Lee ◽  
Adam Bajinting ◽  
Abby Lunneen ◽  
Colleen M. Fitzpatrick ◽  
Gustavo A. Villalona
Keyword(s):  
Literature Review ◽  
Retrospective Review ◽  
Review Of The Literature ◽  
Rare Presentation ◽  
Spontaneous Pneumomediastinum ◽  
Nonaccidental Trauma ◽  
Comprehensive Literature Review ◽  
Healthy Infants ◽  
History Of

AbstractReports of incidental pneumomediastinum in infants secondary to inflicted trauma are limited. A retrospective review of infants with pneumomediastinum and history of inflicted trauma was performed. A comprehensive literature review was performed. Three infants presented with pneumomediastinum associated with inflicted trauma. Mean age was 4.6 weeks. All patients underwent diagnostic studies, as well as a standardized evaluation for nonaccidental trauma. All patients with pneumomediastinum were resolved at follow-up. Review of the literature identified other cases with similar presentations with related oropharyngeal injuries. Spontaneous pneumomediastinum in previously healthy infants may be associated with inflicted injuries. Clinicians should be aware of the possibility of an oropharyngeal perforation related to this presentation.

Diabetes mellitus type I and perinatal result

2007 ◽  
Vol 2 (04) ◽  
Author(s):  
N Kyriakopoulos ◽  
C Gavala ◽  
I Georgantis ◽  
S Patiakas ◽  
S Tsitlakidou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Mellitus Type ◽  
Type I ◽  
Diabetes Mellitus Type I

The Diagnostic Value of Pericardial Fluid and Pericardial Biopsy: Single Center Experiences

2016 ◽  
Vol 19 (1) ◽  
pp. 023 ◽  
Author(s):  
Mehmet Yildirim ◽  
Recep Ustaalioglu ◽  
Murat Erkan ◽  
Bala Basak Oven Ustaalioglu ◽  
Hatice Demirbag ◽  
...  
Keyword(s):  
Pericardial Effusion ◽  
Thoracoscopic Surgery ◽  
Pericardial Tamponade ◽  
Pericardial Fluid ◽  
Pathological Examination ◽  
Common Disease ◽  
Pericardial Window ◽  
Surgical Interventions ◽  
History Of ◽  
Recurrent Pericardial Effusion

<strong>Background:</strong> Patients with recurrent pericardial effusion and pericardial tamponade are usually treated in thoracic surgery clinics by VATS (video-assisted thoracoscopic surgery) or open pericardial window operation. The diagnostic importance of pathological evaluation of the pericardial fluid and tissue in the same patients has been reported in few studies. We reviewed pathological examination of the pericardial tissue and fluid specimens and the effect on the clinical treatment in our clinic, and compared the results with the literature. <br /><strong>Methods:</strong> We retrospectively analyzed 174 patients who underwent pericardial window operation due to pericardial tamponade or recurrent pericardial effusion. For all patients both the results of the pericardial fluid and pericardial biopsy specimen were evaluated. Clinicopathological factors were analyzed by using descriptive analysis. <br /><strong>Results:</strong> Median age was 61 (range, 20-94 years). The most common benign diagnosis was chronic inflammation (94 patients) by pericardial biopsy. History of malignancy was present in 28 patients (16.1%) and the most common disease was lung cancer (14 patients). A total of 24 patients (13.8%) could be diagnosed as having malignancy by pericardial fluid or pericardial biopsy examination. The malignancy was recognized for 12 patients who had a history of cancer; 9 of 12 with pericardial biopsy, 7 diagnosed by pericardial fluid. Twelve of 156 patients were recognized as having underlying malignancy by pericardial biopsy (n = 9) or fluid examination (n = 10), without known malignancy previously. <br /><strong>Conclusion:</strong> Recurrent pericardial effusion/pericardial tamponade are entities frequently diagnosed, and surgical interventions may be needed either for diagnosis and/or treatment, but specific etiology can rarely be obtained in spite of pathological examination of either pericardial tissue or fluid. For increasing the probability of a specific diagnosis both the pericardial fluid and the pericardial tissues have to be sent for pathologic examination.

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