scholarly journals The Role of Habenula in Motivation and Reward

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Marc Fakhoury ◽  
Sergio Domínguez López
Keyword(s):  
Mood Disorder ◽  
Limbic System ◽  
Anatomical Structure ◽  
Lateral Habenula ◽  
Electrolytic Lesions ◽  
Motivational Control

Located centrally along the dorsal diencephalic system, the habenula is divided into two structures: the medial and the lateral portions. It serves as an important relay between the forebrain and several hindbrain sites. In the last few years, a huge attention has been devoted to this structure, especially the lateral habenula (LHb), which seems to play an important role in emotion, motivation, and reward. Recent studies using techniques such as electrophysiology and neuroimaging have shown that the LHb is involved in motivational control of behavior. Its dysfunction is often associated with depression, schizophrenia, and mood disorder. This review focuses on providing a neuroanatomical and behavioral overview of some of the research previously done on the LHb. First, we describe the anatomical structure of the habenula and we explain how it is involved in reward and motivation. Then, we will discuss how this structure is linked to the limbic system, to finally provide a comparison between several studies that have used electrolytic lesions.

ROLE OF THE LIMBIC SYSTEM IN MAINTENANCE OF CONSCIOUSNESS

1963 ◽  
Vol 42 (6) ◽  
pp. 748???751 ◽  
Author(s):  
MARY A. B. BRAZIER
Keyword(s):  
Limbic System

PVN lesions prevent the endothelin 1-induced increase in arterial pressure and vasopressin

2001 ◽  
Vol 280 (2) ◽  
pp. E349-E356 ◽  
Author(s):  
Noreen F. Rossi ◽  
Haiping Chen
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Arterial Pressure ◽  
Paraventricular Nuclei ◽  
Artificial Cerebrospinal Fluid ◽  
Electrolytic Lesions ◽  
The Central Nervous System ◽  
Baseline Values ◽  
Long Evans

Endothelin (ET) acts within the central nervous system to increase arterial pressure and arginine vasopressin (AVP) secretion. This study assessed the role of the paraventricular nuclei (PVN) in these actions. Intracerebroventricular ET-1 (10 pmol) or the ETA antagonist BQ-123 (40 nmol) was administered in conscious intact or sinoaortic-denervated (SAD) Long-Evans rats with sham or bilateral electrolytic lesions of the magnocellular region of the PVN. Baseline values did not differ among groups, and artificial cerebrospinal fluid (CSF) induced no significant changes. In sham-lesioned rats, ET-1 increased mean arterial pressure (MAP) 15.9 ± 1.3 mmHg in intact and 22.3 ± 2.7 mmHg in SAD ( P < 0.001 ET-1 vs. CSF) rats. PVN lesions abolished the rise in MAP: −0.1 ± 2.8 mmHg in intact and 0.0 ± 2.9 mmHg in SAD. AVP increased in only in the sham-lesioned SAD group 8.6 ± 3.5 pg/ml ( P < 0.001 ET-1 vs. CSF). BQ-123 blocked the responses. Thus the integrity of the PVN is required for intracerebroventricularly administered ET-1 to exert pressor and AVP secretory effects.

scholarly journals Subclinical Visuospatial Impairment in Parkinson’s Disease: The Role of Basal Ganglia and Limbic System

2014 ◽  
Vol 5 ◽  
Author(s):  
Stefano Caproni ◽  
Marco Muti ◽  
Antonio Di Renzo ◽  
Massimo Principi ◽  
Nevia Caputo ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Limbic System

Relationships Among Childhood Maltreatment, Limbic System Dysfunction, and Eating Disorders in College Women

2020 ◽  
pp. 088626052091259
Author(s):  
Andrea E. Mercurio ◽  
Fang Hong ◽  
Carolyn Amir ◽  
Amanda R. Tarullo ◽  
Anna Samkavitz ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Eating Disorder ◽  
College Women ◽  
Limbic System ◽  
Indirect Effect ◽  
Childhood Maltreatment ◽  
Eating Pathology ◽  
Convenience Sample ◽  
Eating Disorder Symptoms

The mechanisms linking childhood maltreatment and eating pathology are not fully understood. We examined the mediating role of limbic system dysfunction in the relationships between three forms of childhood maltreatment (parental psychological maltreatment, parental physical maltreatment, and parental emotional neglect) and eating disorder symptoms. A convenience sample of college women ( N = 246, M age = 19.62, SD = 2.41) completed measures of maltreatment (Parent-Child Conflict Tactics Scales and the Parental Bonding Instrument), limbic system dysfunction (Limbic System Questionnaire), and eating pathology (Eating Disorder Examination Questionnaire). We hypothesized that there would be an indirect effect of each type of childhood maltreatment on eating disorder symptoms via limbic system irritability. Results generally supported the hypotheses. Examination of the individual paths that defined the indirect effect indicated that higher reported childhood maltreatment was associated with greater limbic irritability symptoms, and higher limbic irritability symptomatology was related to higher total eating disorder scores. There were no significant direct effects for any of the proposed models. Findings are in line with research supporting the role of limbic system dysfunction as a possible pathway in the maltreatment-eating disorder link. Given that limbic system dysfunction may underlie behavioral symptoms of eating disorders, efforts targeting limbic system dysfunction associated with child maltreatment might best be undertaken at an early developmental stage, although interventions for college women struggling with eating disorders are also crucial.

scholarly journals Role of Leptin in Mood Disorder and Neurodegenerative Disease

2019 ◽  
Vol 13 ◽  
Author(s):  
Xiaohan Zou ◽  
Lili Zhong ◽  
Cuilin Zhu ◽  
Haisheng Zhao ◽  
Fangyi Zhao ◽  
...  
Keyword(s):  
Neurodegenerative Disease ◽  
Mood Disorder
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