scholarly journals Excessive Refined Carbohydrates and Scarce Micronutrients Intakes Increase Inflammatory Mediators and Insulin Resistance in Prepubertal and Pubertal Obese Children Independently of Obesity

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Mardia López-Alarcón ◽  
Otilia Perichart-Perera ◽  
Samuel Flores-Huerta ◽  
Patricia Inda-Icaza ◽  
Maricela Rodríguez-Cruz ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Vitamin D ◽  
Serum Insulin ◽  
Low Grade ◽  
Omega 3 Fatty Acids ◽  
Central Adiposity ◽  
Omega 3 ◽  
Calcium Magnesium ◽  
Refined Carbohydrates

Background.Low-grade inflammation is the link between obesity and insulin resistance. Because physiologic insulin resistance occurs at puberty, obese pubertal children are at higher risk for insulin resistance. Excessive diets in refined carbohydrates and saturated fats are risk factors for insulin resistance, but calcium, magnesium, vitamin-D, and the omega-3 fatty acids likely protect against inflammation and insulin resistance.Objective.To analyze interactions among dietary saturated fat, refined carbohydrates, calcium, magnesium, vitamin D, and omega-3 fatty acids on the risk of inflammation and insulin resistance in a sample of prepubertal and pubertal children.Methods.A sample of 229 children from Mexico City was analyzed in a cross-sectional design. Anthropometric measurements, 24 h recall questionnaires, and blood samples were obtained. Serum insulin, glucose, calcium, magnesium, 25-OHD3, C-reactive protein, leptin, adiponectin, and erythrocytes fatty acids were measured. Parametric and nonparametric statistics were used for analysis.Results.While mean macronutrients intake was excessive, micronutrients intake was deficient(P<0.01). Inflammation determinants were central obesity and magnesium-deficient diets. Determinants of insulin resistance were carbohydrates intake and circulating magnesium and adiponectin.Conclusions.Magnesium-deficient diets are determinants of inflammation, while high intake of refined carbohydrates is a risk factor for insulin resistance, independently of central adiposity.

Evidence of muscle loss delay and improvement of hyperinsulinemia and insulin resistance in Duchenne muscular dystrophy supplemented with omega-3 fatty acids: A randomized study

2019 ◽  
Vol 38 (5) ◽  
pp. 2087-2097 ◽  
Author(s):  
Maricela Rodríguez-Cruz ◽  
Salvador Atilano-Miguel ◽  
Lourdes Barbosa-Cortés ◽  
Mariela Bernabé-García ◽  
Tomas Almeida-Becerril ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Randomized Study ◽  
Muscle Loss ◽  
Omega 3 Fatty Acids ◽  
Omega 3

scholarly journals EFFECT OF OMEGA-3 FATTY ACIDS ENRICHED FISH OIL ON DEXAMETHASONE INDUCED INSULIN RESISTANCE AND HYPERTENSION IN RATS

2019 ◽  
Vol 6 (1) ◽  
pp. 1796-1803
Author(s):  
Rashmi S. Chouthe ◽  
◽  
Santosh D Shelke ◽  
Rahul P. Kshirsagar ◽  
◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Fish Oil ◽  
Omega 3 Fatty Acids ◽  
Omega 3

scholarly journals Could Omega 3 Fatty Acids Preserve Muscle Health in Rheumatoid Arthritis?

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 223
Author(s):  
Kassandra Lanchais ◽  
Frederic Capel ◽  
Anne Tournadre
Keyword(s):  
Rheumatoid Arthritis ◽  
Insulin Resistance ◽  
Fatty Acids ◽  
Density Lipoprotein ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Cvd Risk ◽  
Cardiometabolic Diseases ◽  
Increased Risk ◽  
Muscle Health

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by a high prevalence of death due to cardiometabolic diseases. As observed during the aging process, several comorbidities, such as cardiovascular disorders (CVD), insulin resistance, metabolic syndrome and sarcopenia, are frequently associated to RA. These abnormalities could be closely linked to alterations in lipid metabolism. Indeed, RA patients exhibit a lipid paradox, defined by reduced levels of total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol whereas the CVD risk is increased. Moreover, the accumulation of toxic lipid mediators (i.e., lipotoxicity) in skeletal muscles can induce mitochondrial dysfunctions and insulin resistance, which are both crucial determinants of CVD and sarcopenia. The prevention or reversion of these biological perturbations in RA patients could contribute to the maintenance of muscle health and thus be protective against the increased risk for cardiometabolic diseases, dysmobility and mortality. Yet, several studies have shown that omega 3 fatty acids (FA) could prevent the development of RA, improve muscle metabolism and limit muscle atrophy in obese and insulin-resistant subjects. Thereby, dietary supplementation with omega 3 FA should be a promising strategy to counteract muscle lipotoxicity and for the prevention of comorbidities in RA patients.

scholarly journals Omega-3 Fatty Acids and Vitamin D Decrease Plasma T-tau, GFAP, and UCH-L1 in Experimental Traumatic Brain Injury

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 924-924
Author(s):  
Angus Scrimgeour ◽  
Michelle Condlin ◽  
Andrei Loban ◽  
James DeMar
Keyword(s):  
Fatty Acids ◽  
Vitamin D ◽  
Cognitive Deficits ◽  
Plasma Levels ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Post Injury ◽  
Voluntary Running ◽  
Anti Inflammatory ◽  
T Tau

Abstract Objectives Traumatic brain injury (TBI) results in neuronal, axonal and glial damage. Interventions targeting neuroinflammation to enhance recovery from TBI are needed. Exercise is known to improve cognitive function in TBI patients. Omega-3 fatty acids and vitamin D reportedly reduce inflammation, and in combination, might improve TBI outcomes. This study examined how an anti-inflammatory diet affected plasma TBI biomarkers, voluntary exercise and behavior following exposure to mild TBI (mTBI). Methods Adult, male rats were individually housed in cages fitted with voluntary running wheels and daily running distance was recorded during the study. A modified weight drop method induced mTBI, and during 30 days post-injury, rats were fed diets supplemented with omega-3 fatty acids and vitamin D3 (AIDM diet), or non-supplemented AIN-76A diets (CON diet). Behavioral tests were periodically conducted to assess functional deficits. Plasma levels of Total tau (T-tau), glial fibrillary acidic protein (GFAP), ubiquitin c-terminal hydrolase L1 (UCH-L1) and neurofilament light chain (NF-L) were measured at 48 h, 14 d and 30 d post-injury. Fatty acid composition of food, plasma and brain tissues was determined. Results In rats exposed to mTBI, NF-L levels were significantly elevated at 48 h post-injury (P &lt; 0.005), and decreased to levels seen in uninjured rats by 14 d post-injury. T-tau, GFAP and UCH-L1 plasma levels did not change at 48 h or 14 d post-injury. However, at 30 d post-injury, T-tau, GFAP and UCH-L1 all significantly increased in rats exposed to mTBI and fed CON diets (P &lt; 0.005), but not in rats fed AIDM diets. Behavioral tests conducted post-injury showed that exercise counteracted cognitive deficits associated with mTBI. The AIDM diets significantly increased docosahexaenoic acid levels in plasma and brain tissue (P &lt; 0.05), and in serum levels of vitamin D (P &lt; 0.05). Conclusions The anti-inflammatory diet significantly altered the temporal profiles of plasma T-tau, GFAP and UCH-L1 following mTBI. Voluntary running exercise protected against mTBI-induced cognitive deficits, but had no impact on plasma levels of neurotrauma biomarkers. Thus the prophylactic effect of exercise, when combined with an anti-inflammatory diet, may facilitate recovery in patients with mTBI. Funding Sources U.S. Army MRDC.

scholarly journals ANTICOID PRODUCTS FROM AQUATIC BIOLOGICAL RESOURCES

Fisheries ◽  
2021 ◽  
Vol 2021 (2) ◽  
pp. 4-8
Author(s):  
Elena Kharenko ◽  
Anna Sopina
Keyword(s):  
Fatty Acids ◽  
Vitamin D ◽  
Innate Immunity ◽  
Biological Activity ◽  
Human Body ◽  
Wide Spectrum ◽  
State Of Health ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Inflammatory Processes

The formation of collective immunity, in the context of the COVID-19 pandemic, is directly related to the state of health of each member of the community, therefore, taking care of the health of citizens becomes one of the priority tasks of any state. Recent studies have shown that vitamin D, essentially being a hormone D, strengthens the innate immunity associated with the exchange of zinc in the human body, which, in turn, affects the replication of viruses and accel-erates their excretion. Omega-3 fatty acids have a wide spectrum of biological activity, includ-ing in the treatment of inflammatory processes of various etiologies.

Guidelines for the pre-conception period

2015 ◽  
Author(s):  
Sir Peter Gluckman ◽  
Mark Hanson ◽  
Chong Yap Seng ◽  
Anne Bardsley
Keyword(s):  
Fatty Acids ◽  
Vitamin D ◽  
Folic Acid ◽  
Vitamin D Supplementation ◽  
Nutritional Requirements ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Balanced Diet ◽  
Oily Fish ◽  
Inadequate Nutrition

Where possible, pre-conception counselling is desirable for both prospective parents in order to address issues of lifestyle and nutrition so that pregnancy can proceed with the best possible start. If dieting is necessary this should be initiated as far in advance of the pregnancy as possible, because inadequate nutrition around the time of conception can influence the fetal growth trajectory and weight at birth. Regardless of BMI, women should also be encouraged to engage in regular aerobic exercise. Nutritional requirements in the pre-conception period include adequate amounts of oily fish to provide omega-3 fatty acids. All women planning a pregnancy should receive 400 #amp;#x00B5;g of folic acid daily, and vitamin B12 and vitamin D supplementation may be necessary, particular for vegetarians. Other vitamins and minerals should be considered, particularly iron and iodine, but most should be obtainable from a balanced diet. Harmful behaviours and environmental exposures should be avoided.

scholarly journals Effects of vitamin D and omega-3 fatty acids co-supplementation on inflammatory biomarkers, tumor marker CEA, and nutritional status in patients with colorectal cancer: a study protocol for a double blind randomized controlled trial

Trials ◽  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Fatemeh Haidari ◽  
Behnaz Abiri ◽  
Masood Iravani ◽  
Seyed-Mohsen Razavi ◽  
Parvin Sarbakhsh ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fatty Acids ◽  
Vitamin D ◽  
Nutritional Status ◽  
Tumor Marker ◽  
Inflammatory Biomarkers ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Double Blind ◽  
Colorectal Cancer Patients

Abstract Background Much evidence is available demonstrating that both vitamin D and omega-3 fatty acids block the development and progression of colonic carcinogenesis. The results of animal studies have shown that the consumption of omega-3 fatty acids can decrease inflammatory biomarkers, enhance the efficacy of chemotherapy, and decrease the side effects of chemotherapy or cancer. Also, observational studies propose that higher levels of 25(OH)D are related to improved survival of colorectal cancer patients. This study will aim to evaluate the effects of vitamin D and omega-3 fatty acids co-supplementation on inflammatory biomarkers, tumor marker CEA, and nutritional status in colorectal cancer patients. Methods/design We will carry out an 8-week double-blind randomized, placebo-controlled clinical trial to evaluate the effects of vitamin D and omega-3 fatty acids co-supplementation on inflammatory biomarkers, tumor marker CEA, and nutritional status in patients with stage ӀӀ or ӀӀӀ colorectal cancer undergoing chemotherapy. Discussion Because of the important effects of vitamin D and omega-3 fatty acids on molecular pathways involved in cancer development and progression, it seems that both vitamin D and omega-3 fatty acids may provide a new adjuvant therapy by decreasing inflammatory biomarkers and resistance to cancer treatment in patients with colorectal cancer. Trial registration Iranian Registry of Clinical Trials IRCT20180306038979N1. Registered on 16 March 2018.

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