scholarly journals Clinical Relevance of HLA Antibody Monitoring after Kidney Transplantation

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Christian Morath ◽  
Gerhard Opelz ◽  
Martin Zeier ◽  
Caner Süsal
Keyword(s):  
Risk Factors ◽  
Kidney Transplantation ◽  
Organ Transplantation ◽  
Clinical Relevance ◽  
De Novo ◽  
Graft Loss ◽  
Specific Antibodies ◽  
Graft Outcome ◽  
The Impact ◽  
Hla Antibody

In kidney transplantation, antibody-mediated allograft injury caused by donor HLA-specific antibodies (DSA) has recently been identified as one of the major causes of late graft loss. This paper gives a brief overview on the impact of DSA development on graft outcome in organ transplantation with a focus on risk factors forde novoalloantibody induction and recently published guidelines for monitoring of DSA during the posttransplant phase.

scholarly journals Recurrence of IgA Nephropathy after Kidney Transplantation in Adults

2021 ◽  
Vol 16 (8) ◽  
pp. 1247-1255
Author(s):  
Audrey Uffing ◽  
Maria José Pérez-Saéz ◽  
Thomas Jouve ◽  
Mathilde Bugnazet ◽  
Paolo Malvezzi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Transplantation ◽  
Confidence Interval ◽  
Iga Nephropathy ◽  
Graft Loss ◽  
Hazard Ratio ◽  
Content Type ◽  
Specific Antibodies ◽  
Donor Specific Antibodies ◽  
Recurrent Iga Nephropathy

Background and objectivesIn patients with kidney failure due to IgA nephropathy, IgA deposits can recur in a subsequent kidney transplant. The incidence, effect, and risk factors of IgA nephropathy recurrence is unclear, because most studies have been single center and sample sizes are relatively small.Design, setting, participants, & measurementsWe performed a multicenter, international, retrospective study to determine the incidence, risk factors, and treatment response of recurrent IgA nephropathy after kidney transplantation. Data were collected from all consecutive patients with biopsy-proven IgA nephropathy transplanted between 2005 and 2015, across 16 “The Post-Transplant Glomerular Disease” study centers in Europe, North America, and South America.ResultsOut of 504 transplant recipients with IgA nephropathy, recurrent IgA deposits were identified by kidney biopsy in 82 patients; cumulative incidence of recurrence was 23% at 15 years (95% confidence interval, 14 to 34). Multivariable Cox regression revealed a higher risk for recurrence of IgA deposits in patients with a pre-emptive kidney transplant (hazard ratio, 3.45; 95% confidence interval, 1.31 to 9.17) and in patients with preformed donor-specific antibodies (hazard ratio, 2.59; 95% confidence interval, 1.09 to 6.19). After kidney transplantation, development of de novo donor-specific antibodies was associated with subsequent higher risk of recurrence of IgA nephropathy (hazard ratio, 6.65; 95% confidence interval, 3.33 to 13.27). Immunosuppressive regimen was not associated with recurrent IgA nephropathy in multivariable analysis, including steroid use. Graft loss was higher in patients with recurrence of IgA nephropathy compared with patients without (hazard ratio, 3.69; 95% confidence interval, 2.04 to 6.66), resulting in 32% (95% confidence interval, 50 to 82) graft loss at 8 years after diagnosis of recurrence.ConclusionsIn our international cohort, cumulative risk of IgA nephropathy recurrence increased after transplant and was associated with a 3.7-fold greater risk of graft loss.

Early Graft Loss After Kidney Transplantation: Risk Factors and Consequences.

2014 ◽  
Vol 98 ◽  
pp. 629-630 ◽  
Author(s):  
M. Hamed ◽  
L. Pasea ◽  
J. Bradley ◽  
G. Pettigrew ◽  
K. Saeb-Parsy
Keyword(s):  
Risk Factors ◽  
Kidney Transplantation ◽  
Graft Loss ◽  
Early Graft

Risk Factors Associated With Graft Loss and Patient Survival After Kidney Transplantation

2009 ◽  
Vol 41 (9) ◽  
pp. 3667-3670 ◽  
Author(s):  
K.M. Harada ◽  
E.L. Mandia-Sampaio ◽  
T.V. de Sandes-Freitas ◽  
C.R. Felipe ◽  
S.I. Park ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Transplantation ◽  
Patient Survival ◽  
Graft Loss ◽  
Factors Associated

Epidemiology of de novo malignancies after solid-organ transplantation: Immunosuppression, infection and other risk factors

2014 ◽  
Vol 28 (8) ◽  
pp. 1251-1265 ◽  
Author(s):  
Pierluca Piselli ◽  
Diana Verdirosi ◽  
Claudia Cimaglia ◽  
Ghil Busnach ◽  
Lucia Fratino ◽  
...  
Keyword(s):  
Risk Factors ◽  
Organ Transplantation ◽  
De Novo ◽  
Solid Organ Transplantation ◽  
Solid Organ
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