scholarly journals Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Miguel Roehrs ◽  
Cassieli Gehlen Figueiredo ◽  
Mariane Magalhães Zanchi ◽  
Guilherme Vargas Bochi ◽  
Rafael Noal Moresco ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Protein Oxidation ◽  
Ldl Cholesterol ◽  
Diabetic Rats ◽  
Lipid Profiles ◽  
Water Soluble ◽  
Glucose Levels ◽  
Prooxidant Action ◽  
And Oxidative Stress

The present study investigated the effects of oral administration of annatto carotenoids (bixin (BIX) and norbixin (NBIX)) on glucose levels, lipid profiles, and oxidative stress parameters in streptozotocin (STZ)-induced diabetic rats. Animals were treated for 30 days in the following groups: nondiabetic control, diabetic vehicle, diabetic 10 mg/kg BIX, diabetic 100 mg/kg BIX, diabetic 10 mg/kg NBIX, diabetic 100 mg/kg NBIX, diabetic metformin, and diabetic insulin. Blood glucose, LDL cholesterol, and triglyceride levels were reduced in the diabetic rats treated with BIX. BIX treatment prevented protein oxidation and nitric oxide production and restored superoxide dismutase activity. NBIX treatment did not change most parameters assessed, and at the highest dose, it increased LDL cholesterol and triglycerides levels and showed prooxidant action (increased protein oxidation and nitric oxide levels). These findings suggested that BIX could have an antihyperglycemic effect, improve lipid profiles, and protect against damage induced by oxidative stress in the diabetic state. Because NBIX is a water-soluble analog of BIX, we propose that lipophilicity is crucial for the protective effect of annatto carotenoids against streptozotocin-induced diabetes.

Proteasome activity in experimental diabetes

2006 ◽  
Vol 1 (2) ◽  
pp. 289-298 ◽  
Author(s):  
Albena Alexandrova ◽  
Lubomir Petrov ◽  
Margarita Kirkova
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Protein Oxidation ◽  
Experimental Diabetes ◽  
Diabetic Rats ◽  
Ubiquitin Proteasome Pathway ◽  
Ubiquitin Proteasome ◽  
Proteasome Pathway ◽  
And Oxidative Stress

AbstractNumerous studies have indicated that oxidative stress contributes to the development and progression of diabetes and other related complications. Since the ubiquitin-proteasome pathway is involved in degradation of oxidized proteins, it is to be expected that alterations in proteasome-dependent proteolysis accompany diabetes. This paper focuses on the role of the proteasome in alloxan-induced experimental diabetes. The changes in proteasomal activity and oxidative stress indices (protein oxidation and lipid peroxidation) were evaluated. The obtained results revealed increased protein oxidation and lipid peroxidation, as well as alterations in proteasomal activities in diabetic rats. Our data indicates a significant decrease in chymotryptic-like activity; increased tryptic-like activity; and unchanged post-glutamyl peptide hydrolytic-like activity. These findings suggest the presence of oxidative stress in diabetes that appears to result in changes to the ubiquitin-proteasome pathway.

Fenugreek seed extract ameliorates cognitive deficits in streptozotocin-induced diabetic rats

2019 ◽  
Vol 30 (4) ◽  
Author(s):  
Praveen K. Kodumuri ◽  
Christofer Thomas ◽  
Raghu Jetti ◽  
Anil Kumar Pandey
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Cognitive Dysfunction ◽  
Memory Impairment ◽  
Neuronal Loss ◽  
Diabetic Rats ◽  
Seed Extract ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
And Oxidative Stress

Abstract Background Natural medicinal plants have been the focus of current research for developing neuroprotective agents to be used in the diabetes-linked cognitive dysfunction. Trigonella foenum-graecum seeds (known as fenugreek, methi in Hindi), is a well-known traditional medicinal herb and possesses anti-diabetic, anti-oxidant, and anti-inflammatory properties. Purpose This study was undertaken to explore the ameliorative effects of T. foenum-graecum seed extract on diabetes-induced cognitive dysfunction. Methods Experimental diabetes was induced by administering a single dose of streptozotocin (60 mg/kg) through intraperitoneal dose. Cognitive function was assessed using a T-maze and the Morris water maze. Lipid peroxidation levels and oxidative stress in the hippocampus was measured. Quantification of hippocampal CA1 and CA3 regions was done using cresyl violet stain. Results Diabetic rats demonstrated learning and memory impairment, which was evident from poor performance in behavioral tasks, i.e. T-maze and Morris water maze tasks. Learning and memory impairment in diabetic animals is associated with increased blood glucose levels, increased oxidative stress in the hippocampus and decreased number of neurons in the CA1 and CA3 regions of the hippocampus. The diabetic rats administered with T. foenum-graecum showed improved performance in behavioral tasks, and these changes were associated with decreased blood glucose levels, decreased oxidative stress in the hippocampus, and decreased neuronal loss from the CA1 and CA3 regions of the hippocampus. Conclusion In conclusion, administration of T. foenum-graecum seed extract ameliorates diabetes-linked cognitive dysfunction in rats by decreasing blood glucose levels, reducing lipid peroxidation and oxidative stress in the hippocampus, and preventing neuronal loss from the hippocampus.

The sesame lignan sesamin attenuates vascular dysfunction in streptozotocin diabetic rats: Involvement of nitric oxide and oxidative stress

2013 ◽  
Vol 698 (1-3) ◽  
pp. 316-321 ◽  
Author(s):  
Tourandokht Baluchnejadmojarad ◽  
Mehrdad Roghani ◽  
Mohammad-Reza Jalali Nadoushan ◽  
Mohammad-Reza Vaez Mahdavi ◽  
Hamid Kalalian-Moghaddam ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Vascular Dysfunction ◽  
Diabetic Rats ◽  
Streptozotocin Diabetic Rats ◽  
And Oxidative Stress

scholarly journals Accumulation of α-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Volkan Solmaz ◽  
Hatice Köse Özlece ◽  
Hüseyin Avni Eroglu ◽  
Hüseyin Aktuğ ◽  
Oytun Erbaş ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Marker ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Control Group ◽  
Pentraxin 3 ◽  
Oxidative Stress Markers ◽  
Glucose Levels ◽  
Stress Markers ◽  
And Oxidative Stress

Objective. The present study was conducted to evaluate the relationship between plasma oxidative stress markers such as malondialdehyde (MDA) and glutathione (GSH), inflammatory marker pentraxin-3 (PTX3), and cerebellar accumulation of α-synuclein in streptozotocin- (STZ-) induced diabetes model in rats. Methods. Twelve rats were included in the study. Diabetes (n=6) was induced with a single intraperitoneal injection of streptozotocin (STZ, 60 mg/kg). Diabetes was verified after 48 h by measuring blood glucose levels. Six rats served as controls. Following 8 weeks, rats were sacrificed for biochemical and immunohistochemical evaluation. Results. Plasma MDA levels were significantly higher in diabetic rats when compared with the control rats (p<0.01), while plasma GSH levels were lower in the diabetic group than in the control group (p<0.01). Also, plasma pentraxin-3 levels were statistically higher in diabetic rats than in the control rats (p<0.01). The analysis of cerebellar α-synuclein immunohistochemistry showed a significant increase in α-synuclein immunoexpression in the diabetic group compared to the control group (p<0.01). Conclusion. Due to increased inflammation and oxidative stress in the chronic period of hyperglycemia linked to diabetes, there may be α-synuclein accumulation in the cerebellum and the plasma PTX3 levels may be assessed as an important biomarker of this situation.

scholarly journals Tetrahydrocurcumin alleviates hypertension, aortic stiffening and oxidative stress in rats with nitric oxide deficiency

2011 ◽  
Vol 35 (4) ◽  
pp. 418-425 ◽  
Author(s):  
Saowanee Nakmareong ◽  
Upa Kukongviriyapan ◽  
Poungrat Pakdeechote ◽  
Veerapol Kukongviriyapan ◽  
Bunkerd Kongyingyoes ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Nitric Oxide Deficiency ◽  
Aortic Stiffening ◽  
And Oxidative Stress
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