scholarly journals HLA-G Polymorphism (rs16375) and Acute Rejection in Liver Transplant Recipients

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Negar Azarpira ◽  
Mahdokht H. Aghdaie ◽  
Kurosh Kazemi ◽  
Bita Geramizadeh ◽  
Masumeh Darai
Keyword(s):  
Acute Rejection ◽  
Liver Transplant ◽  
Normal Liver ◽  
Meld Score ◽  
Transplant Recipients ◽  
Deletion Polymorphism ◽  
Study Results ◽  
Significant Difference ◽  
The Stability ◽  
Liver Transplant Recipients

Background. HLA-G molecules exhibit immunomodulatory properties that can delay graft rejection. The 14 bp insertion/deletion polymorphism (INDEL) (rs16375) influences the stability of final HLA-G mRNA and its soluble isoforms.Objective. The present study aimed to investigate the possible association between this polymorphism and the incidence of acute rejection in Iranian liver transplant recipients.Methods. Different genotypes were evaluated by PCR. The patients who had acute rejection within 6 months after transplantation were classified as acute rejection (AR) group, while others were considered as nonacute rejection (NAR) group.Results. Among the recipients, 21 patients (21%) had at least one episode of AR, while the other 79 patients (79%) had normal liver function. No significant differences were found between the two groups regarding sex, MELD score, and primary liver disease. Also, no difference was observed concerning rs16375 genotype and allele frequency (P=0.44, OR: 0.69; CI: 0.21–2.10).Conclusion. The study results revealed no significant difference between the AR and the NAR groups regarding the 14 bp INDEL genotypes and alleles. Further studies are recommended to be conducted on other polymorphic sites as well as monitoring of serum HLA-G concentration in order to ascertain the potential implications of this marker in our population.

scholarly journals Delta bilirubin: a sensitive and predictive marker for acute rejection in liver transplant recipients

2018 ◽  
Vol 6 (3) ◽  
pp. 945
Author(s):  
Deepa Gupta ◽  
Aditi Gupta ◽  
Arun Raizada
Keyword(s):  
Acute Rejection ◽  
Liver Transplant ◽  
Predictive Value ◽  
Predictive Marker ◽  
Transplant Recipients ◽  
Serial Measurement ◽  
Significant Difference ◽  
Major Operation ◽  
Sensitivity Specificity ◽  
Liver Transplant Recipients

Background: This study was aimed to investigate the diagnostic utility of delta bilirubin for acute rejection in liver transplant recipients.Methods: The present study was conducted on 80 patients (56 men and 24 women) who were admitted for a major operation of liver transplantation at super-speciality hospital, Medanta-The Medicity, Gurgaon. The average age of the patients was 43±19 years. Data was analyzed as mean, standard deviation; student t test by using statistical package for social sciences (SPSS) software. Sensitivity, specificity, positive predictive value and negative predictive value were calculated in percentage.Results: The result from the present study indicates that delta bilirubin had highest sensitivities of 93% whereas conjugated bilirubin has 43% while AST, ALT, GGT and ALKP had sensitivities of 61%, 81%, 80% and 31% respectively. There was a significant difference of delta bilirubin between rejection and non rejection transplant recipients.Conclusions: Our findings supported that the serial measurement of delta bilirubin would be a reliable marker for recognizing early rejection in liver transplant recipients.

The majority of liver transplant recipients with normal liver enzyme tests (LET) exhibit long term liver graft lesions

2000 ◽  
Vol 118 (4) ◽  
pp. A1426
Author(s):  
Michael Bismuth ◽  
Georges-Philippe Pageaux ◽  
Christophe Duvoux ◽  
Val\'erie Costes ◽  
Elie-Serge Zafrani ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Liver Enzyme ◽  
Normal Liver ◽  
Liver Graft ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

Comparison between kidney and liver transplant recipients admitted to a referral center regarding coronavirus-2019 manifestations in the Northeast of Iran during three peaks of pandemic

2021 ◽  
Vol 17 ◽  
Author(s):  
Mohsen Aliakbarian ◽  
Rozita Khodashahi ◽  
Mahin Ghorban Sabbagh ◽  
Hamid Reza Naderi ◽  
Mandana Khodashahi ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
High Risk ◽  
Liver Transplant ◽  
Severe Infection ◽  
Clinical Findings ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Cross Sectional ◽  
Significant Difference ◽  
Liver Transplant Recipients

Background: Transplant recipients are at high risk for severe Coronavirus disease-2019 (COVID-19). Transplant recipients are immune-compromised individuals at high risk for severe infection. This study aimed to compare the presentations and outcomes of liver and kidney transplant recipients who were infected with COVID-19 in the Iranian population. Methods: This cross-sectional study was conducted at Imam Reza and Montaserieh Hospitals affiliated with Mashhad University of Medical Sciences, Mashhad, Iran, between 2020 and 2021. In general, 52 patients were selected and divided into two groups of the kidney (n=28) and liver (n=24) transplantation. Two groups were compared in terms of demographic characteristics and clinical findings. Results: Of 52 patients, severe COVID-19 infection was reported in 61% of the patients. There was no significant difference between the two groups in terms of symptoms, except for cough (χ2=8.09; P=0.004), clinical condition, and laboratory symptoms, except for creatinine (Z=14; P<0.005), alkaline phosphatase (Z=4.55; P=0.03), total bilirubin (Z=8.93; P=0.03), and partial thromboplastin time (Z=5.97; P=0.01). There was no relationship between the outcome and the use of immunosuppressive medications (P>0.05). All patients with kidney transplantation survived, while two cases in the liver transplantation group failed to survive (χ2=2.42; P=0.11). Conclusion: The mortality rate was higher in the liver transplant recipients, compared to the patients who underwent kidney transplantation.

Pleural Effusions Following Liver Transplantation: A Single-Center Experience

2020 ◽  
pp. 088506662093244
Author(s):  
Justin K. Lui ◽  
Lidia Spaho ◽  
Shahrad Hakimian ◽  
Michael Devine ◽  
Rosa Bui ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Liver Transplant ◽  
Hospital Length Of Stay ◽  
Transplant Recipients ◽  
Single Center ◽  
Pleural Effusions ◽  
Post Transplantation ◽  
Significant Difference ◽  
Liver Transplant Recipients

Introduction: This was a single-center retrospective study to evaluate incidence, prognosis, and risk factors in patients with postoperative pleural effusions, a common pulmonary complication following liver transplantation. Methods: A retrospective review was performed on 374 liver transplantation cases through a database within the timeframe of January 1, 2009 through December 31, 2015. Demographics, pulmonary and cardiac function testing, laboratory studies, intraoperative transfusion/infusion volumes, postoperative management, and outcomes were analyzed. Results: In the immediate postoperative period, 189 (50.5%) developed pleural effusions following liver transplantation of which 145 (76.7%) resolved within 3 months. Those who developed pleural effusions demonstrated a lower fibrinogen (149.6 ± 66.3 mg/dL vs 178.4 ± 87.3 mg/dL; P = .009), total protein (5.8 ± 1.0 mg/dL vs 6.1 ± 1.2 mg/dL; P = .04), and hemoglobin (9.8 ± 1.8 mg/dL vs 10.3 ± 1.9 mg/dL; P = .004). There was not a statistically significant difference in 1-year all-cause mortality and in-hospital mortality between liver transplant recipients with and without pleural effusions. Liver transplant recipients who developed pleural effusions had a longer hospital length of stay (16.4 ± 10.9 days vs 14.0 ± 16.5 days; P = .1), but the differences were not statistically significant. However, there was a significant difference in tracheostomy rates (11.6% vs 5.4%; P = .03) in recipients who developed pleural effusions compared to recipients who did not. Conclusions: In summary, pleural effusions are common after liver transplantation and are associated with increased morbidity. Pre- and intraoperative risk factors can offer both predictive and prognostic value for post-transplantation pleural effusions. Further prospective studies will be needed to further evaluate the relevance of these findings to limit instances of postoperative pleural effusions.

Ursodeoxycholic acid for prevention of acute rejection in liver transplant recipients

The Lancet ◽  
1990 ◽  
Vol 336 (8706) ◽  
pp. 52-53 ◽  
Author(s):  
Hans Persson ◽  
Styrbjörn Friman ◽  
Tore Scherstén ◽  
Joar Svanvik ◽  
Ingvar Karlberg
Keyword(s):  
Acute Rejection ◽  
Liver Transplant ◽  
Ursodeoxycholic Acid ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

scholarly journals Low incidence of acute rejection in hepatitis B virus positive liver transplant recipients and the impact of hepatitis B immunoglobulin

2016 ◽  
Vol 77 (4) ◽  
pp. 367-374 ◽  
Author(s):  
Annapoorani Veerappan ◽  
Lisa B. VanWagner ◽  
James M. Mathew ◽  
Xuemei Huang ◽  
Joshua Miller ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Acute Rejection ◽  
Liver Transplant ◽  
Transplant Recipients ◽  
B Virus ◽  
Hepatitis B Immunoglobulin ◽  
Low Incidence ◽  
Liver Transplant Recipients ◽  
The Impact
Sign in / Sign up

Export Citation Format

Share Document