scholarly journals CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Matteo Santoni ◽  
Sergio Bracarda ◽  
Massimo Nabissi ◽  
Francesco Massari ◽  
Alessandro Conti ◽  
...  
Keyword(s):  
Chronic Inflammation ◽  
Current Literature ◽  
Tumor Angiogenesis ◽  
Binding Proteins ◽  
Potential Role ◽  
Tumor Development ◽  
Therapeutic Targets ◽  
Heparin Binding ◽  
Cc Chemokines

Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. The imbalance between angiogenic and angiostatic chemokine activities can lead to abnormalities, such as chronic inflammation, dysplastic transformation, and even tumor development and spreading. In this review, we summarize the current literature regarding the role of chemokines as modulators of tumor angiogenesis and their potential role as therapeutic targets in patients with nonhaematological tumors.

scholarly journals Role of Histone Deacetylases in Carcinogenesis: Potential Role in Cholangiocarcinoma

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 780
Author(s):  
Kishor Pant ◽  
Estanislao Peixoto ◽  
Seth Richard ◽  
Sergio A. Gradilone
Keyword(s):  
Histone Deacetylases ◽  
Potential Role ◽  
Chemotherapy Resistance ◽  
Tumor Development ◽  
Therapeutic Targets ◽  
Cellular Proteins ◽  
Epigenetic Changes ◽  
Post Translational Modifications ◽  
Frequent Relapse

Cholangiocarcinoma (CCA) is a highly invasive and metastatic form of carcinoma with bleak prognosis due to limited therapies, frequent relapse, and chemotherapy resistance. There is an urgent need to identify the molecular regulators of CCA in order to develop novel therapeutics and advance diseases diagnosis. Many cellular proteins including histones may undergo a series of enzyme-mediated post-translational modifications including acetylation, methylation, phosphorylation, sumoylation, and crotonylation. Histone deacetylases (HDACs) play an important role in regulating epigenetic maintenance and modifications of their targets, which in turn exert critical impacts on chromatin structure, gene expression, and stability of proteins. As such, HDACs constitute a group of potential therapeutic targets for CCA. The aim of this review was to summarize the role that HDACs perform in regulating epigenetic changes, tumor development, and their potential as therapeutic targets for CCA.

Using serum biomarkers for identifying unstable carotid plaque: update of current evidence

2020 ◽  
Vol 26 ◽  
Author(s):  
Areti Sofogianni ◽  
Konstantinos Tziomalos ◽  
Triantafyllia Koletsa ◽  
Apostolos G. Pitoulias ◽  
Lemonia Skoura ◽  
...  
Keyword(s):  
High Risk ◽  
Great Proportion ◽  
Current Literature ◽  
Early Identification ◽  
Carotid Plaque ◽  
Potential Role ◽  
Carotid Atherosclerosis ◽  
Serum Biomarkers ◽  
Current Evidence

: Carotid atherosclerosis is responsible for a great proportion of ischemic strokes. Early identification of unstable or vulnerable carotid plaques and therefore of patients at high risk for stroke is of significant medical and socioeconomical value. We reviewed the current literature and discuss the potential role of the most important serum biomarkers in identifying patients with carotid atherosclerosis who are at high risk for atheroembolic stroke.

scholarly journals Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review

Life ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 326
Author(s):  
Magdalena Ciążyńska ◽  
Irmina Olejniczak-Staruch ◽  
Dorota Sobolewska-Sztychny ◽  
Joanna Narbutt ◽  
Małgorzata Skibińska ◽  
...  
Keyword(s):  
Ultraviolet Radiation ◽  
Chronic Inflammation ◽  
Potential Role ◽  
Tumor Formation ◽  
Skin Carcinogenesis ◽  
Molecular Networks ◽  
Cancer Therapies ◽  
Inflammatory Microenvironment ◽  
Skin Cancers

The process of skin carcinogenesis is still not fully understood. Both experimental and epidemiological evidence indicate that chronic inflammation is one of the hallmarks of microenvironmental-agent-mediated skin cancers and contributes to its development. Maintaining an inflammatory microenvironment is a condition leading to tumor formation. Multiple studies focus on the molecular pathways activating tumorigenesis by inflammation and indicate several biomarkers and factors that can improve diagnostic and prognostic processes in oncology and dermatology. Reactive oxygen species produced by ultraviolet radiation, oxidizers, or metabolic processes can damage cells and initiate pro-inflammatory cascades. Considering the potential role of inflammation in cancer development and metastasis, the identification of early mechanisms involved in carcinogenesis is crucial for clinical practice and scientific research. Moreover, it could lead to the progress of advanced skin cancer therapies. We focus on a comprehensive analysis of available evidence and on understanding how chronic inflammation and ultraviolet radiation can result in skin carcinogenesis. We present the inflammatory environment as complex molecular networks triggering tumorigenesis and constituting therapeutic targets.

scholarly journals Individual Expectation: An Overlooked, but Pertinent, Factor in the Treatment of Individuals Experiencing Musculoskeletal Pain

2010 ◽  
Vol 90 (9) ◽  
pp. 1345-1355 ◽  
Author(s):  
Joel E. Bialosky ◽  
Mark D. Bishop ◽  
Joshua A. Cleland
Keyword(s):  
Clinical Practice ◽  
Clinical Outcomes ◽  
Musculoskeletal Pain ◽  
Current Literature ◽  
Potential Role ◽  
Physical Therapists ◽  
Clinical Perspective ◽  
The Relationship

Physical therapists consider many factors in the treatment of patients with musculoskeletal pain. The current literature suggests expectation is an influential component of clinical outcomes related to musculoskeletal pain for which physical therapists frequently do not account. The purpose of this clinical perspective is to highlight the potential role of expectation in the clinical outcomes associated with the rehabilitation of individuals experiencing musculoskeletal pain. The discussion focuses on the definition and measurement of expectation, the relationship between expectation and outcomes related to musculoskeletal pain conditions, the mechanisms through which expectation may alter musculoskeletal pain conditions, and suggested ways in which clinicians may integrate the current literature regarding expectation into clinical practice.

Trypanosoma cruzi heparin-binding proteins mediate the adherence of epimastigotes to the midgut epithelial cells of Rhodnius prolixus

Parasitology ◽  
2012 ◽  
Vol 139 (6) ◽  
pp. 735-743 ◽  
Author(s):  
F. O. R. OLIVEIRA ◽  
C. R. ALVES ◽  
F. SOUZA-SILVA ◽  
C. M. CALVET ◽  
L. M. C. CÔRTES ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Trypanosoma Cruzi ◽  
Mammalian Cells ◽  
Binding Proteins ◽  
Rhodnius Prolixus ◽  
Insect Vector ◽  
Heparin Binding ◽  
Molecular Masses ◽  
Pre Treatment

SUMMARYHeparin-binding proteins (HBPs) have been demonstrated in both infective forms of Trypanosoma cruzi and are involved in the recognition and invasion of mammalian cells. In this study, we evaluated the potential biological function of these proteins during the parasite-vector interaction. HBPs, with molecular masses of 65·8 kDa and 59 kDa, were isolated from epimastigotes by heparin affinity chromatography and identified by biotin-conjugated sulfated glycosaminoglycans (GAGs). Surface plasmon resonance biosensor analysis demonstrated stable receptor-ligand binding based on the association and dissociation values. Pre-incubation of epimastigotes with GAGs led to an inhibition of parasite binding to immobilized heparin. Competition assays were performed to evaluate the role of the HBP-GAG interaction in the recognition and adhesion of epimastigotes to midgut epithelial cells of Rhodnius prolixus. Epithelial cells pre-incubated with HBPs yielded a 3·8-fold inhibition in the adhesion of epimastigotes. The pre-treatment of epimastigotes with heparin, heparan sulfate and chondroitin sulfate significantly inhibited parasite adhesion to midgut epithelial cells, which was confirmed by scanning electron microscopy. We provide evidence that heparin-binding proteins are found on the surface of T. cruzi epimastigotes and demonstrate their key role in the recognition of sulfated GAGs on the surface of midgut epithelial cells of the insect vector.

scholarly journals Potential role of p62 in tumor development

Autophagy ◽  
2011 ◽  
Vol 7 (9) ◽  
pp. 1088-1090 ◽  
Author(s):  
Masaaki Komatsu
Keyword(s):  
Potential Role ◽  
Tumor Development

scholarly journals The system of nitrogen oxide generation of small intestine in experimental gastroenterocolitis

2014 ◽  
Vol 18 (2 (70)) ◽  
Author(s):  
A. S. Tkachenko ◽  
V. H. Hopkalov ◽  
M. A. Orlova
Keyword(s):  
Small Intestine ◽  
Nitrogen Oxide ◽  
Chronic Inflammation ◽  
Potential Role ◽  
Food Additive ◽  
Enos Activity ◽  
Microcirculatory Disorders

The activity of endothelial and inducible NO-synthases and the content of S-nitrosothiols were studied in the small intestine homogenates of rats with chronic experimental gastroenterocolitis caused by food additive carrageenan intake during 2 and 4 weeks. It was established that carrageenan intake during 2 weeks led to a decrease of eNOS activity and increased the activity of iNOS in small intestine homogenate, causing increased production of NO and, therefore of Snitrosothiols. A decreased NO synthesis in four-week use of carrageenan indicated a potential role of NO deficiency in the development of microcirculatory disorders and chronic inflammation.

scholarly journals Potential Role of CC Chemokines and their Receptors in the Development of Respiratory Diseases

2009 ◽  
Vol 1 (1) ◽  
pp. 76-84 ◽  
Author(s):  
Lin Tong ◽  
YaoLi Wang ◽  
Jing Bi ◽  
Dong Yang ◽  
ChunXue Bai ◽  
...  
Keyword(s):  
Respiratory Diseases ◽  
Potential Role ◽  
Cc Chemokines
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