scholarly journals Metachronous Bilateral Granulocytic Sarcoma of the Testis in a Young Adult: A Report of an Unusual Entity

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Fatih Hızlı ◽  
Hakan Aksüt ◽  
Aslı Mengeloğlu ◽  
İbrahim Sarı ◽  
Eşref Oğuz Güven ◽  
...  
Keyword(s):  
Young Adult ◽  
Blood Cells ◽  
English Literature ◽  
Granulocytic Sarcoma ◽  
Testicular Mass ◽  
Rare Tumors ◽  
Hematologic Disorder ◽  
Hematologic Cancer ◽  
Acute Nonlymphoblastic Leukemia

Granulocytic sarcomas are rare tumors composed of neoplastic blood cells, typically occurring during the course of acute nonlymphoblastic leukemia or before its onset. We present a case of a 23-year-old young adult man with metachronous granulocytic sarcoma of the testis without hematologic manifestations who was diagnosed with granulocytic sarcoma (GS). The patient was treated with right orchiectomy but relapsed with a left testicular mass 16 months later when a left orchiectomy was performed. The patient has been free of disease for 13 months following the left orchiectomy. This case highlights a rare hematologic cancer that urologists and pathologists should be aware of since it can present as a testicular mass. Only 3 cases of testicular GS without an associated hematologic disorder have been described. To the best of our knowledge, our patient is the first reported case in the English literature of metachronous GS of the testis with no evidence of hematologic disorder.

scholarly journals Body Image Discomfort of Adolescent and Young Adult Hematologic Cancer Survivors

2017 ◽  
Vol 6 (2) ◽  
pp. 377-380 ◽  
Author(s):  
Giulia Zucchetti ◽  
Simona Bellini ◽  
Marina Bertolotti ◽  
Francesca Bona ◽  
Eleonora Biasin ◽  
...  
Keyword(s):  
Body Image ◽  
Young Adult ◽  
Cancer Survivors ◽  
Adolescent And Young Adult ◽  
Hematologic Cancer

Paratesticular Paraganglioma: A Rare Cause of an Intrascrotal Mass

2009 ◽  
Vol 133 (5) ◽  
pp. 811-813
Author(s):  
Ruta Gupta ◽  
R. Spencer Howell ◽  
Mahul B. Amin
Keyword(s):  
Lymphovascular Invasion ◽  
English Literature ◽  
Differential Diagnoses ◽  
Review Of Literature ◽  
Malignant Paraganglioma ◽  
Scrotal Mass ◽  
Rare Tumors ◽  
Clinical Surveillance ◽  
Radical Orchiectomy ◽  
Histology And Immunohistochemistry

Abstract We describe a case of a paratesticular paraganglioma in a 33-year-old man who presented with a scrotal mass and underwent a right testicular exploration. Metastasis is the only definite criterion for diagnosis of a malignant paraganglioma; however, lymphovascular invasion was noted in this case, which warranted a close clinical surveillance. The patient is currently well with no evidence of disease 18 months after radical orchiectomy. Paratesticular paragangliomas are extremely rare tumors with 6 cases reported in English literature. The histogenesis of these tumors is unknown. Though the histology and immunohistochemistry resemble those of paragangliomas at any other location, these tumors raise a plethora of differential diagnoses especially with the more commonly occurring tumors. Herein the relevant histopathologic differential diagnoses are discussed along with a brief review of literature.

scholarly journals Blood-feeding in the young adult filarial wormsLitomosoides sigmodontis

Parasitology ◽  
2004 ◽  
Vol 130 (4) ◽  
pp. 421-428 ◽  
Author(s):  
T. ATTOUT ◽  
S. BABAYAN ◽  
A. HOERAUF ◽  
D. W. TAYLOR ◽  
W. J. KOZEK ◽  
...  
Keyword(s):  
Life Cycle ◽  
Young Adult ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Blood Feeding ◽  
Post Inoculation ◽  
Mongolian Gerbils ◽  
Litomosoides Sigmodontis ◽  
Precise Moment ◽  
Kinetics Of

In this study with the filarial modelLitomosoides sigmodontis, we demonstrate that the worms ingest host red blood cells at a precise moment of their life-cycle, immediately after the fourth moult. The red blood cells (RBC) were identified microscopically in live worms immobilized in PBS at 4 °C, and their density assessed. Two hosts were used: Mongolian gerbils, where microfilaraemia is high, and susceptible BALB/c mice with lower microfilaraemia. Gerbils were studied at 12 time-points, between day 9 post-inoculation (the worms were young 4th stage larvae) and day 330 p.i. (worms were old adults). Only the very young adult filarial worms had red blood cells in their gut. Haematophagy was observed between days 25 and 56 p.i. and peaked between day 28 and day 30 p.i. in female worms. In males, haematophagy was less frequent and intense. Similar kinetics of haematophagy were found in BALB/c mice, but frequency and intensity tended to be lower. Haematophagy seems useful to optimize adult maturation. These observations suggest that haematophagy is an important step in the life-cycle ofL. sigmodontis. This hitherto undescribed phenomenon might be characteristic of other filarial species including human parasites.

scholarly journals Rituximab Use in Warm and Cold Autoimmune Hemolytic Anemia

2020 ◽  
Vol 9 (12) ◽  
pp. 4034
Author(s):  
Irina Murakhovskaya
Keyword(s):  
Hemolytic Anemia ◽  
Autoimmune Hemolytic Anemia ◽  
Blood Cells ◽  
Rare Condition ◽  
Cold Agglutinin ◽  
Toxicity Profile ◽  
Cold Agglutinin Disease ◽  
First Line ◽  
Hematologic Disorder

Autoimmune hemolytic anemia is a rare condition characterized by destruction of red blood cells with and without involvement of complement. It is associated with significant morbidity and mortality. In warm autoimmune hemolytic anemia, less than 50% of patients remain in long-term remission following initial steroid therapy and subsequent therapies are required. Cold agglutinin disease is a clonal hematologic disorder that requires therapy in the majority of patients and responds poorly to steroids and alkylators. Rituximab has a favorable toxicity profile and has demonstrated efficacy in autoimmune hemolytic anemia in first-line as well as relapsed settings. Rituximab is the preferred therapy for steroid refractory warm autoimmune hemolytic anemia (wAIHA) and as part of the first- and second-line treatment of cold agglutinin disease. This article reviews the mechanism of action of rituximab and the current literature on its role in the management of primary and secondary warm autoimmune hemolytic anemia and cold agglutinin disease.

scholarly journals Rituximab use in Warm and Cold Autoimmune Hemolytic Anemia

2020 ◽  
Author(s):  
Irina Murakhovskaya
Keyword(s):  
Hemolytic Anemia ◽  
Autoimmune Hemolytic Anemia ◽  
Blood Cells ◽  
Rare Condition ◽  
Cold Agglutinin ◽  
Toxicity Profile ◽  
Cold Agglutinin Disease ◽  
First Line ◽  
Hematologic Disorder

Autoimmune hemolytic anemia is a rare condition characterized by destruction of red blood cells with and without involvement of complement. It is associated with significant morbidity and mortality. In warm autoimmune hemolytic anemia less than 50% of patients remain in a long-term remission following initial steroid therapy and subsequent therapies are required. Cold agglutinin disease is a clonal hematologic disorder which requires therapy in majority of patients and responds poorly to steroids and alkylators. Rituximab has a favorable toxicity profile and has demonstrated efficacy in autoimmune hemolytic anemia in first line as well as relapsed setting. Rituximab is the preferred therapy for steroid refractory wAIHA and as part of the first- and second-line treatment of cold agglutinin disease. This article reviews the mechanism of action of the rituximab and current literature its role in management of primary and secondary warm autoimmune hemolytic anemia and cold agglutinin disease.

Reference ranges of white blood cells and platelets counts among Sudanese young adult males in Khartoum state

2017 ◽  
Vol 3 (3) ◽  
pp. 9
Author(s):  
Abdalla Mohamed Mohi Eldin ◽  
Mustafa Hussien ◽  
Rehab Badi ◽  
Nisreen Daffa Alla
Keyword(s):  
Young Adult ◽  
Blood Cells ◽  
White Blood Cells ◽  
Reference Ranges ◽  
Adult Males ◽  
Young Adult Males
Sign in / Sign up

Export Citation Format

Share Document