scholarly journals Comparison of Structural Architecture of HCV NS3 Genotype 1 versus Pakistani Genotype 3a

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Kaneez Fatima ◽  
Esam Azhar ◽  
Shilu Mathew ◽  
Ghazi Damanhouri ◽  
Ishtiaq Qadri
Keyword(s):  
Amino Acids ◽  
Structural Characterization ◽  
Antiviral Agents ◽  
Interaction Patterns ◽  
Genotype 1 ◽  
Genome Variability ◽  
Structural Architecture ◽  
Genotype 3A

This study described the structural characterization of Pakistani HCV NS3 GT3a in parallel with genotypes 1a and 1b NS3. We investigated the role of amino acids and their interaction patterns in different HCV genotypes by crystallographic modeling. Different softwares were used to study the interaction pattern, for example, CLCBIO sequence viewer, MODELLER, NMRCLUST, ERRAT score, and MODELLER. Sixty models were produced and clustered into groups and the best model of PK-NCVI/Pk3a NS3 was selected and studied further to check the variability with other HCV NS3 genotypes. This study will help in future to understand the structural architecture of HCV genome variability and to further define the conserved targets for antiviral agents.

scholarly journals Characterization of Naturally Occurring NS5A and NS5B Polymorphisms in Patients Infected with HCV Genotype 3a Treated with Direct-Acting Antiviral Agents

Viruses ◽  
2017 ◽  
Vol 9 (8) ◽  
pp. 212 ◽  
Author(s):  
Barbara Bartolini ◽  
Emanuela Giombini ◽  
Chiara Taibi ◽  
Raffaella Lionetti ◽  
Marzia Montalbano ◽  
...  
Keyword(s):  
Antiviral Agents ◽  
Hcv Genotype ◽  
Direct Acting Antiviral ◽  
Naturally Occurring ◽  
Direct Acting ◽  
Direct Acting Antiviral Agents ◽  
Genotype 3A

Structural characterization of folded and extended conformations in peptides containing γ amino acids with proteinogenic side chains: crystal structures of γn, (αγ)n and γγδγ sequences

2015 ◽  
Vol 39 (5) ◽  
pp. 3319-3326 ◽  
Author(s):  
Madhusudana M. B. Reddy ◽  
K. Basuroy ◽  
S. Chandrappa ◽  
B. Dinesh ◽  
B. Vasantha ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Crystal Structures ◽  
Structural Characterization ◽  
Side Chains ◽  
Amino Acid Residues

γn amino acid residues can be incorporated into structures in γn and hybrid sequences containing folded and extended α and δ residues.

scholarly journals Functional and structural characterization of IdnL7, an adenylation enzyme involved in incednine biosynthesis

2019 ◽  
Vol 75 (4) ◽  
pp. 299-306
Author(s):  
Jolanta Cieślak ◽  
Akimasa Miyanaga ◽  
Makoto Takaishi ◽  
Fumitaka Kudo ◽  
Tadashi Eguchi
Keyword(s):  
Amino Acids ◽  
Substrate Specificity ◽  
Natural Product ◽  
Structural Characterization ◽  
Biochemical Analysis ◽  
Natural Product Biosynthesis ◽  
Broad Substrate Specificity ◽  
Selective Incorporation ◽  
Polyketide Antibiotic

Adenylation enzymes play an important role in the selective incorporation of the cognate carboxylate substrates in natural product biosynthesis. Here, the biochemical and structural characterization of the adenylation enzyme IdnL7, which is involved in the biosynthesis of the macrolactam polyketide antibiotic incednine, is reported. Biochemical analysis showed that IdnL7 selects and activates several small amino acids. The structure of IdnL7 in complex with an L-alanyl-adenylate intermediate mimic, 5′-O-[N-(L-alanyl)sulfamoyl]adenosine, was determined at 2.1 Å resolution. The structure of IdnL7 explains the broad substrate specificity of IdnL7 towards small L-amino acids.

scholarly journals Inside Cover: Synthesis and Structural Characterization of Homochiral Homo-oligomers of Parent cis- and trans-Furanoid-β-Amino Acids (Chem. Eur. J. 46/2011)

2011 ◽  
Vol 17 (46) ◽  
pp. 12834-12834
Author(s):  
Sunil K. Pandey ◽  
Ganesh F. Jogdand ◽  
João C. A. Oliveira ◽  
Ricardo A. Mata ◽  
Pattuparambil R. Rajamohanan ◽  
...  
Keyword(s):  
Amino Acids ◽  
Structural Characterization ◽  
Cis And Trans

Synthesis and Structural Characterization of Homochiral Homo-Oligomers of cis-γ-Methoxy-Substituted cis- and trans-Furanoid-β-Amino Acids

2012 ◽  
Vol 2012 (13) ◽  
pp. 2656-2663 ◽  
Author(s):  
Awadut G. Giri ◽  
Ganesh F. Jogdand ◽  
Pattuparampil R. Rajamohanan ◽  
Sunil K. Pandey ◽  
Chepuri V. Ramana
Keyword(s):  
Amino Acids ◽  
Structural Characterization ◽  
Cis And Trans
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