scholarly journals Skin Recurrence of Transformed Mycosis Fungoides Postumbilical Cord Blood Transplant despite Complete Donor Chimerism

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
Rahul Pawar ◽  
Anup Kasi Loknath Kumar ◽  
Janet Woodroof ◽  
Wei Cui ◽  
Joseph McGuirk ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cord Blood ◽  
Mycosis Fungoides ◽  
Cell Transformation ◽  
Large Cell ◽  
Pet Scan ◽  
Cord Blood Transplant ◽  
Donor Cells ◽  
Large Cell Transformation ◽  
Bone Marrow Chimerism

Background.Allogeneic stem cell transplant is the treatment of choice for systemic cutaneous T-cell lymphoma (CTCL) which provides graft-versus-lymphoma effect. Herein we discuss a case of recurrence of CTCL skin lesions after cord blood transplant in a patient who continued to have 100% donor chimerism in bone marrow.Case Presentation.A 48-year-old female with history of mycosis fungoides (MF) presented with biopsy proven large cell transformation of MF. PET scan revealed multiple adenopathy in abdomen and chest suspicious for lymphoma and skin biopsy showed large cell transformation. She was treated with multiple cycles of chemotherapy. Posttherapy PET scan showed resolution of lymphadenopathy. Later she underwent ablative preparative regimen followed by single cord blood transplant. Bone marrow chimerism studies at day +60 after transplant showed 100% donor cells without presence of lymphoma. However 5 months after transplant she had recurrence of MF with the same genotype as prior skin lesion. Bone marrow chimerism study continued to show 100% donor cells.Conclusion.A differential graft-versus-lymphoma effect in our case prevented lymphoma recurrence systemically but failed to do so in skin. We hypothesize that this response may be due to presence of other factors in the bone marrow and lymph node microenvironments preventing recurrence in these sites.

Poikilodermatous mycosis fungoides with CD30‐positive large cell transformation successfully treated by brentuximab vedotin

2019 ◽  
Vol 33 (1) ◽  
Author(s):  
Svetlana Popadic ◽  
Branislav Lekic ◽  
Srdjan Tanasilovic ◽  
Martina Bosic ◽  
Milos Nikolic
Keyword(s):  
Mycosis Fungoides ◽  
Cell Transformation ◽  
Large Cell ◽  
Brentuximab Vedotin ◽  
Large Cell Transformation

Transformation of Mycosis Fungoides/Sezary Syndrome: Clinical Characteristics and Prognosis

Blood ◽  
1998 ◽  
Vol 92 (4) ◽  
pp. 1150-1159 ◽  
Author(s):  
Eleni Diamandidou ◽  
Maria Colome-Grimmer ◽  
Luis Fayad ◽  
Madeleine Duvic ◽  
Razelle Kurzrock
Keyword(s):  
Mycosis Fungoides ◽  
Median Survival ◽  
Cell Transformation ◽  
Large Cell ◽  
Lactic Dehydrogenase ◽  
Cumulative Probability ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Large Cell Transformation ◽  
American Society

Abstract The occurrence of large cell transformation has been well documented in a subgroup of patients with mycosis fungoides/Sezary syndrome (MF/SS). However, because of the rarity of MF/SS, little is known about the influence of clinicopathologic features in predicting large cell transformation and about outcome in the transformed cases. We evaluated all patients with MF/SS who were registered in our clinic during the study period and for whom pathologic slides for review were available or could be obtained. Disease was classified as transformed if biopsy showed large cells (≥4 times the size of a small lymphocyte) in more than 25% of the infiltrate or if they formed microscopic nodules. Twenty-six patients with transformation were identified from a total of 115 evaluable cases with a diagnosis of MF/SS. The actuarial cumulative probability of transformation reached 39% in 12 years. The median time from diagnosis of MF/SS to transformation was 12 months (range, 0 to 128 months). Thirty-one percent of all patients with stage IIB-IV disease at presentation eventually transformed versus 14% of those with stage I-IIA (P= .03), with transformation being especially common in patients with tumors (T3), 46% of whom transformed. Combining elevated β2 microglobulin and lactic dehydrogenase (neither elevated v one or both elevated) was also predictive for transformation (P = .009). The median survival from initial diagnosis of MF/SS for the transformed patients was 37 months versus 163 months for the untransformed group (P = .0029). The median survival from transformation was 19.4 months (range, 2+ to 138 months). The following characteristics were associated with an inferior survival in transformed patients: (1) early transformation (<2 years from the diagnosis v ≥2 years; P = .011) and (2) advanced stage (IIB-IV v I-IIA; 2-year survival, 23% v 86%;P = .0035). We conclude that MF/SS patients with stages IIB-IV disease and, in particular, those with tumors have a high incidence of large-cell transformation. Patients with transformation have a relatively poor survival, especially if transformation occurs early (within 2 years) in the course of disease or if they are staged as IIB or higher. © 1998 by The American Society of Hematology.

scholarly journals Large Cell Transformation of Oral Mycosis Fungoides

2017 ◽  
Vol 12 (2) ◽  
pp. 247-251 ◽  
Author(s):  
Ahmed S. Sultan ◽  
Behzad Mostoufi ◽  
John C. Papadimitriou ◽  
Rima Koka ◽  
John Basile ◽  
...  
Keyword(s):  
Mycosis Fungoides ◽  
Cell Transformation ◽  
Large Cell ◽  
Large Cell Transformation

Transformation of Mycosis Fungoides/Sezary Syndrome: Clinical Characteristics and Prognosis

Blood ◽  
1998 ◽  
Vol 92 (4) ◽  
pp. 1150-1159 ◽  
Author(s):  
Eleni Diamandidou ◽  
Maria Colome-Grimmer ◽  
Luis Fayad ◽  
Madeleine Duvic ◽  
Razelle Kurzrock
Keyword(s):  
Mycosis Fungoides ◽  
Median Survival ◽  
Cell Transformation ◽  
Large Cell ◽  
Lactic Dehydrogenase ◽  
Cumulative Probability ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Large Cell Transformation ◽  
American Society

The occurrence of large cell transformation has been well documented in a subgroup of patients with mycosis fungoides/Sezary syndrome (MF/SS). However, because of the rarity of MF/SS, little is known about the influence of clinicopathologic features in predicting large cell transformation and about outcome in the transformed cases. We evaluated all patients with MF/SS who were registered in our clinic during the study period and for whom pathologic slides for review were available or could be obtained. Disease was classified as transformed if biopsy showed large cells (≥4 times the size of a small lymphocyte) in more than 25% of the infiltrate or if they formed microscopic nodules. Twenty-six patients with transformation were identified from a total of 115 evaluable cases with a diagnosis of MF/SS. The actuarial cumulative probability of transformation reached 39% in 12 years. The median time from diagnosis of MF/SS to transformation was 12 months (range, 0 to 128 months). Thirty-one percent of all patients with stage IIB-IV disease at presentation eventually transformed versus 14% of those with stage I-IIA (P= .03), with transformation being especially common in patients with tumors (T3), 46% of whom transformed. Combining elevated β2 microglobulin and lactic dehydrogenase (neither elevated v one or both elevated) was also predictive for transformation (P = .009). The median survival from initial diagnosis of MF/SS for the transformed patients was 37 months versus 163 months for the untransformed group (P = .0029). The median survival from transformation was 19.4 months (range, 2+ to 138 months). The following characteristics were associated with an inferior survival in transformed patients: (1) early transformation (<2 years from the diagnosis v ≥2 years; P = .011) and (2) advanced stage (IIB-IV v I-IIA; 2-year survival, 23% v 86%;P = .0035). We conclude that MF/SS patients with stages IIB-IV disease and, in particular, those with tumors have a high incidence of large-cell transformation. Patients with transformation have a relatively poor survival, especially if transformation occurs early (within 2 years) in the course of disease or if they are staged as IIB or higher. © 1998 by The American Society of Hematology.

CD30-Positive Large Cell Transformation of Mycosis Fungoides

2008 ◽  
Vol 32 (1) ◽  
pp. 118-118
Author(s):  
JS Susa ◽  
WA High ◽  
S Yegappan ◽  
MP Hoang
Keyword(s):  
Mycosis Fungoides ◽  
Cell Transformation ◽  
Large Cell ◽  
Large Cell Transformation
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