scholarly journals Factors Affecting Health-Related Quality of Life and Physical Activity after Liver Transplantation for Autoimmune and Nonautoimmune Liver Diseases: A Prospective, Single Centre Study

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Katarzyna Kotarska ◽  
Ewa Wunsch ◽  
Agnieszka Kempińska-Podhorodecka ◽  
Joanna Raszeja-Wyszomirska ◽  
Dimitrios P. Bogdanos ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Health Related Quality ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related ◽  
Group A ◽  
Group B ◽  
Autoimmune Etiology

Background/Aim.With the improvement of the outcomes after liver transplantation (LTx), health-related quality of life (HRQoL) and physical activity are becoming significant outcome parameters. We prospectively assessed these parameters in patients with autoimmune and nonautoimmune liver disorders undergoing LTx.Materials and Methods.Patients (n=107) were subdivided into 3 groups depending on the time after LTx: group-A (n=21): 6–12 months; group-B (n=48): 13–36 months; and group-C (n=38): >37 months. SF-36 and IPAQ were applied in HRQoL and physical activity assessment.Results.Females had impaired HRQoL in most SF-36 domains. Younger patients showed higher scores at SF-36physical functioningdomain but IPAQ was not influenced by age. Group-B had highergeneral healthandphysical component summarythan group-A (P=0.037,P=0.04, resp.) and total IPAQ than group-C (P=0.047). Thesitting timedomain was longer in group-A than in group-B and group-C (P=0.0157;  P=0.042, resp.). Employed patients had better HRQoL and higher physical activity than those not working. SF-36 and IPAQ were unrelated to the autoimmune etiology of liver disease.Conclusions.These findings show that female and unemployed patients have worse HRQoL, while gender and age at LTx time do not affect IPAQ’s physical activity. The autoimmune etiology of liver disease does not influence HRQoL and physical activity after LTx.

scholarly journals The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

2020 ◽  
Vol 17 (10) ◽  
pp. 3728
Author(s):  
Alba Marcos-Delgado ◽  
Tania Fernández-Villa ◽  
Miguel Ángel Martínez-González ◽  
Jordi Salas-Salvadó ◽  
Dolores Corella ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Health Related Quality ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related

The main objective of this study was to examine the relationship between the level of physical activity (PA) and the degree of obesity with health-related quality of life (HRQoL) in individuals with metabolic syndrome (MetS) who participated in the Predimed-Plus study. A total of 6875 subjects between 55 and 75 years of age with MetS were selected and randomized in 23 Spanish centers. Subjects were classified according to categories of body mass index (BMI). PA was measured with the validated Registre Gironí del Cor (REGICOR) questionnaire and subjects were classified according to their PA level (light, moderate, vigorous) and the HRQoL was measured with the validated short-form 36 (SF-36) questionnaire. By using the ANOVA model, we found a positive and statistically significant association between the level of PA and the HRQoL (aggregated physical and mental dimensions p < 0.001), but a negative association with higher BMI in aggregated physical dimensions p < 0.001. Furthermore, women obtained lower scores compared with men, more five points in all fields of SF-36. Therefore, it is essential to promote PA and body weight control from primary care consultations to improve HRQoL, paying special attention to the differences that sex incurs.

Development and Validation of a New Instrument to Measure Health-related Quality of Life in Patients with Psoriatic Arthritis: The VITACORA-19

2014 ◽  
Vol 41 (10) ◽  
pp. 2008-2017 ◽  
Author(s):  
Juan Carlos Torre-Alonso ◽  
Jordi Gratacós ◽  
José Santos Rey-Rey ◽  
Juan Pablo Valdazo de Diego ◽  
Ana Urriticoechea-Arana ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Psoriatic Arthritis ◽  
Health State ◽  
Sensitivity To Change ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Group A ◽  
Group B

Objective.To develop/validate an instrument to measure health-related quality of life (HRQoL) in patients with psoriatic arthritis (PsA), for use in clinical studies.Methods.An item pool of 35 items was generated following standardized procedures. Item reduction was performed using clinimetric and psychometric approaches after administration to 66 patients with PsA. The resulting instrument, the VITACORA-19, consists of 19 items. Its validity content, internal consistency, test-retest reliability, known groups/convergent validity, and sensitivity to change were tested in a longitudinal and multicenter study conducted in 10 hospitals in Spain, with 323 patients who also completed the EuroQol 5-dimensional questionnaire (EQ-5D) and a health status transition item. There were 3 study groups: group A (n = 209, patients with PsA), group B (n = 71, patients with arthritis without psoriatic aspect, patients with arthrosis, and patients with dermatitis), and group C (n = 43, healthy controls).Results.The questionnaire was considered easy/very easy to answer by 94.7% of the patients with PsA. The factorial analysis clearly identified only 1 factor. Cronbach’s alpha coefficient and interclass correlation coefficients exceeded 0.90. Statistically significant differences (p < 0.001) were observed between groups: subjects from group C had better HRQoL, followed by group B, and finally group A had the worst HRQoL. The VITACORA-19 scores showed significant correlations (p < 0.001) to PsA disease activity, EQ-5D, and perceived health state, scoring the patients with better health state higher. The minimum important difference was established as an 8-point change in the global score.Conclusion.The Spanish-developed VITACORA-19, designed to measure HRQoL in patients with PsA, has good validity, reliability, and sensitivity to change.

scholarly journals Regular Dental Visits: Influence on Health-Related Quality of Life in 1,607 Patients with Oral Squamous Cell Carcinoma

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Simon Spalthoff ◽  
Henrik Holtmann ◽  
Gertrud Krüskemper ◽  
Rüdiger Zimmerer ◽  
Jörg Handschel ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Health Related Quality ◽  
Tumor Treatment ◽  
Related Quality ◽  
Health Related ◽  
Group A ◽  
Group B

Background. The incidence of oral squamous cell carcinoma (OSCC) is in the top 10 of all cancer entities. Regular oral examinations by dentists play an important role in oral cancer prevention.Methods. Patients with OSCC (n=1,607) and physicians (n=1,489) completed questionnaires during the DÖSAK Rehab Study. The psychosocial and functional factors collected in these questionnaires were assessed in the present study. We compared patients who visited their dentist at least once a year (group A) with those who visited their dentist less than once a year (group B).Results. Patients in group A had significantly better health-related quality of life after tumor treatment than patients in group B. Patients in group A also had a smaller tumor size and less lymph node metastasis and lost fewer teeth during the treatment. This resulted in better prosthetic rehabilitation and better psychological status after tumor treatment.Conclusions. Dentists play an important role in the early recognition of oral cancer. This study should encourage dentists to take a more active role in oral cancer prevention.

P0843EFFECT OF GROUP PSYCHO SOCIAL SUPPORT ON QUALITY OF LIFE AND MORTALITY WITH END STAGE KIDNEY DISEASE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Zara Nisar ◽  
Hassan Sajjad ◽  
Nisar Anwar
Keyword(s):  
Quality Of Life ◽  
Group Therapy ◽  
Health Related Quality ◽  
End Stage Kidney Disease ◽  
Related Quality ◽  
Health Related ◽  
Group A ◽  
Group B ◽  
End Stage

Abstract Background and Aims The patients of end stage renal disease suffer a lot of psychological trauma as well as feel a lot of social burden. They mostly show psychological distress in different forms, be it impaired quality of life, depression or anxiety. The aim of our study was to find out the effect of supportive-expressive group therapy in end stage kidney disease patients in the outcome of better health related quality of life and survival. Method 181 patients were recruited in the study after consent between June 2012-June 2017. They were then assigned randomly to Group A supportive-expressive group therapy or to a Group B control group (no intervention). It was a double blinded randomized control trial. 115 patients were assigned to Group A and 66 were assigned to group B. The primary outcome was the effect on health related quality of life. Secondly, if it had any impact on survival. Significant predictors of survival were not analysed. Analysis was done by intention to treat. Results The patients of group A showed decrease in physical pain(p=0.002), mood elevation (p=0.04), compliance with treatment (p=0.001), reduced hopelessness (p=0.004), newly diagnosed depressive disorders (p=0.01) and better social life (p=0.003). Group A had 97% survival rate as compared to group B with 77%. Conclusion Supportive-expressive group therapy to patients with end stage kidney disease improves health related quality of life. It also has an effect on survival maybe because of compliance with treatment. We would like to further explore the role of Supportive-expressive group therapy in survival. Support groups should be provided to patients in developing countries like the setup of ours because it has a great impact on the betterment of the patient.

scholarly journals The association of pulmonary function, physical activity, cardiorespiratory fitness, Borg dyspnea scales and health related quality of life in patients with resected lung cancer

2021 ◽  
Author(s):  
Xinping Li ◽  
Yi Chen ◽  
Shuangchun Liu ◽  
Mingsheng Zhang
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Lung Cancer ◽  
Pulmonary Function ◽  
Cardiorespiratory Fitness ◽  
Health Related Quality ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related

Abstract Background Understanding the determinants of quality of life for the patients after lung resection would be beneficial to affect the prevention programs and the treatment strategies. This novel study aims to explore the relationship between pulmonary function, physical activity, cardiorespiratory fitness (CRF), dyspnea, and the health-related quality of life (HRQoL) of patients with resected lung cancer. Methods A cross-sectional study design with 38 lung cancer survivors after surgery for one month was conducted. We assessed CRF by measuring maximal oxygen consumption (VO2max) and anaerobic threshold (VT).Forced vital capacity (FVC) was measured using a spirometer. Physical activity, dyspnea, and HRQoLwereinvestigated by 6-minute walking distance (6MWD), Borg dyspnea scales, and the SF-36 Health Survey (SF-36), respectively.Data analyses were conducted using SmartPLS to examine path analyses between the measures. Results There was a significant relationship between CRF andHRQoL in this cohort of cancer survivors.FVC (f2 = 0.265) and 6MWD (f2 = 0.389) have a medium to large effect size on the perceived CRF while CRF (f2 = 0.467) was found to have large effect sizes on perceived QoL. More importantly, our results showed that CRF positively and significantly mediated the paths betweenFVC, 6MWD, andHRQoL[β = 0.22 (0.457*0.474),P < 0.01; β = 0.28 (0.525*0.540), P < 0.01; respectively]. Conclusions Pulmonary function, physical activity, and dyspnea had an indirect effect on the quality of life in patients with resected lung cancer. Furthermore, CRF mediates pulmonary function and physical activity to produces an impact on their quality of life.

scholarly journals QUALIDADE DE VIDA RELACIONADA À SAÚDE (HRQL) DE ADULTOS ENTRE 50 E 80 ANOS PRATICANTES DE ATIVIDADE FÍSICA REGULAR: APLICAÇÃO DO SF-36

2011 ◽  
Vol 16 (esp) ◽  
Author(s):  
Andréa Kruger Gonçalves ◽  
Adriane Ribeiro Teixeira ◽  
Cíntia De la Rocha Freitas ◽  
Eliane Jost Blessmann ◽  
Laysla Roedel ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Short Form ◽  
Well Being ◽  
Health Related Quality ◽  
Cross Sectional ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related

A qualidade de vida relacionada à saúde-HRQL possui um caráter multidimensional com integração da saúde física, do bem-estar psicológico e da satisfação social. O objetivo foi avaliar a qualidade de vida relacionada à saúde (HRQL) de participantes de meia-idade e de idosos de um projeto de atividade física regular. O tipo de estudo foi descritivo, com corte transversal, sendo que a amostra foi composta por 40 adultos com idade entre 50 e 80 anos, integrantes do CELARI da ESEF/UFRGS. O instrumento utilizado foi o SF-36 e a análise empregada utilizou a estatística descritiva e o teste de correlação de Pearson. A pontuação dos domínios por ordem decrescente foi: AS, AF, AE, EGS, CF, SM, VIT, DOR. Houve correlação positiva significativa entre a maioria dos domínios do SF-36. As correlações não significativas ocorreram entre EGS x AS, SM x AF. A idade apenas correlacionou-se com o domínio EGS. A HRQL da amostra mostrou-se com valores superiores, ao ser comparada com a de outros estudos. Os valores atingiram no mínimo 70% de pontuação, na média dos domínios. Os resultados indicaram um nível satisfatório de HRQL e relação entre os domínios do SF-36. palavras-chave Envelhecimento. Qualidade de Vida. Atividade Física. Saúde. abstract The health-related quality of life – HRQOL is a multidimensional issue with integration of physical health, psychological well-being and social satisfaction factors. The aim of this study was to evaluate the health-related quality of life – HRQOL in ageing people who practice regular physical activity. This study was a descriptive cross-sectional and  the sample included 40 adults, aged between 50 and 80 years, attending a University Extension Program. The instrument used was the Brazilian version of Short Form-36. Descriptive statistical analysis was used to summarize HRQL data and Pearson’s correlation for comparison between domains. The score of the domains in descending order were: AS, AF, AE, EGS, CF, SM, VIT, DOR. There was a significant positive correlation between the majority of SF-36. The correlations were not significant between EGS x AS, SM x AF. The age was correlated only with the EGS field. The HRQL of the sample proved to be higher, when compared with other studies. The values ​​reached a minimum score of 70% in average scores. The results indicated a satisfactory level of HRQOL and a significant relationship between different aspects of health-related quality of life. keywords Aging. Quality of Life. Physical Activity. Health.

scholarly journals The Association of Pulmonary Function, Physical Activity, Cardiorespiratory Fitness, Borg Dyspnea Scales and Health Related Quality of Life in Patients With Resected Lung Cancer

2021 ◽  
Author(s):  
Xinping Li ◽  
Yi Chen ◽  
Shuangchun Liu ◽  
Mingsheng Zhang
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Lung Cancer ◽  
Pulmonary Function ◽  
Cardiorespiratory Fitness ◽  
Health Related Quality ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related

Abstract Purpose This novel study aims to explore the relationship between pulmonary function, physical activity, cardiorespiratory fitness (CRF), dyspnea, and the health-related quality of life (HRQoL) of patients with resected lung cancer. Methods A cross-sectional study design with 38 lung cancer survivors after surgery for one month was conducted. We assessed CRF by measuring maximal oxygen consumption (VO2max) and anaerobic threshold (VT). Forced vital capacity (FVC) was measured using a spirometer. Physical activity, dyspnea, and HRQoL were investigated by 6-minute walking distance (6MWD), Borg dyspnea scales, and the SF-36 Health Survey (SF-36), respectively. Data analyses were conducted using SmartPLS to examine path analyses between the measures. Results There was a significant relationship between CRF and HRQoL in this cohort of cancer survivors. FVC (f2 = 0.265) and 6MWD (f2 = 0.389) have a medium to large effect size on the perceived CRF while CRF (f2 = 0.467) was found to have large effect sizes on perceived QoL. More importantly, our results showed that CRF positively and significantly mediated the paths between FVC, 6MWD, and HRQoL [β = 0.22 (0.457*0.474),P < 0.01; β = 0.28 (0.525*0.540), P < 0.01; respectively]. Conclusions Pulmonary function, physical activity, and dyspnea had an indirect effect on the quality of life in patients with resected lung cancer. Furthermore, CRF mediates pulmonary function and physical activity to produce an impact on their quality of life.

scholarly journals Specialist rehabilitation for people with Parkinson’s disease in the community: a randomised controlled trial

2014 ◽  
Vol 2 (51) ◽  
pp. 1-376 ◽  
Author(s):  
Heather Gage ◽  
Linda Grainger ◽  
Sharlene Ting ◽  
Peter Williams ◽  
Christina Chorley ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Well Being ◽  
Health Related Quality ◽  
Psychological Well Being ◽  
Related Quality ◽  
Health Related ◽  
Group A ◽  
Group B

BackgroundMultidisciplinary rehabilitation is recommended for Parkinson’s disease, but evidence suggests that benefit is not sustained.Objectives(1) Implement a specialist domiciliary rehabilitation service for people with Parkinson’s and carers. (2) Provide continuing support from trained care assistants to half receiving the rehabilitation. (3) Evaluate the clinical effectiveness of the service, and the value added by the care assistants, compared with usual care. (4) Assess the costs of the interventions. (5) Investigate the acceptability of the service. (6) Deliver guidance for commissioners.DesignPragmatic three-parallel group randomised controlled trial.SettingCommunity, county of Surrey, England, 2010–11.ParticipantsPeople with Parkinson’s, at all stages of the disease, and live-in carers.InterventionsGroups A and B received specialist rehabilitation from a multidisciplinary team (MDT) – comprising Parkinson’s nurse specialists, physiotherapists, occupational therapists, and speech and language therapists – delivered at home, tailored to individual needs, over 6 weeks (about 9 hours’ individual therapy per patient). In addition to the MDT, participants in group B received ongoing support for a further 4 months from a care assistant trained in Parkinson’s (PCA), embedded in the MDT (1 hour per week per patient). Participants in control group (C) received care as usual (no co-ordinated MDT or ongoing support).Main outcome measuresFollow-up assessments were conducted in participants’ homes at 6, 24 and 36 weeks after baseline. Primary outcomes: Self-Assessment Parkinson’s Disease Disability Scale (patients); the Modified Caregiver Strain Index (carers). Secondary outcomes included: for patients, disease-specific and generic health-related quality of life, psychological well-being, self-efficacy, mobility, falls and speech; for carers, strain, stress, health-related quality of life, psychological well-being and functioning.ResultsA total of 306 people with Parkinson’s (and 182 live-in carers) were randomised [group A,n = 102 (n = 61); group B,n = 101 (n = 60); group C,n = 103 (n = 61)], of whom 269 (155) were analysed at baseline, pilot cohort excluded. Attrition occurred at all stages. A per-protocol analysis [people with Parkinson’s,n = 227 (live-in carers,n = 125)] [group A,n = 75 (n = 45); group B,n = 69 (n = 37); group C,n = 83 (n = 43)] showed that, at the end of the MDT intervention, people with Parkinson’s in groups A and B, compared with group C, had reduced anxiety (p = 0.02); their carers had improved psychological well-being (p = 0.02). People with Parkinson’s in groups A and B also had marginally reduced disability (primary outcome,p = 0.09), and improved non-motor symptoms (p = 0.06) and health-related quality of life (p = 0.07), compared with C. There were significant differences in change scores between week 6 (end of MDT) and week 24 (end of PCA for group B) in favour of group B, owing to worsening in group A (no PCA support) in posture (p = 0.001); non-motor symptoms (p = 0.05); health-related quality of life (p = 0.07); and self-efficacy (p = 0.09). Carers in group B (vs. group A) reported a tendency for reduced strain (p = 0.06). At 36 weeks post recruitment, 3 months after the end of PCA support for group B, there were few differences between the groups. Participants reported learning about Parkinson’s, and valued individual attention. The MDT cost £833; PCA support was £600 extra, per patient (2011 Great British pounds).ConclusionsFurther research is needed into ways of sustaining benefits from rehabilitation including the use of care assistants.Study registrationCurrent Controlled Trials: ISRCTN44577970.FundingThis project was funded by the National Institute for Health Research Health Services and Delivery Research programme and the South East Coast Dementias and Neurodegenerative Disease Research Network (DeNDRoN), and the NHS South East Coast. The report will be published in full inHealth Services and Delivery Research; Vol. 2, No. 51. See the NIHR Journals Library website for further project information.

scholarly journals Evaluation of efficacy and safety of doxofylline 800mg sustained release tablet in treatment of patients with COPD: an open label, prospective and RCT

2018 ◽  
Vol 7 (4) ◽  
pp. 644
Author(s):  
Prakash Narayan Khandelwal ◽  
Syed H. Maaz ◽  
Dhammraj M. Borade
Keyword(s):  
Quality Of Life ◽  
Sustained Release ◽  
Outcome Measure ◽  
Health Related Quality ◽  
Sustained Release Tablet ◽  
Related Quality ◽  
Health Related ◽  
Group A ◽  
Group B

Background: COPD is a major cause of health care burden worldwide and leading cause of death that is increasing in prevalence. Methylxanthines are used in the treatment of patients with asthma and COPD. Doxofylline (methylxanthine) shows improved disease control, reduced total daily dose of inhaled b2 agonists and improved patient compliance.Methods: This was a prospective, open labelled, randomized, two-arm, parallel group, controlled, clinical trial. 115 patients were randomized to two groups. Patients in group A received tablet doxofylline 400mg BD whereas patients in group B received tablet doxofylline 800mg SR for 4 weeks. Primary outcome measure of trial was change in FEV1 and secondary outcome measure were change in FVC/FEV1, change in symptoms score, effect on health-related quality of life (HRQOL) and safety of study medication.Results: At 4 week the FEV1increase by 13.028% and 17.647% in group A and B respectively. In group A FEV1/FVC increase by 5.79% and in group B it increases by 9.57% at 4 weeks. The symptom score of cough decrease by 77.35% and 97.43% in group A and group B respectively at 4 weeks. In group A shortness of breath decrease by 77.60% and in group B it decreases by 95.90% at 4 weeks. Tightness in chest decrease by 86.29% and 98.40% in group A and group B respectively at 4 weeks.Conclusions:Doxofylline 800mg sustained release tablet provided significantly greater improvement in FEV1, symptomatic control and health related quality of life compared to doxofylline 400mg. 

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