scholarly journals A New Method to Make 24-Hour Urine Collection More Convenient: A Validity Study

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Pooneh Nabavizadeh ◽  
Shadi Ghadermarzi ◽  
Mohammad Fakhri
Keyword(s):  
Healthy Volunteers ◽  
Sampling Method ◽  
Urine Volume ◽  
New Method ◽  
Validity Study ◽  
Urine Collection ◽  
Protein Levels ◽  
Collection Device ◽  
Fixed Proportion ◽  
High Degree

Background and Objectives. This study proposes a novel urine collection device that can divide each urine collection into 20 parts and store and cool just one part. The aim of the current study is to compare measured biomarkers from the proposed urine collection device to those of conventional 24-hour sampling method. We also hypothesized that the new method would significantly increase patients’ adherence to the timed urine collection.Methods. Two 24-hour urine samples with the conventional method and with the new automated urine collection device that uses just one-twentieth of each void were obtained from 40 healthy volunteers. Urine parameters including volume, creatinine, and protein levels were compared between the two methods and the agreement of two measurements for each subject was reported through Bland-Altman plots.Results. Our results confirmed that for all three variables, there is a positive correlationP<0.001between the two measurements and high degree of agreement could be seen in Bland-Altman plots. Moreover, more subjects reported the new method as “more convenient” for 24-hour urine collection.Conclusions. Our results clearly indicate that a fixed proportion of each void may significantly reduce the urine volume in timed collections and this, in turn, may increase subjects’ adherence to this difficult sampling.

scholarly journals False elevations in urinary metanephrines: under-recognised pitfall with 24-hour urinary volume collection

2021 ◽  
Vol 14 (2) ◽  
pp. e241147
Author(s):  
Terry Shin ◽  
Thanh Duc Hoang ◽  
Mary Thomas Plunkett ◽  
Mohamed K M Shakir
Keyword(s):  
African American Woman ◽  
Urine Volume ◽  
American Woman ◽  
Secondary Hypertension ◽  
Reference Laboratory ◽  
Urine Collection ◽  
Urinary Volume ◽  
Normal Limits ◽  
Incorrect Diagnosis ◽  
Urinary Metanephrines

One pitfall in 24-hour urine collection is the input of incorrect urinary volume by the reference laboratory. This may lead to an incorrect diagnosis of pheochromocytoma or paraganglioma. A 48-year-old African-American woman was seen in the clinic for an elevated 24-hour urine metanephrine screen during workup for secondary hypertension. Urine volume was found to be incorrectly inputted by the lab as 9750 mL rather than 975 mL. The urinary metanephrines were then recalculated and the 24-hour urinary metanephrines resulted within normal limits. This case highlights this unique and potentially under-recognised error in testing with 24-hour urine volume collection.

THALLIUM POISONING

PEDIATRICS ◽  
1958 ◽  
Vol 22 (6) ◽  
pp. 1170-1182
Author(s):  
Philip H. Chamberlain ◽  
William B. Stavinoha ◽  
Helen Davis ◽  
William T. Kniker ◽  
Theodore C. Panos
Keyword(s):  
Urinary Excretion ◽  
Clinical Improvement ◽  
Clinical Picture ◽  
Urine Volume ◽  
Acute Onset ◽  
Neurologic Symptoms ◽  
Thallium Poisoning ◽  
High Degree

Fourteen children with thallium poisoning are described. Alopecia and neurologic symptoms dominate the clinical picture. In the absence of alopecia, the diagnosis depends upon a high degree of suspicion in regard to any child presenting bizarre neurologic complaints with acute onset. The best means of confirming a diagnosis of thallotoxicosis is by finding thallium in the urine. Dithizon appeared to be beneficial treatment in five of six severely ill patients. Further cautious trials of this drug are indicated. On the basis of the few patients studied, it appears that increased urinary excretion of thallium is not correlated with urine volume, clinical improvement or the use of dithizon.

scholarly journals The impact of lower urinary tract symptomatology on urine volumes in stone formers

2018 ◽  
Vol 13 (8) ◽  
Author(s):  
Nathan Y. Hoy ◽  
Nick S. Dean ◽  
Jeremy Wu ◽  
Timothy A. Wollin ◽  
Shubha K. De
Keyword(s):  
Urinary Tract ◽  
Urine Output ◽  
Lower Urinary Tract ◽  
Urine Volume ◽  
Urine Collection ◽  
Inclusion Criteria ◽  
Stone Formers ◽  
Number Of Patients ◽  
The Impact ◽  
Lower Urinary

Introduction: We aimed to determine if there is a correlation between International Prostate Symptom scores (IPSS) and 24-hour urine collection volumes, as patients experiencing lower urinary tract symptoms (LUTS) may have impaired ability to increase fluid intake for stone prevention.Methods: We conducted a single-centre, retrospective review was performed of stone-formers presenting from 2014‒2016. Inclusion criteria were completion of an IPSS questionnaire and a 24-hour urine collection. Exclusion criteria included symptomatic stone or urinary tract infection at time of IPSS completion, inadequate 24-hour collection, or incomplete IPSS questionnaire.Results: A total of 131 patients met inclusion criteria. Stratification by IPSS severity into mild (0‒7), moderate (8‒19), and severe (20‒35) yielded groups of n=96, 28, and 7, respectively. Linear regression modelling did not reveal a correlation between IPSS score and volume (p=0.10). When compared to those with adequate urine volumes (>2 L/day, n=65), low-volume patients (<1 L/day, n=10) had a significantly higher total IPSS (11.7 vs. 6.1; p=0.036). These groups showed significant differences in their responses to questions about incomplete emptying (p=0.031), intermittency (p=0.011), and stranguria (p=0.0020), with higher scores noted in the low urine output group.Conclusions: This study is the first to examine the correlation between IPSS and 24-hour urine volume. Though our data does not show a linear relationship between urine output and IPSS, those with lower urine volumes appear to have worse self-reported voiding symptoms when compared to those with adequate volumes (>2 L/day) for stone prevention. The overall number of patients in our study is relatively small, which may account for the lack of a relationship between IPSS and 24-hour urine volumes.

The Identification of Accelerated Coagulability

1977 ◽  
Author(s):  
J.A. Caprini ◽  
L. Zuckerman ◽  
E. Cohen ◽  
J.P. Vagher ◽  
V. Lipp
Keyword(s):  
General Population ◽  
Cancer Patients ◽  
Whole Blood ◽  
Clinical Applications ◽  
New Method ◽  
Blood Collection ◽  
Normal Individuals ◽  
Coagulation Tests ◽  
High Degree ◽  
Incorrect Classification

This report describes a new method for comparing overall clotting characteristics between normal individuals and those with proven malignancy using thrombelastographic (TEG) comparison of native and celite-activated specimens. Native whole blood TEG, celite-activated TEG, and standard coagulation tests were performed on the same blood collection in 90 normals and 90 patients with new malignancies and the results were used to derive a discriminate equation This equation classified correctly all 90 normals and 88 out of 90 cancer patients. The formulation was verified with an additional 82 patients with only one incorrect classification in the 31 cancer subjects. The standard coagulation tests did not discriminate without significant overlap between cancer patients and normals. The high degree of discrimination obtained with our TEG analysis provides a new tool to compare individual clotting differences that may have important clinical applications. However, the results cannot be extrapolated to selectively identify those with malignancy among the general population since many other stimuli may produce accelerated coagulability. This analysis does provide identification of accelerated coagulability in association with new malignancies.

A New Method for High-Degree Spline Interpolation: Proof of Continuity for Piecewise Polynomials

2019 ◽  
Vol 63 (3) ◽  
pp. 655-669
Author(s):  
A. Pepin ◽  
S. S. Beauchemin ◽  
S. Léger ◽  
N. Beaudoin
Keyword(s):  
Fourier Transform ◽  
Discrete Fourier Transform ◽  
Spline Interpolation ◽  
Higher Order ◽  
New Method ◽  
System Of Equations ◽  
Piecewise Polynomials ◽  
Odd Degree ◽  
High Degree

AbstractEffective and accurate high-degree spline interpolation is still a challenging task in today’s applications. Higher degree spline interpolation is not so commonly used, because it requires the knowledge of higher order derivatives at the nodes of a function on a given mesh.In this article, our goal is to demonstrate the continuity of the piecewise polynomials and their derivatives at the connecting points, obtained with a method initially developed by Beaudoin (1998, 2003) and Beauchemin (2003). This new method, involving the discrete Fourier transform (DFT/FFT), leads to higher degree spline interpolation for equally spaced data on an interval $[0,T]$. To do this, we analyze the singularities that may occur when solving the system of equations that enables the construction of splines of any degree. We also note an important difference between the odd-degree splines and even-degree splines. These results prove that Beaudoin and Beauchemin’s method leads to spline interpolation of any degree and that this new method could eventually be used to improve the accuracy of spline interpolation in traditional problems.

scholarly journals Cerebrospinal fluid examination may be useful in diagnosing neurosyphilis in asymptomatic HIV+ patients with syphilis

2016 ◽  
Vol 74 (2) ◽  
pp. 128-132 ◽  
Author(s):  
Ronald Salamano ◽  
Raquel Ballesté ◽  
Abayubá Perna ◽  
Natalia Rodriguez ◽  
Diego Lombardo ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Venereal Disease ◽  
Treponema Pallidum ◽  
Hiv Patients ◽  
Hemagglutination Assay ◽  
Protein Levels ◽  
Disease Research ◽  
Csf Analysis ◽  
High Degree ◽  
Asymptomatic Hiv

ABSTRACT Lumbar puncture in neurologically asymptomatic HIV+ patients is still under debate. There are different criteria for detecting neurosyphilis through cerebrospinal fluid (CSF), especially in cases that are negative through the Venereal Disease Research Laboratory (VDRL), regarding cellularity and protein content. However, a diagnosis of neurosyphilis can still exist despite negative VDRL. Treponema pallidum hemagglutination assay (TPHA) titers and application of the TPHA index in albumin and IgG improve the sensitivity, with a high degree of specificity. Thirty-two patients were selected for this study. VDRL was positive in five of them. The number of diagnoses reached 14 when the other techniques were added. It was not determined whether cellularity and increased protein levels were auxiliary tools in the diagnosis. According to our investigation, CSF analysis using the abovementioned techniques may be useful in diagnosing neurosyphilis in these patients.

In-Flight Urine Collection Device: Efficacy, Maintenance, and Complications in U-2 Pilots

2011 ◽  
Vol 82 (2) ◽  
pp. 116-122 ◽  
Author(s):  
Genevieve H. Von Thesling ◽  
Charles B. Coffman ◽  
Gregory L. Hundemer ◽  
Rory P. Stuart
Keyword(s):  
Urine Collection ◽  
Collection Device
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