scholarly journals Monocyte Subsets in Schistosomiasis Patients with Periportal Fibrosis

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Jamille Souza Fernandes ◽  
Maria Ilma Araujo ◽  
Diego Mota Lopes ◽  
Robson da Paixão de Souza ◽  
Edgar M. Carvalho ◽  
...  
Keyword(s):  
Experimental Studies ◽  
Protective Role ◽  
The Other ◽  
Monocyte Subsets ◽  
Periportal Fibrosis ◽  
Hla Dr ◽  
Low Levels ◽  
Classical Monocytes ◽  
Severe Fibrosis

A major issue withSchistosoma mansoniinfection is the development of periportal fibrosis, which is predominantly caused by the host immune response to egg antigens. Experimental studies have pointed to the participation of monocytes in the pathogenesis of liver fibrosis. The aim of this study was to characterize the subsets of monocytes in individuals with different degrees of periportal fibrosis secondary to schistosomiasis. Monocytes were classified into classical (CD14++CD16−), intermediate (CD14++CD16+), and nonclassical (CD14+CD16++). The expressions of monocyte markers and cytokines were assessed using flow cytometry. The frequency of classical monocytes was higher than the other subsets. The expression of HLA-DR, IL-6, TNF-α, and TGF-βwas higher in monocytes from individuals with moderate to severe fibrosis as compared to other groups. Although no differences were observed in receptors expression (IL-4R and IL-10R) between groups of patients, the expression of IL-12 was lower in monocytes from individuals with moderate to severe fibrosis, suggesting a protective role of this cytokine in the development of fibrosis. Our data support the hypothesis that the three different monocyte populations participate in the immunopathogenesis of periportal fibrosis, since they express high levels of proinflammatory and profibrotic cytokines and low levels of regulatory markers.

scholarly journals Effort investment in uncontrollable situations: The moderating role of motivation toward closure

2021 ◽  
Vol 45 (2) ◽  
pp. 186-196
Author(s):  
Paulina Szwed ◽  
Małgorzata Kossowska ◽  
Marcin Bukowski
Keyword(s):  
Blood Pressure ◽  
Experimental Studies ◽  
The Other ◽  
Need For Closure ◽  
Extra Effort ◽  
Moderating Role ◽  
Energy Conservation Principle ◽  
Principle Of Energy Conservation ◽  
Investment Behaviour

AbstractAccording to the principle of energy-conservation principle, effort investment is usually reduced in situations that are perceived as uncontrollable. This is because when success is recognized as impossible, any effortful actions are no longer justified. However, we predicted that individual differences in uncertainty tolerance, i.e., the need for closure (NFC), may moderate effort investment in uncontrollable situations. We tested this prediction in two experimental studies in which we exposed participants with differing levels of NFC to uncontrollable events, and indexed effort through the assessment of systolic blood pressure (SBP) responses. As predicted, in the uncontrollability (vs. controllability) condition, effort investment decreased significantly among low- but not high-NFC participants. Since gaining certainty and achieving closure is not a critical epistemic goal for low-NFC individuals, exerting extra effort to gain certainty is therefore no longer justified. On the other hand, high-NFC participants do not withhold their efforts, as they are highly motivated to obtain certainty. These results may help to account for contradictory findings in effort-investment behaviour and add substantively to the literature concerning motivation toward closure.

Identity, Community and Belonging in gcc States

2018 ◽  
Vol 6 (4) ◽  
pp. 401-428
Author(s):  
Miriam R. Lowi
Keyword(s):  
Religious Affiliation ◽  
Protective Role ◽  
The Other ◽  
National Project ◽  
Scholarly Literature ◽  
National Community ◽  
The Difference ◽  
Definition Of

Studies of identity and belonging in Gulf monarchies tend to privilege tribal or religious affiliation, if not the protective role of the ruler as paterfamilias. I focus instead on the ubiquitous foreigner and explore ways in which s/he contributes to the definition of national community in contemporary gcc states. Building upon and moving beyond the scholarly literature on imported labor in the Gulf, I suggest that the different ‘categories’ of foreigners impact identity and the consolidation of a community of privilege, in keeping with the national project of ruling families. Furthermore, I argue that the ‘European,’ the non-gcc Arab, and the predominantly Asian (and increasingly African) laborer play similar, but also distinct roles in the delineation of national community: while they are differentially incorporated in ways that protect the ‘nation’ and appease the citizen-subject, varying degrees of marginality reflect Gulf society’s perceptions or aspirations of the difference between itself and ‘the other(s).’

scholarly journals Physico-technical approach to design of composites from mineral and polymer technogenic resources

2015 ◽  
Vol 1 ◽  
pp. 162 ◽  
Author(s):  
Gotfrīds Noviks
Keyword(s):  
Composite Materials ◽  
Experimental Studies ◽  
Process Efficiency ◽  
Operating Characteristics ◽  
Forming Process ◽  
Polymer Waste ◽  
Composite Forming ◽  
Different Types ◽  
Low Levels

<p class="R-AbstractKeywords"><span lang="EN-US">Artificial composite materials are currently being produced in large quantities, they are diverse and they are widely used in the economy. There have been extensive theoretical and experimental studies of different types of components, developed the calculation methods of composites production with predefined properties.</span></p><p class="R-AbstractKeywords"><span lang="EN-US">At the same time industry produces a lot of mineral and polymer waste, which are practically technogenic resources, but their use is currently at quite low levels. The paper examines the possibilities to use technogenic resources- mineral (such as ash and clay) and organic (polymers -PET containers) for producing qualitative composite materials. For this purpose theoretical analysis and calculations of the physical properties of components and process parameters that determine the operating characteristics of the composite material were carried out.</span></p><p class="R-AbstractKeywords"><span lang="EN-US">Composite-forming process efficiency determinative parameters were analysed: adhesion, the specific surface energy, specific free surface, adsorption capacity and the degree of dispersion of the particles.</span></p><p class="R-AbstractKeywords"><span lang="EN-US">The role of external factors in processing of composite were examined – temperature, concentration of components.</span></p><p class="R-AbstractKeywords"><span lang="EN-US">The characteristics of prepared samples of composites showed the possibility to use these waste for the development of qualitative products for different purposes.</span></p>

scholarly journals Effects of Polyphenols in a Mediterranean Diet on Symptoms of Depression: A Systematic Literature Review

2019 ◽  
Vol 11 (3) ◽  
pp. 602-615 ◽  
Author(s):  
Jessica Bayes ◽  
Janet Schloss ◽  
David Sibbritt
Keyword(s):  
Depressive Symptoms ◽  
Literature Review ◽  
Mediterranean Diet ◽  
Systematic Literature Review ◽  
Experimental Studies ◽  
Protective Role ◽  
Original Research ◽  
Inclusion Criteria ◽  
Symptoms Of Depression

ABSTRACT Depression is a mood disorder which currently affects 350 million individuals worldwide. Recently, research has suggested a protective role of diet for depression. The Mediterranean-style dietary pattern has been highlighted in several systematic reviews as a promising candidate for reducing depressive symptoms. It has been speculated that this could be due to the high polyphenol content of foods commonly found in the diet. Therefore, the aim of this review was to assess the effects of polyphenols found in a Mediterranean diet on the symptoms of depression. A systematic literature review was conducted of original research which assessed the role of polyphenols on the symptoms of depression in humans. The following databases were searched: PROQUEST, SCOPUS (Elsevier), MEDLINE (EBSCO), CINAHL, and EMBase, up to 18 February, 2019. The inclusion criteria consisted of both observational and experimental research in adults aged 18–80 y that assessed depression scores in relation to polyphenol intake. A total of 37 studies out of 12,084 met the full inclusion criteria. Of these, 17 were experimental studies and 20 were observational studies. Several different polyphenols were assessed including those from tea, coffee, citrus, nuts, soy, grapes, legumes, and spices. Twenty-nine of the studies found a statistically significant effect of polyphenols for depression. This review has found both an association between polyphenol consumption and depression risk, as well as evidence suggesting polyphenols can effectively alleviate depressive symptoms. The review uncovered gaps in the literature regarding the role of polyphenols for depressive symptoms in both young adults and men. This review was registered at www.crd.york.ac.uk/PROSPERO as CRD42019125747.

The role of implicit learning in logo substitution

2019 ◽  
Vol 36 (5) ◽  
pp. 610-619 ◽  
Author(s):  
Rafal Ohme ◽  
Christo Boshoff
Keyword(s):  
Implicit Learning ◽  
Experimental Studies ◽  
Target Market ◽  
Human Beings ◽  
Content Type ◽  
Quasi Experimental ◽  
Low Levels ◽  
The Impact ◽  
A Company

Purpose Some marketers have challenged psychologists’ contention that human beings can only learn by using conscious effort. They argue that advertising can be effective at low levels of (or even no) attention. Also, despite the absence of (or low levels of) consciousness, these subconscious responses can be linked to brands. The purpose of this study is to investigate the impact of implicit learning in the context of logo substitution – an image that may not look like the original logo, and may not even be consciously associated with the original brand or its logo. Design/methodology/approach Data were collected by means of two quasi-experimental studies. Findings The results suggest that, thanks to implicit learning, logo substitution can be effective. Research limitations/implications One limitation was that data were collected from two relatively small convenience samples. Practical implications Logo substitution can be of value when a company faces a situation when advertising is banned or restricted, when the target market is saturated with marketing stimuli (clutter) and when there is a risk that aggressive advertising can lead to psychological reactance. The purpose of logo substitution would then be to unobtrusively activate mental representations closely related to the original logo. Originality/value The central contribution of this study is that it demonstrates how the principles of implicit social cognition, implicit learning and logo substitution can be used by marketers to overcome the undesirable and even adverse advertising circumstances they sometimes face.

scholarly journals The Effect of a Mediterranean Meal on Sprague Dawley Rats DMBA-Induced Mammary Tumors

2010 ◽  
Vol 3 ◽  
pp. CGM.S5894
Author(s):  
Paula C. Pereira ◽  
A. Filipa Vicente ◽  
Maria F. Mesquita ◽  
Antonio S. Cabrita
Keyword(s):  
Experimental Studies ◽  
Protective Role ◽  
Female Rats ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Total Cancer ◽  
Group A ◽  
Histopathologic Analysis ◽  
Group B

The present study intents to find a possible protective role of a Mediterranean type meal on mammary carcinogenesis. Several factors have been associated with breast cancer risk, genetics and environment are the most pointed out in epidemiologic and experimental studies. Diet is an environmental factor that can promote or prevent disease, being responsible for almost 35% of total cancer cases. A total of 72 female rats 50 days old were randomly divided in three groups of 24 rats and housed 4 in each plastic cage in a holding room under constant conditions of 22 ± 2 °C, 55 ± 10% humidity and a 12 h light/dark cycle. All the animals were submitted to the administration of 20 mg of 7, 12 dimethylbenzanthracene (DMBA) in olive oil, by gavages, except group A. The same defined standard food was provided for all the animals in group A and B, supplemented with a Mediterranean meal in group C. All the animals were sacrificed by the end of 150 days. Total carcinoma number did not differ significantly between Groups B and C and there were not found any neoplastic lesions in Group A. Most tumors showed a mixed architectural pattern, with cribriform and papillary areas, comedocarcinoma and necrosis was only seen in Group B. Histopathologic analysis showed that Group C tumors had lower mitotic activity and Pattern Grades, but higher Nuclear Grades. Mediterranean diet type meal showed lower Pattern Grades and lower Mitotic count in spite of that a higher nuclear pleomorphism was also found. Even so, tumors from Group C were better differentiated which can indicate lower malignancy.

The other side of the coin: The protective role of the TH2 cytokines

2001 ◽  
Vol 107 (5) ◽  
pp. 772-780 ◽  
Author(s):  
Fred D. Finkelman ◽  
Joseph F. Urban
Keyword(s):  
Protective Role ◽  
The Other ◽  
Th2 Cytokines

scholarly journals When and How Do Emotional Intelligence and Flourishing Protect against Suicide Risk in Adolescent Bullying Victims?

2019 ◽  
Vol 16 (12) ◽  
pp. 2114 ◽  
Author(s):  
Lourdes Rey ◽  
Sergio Mérida-López ◽  
Nicolás Sánchez-Álvarez ◽  
Natalio Extremera
Keyword(s):  
Emotional Intelligence ◽  
Suicide Risk ◽  
Current Knowledge ◽  
Protective Role ◽  
Proposed Model ◽  
Mediator Role ◽  
Low Levels ◽  
Bullying Victims ◽  
The Relationship

This study contributes to current knowledge on the protective role of emotional intelligence and flourishing in cases of suicide risk (namely depressive symptoms and suicidal ideation) in a sample of adolescent victims of traditional bullying. The proposed model tested the mediator role of flourishing in the relationship between emotional intelligence (EI) and suicide risk together with the moderating effect of EI in the relationship between low flourishing and increased suicide risk. Considering an initial sample of 1847 adolescents (52.5% female), a subsample of 494 pure bullying victims (61.3% female) took part in this research. The main results showed EI to be linked to decreased suicide risk through levels of flourishing. Moreover, EI buffered the relationship between low flourishing and the associated suicide risk. Victimized adolescents with both low levels of EI and of flourishing reported higher levels of suicide risk than their counterparts with high EI levels. This suggests the protective role of EI of both predicting higher flourishing and reducing the likelihood of suicide risk among victimized adolescents with low levels of flourishing. Finally, the practical implications of these novel findings regarding the role of EI and flourishing in the prevention of suicide risk among victimized adolescents are discussed.

scholarly journals The Protective Role of Heme Oxygenase-1 in Atherosclerotic Diseases

2019 ◽  
Vol 20 (15) ◽  
pp. 3628 ◽  
Author(s):  
Yoshimi Kishimoto ◽  
Kazuo Kondo ◽  
Yukihiko Momiyama
Keyword(s):  
Animal Models ◽  
Heme Oxygenase ◽  
Protective Role ◽  
Heme Oxygenase 1 ◽  
Intracellular Enzyme ◽  
Anti Oxidant ◽  
Low Levels ◽  
Artery Disease ◽  
Accelerate Atherosclerosis

Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate ferrous iron, carbon monoxide (CO), and biliverdin, which is subsequently converted to bilirubin. These products have anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-thrombotic properties. Although HO-1 is expressed at low levels in most tissues under basal conditions, it is highly inducible in response to various pathophysiological stresses/stimuli. HO-1 induction is thus thought to be an adaptive defense system that functions to protect cells and tissues against injury in many disease settings. In atherosclerosis, HO-1 may play a protective role against the progression of atherosclerosis, mainly due to the degradation of pro-oxidant heme, the generation of anti-oxidants biliverdin and bilirubin and the production of vasodilator CO. In animal models, a lack of HO-1 was shown to accelerate atherosclerosis, whereas HO-1 induction reduced atherosclerosis. It was also reported that HO-1 induction improved the cardiac function and postinfarction survival in animal models of heart failure or myocardial infarction. Recently, we and others examined blood HO-1 levels in patients with atherosclerotic diseases, e.g., coronary artery disease (CAD) and peripheral artery disease (PAD). Taken together, these findings to date support the notion that HO-1 plays a protective role against the progression of atherosclerotic diseases. This review summarizes the roles of HO-1 in atherosclerosis and focuses on the clinical studies that examined the relationships between HO-1 levels and atherosclerotic diseases.

scholarly journals Exposure risk to carbonyl compounds and furfuryl alcohol through the consumption of sparkling wines

2019 ◽  
Vol 49 (3) ◽  
Author(s):  
Gabriela Pelizza Peterle ◽  
Karolina Cardoso Hernandes ◽  
Luana Schmidt ◽  
Júlia Barreto Hoffmann Maciel ◽  
Claudia Alcaraz Zini ◽  
...  
Keyword(s):  
Environmental Contamination ◽  
Carbonyl Compounds ◽  
Furfuryl Alcohol ◽  
Ethyl Carbamate ◽  
The Other ◽  
Exposure Risk ◽  
Low Levels ◽  
First Time

ABSTRACT: The goals of this study were to verify the occurrence of furfuryl alcohol (FA) and carbonyl compounds (acetaldehyde, acrolein, ethyl carbamate (EC), formaldehyde and furfural) in sparkling wines and to evaluate, for the first time, whether the consumption of the samples under study could represent risk to consumers health. These compounds are electrophilic; and therefore, may covalently bind to DNA, which may result in mutagenicity. EC and formaldehyde were present at low levels (<1μg L-1) in all samples. Acetaldehyde, furfural and acrolein were also found in low levels (<1.5, 1.4 and 1.0μg L-1, respectively) in 57, 71 and 76% of samples. In the other samples, levels of acetaldehyde, furfural and acrolein ranged from 5.2 to 54.8, 10.5 to 41.0 and 20.3 to 36.7μg L-1, respectively. Furfuryl alcohol was also reported in all samples in levels from 10.4 to 33.5μg L-1. Acrolein was the only compound reported at levels sufficient to represent risk to health, which occurred in 24% of the samples. A study focused on the origin of acrolein deserves attention, investigating the influence of the concentration of precursors and the role of fermentation in the formation of this aldehyde, besides the evaluation of possible environmental contamination of grapes during cultivation.

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