scholarly journals Effect of Extracts ofTerminalia chebulaon Proliferation of Keratinocytes and Fibroblasts Cells: An Alternative Approach for Wound Healing

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Dolly Singh ◽  
Deepti Singh ◽  
Soon Mo Choi ◽  
Sun Mi Zo ◽  
Rakesh Mohan Painuli ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Wound Healing ◽  
Free Radical ◽  
Radical Scavenging ◽  
Ammonia Toxicity ◽  
Limiting Factor ◽  
Traditional Medicines ◽  
Cytoskeletal Structure ◽  
The Media ◽  
Radical Scavenging Ability

Terminalia chebulais one of the traditional medicines used in the treatment of many diseases. In the present work, different concentrations of various organic and aqueous extracts (solvent-free) ofT. chebulawere tested on fibroblast (L929) and keratinocytes cells to evaluate its biocompatible concentration by using MTT and live-dead viability/cytotoxic assay. These extracts were found to be effective in decreasing the ammonia accumulation in the media, thereby reducing its toxic effect on cells. DPPH assay further confirmed the free-radical scavenging ability of the extracts which increased with the increase in concentration of each extract. Cell proliferation/apoptosis, cytoskeletal structure, and ECM production were further evaluated by live-dead assay and phalloidin/cytokeratin staining, respectively. The cytoskeletal structure and ECM secretion of the cells treated with extracts showed higher cellular activity in comparison to control. In conclusion, we have demonstrated the effect of these extracts ofT. chebulaon both types of skin cells and optimized concentration in which it could be used as a bioactive component for wound healing applications by increasing cell proliferation and decreasing free-radical production without affecting the normal cellular matrix. It can also find applications in other therapeutics applications where ammonia toxicity is a limiting factor.

scholarly journals Awareness on the wound healing effects of curcumin therapy among dental students

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 545-548
Author(s):  
Nithyanandham Masilamani ◽  
Dhanraj Ganapathy
Keyword(s):  
Wound Healing ◽  
Free Radical ◽  
Curcuma Longa ◽  
Radical Scavenging ◽  
Cross Sectional Study ◽  
Dental Students ◽  
Free Radical Scavenging ◽  
Cross Sectional ◽  
Traditional Medicines ◽  
Collagen Expression

Turmeric also known as Curcuma longa is a rhizome used commonly in traditional medicines for decades to treat a number of inflammatory disorders and other ailments. Its therapeutic properties were primarily attributable to curcuminoids. The purpose of the study was for assessment of awareness of Curcumin's wound healing effects amongst dental students. A cross sectional study was done with a self-administered questionnaire comprising of 10 questions circulated among 100 dental students. The questionnaire assessed the awareness about wound healing effects Curcumin therapy, their effect on collagen expression, the effect on neovascularization, effect on reepithelization and effect on free radical scavenging. The responses were recorded and analysed.78% of the respondents were not aware of the wound healing effects of curcumin therapy. 84% were not aware of the effect of curcumin in collagen expression. 88% were not aware of the effect of curcumin on neovascularization. 80% were not aware of the effect of curcumin on reepithelization. 94% were not aware of the effect of curcumin on free radical scavenging. The awareness about the use of Curcumin therapy in wound healing applications is very less among dental students. Increased awareness programs and sensitization and continuing dental education programs along with greater importance to the curricular modifications should be incorporated to improve the awareness levels.

scholarly journals Research antioxidant activity of chitooligosacchride by UV-VIS absorption spectrocopy

2020 ◽  
Vol 8 (1) ◽  
pp. 75-81
Author(s):  
Bui Van Hoai ◽  
Ngo Dai Nghiep ◽  
Dao An Quang ◽  
Nguyen Thi Nam Phuong
Keyword(s):  
Molecular Weight ◽  
Antioxidant Activity ◽  
Absorption Spectrum ◽  
Free Radical ◽  
Trichoderma Viride ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Free Radical Scavenging ◽  
Degree Of Deacetylation ◽  
Radical Scavenging Ability

Chitosan with 80% degree of deacetylation was hydrolyzed by cellulase of Trichoderma viride to prepare chitooligosaccharides (COSs) by the fractionation of the COSs with ultrafiltration membrane. The antioxidant activities of the COSs were clarified in this study by reducing power and free radical scavenging ability assay by UV-VIS absorption spectrum. The results show that the COS 1 (10,000-5,000 Da), COS 2 (5,000-3,000 Da), COS 3 (3,000-1,000 Da) and COS 4 (less than1,000 Da) segments have antioxidant properties.The antioxidant activitives of the COSs increased with the increment of concentration, and they also depended on molecular weight.

Hydroxyl functionalized carbon dots with strong radical scavenging ability promote cell proliferation

2019 ◽  
Vol 6 (6) ◽  
pp. 065030 ◽  
Author(s):  
Fang Lu ◽  
Siwei Yang ◽  
Yuxiang Song ◽  
Changming Zhai ◽  
Qingguo Wang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Carbon Dots ◽  
Radical Scavenging ◽  
Promote Cell Proliferation ◽  
Radical Scavenging Ability

Potential hepatoprotective effects of fullerenol nanoparticles on alcohol-induced oxidative stress by ROS

RSC Advances ◽  
2016 ◽  
Vol 6 (37) ◽  
pp. 31122-31130 ◽  
Author(s):  
Y. Li ◽  
H. B. Luo ◽  
H. Y. Zhang ◽  
Q. Guo ◽  
H. C. Yao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Hepatoprotective Effects ◽  
Radical Scavenging Ability

The free radical scavenging ability of fullerenols is their most exploited property in biomedical studies.

scholarly journals Construction of poly(dopamine) doped oligopeptide hydrogel

RSC Advances ◽  
2017 ◽  
Vol 7 (80) ◽  
pp. 50425-50429 ◽  
Author(s):  
Chen-Ming Zhang ◽  
Si-Yong Qin ◽  
Yin-Jia Cheng ◽  
Ai-Qing Zhang
Keyword(s):  
Free Radical ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Radical Scavenging Ability

Incorporation of poly(dopamine) (PDA) into the native oligopeptide hydrogel not only improve the rigidity but also endow the hydrogel with efficient free radical scavenging ability.

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